(Q35937600)

11 August 2017

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title

Genetics in zebrafish, mice, and humans to dissect congenital heart disease: insights in the role of VEGF. (English)

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11 August 2017

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congenital heart disease

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1

Diether Lambrechts

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11 August 2017

2

Peter Carmeliet

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11 August 2017

publication date

1 January 2004

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Current Topics in Developmental Biology

11 August 2017

published in

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11 August 2017

volume

62

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11 August 2017

page(s)

189-224

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Development of the heart: (2) Septation of the atriums and ventricles

11 August 2017

cites work

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7 January 2021

Development of the heart: (3) formation of the ventricular outflow tracts, arterial valves, and intrapericardial arterial trunks

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7 January 2021

Beyond Mendel: an evolving view of human genetic disease transmission

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7 January 2021

Heterozygous mutations in BBS1, BBS2 and BBS6 have a potential epistatic effect on Bardet-Biedl patients with two mutations at a second BBS locus

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7 January 2021

Semaphorin 3A-vascular endothelial growth factor-165 balance mediates migration and apoptosis of neural progenitor cells by the recruitment of shared receptor.

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7 January 2021

Mutations in human TBX5 [corrected] cause limb and cardiac malformation in Holt-Oram syndrome

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7 January 2021

Mutations in the cardiac transcription factor NKX2.5 affect diverse cardiac developmental pathways

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7 January 2021

Coordinate expression of vascular endothelial growth factor receptor-1 (flt-1) and its ligand suggests a paracrine regulation of murine vascular development

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7 January 2021

A chromosomal deletion map of human malformations.

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7 January 2021

A chromosomal duplication map of malformations: regions of suspected haplo- and triplolethality--and tolerance of segmental aneuploidy--in humans

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7 January 2021

Mutations in a novel factor, glomulin, are responsible for glomuvenous malformations ("glomangiomas")

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7 January 2021

Vascular malformations: localized defects in vascular morphogenesis

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7 January 2021

Mechanisms of left-right determination in vertebrates

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7 January 2021

Generating mice with targeted mutations

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7 January 2021

Monitoring of congenital cardiac defects

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7 January 2021

Mechanisms of angiogenesis and arteriogenesis

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7 January 2021

Blood vessels and nerves: common signals, pathways and diseases

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7 January 2021

Role of vascular endothelial growth factor and vascular endothelial growth factor receptors in vascular development.

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7 January 2021

Abnormal blood vessel development and lethality in embryos lacking a single VEGF allele

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7 January 2021

Impaired myocardial angiogenesis and ischemic cardiomyopathy in mice lacking the vascular endothelial growth factor isoforms VEGF164 and VEGF188

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7 January 2021

Neuropilin-2 regulates the development of selective cranial and sensory nerves and hippocampal mossy fiber projections.

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7 January 2021

Genomic circuits and the integrative biology of cardiac diseases

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7 January 2021

Recombineering: a powerful new tool for mouse functional genomics

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7 January 2021

Role of cardiac neural crest cells in cardiovascular development

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7 January 2021

Role of the NF-ATc transcription factor in morphogenesis of cardiac valves and septum

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7 January 2021

The fms-like tyrosine kinase, a receptor for vascular endothelial growth factor

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https://api.crossref.org/works/10.1016%2FS0070-2153%2804%2962007-2

7 January 2021

The annual incidence of DiGeorge/velocardiofacial syndrome

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https://api.crossref.org/works/10.1016%2FS0070-2153%2804%2962007-2

7 January 2021

Zebrafish: bridging the gap between development and disease

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https://api.crossref.org/works/10.1016%2FS0070-2153%2804%2962007-2

7 January 2021

Genetic basis of DiGeorge and velocardiofacial syndromes.

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7 January 2021

Vascularization of the mouse embryo: A study of flk‐1, tek, tie, and vascular endothelial growth factor expression during development

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7 January 2021

Molecular regulation of atrioventricular valvuloseptal morphogenesis

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https://api.crossref.org/works/10.1016%2FS0070-2153%2804%2962007-2

7 January 2021

Cardiac homeobox gene NKX2-5 mutations and congenital heart disease: associations with atrial septal defect and hypoplastic left heart syndrome.

1 reference

https://api.crossref.org/works/10.1016%2FS0070-2153%2804%2962007-2

7 January 2021

Elevated glucose inhibits VEGF-A-mediated endocardial cushion formation: modulation by PECAM-1 and MMP-2.

