(Q35900943)

English

JS-K, a GST-activated nitric oxide generator, induces DNA double-strand breaks, activates DNA damage response pathways, and induces apoptosis in vitro and in vivo in human multiple myeloma cells

scientific article published on 23 March 2007

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scholarly article

1 reference

Europe PubMed Central

PMC publication ID

11 August 2017

JS-K, a GST-activated nitric oxide generator, induces DNA double-strand breaks, activates DNA damage response pathways, and induces apoptosis in vitro and in vivo in human multiple myeloma cells (English)

1 reference

Europe PubMed Central

PMC publication ID

11 August 2017

0 references

multiple myeloma

1 reference

based on heuristic

inferred from title

apoptotic process

1 reference

based on heuristic

inferred from title

Kenneth C. Anderson

18

object named as

Kenneth C Anderson

1 reference

Europe PubMed Central

PMC publication ID

11 August 2017

Tanyel Kiziltepe

1

object named as

Tanyel Kiziltepe

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11 August 2017

author name string

Teru Hideshima

2

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11 August 2017

Kenji Ishitsuka

3

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11 August 2017

Enrique M Ocio

4

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11 August 2017

Noopur Raje

5

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11 August 2017

Laurence Catley

6

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11 August 2017

Chun-Qi Li

7

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11 August 2017

Laura J Trudel

8

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11 August 2017

Hiroshi Yasui

9

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11 August 2017

Sonia Vallet

10

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11 August 2017

Jeffery L Kutok

11

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11 August 2017

Dharminder Chauhan

12

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11 August 2017

Constantine S Mitsiades

13

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11 August 2017

Joseph E Saavedra

14

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11 August 2017

Gerald N Wogan

15

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11 August 2017

Larry K Keefer

16

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11 August 2017

Paul J Shami

17

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11 August 2017

language of work or name

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publication date

23 March 2007

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Europe PubMed Central

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11 August 2017

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Europe PubMed Central

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11 August 2017

110

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11 August 2017

2

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11 August 2017

709-718

1 reference

Europe PubMed Central

PMC publication ID

11 August 2017

Threshold effects of nitric oxide-induced toxicity and cellular responses in wild-type and p53-null human lymphoblastoid cells

1 reference

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27 July 2018

DNA damage checkpoints in mammals

1 reference

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Targeting chk2 kinase: molecular interaction maps and therapeutic rationale

1 reference

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The two edges of the ATM sword: co-operation between repair and checkpoint functions

1 reference

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27 July 2018

Perspectives for combination therapy to overcome drug-resistant multiple myeloma

1 reference

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27 July 2018

Nitric oxide as a modulator of apoptosis

1 reference

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27 July 2018

Advances in biology of multiple myeloma: clinical applications

1 reference

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Phosphorylation of BCL-2 regulates ER Ca2+ homeostasis and apoptosis.

1 reference

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A double-strand break repair defect in ATM-deficient cells contributes to radiosensitivity

1 reference

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The role of glutathione-S-transferase in anti-cancer drug resistance

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Pathways of DNA double-strand break repair during the mammalian cell cycle

1 reference

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Novel therapeutic approaches for multiple myeloma

1 reference

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A phase 2 study of bortezomib in relapsed, refractory myeloma

1 reference

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27 July 2018

Apoptosis induced by topoisomerase inhibitors

1 reference

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27 July 2018

JS-K, a glutathione/glutathione S-transferase-activated nitric oxide donor of the diazeniumdiolate class with potent antineoplastic activity

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=1924477

27 July 2018

Molecular mechanisms of novel therapeutic approaches for multiple myeloma

1 reference

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27 July 2018

Proteasome inhibitor PS-341 inhibits human myeloma cell growth in vivo and prolongs survival in a murine model

1 reference

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27 July 2018

Sensing and repairing DNA double-strand breaks

1 reference

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27 July 2018

ATM phosphorylates histone H2AX in response to DNA double-strand breaks

1 reference

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27 July 2018

The regulatory role of nitric oxide in apoptosis

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=1924477

27 July 2018

SHP2 mediates the protective effect of interleukin-6 against dexamethasone-induced apoptosis in multiple myeloma cells

