(Q35934180)

11 August 2017

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title

Recent developments in the transcriptional regulation of cytolytic effector cells (English)

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11 August 2017

1

Laurie H Glimcher

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11 August 2017

Michael J Townsend

2

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11 August 2017

Brandon M Sullivan

series ordinal

3

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11 August 2017

Graham M Lord

series ordinal

4

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11 August 2017

language of work or name

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1 November 2004

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Nature Reviews Immunology

11 August 2017

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11 August 2017

4

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11 August 2017

900-911

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11 August 2017

11

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https://scigraph.springernature.com/pub.10.1038/nri1490

11 August 2017

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T-bet is rapidly induced by interferon-gamma in lymphoid and myeloid cells

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Antigen-driven effector CD8 T cell function regulated by T-bet

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T-bet controls autoaggressive CD8 lymphocyte responses in type 1 diabetes

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c-Rel is crucial for lymphocyte proliferation but dispensable for T cell effector function

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What does it take to make a natural killer?

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UL16-binding proteins, novel MHC class I-related proteins, bind to NKG2D and activate multiple signaling pathways in primary NK cells

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Human NKT cells mediate antitumor cytotoxicity directly by recognizing target cell CD1d with bound ligand or indirectly by producing IL-2 to activate NK cells

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Requirement for Valpha14 NKT cells in IL-12-mediated rejection of tumors

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The unconventional lifestyle of NKT cells

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Cutting edge: the Ets1 transcription factor is required for the development of NK T cells in mice

31 March 2020

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Distinct effects of T-bet in TH1 lineage commitment and IFN-gamma production in CD4 and CD8 T cells

31 March 2020

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The ABCs of granule-mediated cytotoxicity: new weapons in the arsenal

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Apo2L/TRAIL-dependent recruitment of endogenous FADD and caspase-8 to death receptors 4 and 5.

31 March 2020

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FADD/MORT1 and caspase-8 are recruited to TRAIL receptors 1 and 2 and are essential for apoptosis mediated by TRAIL receptor 2

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Concerted action of the FasL/Fas and perforin/granzyme A and B pathways is mandatory for the development of early viral hepatitis but not for recovery from viral infection

31 March 2020

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Concerted action of perforin and granzymes is critical for the elimination of Trypanosoma cruzi from mouse tissues, but prevention of early host death is in addition dependent on the FasL/Fas pathway

31 March 2020

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Identification of a killer cell-specific regulatory element of the mouse perforin gene: an Ets-binding site-homologous motif that interacts with Ets-related proteins

31 March 2020

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Interleukin 2 receptor signaling regulates the perforin gene through signal transducer and activator of transcription (Stat)5 activation of two enhancers

31 March 2020

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The human perforin gene is a direct target of STAT4 activated by IL-12 in NK cells

31 March 2020

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A role for NF-kappa B activation in perforin expression of NK cells upon IL-2 receptor signaling

31 March 2020

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The genes for perforin, granzymes A-C and IFN-gamma are differentially expressed in single CD8(+) T cells during primary activation

31 March 2020

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Differential expression of granzymes A and B in human cytotoxic lymphocyte subsets and T regulatory cells

31 March 2020

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Long-range disruption of gene expression by a selectable marker cassette

31 March 2020

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A promoter element of the human serine esterase granzyme B gene controls specific transcription in activated T cells

31 March 2020

1 reference

Identification of human granzyme B promoter regulatory elements interacting with activated T-cell-specific proteins: implication of Ikaros and CBF binding sites in promoter activation.

31 March 2020

1 reference

In vivo regulation of murine granzyme B gene transcription in activated primary T cells

31 March 2020

1 reference

Mutational analysis of the murine granzyme B gene promoter in primary T cells and a T cell clone.

31 March 2020

1 reference

Down-regulation of human granzyme B expression by glucocorticoids. Dexamethasone inhibits binding to the Ikaros and AP-1 regulatory elements of the granzyme B promoter

31 March 2020

1 reference

IL-12 synergizes with IL-2 to induce lymphokine-activated cytotoxicity and perforin and granzyme gene expression in fresh human NK cells

31 March 2020

1 reference

Interleukin-15 induces the expression of mRNAs of cytolytic mediators and augments cytotoxic activities in primary murine lymphocytes

31 March 2020

1 reference

Tumor necrosis factor receptor and Fas signaling mechanisms.

31 March 2020

1 reference

Fas ligand-induced apoptosis

31 March 2020

1 reference

Definition of a natural killer NKR-P1A+/CD56-/CD16- functionally immature human NK cell subset that differentiates in vitro in the presence of interleukin 12.

