(Q35937574)

11 August 2017

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title

HIFs, hypoxia, and vascular development (English)

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11 August 2017

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Kelly L Covello

1

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11 August 2017

M Celeste Simon

series ordinal

2

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11 August 2017

language of work or name

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1 January 2004

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Current Topics in Developmental Biology

11 August 2017

published in

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11 August 2017

volume

62

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11 August 2017

page(s)

37-54

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Placental cell fates are regulated in vivo by HIF-mediated hypoxia responses

11 August 2017

cites work

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7 January 2021

Multilineage embryonic hematopoiesis requires hypoxic ARNT activity

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7 January 2021

An essential role for p300/CBP in the cellular response to hypoxia

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7 January 2021

Levels of hypoxia-inducible factor-1 alpha during breast carcinogenesis

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7 January 2021

A conserved family of prolyl-4-hydroxylases that modify HIF

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7 January 2021

Role of HIF-1alpha in hypoxia-mediated apoptosis, cell proliferation and tumour angiogenesis

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7 January 2021

Abnormal blood vessel development and lethality in embryos lacking a single VEGF allele

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7 January 2021

Angiogenesis in cancer and other diseases

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7 January 2021

Redox-regulated recruitment of the transcriptional coactivators CREB-binding protein and SRC-1 to hypoxia-inducible factor 1alpha

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7 January 2021

Mitochondrial reactive oxygen species trigger hypoxia-induced transcription

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7 January 2021

Reactive oxygen species generated at mitochondrial complex III stabilize hypoxia-inducible factor-1alpha during hypoxia: a mechanism of O2 sensing

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7 January 2021

Suppression of glioblastoma angiogenicity and tumorigenicity by inhibition of endogenous expression of vascular endothelial growth factor

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7 January 2021

Hypoxia inducible factor-alpha binding and ubiquitylation by the von Hippel-Lindau tumor suppressor protein

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https://api.crossref.org/works/10.1016%2FS0070-2153%2804%2962002-3

7 January 2021

Loss of HIF-2alpha and inhibition of VEGF impair fetal lung maturation, whereas treatment with VEGF prevents fatal respiratory distress in premature mice

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7 January 2021

The bHLH/PAS factor MOP3 does not participate in hypoxia responses

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https://api.crossref.org/works/10.1016%2FS0070-2153%2804%2962002-3

7 January 2021

HIF-1alpha is essential for myeloid cell-mediated inflammation

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https://api.crossref.org/works/10.1016%2FS0070-2153%2804%2962002-3

7 January 2021

Regulation of transcription by hypoxia requires a multiprotein complex that includes hypoxia-inducible factor 1, an adjacent transcription factor, and p300/CREB binding protein

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7 January 2021

Hypoxia and mitochondrial inhibitors regulate expression of glucose transporter-1 via distinct Cis-acting sequences

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7 January 2021

A novel bHLH-PAS factor with close sequence similarity to hypoxia-inducible factor 1alpha regulates the VEGF expression and is potentially involved in lung and vascular development

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https://api.crossref.org/works/10.1016%2FS0070-2153%2804%2962002-3

7 January 2021

C. elegans EGL-9 and mammalian homologs define a family of dioxygenases that regulate HIF by prolyl hydroxylation

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https://api.crossref.org/works/10.1016%2FS0070-2153%2804%2962002-3

7 January 2021

Coexpression of endothelial PAS protein 1 with essential angiogenic factors suggests its involvement in human vascular development

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https://api.crossref.org/works/10.1016%2FS0070-2153%2804%2962002-3

7 January 2021

Heterozygous embryonic lethality induced by targeted inactivation of the VEGF gene

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https://api.crossref.org/works/10.1016%2FS0070-2153%2804%2962002-3

7 January 2021

The biology of vascular endothelial growth factor

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7 January 2021

Oxygen-regulated control elements in the phosphoglycerate kinase 1 and lactate dehydrogenase A genes: similarities with the erythropoietin 3' enhancer

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https://api.crossref.org/works/10.1016%2FS0070-2153%2804%2962002-3

