(Q35887425)

English

Design of substituted bis-Tetrahydrofuran (bis-THF)-derived Potent HIV-1 Protease Inhibitors, Protein-ligand X-ray Structure, and Convenient Syntheses of bis-THF and Substituted bis-THF Ligands

scientific article published in April 2011

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scholarly article

1 reference

Europe PubMed Central

10 August 2017

Design of substituted bis-Tetrahydrofuran (bis-THF)-derived Potent HIV-1 Protease Inhibitors, Protein-ligand X-ray Structure, and Convenient Syntheses of bis-THF and Substituted bis-THF Ligands (English)

1 reference

Europe PubMed Central

10 August 2017

0 references

object named as

Masayuki Amano

6

1 reference

ORCID Public Data File 2021

7

object named as

Irene T Weber

1 reference

Europe PubMed Central

10 August 2017

author name string

Arun K Ghosh

1

1 reference

Europe PubMed Central

10 August 2017

Cuthbert D Martyr

2

1 reference

Europe PubMed Central

10 August 2017

Melinda Steffey

3

1 reference

Europe PubMed Central

10 August 2017

Yuan-Fang Wang

4

1 reference

Europe PubMed Central

10 August 2017

Johnson Agniswamy

5

1 reference

Europe PubMed Central

10 August 2017

Hiroaki Mitsuya

8

1 reference

Europe PubMed Central

10 August 2017

language of work or name

1 reference

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publication date

1 April 2011

1 reference

Europe PubMed Central

10 August 2017

ACS Medicinal Chemistry Letters

1 reference

Europe PubMed Central

10 August 2017

2

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Europe PubMed Central

10 August 2017

4

1 reference

Europe PubMed Central

10 August 2017

298-302

1 reference

Europe PubMed Central

10 August 2017

Subtype polymorphisms among HIV-1 protease variants confer altered flap conformations and flexibility

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=3325757

11 July 2018

Harnessing nature's insight: design of aspartyl protease inhibitors from treatment of drug-resistant HIV to Alzheimer's disease

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=3325757

11 July 2018

High-resolution structure of unbound human immunodeficiency virus 1 subtype C protease: implications of flap dynamics and drug resistance

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=3325757

11 July 2018

Design of HIV protease inhibitors targeting protein backbone: an effective strategy for combating drug resistance

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=3325757

11 July 2018

Potent New Antiviral Compound Shows Similar Inhibition and Structural Interactions with Drug Resistant Mutants and Wild Type HIV-1 Protease †

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=3325757

11 July 2018

Bis-tetrahydrofuran: a privileged ligand for darunavir and a new generation of hiv protease inhibitors that combat drug resistance

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=3325757

11 July 2018

Novel bis-tetrahydrofuranylurethane-containing nonpeptidic protease inhibitor (PI) UIC-94017 (TMC114) with potent activity against multi-PI-resistant human immunodeficiency virus in vitro.

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=3325757

11 July 2018

A potent human immunodeficiency virus type 1 protease inhibitor, UIC-94003 (TMC-126), and selection of a novel (A28S) mutation in the protease active site

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=3325757

11 July 2018

Nonpeptidal P2 ligands for HIV protease inhibitors: structure-based design, synthesis, and biological evaluation

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=3325757

11 July 2018

Potential inhibitors of S-adenosylmethionine-dependent methyltransferases. 11. Molecular dissections of neplanocin A as potential inhibitors of S-adenosylhomocysteine hydrolase

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=3325757

11 July 2018

A simple, continuous fluorometric assay for HIV protease

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=3325757

11 July 2018

Ultra-potent P1 modified arylsulfonamide HIV protease inhibitors: the discovery of GW0385.

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=3325757

24 September 2018

Stereoselective photochemical 1,3-dioxolane addition to 5-alkoxymethyl-2(5H)-furanone: synthesis of bis-tetrahydrofuranyl ligand for HIV protease inhibitor UIC-94017 (TMC-114).

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=3325757

24 September 2018

High resolution crystal structures of HIV-1 protease with a potent non-peptide inhibitor (UIC-94017) active against multi-drug-resistant clinical strains

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=3325757

24 September 2018

Stereoselective and efficient synthesis of (3R,3aS,6aR)-hexahydrofuro[2,3-b]furan-3-ol

1 reference

https://pubmed.ncbi.nlm.nih.gov/22509432

12 December 2020

based on heuristic

inferred from PubMed ID database lookup

Mechanism of drug resistance revealed by the crystal structure of the unliganded HIV-1 protease with F53L mutation

1 reference

https://pubmed.ncbi.nlm.nih.gov/22509432

12 December 2020

based on heuristic

inferred from PubMed ID database lookup

Suppression of HIV-1 protease inhibitor resistance by phosphonate-mediated solvent anchoring

1 reference

https://pubmed.ncbi.nlm.nih.gov/22509432

12 December 2020

based on heuristic

inferred from PubMed ID database lookup

SYNTHESIS AND OPTICAL RESOLUTION OF HIGH AFFINITY P2-LIGANDS FOR HIV-1 PROTEASE INHIBITORS

1 reference

https://pubmed.ncbi.nlm.nih.gov/22509432

12 December 2020

based on heuristic

inferred from PubMed ID database lookup

A Stereoselective Anti-Aldol Route to (3R,3aS,6aR)-Hexahydrofuro[2,3-b] furan-3-ol: A Key Ligand for a New Generation of HIV Protease Inhibitors

1 reference

https://pubmed.ncbi.nlm.nih.gov/22509432

12 December 2020

based on heuristic

inferred from PubMed ID database lookup

Identifiers

10.1021/ML100289M

1 reference

Europe PubMed Central

10 August 2017

1 reference

Europe PubMed Central

10 August 2017

1 reference

Europe PubMed Central

10 August 2017

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