1 reference

https://api.crossref.org/works/10.1016%2FS0070-2153%2804%2962007-2

7 January 2021

Developing models of DiGeorge syndrome

1 reference

https://api.crossref.org/works/10.1016%2FS0070-2153%2804%2962007-2

7 January 2021

https://api.crossref.org/works/10.1016%2FS0070-2153%2804%2962007-2

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7 January 2021

Congenital heart disease: prevalence at livebirth. The Baltimore-Washington Infant Study

1 reference

https://api.crossref.org/works/10.1016%2FS0070-2153%2804%2962007-2

7 January 2021

Heterozygous embryonic lethality induced by targeted inactivation of the VEGF gene

1 reference

https://api.crossref.org/works/10.1016%2FS0070-2153%2804%2962007-2

7 January 2021

The biology of VEGF and its receptors

1 reference

https://api.crossref.org/works/10.1016%2FS0070-2153%2804%2962007-2

7 January 2021

Role of the Flt-1 receptor tyrosine kinase in regulating the assembly of vascular endothelium

1 reference

https://api.crossref.org/works/10.1016%2FS0070-2153%2804%2962007-2

7 January 2021

Vessel patterning in the embryo of the zebrafish: guidance by notochord

1 reference

https://api.crossref.org/works/10.1016%2FS0070-2153%2804%2962007-2

7 January 2021

GATA4 mutations cause human congenital heart defects and reveal an interaction with TBX5

1 reference

https://api.crossref.org/works/10.1016%2FS0070-2153%2804%2962007-2

7 January 2021

Neuropilin-2 is required in vivo for selective axon guidance responses to secreted semaphorins.

1 reference

https://api.crossref.org/works/10.1016%2FS0070-2153%2804%2962007-2

7 January 2021

Patterns of recurrence of congenital heart disease: an analysis of 6,640 consecutive pregnancies evaluated by detailed fetal echocardiography

1 reference

https://api.crossref.org/works/10.1016%2FS0070-2153%2804%2962007-2

7 January 2021

Neuropilin-2 is a receptor for the vascular endothelial growth factor (VEGF) forms VEGF-145 and VEGF-165 [corrected]

1 reference

https://api.crossref.org/works/10.1016%2FS0070-2153%2804%2962007-2

7 January 2021

NKX2.5 mutations in patients with tetralogy of fallot

1 reference

https://api.crossref.org/works/10.1016%2FS0070-2153%2804%2962007-2

7 January 2021

Laskers for 2001: knockout mice and test-tube babies

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7 January 2021

Congenital heart disease: incidence in the first year of life. The Alberta Heritage Pediatric Cardiology Program

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7 January 2021

Patterning the pharyngeal arches

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https://api.crossref.org/works/10.1016%2FS0070-2153%2804%2962007-2

7 January 2021

Neuropilin-1 conveys semaphorin and VEGF signaling during neural and cardiovascular development

1 reference

https://api.crossref.org/works/10.1016%2FS0070-2153%2804%2962007-2

7 January 2021

Genetic study of congenital heart defects in Northern Ireland (1974-1978)

1 reference

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7 January 2021

The epidemiology of cardiovascular defects, part 2: a study based on data from three large registries of congenital malformations

1 reference

https://api.crossref.org/works/10.1016%2FS0070-2153%2804%2962007-2

7 January 2021

Differential expression of neuropilin-1 and neuropilin-2 in arteries and veins

1 reference

https://api.crossref.org/works/10.1016%2FS0070-2153%2804%2962007-2

7 January 2021

The incidence of congenital heart disease

1 reference

https://api.crossref.org/works/10.1016%2FS0070-2153%2804%2962007-2

7 January 2021

Structure and function of the developing zebrafish heart.

1 reference

https://api.crossref.org/works/10.1016%2FS0070-2153%2804%2962007-2

7 January 2021

Hypoxia-induced transcriptional activation and increased mRNA stability of vascular endothelial growth factor in C6 glioma cells.