7 January 2021

Hypoxic Regulation of Lactate Dehydrogenase A

1 reference

https://api.crossref.org/works/10.1016%2FS0070-2153%2804%2962002-3

7 January 2021

HRF, a putative basic helix-loop-helix-PAS-domain transcription factor is closely related to hypoxia-inducible factor-1 alpha and developmentally expressed in blood vessels

1 reference

https://api.crossref.org/works/10.1016%2FS0070-2153%2804%2962002-3

7 January 2021

Angiogenesis in cancer, vascular, rheumatoid and other disease

1 reference

https://api.crossref.org/works/10.1016%2FS0070-2153%2804%2962002-3

7 January 2021

Regulation of flt-1 expression during mouse embryogenesis suggests a role in the establishment of vascular endothelium

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https://api.crossref.org/works/10.1016%2FS0070-2153%2804%2962002-3

7 January 2021

Role of the Flt-1 receptor tyrosine kinase in regulating the assembly of vascular endothelium

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7 January 2021

Activation of vascular endothelial growth factor gene transcription by hypoxia-inducible factor 1

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https://api.crossref.org/works/10.1016%2FS0070-2153%2804%2962002-3

7 January 2021

Differential transcriptional regulation of the two vascular endothelial growth factor receptor genes. Flt-1, but not Flk-1/KDR, is up-regulated by hypoxia.

1 reference

https://api.crossref.org/works/10.1016%2FS0070-2153%2804%2962002-3

7 January 2021

Relation of hypoxia inducible factor 1 alpha and 2 alpha in operable non-small cell lung cancer to angiogenic/molecular profile of tumours and survival

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https://api.crossref.org/works/10.1016%2FS0070-2153%2804%2962002-3

7 January 2021

Defective placental vasculogenesis causes embryonic lethality in VHL-deficient mice

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https://api.crossref.org/works/10.1016%2FS0070-2153%2804%2962002-3

7 January 2021

Tumour suppression by the human von Hippel-Lindau gene product

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https://api.crossref.org/works/10.1016%2FS0070-2153%2804%2962002-3

7 January 2021

HIFalpha targeted for VHL-mediated destruction by proline hydroxylation: implications for O2 sensing

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https://api.crossref.org/works/10.1016%2FS0070-2153%2804%2962002-3

7 January 2021

Cellular and developmental control of O2 homeostasis by hypoxia-inducible factor 1 alpha

1 reference

https://api.crossref.org/works/10.1016%2FS0070-2153%2804%2962002-3

7 January 2021

Targeting of HIF-alpha to the von Hippel-Lindau ubiquitylation complex by O2-regulated prolyl hydroxylation

1 reference

https://api.crossref.org/works/10.1016%2FS0070-2153%2804%2962002-3

7 January 2021

Dimerization, DNA binding, and transactivation properties of hypoxia-inducible factor 1

1 reference

https://api.crossref.org/works/10.1016%2FS0070-2153%2804%2962002-3

7 January 2021

Transactivation and inhibitory domains of hypoxia-inducible factor 1alpha. Modulation of transcriptional activity by oxygen tension

1 reference

https://api.crossref.org/works/10.1016%2FS0070-2153%2804%2962002-3

7 January 2021

Regulation of the hypoxia-inducible transcription factor 1alpha by the ubiquitin-proteasome pathway

1 reference

https://api.crossref.org/works/10.1016%2FS0070-2153%2804%2962002-3

7 January 2021

Thrombopoietin rescues in vitro erythroid colony formation from mouse embryos lacking the erythropoietin receptor

1 reference

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7 January 2021

Recombinant adenovirus expressing Von Hippel-Lindau-mediated cell cycle arrest is associated with the induction of cyclin-dependent kinase inhibitor p27Kip1

1 reference

https://api.crossref.org/works/10.1016%2FS0070-2153%2804%2962002-3

7 January 2021

The von Hippel-Lindau tumor suppressor gene

1 reference

https://api.crossref.org/works/10.1016%2FS0070-2153%2804%2962002-3

7 January 2021

Inhibition of HIF is necessary for tumor suppression by the von Hippel-Lindau protein