31 March 2020

1 reference

Natural killer (NK) cell-mediated cytotoxicity: differential use of TRAIL and Fas ligand by immature and mature primary human NK cells

31 March 2020

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CD4+ T cells reactivated with superantigen are both more sensitive to FasL-mediated killing and express a higher level of FasL

31 March 2020

1 reference

DNA damaging agents induce expression of Fas ligand and subsequent apoptosis in T lymphocytes via the activation of NF-kappa B and AP-1.

31 March 2020

1 reference

Regulation of fas-ligand expression during activation-induced cell death in T lymphocytes via nuclear factor kappaB.

31 March 2020

1 reference

Proteasome regulation of Fas ligand cytotoxicity

31 March 2020

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Cyclosporin A-sensitive transcription factor Egr-3 regulates Fas ligand expression

31 March 2020

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Role of Egr-2 in up-regulation of Fas ligand in normal T cells and aberrant double-negative lpr and gld T cells

31 March 2020

1 reference

Egr family members regulate nonlymphoid expression of Fas ligand, TRAIL, and tumor necrosis factor during immune responses

31 March 2020

1 reference

Two NFAT transcription factor binding sites participate in the regulation of CD95 (Fas) ligand expression in activated human T cells

31 March 2020

1 reference

Hyperproliferation and dysregulation of IL-4 expression in NF-ATp-deficient mice

31 March 2020

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Inhibitory function of two NFAT family members in lymphoid homeostasis and Th2 development.

31 March 2020

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Sequential involvement of NFAT and Egr transcription factors in FasL regulation

31 March 2020

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Cutting edge: the class II transactivator prevents activation-induced cell death by inhibiting Fas ligand gene expression

31 March 2020

1 reference

Aberrant expression of Fas ligand in mice deficient for the MHC class II transactivator

31 March 2020

1 reference

Structure/function analysis of the murine CD95L promoter reveals the identification of a novel transcriptional repressor and functional CD28 response element.

31 March 2020

1 reference

The regulation of CD95 (Fas) ligand expression in primary T cells: induction of promoter activation in CD95LP-Luc transgenic mice

31 March 2020

1 reference

FasL promoter activation by IL-2 through SP1 and NFAT but not Egr-2 and Egr-3

31 March 2020

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Constitutive Fas ligand gene transcription in Sertoli cells is regulated by Sp1.

31 March 2020

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Ets-1 positively regulates Fas ligand transcription via cooperative interactions with Sp1.

31 March 2020

1 reference

A 'non-canonical' DNA-binding element mediates the response of the Fas-ligand promoter to c-Myc.

31 March 2020

1 reference

Regulation of activation-induced Fas (CD95/Apo-1) ligand expression in T cells by the cyclin B1/Cdk1 complex

31 March 2020

1 reference

Expression of Fas ligand in activated T cells is regulated by c-Myc

31 March 2020

1 reference

Dendritic cells mediate NK cell help for Th1 and CTL responses: two-signal requirement for the induction of NK cell helper function

31 March 2020

1 reference

Decreased tumor surveillance in perforin-deficient mice

31 March 2020

1 reference

Granzyme A is critical for recovery of mice from infection with the natural cytopathic viral pathogen, ectromelia

31 March 2020

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Cutting edge: granzymes A and B are not essential for perforin-mediated tumor rejection

31 March 2020

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Cytotoxic lymphocytes require granzyme B for the rapid induction of DNA fragmentation and apoptosis in allogeneic target cells.

31 March 2020

1 reference

Generalized lymphoproliferative disease in mice, caused by a point mutation in the Fas ligand

31 March 2020

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The Fas/Fas ligand pathway is important for optimal tumor regression in a mouse model of CTL adoptive immunotherapy of experimental CMS4 lung metastases.

31 March 2020

1 reference

Multiple defects of immune cell function in mice with disrupted interferon-gamma genes

31 March 2020

1 reference

An essential role for interferon gamma in resistance to Mycobacterium tuberculosis infection

31 March 2020

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Disseminated tuberculosis in interferon gamma gene-disrupted mice

31 March 2020

1 reference

Loss of T-bet, but not STAT1, prevents the development of experimental autoimmune encephalomyelitis

31 March 2020

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Impaired development of CD4+ CD25+ regulatory T cells in the absence of STAT1: increased susceptibility to autoimmune disease

31 March 2020

1 reference

STAT-4 mediated IL-12 signaling pathway is critical for the development of protective immunity in cutaneous leishmaniasis

31 March 2020

1 reference

The transcription factor T-bet regulates mucosal T cell activation in experimental colitis and Crohn's disease

31 March 2020

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A thymic precursor to the NK T cell lineage

31 March 2020

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inferred from DOI database lookup

7 January 2021

based on heuristic

Identifiers

DOI

10.1038/NRI1490

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Dimensions Publication ID

11 August 2017

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