1 reference

https://api.crossref.org/works/10.1016%2FS0070-2153%2804%2962007-2

7 January 2021

The vascular anatomy of the developing zebrafish: an atlas of embryonic and early larval development

1 reference

https://api.crossref.org/works/10.1016%2FS0070-2153%2804%2962007-2

7 January 2021

Angiogenic network formation in the developing vertebrate trunk

1 reference

https://api.crossref.org/works/10.1016%2FS0070-2153%2804%2962007-2

7 January 2021

DiGeorge syndrome phenotype in mice mutant for the T-box gene, Tbx1

1 reference

https://api.crossref.org/works/10.1016%2FS0070-2153%2804%2962007-2

7 January 2021

VEGF is a modifier of amyotrophic lateral sclerosis in mice and humans and protects motoneurons against ischemic death

1 reference

https://api.crossref.org/works/10.1016%2FS0070-2153%2804%2962007-2

7 January 2021

Initial sequencing and analysis of the human genome

1 reference

https://api.crossref.org/works/10.1016%2FS0070-2153%2804%2962007-2

7 January 2021

sonic hedgehog and vascular endothelial growth factor act upstream of the Notch pathway during arterial endothelial differentiation

1 reference

https://api.crossref.org/works/10.1016%2FS0070-2153%2804%2962007-2

7 January 2021

Arteries and veins: making a difference with zebrafish

1 reference

https://api.crossref.org/works/10.1016%2FS0070-2153%2804%2962007-2

7 January 2021

In vivo imaging of embryonic vascular development using transgenic zebrafish

1 reference

https://api.crossref.org/works/10.1016%2FS0070-2153%2804%2962007-2

7 January 2021

Neuropilin-1 is required for vascular development and is a mediator of VEGF-dependent angiogenesis in zebrafish

1 reference

https://api.crossref.org/works/10.1016%2FS0070-2153%2804%2962007-2

7 January 2021

Jumonji, a nuclear protein that is necessary for normal heart development

1 reference

https://api.crossref.org/works/10.1016%2FS0070-2153%2804%2962007-2

7 January 2021

Defining brain wiring patterns and mechanisms through gene trapping in mice.

1 reference

https://api.crossref.org/works/10.1016%2FS0070-2153%2804%2962007-2

7 January 2021

Holt-Oram syndrome is caused by mutations in TBX5, a member of the Brachyury (T) gene family

1 reference

https://api.crossref.org/works/10.1016%2FS0070-2153%2804%2962007-2

7 January 2021

The role of vascular endothelial growth factor (VEGF) in vasculogenesis, angiogenesis, and hematopoiesis in zebrafish development

1 reference

https://api.crossref.org/works/10.1016%2FS0070-2153%2804%2962007-2

7 January 2021

Chromosomal microdeletions: dissecting del22q11 syndrome

1 reference

https://api.crossref.org/works/10.1016%2FS0070-2153%2804%2962007-2

7 January 2021

Tbx1 haploinsufficieny in the DiGeorge syndrome region causes aortic arch defects in mice

1 reference

https://api.crossref.org/works/10.1016%2FS0070-2153%2804%2962007-2

7 January 2021

Epidemiology of cardiovascular malformations: prevalence and risk factors

1 reference

https://api.crossref.org/works/10.1016%2FS0070-2153%2804%2962007-2

7 January 2021

Maternal diabetes: an independent risk factor for major cardiovascular malformations with increased mortality of affected infants

1 reference

https://api.crossref.org/works/10.1016%2FS0070-2153%2804%2962007-2

7 January 2021

Revascularization of ischemic tissues by PlGF treatment, and inhibition of tumor angiogenesis, arthritis and atherosclerosis by anti-Flt1.

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https://api.crossref.org/works/10.1016%2FS0070-2153%2804%2962007-2

7 January 2021

Molecular determinants of neural crest migration

1 reference

https://api.crossref.org/works/10.1016%2FS0070-2153%2804%2962007-2

7 January 2021

NKX2.5mutations in patients with congenital heart disease

1 reference

https://api.crossref.org/works/10.1016%2FS0070-2153%2804%2962007-2

7 January 2021

TBX1 is responsible for cardiovascular defects in velo-cardio-facial/DiGeorge syndrome

1 reference

https://api.crossref.org/works/10.1016%2FS0070-2153%2804%2962007-2

7 January 2021

Neuropilin-1 mediates collapsin-1/semaphorin III inhibition of endothelial cell motility: functional competition of collapsin-1 and vascular endothelial growth factor-165.