1 reference

https://api.crossref.org/works/10.1016%2FS0070-2153%2804%2962002-3

7 January 2021

ARNT-deficient mice and placental differentiation

1 reference

https://api.crossref.org/works/10.1016%2FS0070-2153%2804%2962002-3

7 January 2021

Suppression of tumor growth through disruption of hypoxia-inducible transcription

1 reference

https://api.crossref.org/works/10.1016%2FS0070-2153%2804%2962002-3

7 January 2021

FIH-1 is an asparaginyl hydroxylase enzyme that regulates the transcriptional activity of hypoxia-inducible factor

1 reference

https://api.crossref.org/works/10.1016%2FS0070-2153%2804%2962002-3

7 January 2021

Asparagine hydroxylation of the HIF transactivation domain a hypoxic switch

1 reference

https://api.crossref.org/works/10.1016%2FS0070-2153%2804%2962002-3

7 January 2021

Transcriptional regulation of the rat vascular endothelial growth factor gene by hypoxia

1 reference

https://api.crossref.org/works/10.1016%2FS0070-2153%2804%2962002-3

7 January 2021

Differential effects of an erythropoietin receptor gene disruption on primitive and definitive erythropoiesis.

1 reference

https://api.crossref.org/works/10.1016%2FS0070-2153%2804%2962002-3

7 January 2021

Hypoxia regulates vascular endothelial growth factor gene expression in endothelial cells. Identification of a 5' enhancer

1 reference

https://api.crossref.org/works/10.1016%2FS0070-2153%2804%2962002-3

7 January 2021

Identification of a hypoxia response element in the transferrin receptor gene

1 reference

https://api.crossref.org/works/10.1016%2FS0070-2153%2804%2962002-3

7 January 2021

FIH-1: a novel protein that interacts with HIF-1alpha and VHL to mediate repression of HIF-1 transcriptional activity

1 reference

https://api.crossref.org/works/10.1016%2FS0070-2153%2804%2962002-3

7 January 2021

Inhibitory PAS domain protein is a negative regulator of hypoxia-inducible gene expression

1 reference

https://api.crossref.org/works/10.1016%2FS0070-2153%2804%2962002-3

7 January 2021

Inhibitory PAS domain protein (IPAS) is a hypoxia-inducible splicing variant of the hypoxia-inducible factor-3alpha locus

1 reference

https://api.crossref.org/works/10.1016%2FS0070-2153%2804%2962002-3

7 January 2021

Abnormal angiogenesis and responses to glucose and oxygen deprivation in mice lacking the protein ARNT.

1 reference

https://api.crossref.org/works/10.1016%2FS0070-2153%2804%2962002-3

7 January 2021

Oxygen, genes, and development: an analysis of the role of hypoxic gene regulation during murine vascular development.

1 reference

https://api.crossref.org/works/10.1016%2FS0070-2153%2804%2962002-3

7 January 2021

The contribution of VHL substrate binding and HIF1-alpha to the phenotype of VHL loss in renal cell carcinoma

1 reference

https://api.crossref.org/works/10.1016%2FS0070-2153%2804%2962002-3

7 January 2021

Independent function of two destruction domains in hypoxia-inducible factor-alpha chains activated by prolyl hydroxylation

1 reference

https://api.crossref.org/works/10.1016%2FS0070-2153%2804%2962002-3

7 January 2021

Hypoxia-inducible factor-1 modulates gene expression in solid tumors and influences both angiogenesis and tumor growth.

1 reference

https://api.crossref.org/works/10.1016%2FS0070-2153%2804%2962002-3

7 January 2021

The tumour suppressor protein VHL targets hypoxia-inducible factors for oxygen-dependent proteolysis

1 reference

https://api.crossref.org/works/10.1016%2FS0070-2153%2804%2962002-3

7 January 2021

A hypoxia-responsive element mediates a novel pathway of activation of the inducible nitric oxide synthase promoter

1 reference

https://api.crossref.org/works/10.1016%2FS0070-2153%2804%2962002-3

7 January 2021

Vascular endothelial growth factor-induced tumor angiogenesis and tumorigenicity in relation to metastasis in a HT1080 human fibrosarcoma cell model.

