(Q35925687)

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In vivo phosphorylation site mapping in mouse cardiac troponin I by high resolution top-down electron capture dissociation mass spectrometry: Ser22/23 are the only sites basally phosphorylated.

scientific article published in September 2009

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3 February 2020

In vivo phosphorylation site mapping in mouse cardiac troponin I by high resolution top-down electron capture dissociation mass spectrometry: Ser22/23 are the only sites basally phosphorylated (English)

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3 February 2020

phosphorylation

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Şerife Ayaz-Güner

1

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3 February 2020

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Jiang Zhang

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3 February 2020

Lin Li

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3 February 2020

Jeffery W Walker

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3 February 2020

Ying Ge

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3 February 2020

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1 September 2009

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3 February 2020

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3 February 2020

48

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3 February 2020

34

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3 February 2020

8161-8170

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3 February 2020

Cardiac myofilaments: from proteome to pathophysiology

1 reference

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1 reference

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1 reference

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2 October 2017

Single amino acid sequence polymorphisms in rat cardiac troponin revealed by top-down tandem mass spectrometry

1 reference

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Quantitative phosphoproteomics by mass spectrometry: past, present, and future

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Multiplex kinase signaling modifies cardiac function at the level of sarcomeric proteins

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Combinatorial modification of human histone H4 quantitated by two-dimensional liquid chromatography coupled with top down mass spectrometry.

1 reference

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2 October 2017

Sarcomeric dysfunction in heart failure.

1 reference

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2 October 2017

Decoding protein modifications using top-down mass spectrometry

1 reference

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2 October 2017

Chemistry. Mass spectrometry: bottom-up or top-down?

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Population proteomics: the concept, attributes, and potential for cancer biomarker research

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2 October 2017

Partial replacement of cardiac troponin I with a non-phosphorylatable mutant at serines 43/45 attenuates the contractile dysfunction associated with PKCepsilon phosphorylation

1 reference

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2 October 2017

Troponin: the biomarker of choice for the detection of cardiac injury

1 reference

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2 October 2017

Functional effects of rho-kinase-dependent phosphorylation of specific sites on cardiac troponin

1 reference

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2 October 2017

Regulation of cardiac contractile function by troponin I phosphorylation

1 reference

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2 October 2017

Genetic causes of human heart failure

1 reference

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2 October 2017

Calcium, thin filaments, and the integrative biology of cardiac contractility

1 reference

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2 October 2017

A non-equilibrium isoelectric focusing method to determine states of phosphorylation of cardiac troponin I: identification of Ser-23 and Ser-24 as significant sites of phosphorylation by protein kinase C

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=3341416

2 October 2017

Protein kinase D is a novel mediator of cardiac troponin I phosphorylation and regulates myofilament function

1 reference

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2 October 2017

Protein kinase Cepsilon overexpression alters myofilament properties and composition during the progression of heart failure

1 reference

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2 October 2017

Global quantitative phosphoprotein analysis using Multiplexed Proteomics technology

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=3341416

2 October 2017

Structure of the core domain of human cardiac troponin in the Ca(2+)-saturated form

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=3341416

2 October 2017

Kinases as therapeutic targets for heart failure

1 reference

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2 October 2017

Phosphorylation or glutamic acid substitution at protein kinase C sites on cardiac troponin I differentially depress myofilament tension and shortening velocity

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=3341416

2 October 2017

Increased Ca2+-sensitivity of the contractile apparatus in end-stage human heart failure results from altered phosphorylation of contractile proteins

1 reference

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2 October 2017

Transgenic mouse model of stunned myocardium

1 reference

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2 October 2017

Troponin I degradation and covalent complex formation accompanies myocardial ischemia/reperfusion injury

1 reference

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2 October 2017

Cardiac troponin I gene knockout: a mouse model of myocardial troponin I deficiency

1 reference

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2 October 2017

In vivo phosphorylation of cardiac troponin I by protein kinase Cbeta2 decreases cardiomyocyte calcium responsiveness and contractility in transgenic mouse hearts

1 reference

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2 October 2017

Phosphorylation specificities of protein kinase C isozymes for bovine cardiac troponin I and troponin T and sites within these proteins and regulation of myofilament properties

1 reference

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2 October 2017

Myofibrillar calcium sensitivity of isometric tension is increased in human dilated cardiomyopathies: role of altered beta-adrenergically mediated protein phosphorylation

1 reference

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Cardiac troponin I mutants. Phosphorylation by protein kinases C and A and regulation of Ca(2+)-stimulated MgATPase of reconstituted actomyosin S-1

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Infrared multiphoton dissociation of large multiply charged ions for biomolecule sequencing

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Identification of sites phosphorylated in bovine cardiac troponin I and troponin T by protein kinase C and comparative substrate activity of synthetic peptides containing the phosphorylation sites

1 reference

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2 October 2017

Unraveling molecular complexity of phosphorylated human cardiac troponin I by top down electron capture dissociation/electron transfer dissociation mass spectrometry

1 reference

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11 July 2018

In vivo and in vitro analysis of cardiac troponin I phosphorylation

1 reference

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11 July 2018

p21-activated kinase increases the calcium sensitivity of rat triton-skinned cardiac muscle fiber bundles via a mechanism potentially involving novel phosphorylation of troponin I.

1 reference

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Phosphorylation of troponin I and the inotropic effect of adrenaline in the perfused rabbit heart

1 reference

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11 July 2018

Quantitative analysis of modified proteins and their positional isomers by tandem mass spectrometry: human histone H4.