1 reference

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27 July 2018

DNA damage-induced activation of p53 by the checkpoint kinase Chk2

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=1924477

27 July 2018

Cell adhesion mediated drug resistance (CAM-DR): role of integrins and resistance to apoptosis in human myeloma cell lines

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=1924477

27 July 2018

The role of the stress-activated protein kinase (SAPK/JNK) signaling pathway in radiation-induced apoptosis

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=1924477

27 July 2018

Mitogen-activated protein kinase cascades as regulators of stress responses

1 reference

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27 July 2018

Interleukin-6-induced inhibition of multiple myeloma cell apoptosis: support for the hypothesis that protection is mediated via inhibition of the JNK/SAPK pathway.

1 reference

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Structure, catalytic mechanism, and evolution of the glutathione transferases

1 reference

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27 July 2018

DNA damage by nitric oxide

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=1924477

27 July 2018

Chemoresistance and multiple myeloma: from biological to clinical aspects

1 reference

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27 July 2018

Interleukin-6 in human multiple myeloma.

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=1924477

27 July 2018

Insulin and IGF-1 increase mitogenesis and glucose metabolism in the multiple myeloma cell line, RPMI 8226

1 reference

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27 July 2018

Molecular mechanisms of mammalian DNA repair and the DNA damage checkpoints

1 reference

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24 September 2018

Inhibition of the insulin-like growth factor receptor-1 tyrosine kinase activity as a therapeutic strategy for multiple myeloma, other hematologic malignancies, and solid tumors

1 reference

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Identification of genes modulated in multiple myeloma using genetically identical twin samples

1 reference

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24 September 2018

MAPK pathways in radiation responses

1 reference

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Thalidomide and immunomodulatory drugs as cancer therapy

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Molecular mechanisms mediating antimyeloma activity of proteasome inhibitor PS-341.

1 reference

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24 September 2018

Immunomodulatory drug CC-5013 overcomes drug resistance and is well tolerated in patients with relapsed multiple myeloma

1 reference

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Activation of NF-kappaB and upregulation of intracellular anti-apoptotic proteins via the IGF-1/Akt signaling in human multiple myeloma cells: therapeutic implications

1 reference

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Genotoxicity, mitochondrial damage, and apoptosis in human lymphoblastoid cells exposed to peroxynitrite generated from SIN-1.

1 reference

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Biologic sequelae of interleukin-6 induced PI3-K/Akt signaling in multiple myeloma

1 reference

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The secondary amine/nitric oxide complex ion R(2)N[N(O)NO](-) as nucleophile and leaving group in S9N)Ar reactions

1 reference

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Regulation of the G2/M transition by p53.

1 reference

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The proteasome inhibitor PS-341 inhibits growth, induces apoptosis, and overcomes drug resistance in human multiple myeloma cells.

1 reference

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DNA-PK, ATM and ATR as sensors of DNA damage: variations on a theme?

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The human homologs of checkpoint kinases Chk1 and Cds1 (Chk2) phosphorylate p53 at multiple DNA damage-inducible sites

1 reference

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A mechanistic analysis of nitric oxide-induced cellular toxicity

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High-resolution genomic profiles define distinct clinico-pathogenetic subgroups of multiple myeloma patients

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Interleukin-6 inhibits Fas-induced apoptosis and stress-activated protein kinase activation in multiple myeloma cells

1 reference

https://pubmed.ncbi.nlm.nih.gov/17384201

12 December 2020

based on heuristic

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Thalidomide--a revival story

1 reference

https://pubmed.ncbi.nlm.nih.gov/17384201

12 December 2020

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inferred from PubMed ID database lookup

Glutathione S-transferases as emerging therapeutic targets

1 reference

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12 December 2020

based on heuristic

inferred from PubMed ID database lookup

Identifiers

10.1182/BLOOD-2006-10-052845

1 reference

Europe PubMed Central

PMC publication ID

11 August 2017

PMC publication ID

1 reference

Europe PubMed Central

PMC publication ID

11 August 2017

PubMed publication ID

1 reference

Europe PubMed Central

PMC publication ID

11 August 2017

ResearchGate publication ID

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