1 reference

https://api.crossref.org/works/10.1016%2FS0070-2153%2804%2962002-3

7 January 2021

Ubiquitination of hypoxia-inducible factor requires direct binding to the beta-domain of the von Hippel-Lindau protein

1 reference

https://api.crossref.org/works/10.1016%2FS0070-2153%2804%2962002-3

7 January 2021

The von Hippel-Lindau tumor suppressor protein is required for proper assembly of an extracellular fibronectin matrix

1 reference

https://api.crossref.org/works/10.1016%2FS0070-2153%2804%2962002-3

7 January 2021

Hypoxia-inducible mammalian gene expression analyzed in vivo at a TATA-driven promoter and at an initiator-driven promoter

1 reference

https://api.crossref.org/works/10.1016%2FS0070-2153%2804%2962002-3

7 January 2021

The von Hippel-Lindau tumor suppressor gene is required for cell cycle exit upon serum withdrawal

1 reference

https://api.crossref.org/works/10.1016%2FS0070-2153%2804%2962002-3

7 January 2021

The transcription factor EPAS-1/hypoxia-inducible factor 2alpha plays an important role in vascular remodeling

1 reference

https://api.crossref.org/works/10.1016%2FS0070-2153%2804%2962002-3

7 January 2021

Activation of Hypoxia-inducible Factor-1; Definition of Regulatory Domains within the α Subunit

1 reference

https://api.crossref.org/works/10.1016%2FS0070-2153%2804%2962002-3

7 January 2021

Functional analysis of an oxygen-regulated transcriptional enhancer lying 3' to the mouse erythropoietin gene

1 reference

https://api.crossref.org/works/10.1016%2FS0070-2153%2804%2962002-3

7 January 2021

Mechanisms of angiogenesis

1 reference

https://api.crossref.org/works/10.1016%2FS0070-2153%2804%2962002-3

7 January 2021

Oxygen-regulated transferrin expression is mediated by hypoxia-inducible factor-1.

1 reference

https://api.crossref.org/works/10.1016%2FS0070-2153%2804%2962002-3

7 January 2021

HIF-1 alpha is required for solid tumor formation and embryonic vascularization.

1 reference

https://api.crossref.org/works/10.1016%2FS0070-2153%2804%2962002-3

7 January 2021

Hypoxia-inducible factor 1alpha (HIF-1alpha) protein is rapidly degraded by the ubiquitin-proteasome system under normoxic conditions. Its stabilization by hypoxia depends on redox-induced changes

1 reference

https://api.crossref.org/works/10.1016%2FS0070-2153%2804%2962002-3

7 January 2021

Multiple organ pathology, metabolic abnormalities and impaired homeostasis of reactive oxygen species in Epas1-/- mice

1 reference

https://api.crossref.org/works/10.1016%2FS0070-2153%2804%2962002-3

7 January 2021

The HIF family member EPAS1/HIF-2α is required for normal hematopoiesis in mice

1 reference

https://api.crossref.org/works/10.1016%2FS0070-2153%2804%2962002-3

7 January 2021

Transcription factor HIF-1 is a necessary mediator of the pasteur effect in mammalian cells.

1 reference

https://api.crossref.org/works/10.1016%2FS0070-2153%2804%2962002-3

7 January 2021

Hypoxia Response Elements in the Aldolase A, Enolase 1, and Lactate Dehydrogenase A Gene Promoters Contain Essential Binding Sites for Hypoxia-inducible Factor 1

1 reference

https://api.crossref.org/works/10.1016%2FS0070-2153%2804%2962002-3

7 January 2021

Hypoxia-inducible nuclear factors bind to an enhancer element located 3' to the human erythropoietin gene

1 reference

https://api.crossref.org/works/10.1016%2FS0070-2153%2804%2962002-3

7 January 2021

A requirement for Flk1 in primitive and definitive hematopoiesis and vasculogenesis