1 reference

https://api.crossref.org/works/10.1016%2FS0070-2153%2804%2962007-2

7 January 2021

High affinity VEGF binding and developmental expression suggest Flk-1 as a major regulator of vasculogenesis and angiogenesis

1 reference

https://api.crossref.org/works/10.1016%2FS0070-2153%2804%2962007-2

7 January 2021

Functional analysis of secreted and transmembrane proteins critical to mouse development.

1 reference

https://api.crossref.org/works/10.1016%2FS0070-2153%2804%2962007-2

7 January 2021

Congenital Heart Disease in 56,109 Births Incidence and Natural History

1 reference

https://api.crossref.org/works/10.1016%2FS0070-2153%2804%2962007-2

7 January 2021

Development of the heart: (1) formation of the cardiac chambers and arterial trunks

1 reference

https://api.crossref.org/works/10.1016%2FS0070-2153%2804%2962007-2

7 January 2021

Clinical analysis of families with heart, midline, and laterality defects

1 reference

https://api.crossref.org/works/10.1016%2FS0070-2153%2804%2962007-2

7 January 2021

Sensory nerves determine the pattern of arterial differentiation and blood vessel branching in the skin

1 reference

https://api.crossref.org/works/10.1016%2FS0070-2153%2804%2962007-2

7 January 2021

Efficient and precise engineering of a 200 kb beta-globin human/bacterial artificial chromosome in E. coli DH10B using an inducible homologous recombination system

1 reference

https://api.crossref.org/works/10.1016%2FS0070-2153%2804%2962007-2

7 January 2021

Effective targeted gene 'knockdown' in zebrafish

1 reference

https://api.crossref.org/works/10.1016%2FS0070-2153%2804%2962007-2

7 January 2021

Distinct requirements for zebrafish angiogenesis revealed by a VEGF-A morphant

1 reference

https://api.crossref.org/works/10.1016%2FS0070-2153%2804%2962007-2

7 January 2021

Vascular endothelial growth factor (VEGF) and its receptors

1 reference

https://api.crossref.org/works/10.1016%2FS0070-2153%2804%2962007-2

7 January 2021

The neuropilins: multifunctional semaphorin and VEGF receptors that modulate axon guidance and angiogenesis

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7 January 2021

The evolution of specific genetic and environmental counseling in congenital heart diseases

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7 January 2021

Gene-dosage-sensitive genetic interactions between inversus viscerum (iv), nodal, and activin type IIB receptor (ActRIIB) genes in asymmetrical patterning of the visceral organs along the left-right axis

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7 January 2021

Genetic aspects of atrioventricular septal defects

1 reference

https://api.crossref.org/works/10.1016%2FS0070-2153%2804%2962007-2

7 January 2021

Hyperglycemia-induced vasculopathy in the murine conceptus is mediated via reductions of VEGF-A expression and VEGF receptor activation

1 reference

https://api.crossref.org/works/10.1016%2FS0070-2153%2804%2962007-2

7 January 2021

The zebrafish van gogh mutation disrupts tbx1, which is involved in the DiGeorge deletion syndrome in humans

1 reference

https://api.crossref.org/works/10.1016%2FS0070-2153%2804%2962007-2

7 January 2021

The endoderm plays an important role in patterning the segmented pharyngeal region in zebrafish (Danio rerio).

1 reference

https://api.crossref.org/works/10.1016%2FS0070-2153%2804%2962007-2

7 January 2021

The epidemiology of cardiovascular defects, part I: a study based on data from three large registries of congenital malformations

1 reference

https://api.crossref.org/works/10.1016%2FS0070-2153%2804%2962007-2

7 January 2021

The transcription factor NF-ATc is essential for cardiac valve formation

1 reference

https://api.crossref.org/works/10.1016%2FS0070-2153%2804%2962007-2

7 January 2021

Deletions of human chromosome 22 and associated birth defects.

1 reference

https://api.crossref.org/works/10.1016%2FS0070-2153%2804%2962007-2

7 January 2021

Engineering a broken heart

1 reference

https://api.crossref.org/works/10.1016%2FS0070-2153%2804%2962007-2

7 January 2021

Getting to the heart of DiGeorge syndrome

1 reference

https://api.crossref.org/works/10.1016%2FS0070-2153%2804%2962007-2

7 January 2021

Congenital heart disease caused by mutations in the transcription factor NKX2-5

1 reference

https://api.crossref.org/works/10.1016%2FS0070-2153%2804%2962007-2

7 January 2021

Failure of blood-island formation and vasculogenesis in Flk-1-deficient mice

1 reference

https://api.crossref.org/works/10.1016%2FS0070-2153%2804%2962007-2

7 January 2021

Forty years with homologous recombination

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https://api.crossref.org/works/10.1016%2FS0070-2153%2804%2962007-2

7 January 2021

A genetic blueprint for cardiac development

1 reference

https://api.crossref.org/works/10.1016%2FS0070-2153%2804%2962007-2

7 January 2021

Zebrafish genetics and vertebrate heart formation.