1 reference

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24 September 2018

Another new kinase targets troponin I.

1 reference

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24 September 2018

Stunned peri-infarct canine myocardium is characterized by degradation of troponin T, not troponin I.

1 reference

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24 September 2018

Protein kinase C and A sites on troponin I regulate myofilament Ca2+ sensitivity and ATPase activity in the mouse myocardium

1 reference

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24 September 2018

Troponin I serines 43/45 and regulation of cardiac myofilament function

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24 September 2018

In vitro motility analysis of thin filaments from failing and non-failing human heart: troponin from failing human hearts induces slower filament sliding and higher Ca(2+) sensitivity

1 reference

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24 September 2018

Phosphorylation of troponin I controls cardiac twitch dynamics: evidence from phosphorylation site mutants expressed on a troponin I-null background in mice

1 reference

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24 September 2018

Top down characterization of larger proteins (45 kDa) by electron capture dissociation mass spectrometry

1 reference

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24 September 2018

Phosphorylation of troponin I by protein kinase A accelerates relaxation and crossbridge cycle kinetics in mouse ventricular muscle

1 reference

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24 September 2018

Left ventricular myofilament dysfunction in rat experimental hypertrophy and congestive heart failure

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14 November 2018

Effect of protein kinase A on calcium sensitivity of force and its sarcomere length dependence in human cardiomyocytes

1 reference

https://pubmed.ncbi.nlm.nih.gov/19637843

12 December 2020

based on heuristic

inferred from PubMed ID database lookup

Protein kinase C, troponin I and heart failure: overexpressed, hyperphosphorylated and underappreciated?

1 reference

https://pubmed.ncbi.nlm.nih.gov/19637843

12 December 2020

based on heuristic

inferred from PubMed ID database lookup

Troponin and tropomyosin: proteins that switch on and tune in the activity of cardiac myofilaments

1 reference

https://pubmed.ncbi.nlm.nih.gov/19637843

12 December 2020

based on heuristic

inferred from PubMed ID database lookup

Augmented protein kinase C-alpha-induced myofilament protein phosphorylation contributes to myofilament dysfunction in experimental congestive heart failure

1 reference

https://pubmed.ncbi.nlm.nih.gov/19637843

12 December 2020

based on heuristic

inferred from PubMed ID database lookup

Troponin phosphorylation and regulatory function in human heart muscle: dephosphorylation of Ser23/24 on troponin I could account for the contractile defect in end-stage heart failure

1 reference

https://pubmed.ncbi.nlm.nih.gov/19637843

12 December 2020

based on heuristic

inferred from PubMed ID database lookup

Collisional activation of large multiply charged ions using Fourier transform mass spectrometry

1 reference

https://pubmed.ncbi.nlm.nih.gov/19637843

12 December 2020

based on heuristic

inferred from PubMed ID database lookup

Electron capture dissociation for structural characterization of multiply charged protein cations

1 reference

https://pubmed.ncbi.nlm.nih.gov/19637843

12 December 2020

based on heuristic

inferred from PubMed ID database lookup

Phosphorylation of troponin I and phospholamban during catecholamine stimulation of rabbit heart

1 reference

https://pubmed.ncbi.nlm.nih.gov/19637843

12 December 2020

based on heuristic

inferred from PubMed ID database lookup

Phosphopeptide/phosphoprotein mapping by electron capture dissociation mass spectrometry

1 reference

https://pubmed.ncbi.nlm.nih.gov/19637843

12 December 2020

based on heuristic

inferred from PubMed ID database lookup

Breakdown and release of myofilament proteins during ischemia and ischemia/reperfusion in rat hearts: identification of degradation products and effects on the pCa-force relation

1 reference

https://pubmed.ncbi.nlm.nih.gov/19637843

12 December 2020

based on heuristic

inferred from PubMed ID database lookup

Beta-adrenergic receptor stimulation increases unloaded shortening velocity of skinned single ventricular myocytes from rats

1 reference

https://pubmed.ncbi.nlm.nih.gov/19637843

12 December 2020

based on heuristic

inferred from PubMed ID database lookup

PKC-betaII sensitizes cardiac myofilaments to Ca2+ by phosphorylating troponin I on threonine-144

1 reference

https://pubmed.ncbi.nlm.nih.gov/19637843

12 December 2020

based on heuristic

inferred from PubMed ID database lookup

Increased contractility and altered Ca(2+) transients of mouse heart myocytes conditionally expressing PKCbeta

1 reference

https://pubmed.ncbi.nlm.nih.gov/19637843

12 December 2020

based on heuristic

inferred from PubMed ID database lookup

Identifiers

10.1021/BI900739F

1 reference

Europe PubMed Central

PMC publication ID

https://www.ebi.ac.uk/europepmc/webservices/rest/search?query=EXT_ID:19637843%20AND%20SRC:MED&resulttype=core&format=json

3 February 2020

PMC publication ID

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Europe PubMed Central

PMC publication ID

https://www.ebi.ac.uk/europepmc/webservices/rest/search?query=EXT_ID:19637843%20AND%20SRC:MED&resulttype=core&format=json

3 February 2020

PubMed publication ID

1 reference

Europe PubMed Central

PMC publication ID

https://www.ebi.ac.uk/europepmc/webservices/rest/search?query=EXT_ID:19637843%20AND%20SRC:MED&resulttype=core&format=json

3 February 2020

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