(Q35913613)

English

Phase II trial of the mTOR inhibitor, temsirolimus and evaluation of circulating tumor cells and tumor biomarkers in persistent and recurrent epithelial ovarian and primary peritoneal malignancies: a Gynecologic Oncology Group study.

scientific article published on 12 July 2011

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7 February 2020

Phase II trial of the mTOR inhibitor, temsirolimus and evaluation of circulating tumor cells and tumor biomarkers in persistent and recurrent epithelial ovarian and primary peritoneal malignancies: a Gynecologic Oncology Group study (English)

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7 February 2020

phase II clinical trial

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gynecologic oncology

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based on heuristic

inferred from title

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7 February 2020

R Katherine Alpaugh

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R Katherine Alpaugh

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Michael W Sill

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Kathleen M Darcy

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Stephen C Rubin

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Robert S Mannel

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7 February 2020

Steven Waggoner

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7 February 2020

Russell J Schilder

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Kathy Q Cai

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Andrew K Godwin

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12 July 2011

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7 February 2020

Gynecologic Oncology

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7 February 2020

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7 February 2020

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7 February 2020

19-26

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7 February 2020

A Gynecologic Oncology Group phase II trial of the protein kinase C-beta inhibitor, enzastaurin and evaluation of markers with potential predictive and prognostic value in persistent or recurrent epithelial ovarian and primary peritoneal malignancie

1 reference

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1 reference

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1 reference

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1 reference

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11 July 2018

mTOR is a promising therapeutic target both in cisplatin-sensitive and cisplatin-resistant clear cell carcinoma of the ovary

1 reference

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1 reference

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Current status on biologic therapies in the treatment of epithelial ovarian cancer

1 reference

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Active-site inhibitors of mTOR target rapamycin-resistant outputs of mTORC1 and mTORC2

1 reference

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Relationship of circulating tumor cells to tumor response, progression-free survival, and overall survival in patients with metastatic colorectal cancer

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Cancer statistics, 2008

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Phase II trial of bevacizumab in persistent or recurrent epithelial ovarian cancer or primary peritoneal cancer: a Gynecologic Oncology Group Study

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Integrating circulating tumor cell assays into the management of breast cancer

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RAD001 inhibits human ovarian cancer cell proliferation, enhances cisplatin-induced apoptosis, and prolongs survival in an ovarian cancer model

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In vivo quantitation of rare circulating tumor cells by multiphoton intravital flow cytometry

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Isolation and characterization of circulating tumor cells in patients with metastatic colorectal cancer

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Ras, PI(3)K and mTOR signalling controls tumour cell growth

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Systemic therapy for ovarian cancer: current status and new treatments

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Mammalian target of rapamycin as a therapeutic target in leukemia

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Epithelial ovarian cancer: a review of current management

1 reference

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Detection of circulating tumor cells from renal carcinoma patients: experiences of a two-center study.

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Tumor cells circulate in the peripheral blood of all major carcinomas but not in healthy subjects or patients with nonmalignant diseases

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Upstream and downstream of mTOR

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In vivo antitumor effects of the mTOR inhibitor CCI-779 against human multiple myeloma cells in a xenograft model

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AKT and mTOR phosphorylation is frequently detected in ovarian cancer and can be targeted to disrupt ovarian tumor cell growth

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Clinical development of mammalian target of rapamycin inhibitors

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[Rapamycin and CCI-779]

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1 reference

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12 December 2020

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10.1016/J.YGYNO.2011.06.022

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7 February 2020

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7 February 2020

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Europe PubMed Central

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7 February 2020

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