1 reference

https://api.crossref.org/works/10.1016%2FS0070-2153%2804%2962007-2

7 January 2021

VEGF: a modifier of the del22q11 (DiGeorge) syndrome?

1 reference

https://api.crossref.org/works/10.1016%2FS0070-2153%2804%2962007-2

7 January 2021

Arteriolar and venular patterning in retinas of mice selectively expressing VEGF isoforms

1 reference

https://api.crossref.org/works/10.1016%2FS0070-2153%2804%2962007-2

7 January 2021

Paradominant inheritance, a hypothesis explaining occasional familial occurrence of sporadic syndromes

1 reference

https://api.crossref.org/works/10.1016%2FS0070-2153%2804%2962007-2

7 January 2021

VEGF: a critical player in neurodegeneration

1 reference

https://api.crossref.org/works/10.1016%2FS0070-2153%2804%2962007-2

7 January 2021

Semaphorins A and E act as antagonists of neuropilin-1 and agonists of neuropilin-2 receptors

1 reference

https://api.crossref.org/works/10.1016%2FS0070-2153%2804%2962007-2

7 January 2021

Identification of the KDR tyrosine kinase as a receptor for vascular endothelial cell growth factor

1 reference

https://api.crossref.org/works/10.1016%2FS0070-2153%2804%2962007-2

7 January 2021

Engineering the mouse genome with bacterial artificial chromosomes to create multipurpose alleles.

1 reference

https://api.crossref.org/works/10.1016%2FS0070-2153%2804%2962007-2

7 January 2021

Organogenesis--heart and blood formation from the zebrafish point of view

1 reference

https://api.crossref.org/works/10.1016%2FS0070-2153%2804%2962007-2

7 January 2021

Molecular determinants of left and right outflow tract obstruction

1 reference

https://api.crossref.org/works/10.1016%2FS0070-2153%2804%2962007-2

7 January 2021

High-throughput engineering of the mouse genome coupled with high-resolution expression analysis

1 reference

https://api.crossref.org/works/10.1016%2FS0070-2153%2804%2962007-2

7 January 2021

The Sequence of the Human Genome

1 reference

https://api.crossref.org/works/10.1016%2FS0070-2153%2804%2962007-2

7 January 2021

Molecular genetics of vascular malformations

1 reference

https://api.crossref.org/works/10.1016%2FS0070-2153%2804%2962007-2

7 January 2021

Population choice in mapping genes for complex diseases

1 reference

https://api.crossref.org/works/10.1016%2FS0070-2153%2804%2962007-2

7 January 2021

Role of TBX1 in human del22q11.2 syndrome

1 reference

https://api.crossref.org/works/10.1016%2FS0070-2153%2804%2962007-2

7 January 2021

Site-specific gene targeting in mouse embryonic stem cells with intact bacterial artificial chromosomes.

1 reference

https://api.crossref.org/works/10.1016%2FS0070-2153%2804%2962007-2

7 January 2021

An efficient recombination system for chromosome engineering in Escherichia coli

1 reference

https://api.crossref.org/works/10.1016%2FS0070-2153%2804%2962007-2

7 January 2021

Disruption and sequence identification of 2,000 genes in mouse embryonic stem cells

1 reference

https://api.crossref.org/works/10.1016%2FS0070-2153%2804%2962007-2

7 January 2021

A new logic for DNA engineering using recombination in Escherichia coli

1 reference

https://api.crossref.org/works/10.1016%2FS0070-2153%2804%2962007-2

7 January 2021

Gridlock signalling pathway fashions the first embryonic artery

1 reference

https://api.crossref.org/works/10.1016%2FS0070-2153%2804%2962007-2

7 January 2021

10.1016/S0070-2153(04)62007-2

Identifiers

DOI

1 reference

11 August 2017

1 reference