1 reference

https://api.crossref.org/works/10.1016%2FS0070-2153%2804%2962002-3

7 January 2021

Failure of blood-island formation and vasculogenesis in Flk-1-deficient mice

1 reference

https://api.crossref.org/works/10.1016%2FS0070-2153%2804%2962002-3

7 January 2021

Transferrin receptor induction by hypoxia. HIF-1-mediated transcriptional activation and cell-specific post-transcriptional regulation

1 reference

https://api.crossref.org/works/10.1016%2FS0070-2153%2804%2962002-3

7 January 2021

The Expression and Distribution of the Hypoxia-Inducible Factors HIF-1α and HIF-2α in Normal Human Tissues, Cancers, and Tumor-Associated Macrophages

1 reference

https://api.crossref.org/works/10.1016%2FS0070-2153%2804%2962002-3

7 January 2021

Mechanism of regulation of the hypoxia-inducible factor-1 alpha by the von Hippel-Lindau tumor suppressor protein

1 reference

https://api.crossref.org/works/10.1016%2FS0070-2153%2804%2962002-3

7 January 2021

The hypoxia-responsive transcription factor EPAS1 is essential for catecholamine homeostasis and protection against heart failure during embryonic development

1 reference

https://api.crossref.org/works/10.1016%2FS0070-2153%2804%2962002-3

7 January 2021

Endothelial PAS domain protein 1 (EPAS1), a transcription factor selectively expressed in endothelial cells

1 reference

https://api.crossref.org/works/10.1016%2FS0070-2153%2804%2962002-3

7 January 2021

Hypoxia-inducible factor 1 is a basic-helix-loop-helix-PAS heterodimer regulated by cellular O2 tension

1 reference

https://api.crossref.org/works/10.1016%2FS0070-2153%2804%2962002-3

7 January 2021

Widespread hypoxia-inducible expression of HIF-2alpha in distinct cell populations of different organs.

1 reference

https://api.crossref.org/works/10.1016%2FS0070-2153%2804%2962002-3

7 January 2021

A protective role for HIF-1 in response to redox manipulation and glucose deprivation: implications for tumorigenesis

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https://api.crossref.org/works/10.1016%2FS0070-2153%2804%2962002-3

7 January 2021

The role of the aryl hydrocarbon receptor nuclear translocator (ARNT) in hypoxic induction of gene expression. Studies in ARNT-deficient cells

1 reference

https://api.crossref.org/works/10.1016%2FS0070-2153%2804%2962002-3

7 January 2021

Selection and analysis of a mutant cell line defective in the hypoxia-inducible factor-1 alpha-subunit (HIF-1alpha). Characterization of hif-1alpha-dependent and -independent hypoxia-inducible gene expression

1 reference

https://api.crossref.org/works/10.1016%2FS0070-2153%2804%2962002-3

7 January 2021

Generation of committed erythroid BFU-E and CFU-E progenitors does not require erythropoietin or the erythropoietin receptor

1 reference

https://api.crossref.org/works/10.1016%2FS0070-2153%2804%2962002-3

7 January 2021

Impaired physiological responses to chronic hypoxia in mice partially deficient for hypoxia-inducible factor 1alpha

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https://api.crossref.org/works/10.1016%2FS0070-2153%2804%2962002-3

7 January 2021

HIF-1alpha binding to VHL is regulated by stimulus-sensitive proline hydroxylation

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https://api.crossref.org/works/10.1016%2FS0070-2153%2804%2962002-3

7 January 2021

Expression of hypoxia-inducible factor 1? in brain tumors

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https://api.crossref.org/works/10.1016%2FS0070-2153%2804%2962002-3

7 January 2021

Enhancement of tumor growth and vascular density by transfection of vascular endothelial cell growth factor into MCF-7 human breast carcinoma cells

1 reference

https://api.crossref.org/works/10.1016%2FS0070-2153%2804%2962002-3

7 January 2021

10.1016/S0070-2153(04)62002-3

Identifiers

DOI

1 reference

11 August 2017

1 reference