(Q35951590)

11 August 2017

De novo peptide design with C3a receptor agonist and antagonist activities: theoretical predictions and experimental validation (English)

1 reference

11 August 2017

Owen A Hawksworth

9

0 references

Chris A. Kieslich

Chris A Kieslich

4

0 references

Peter N. Monk

Peter N Monk

8

0 references

Trent M. Woodruff

Trent M Woodruff

10

0 references

Dimitrios Morikis

Dimitrios Morikis

6

0 references

Christodoulos Floudas

3

Christodoulos A Floudas

0 references

author name string

Meghan L Bellows-Peterson

1

1 reference

11 August 2017

Ho Ki Fung

2

1 reference

11 August 2017

Li Zhang

5

1 reference

11 August 2017

Kathryn J Wareham

7

1 reference

11 August 2017

language of work or name

English

0 references

publication date

20 April 2012

1 reference

Journal of Medicinal Chemistry

11 August 2017

1 reference

11 August 2017

55

1 reference

11 August 2017

9

1 reference

11 August 2017

4159-4168

1 reference

An evaluation of Poisson-Boltzmann electrostatic free energy calculations through comparison with experimental mutagenesis data.

11 August 2017

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=3349770

A new generation of potent complement inhibitors of the Compstatin family

2 October 2017

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=3349770

Electrostatic clustering and free energy calculations provide a foundation for protein design and optimization.

2 October 2017

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=3349770

Discovery of entry inhibitors for HIV-1 via a new de novo protein design framework.

2 October 2017

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=3349770

Species specificity of the complement inhibitor compstatin investigated by all-atom molecular dynamics simulations

2 October 2017

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=3349770

New compstatin variants through two de novo protein design frameworks

2 October 2017

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=3349770

Reconstitution and engineering of apoptotic protein interactions on the bacterial cell surface

2 October 2017

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=3349770

Complement factors C3a and C5a have distinct hemodynamic effects in the rat.

2 October 2017

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=3349770

Toward full-sequence de novo protein design with flexible templates for human beta-defensin-2.

2 October 2017

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=3349770

PDB2PQR: expanding and upgrading automated preparation of biomolecular structures for molecular simulations

2 October 2017

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=3349770

Structures of complement component C3 provide insights into the function and evolution of immunity

2 October 2017

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=3349770

Synthetic small-molecule complement inhibitors.

2 October 2017

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=3349770

UCSF Chimera--a visualization system for exploratory research and analysis

2 October 2017

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=3349770

ASTRO-FOLD: A Combinatorial and Global Optimization Framework for Ab Initio Prediction of Three-Dimensional Structures of Proteins from the Amino Acid Sequence

2 October 2017

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=3349770

Hybrid global optimization algorithms for protein structure prediction: alternating hybrids

2 October 2017

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=3349770

The orphan receptor C5L2 has high affinity binding sites for complement fragments C5a and C5a des-Arg(74)

2 October 2017

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=3349770

Electrostatics of nanosystems: application to microtubules and the ribosome

2 October 2017

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=3349770

Structure and biology of complement protein C3, a connecting link between innate and acquired immunity

2 October 2017

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=3349770

Identification of ligand effector binding sites in transmembrane regions of the human G protein-coupled C3a receptor

2 October 2017

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=3349770

C3a and C5a stimulate chemotaxis of human mast cells

2 October 2017

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=3349770

C3a is a chemotaxin for human eosinophils but not for neutrophils. I. C3a stimulation of neutrophils is secondary to eosinophil activation

2 October 2017

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=3349770

Effects of the anaphylatoxins on circulation

2 October 2017

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=3349770

Designing synthetic superagonists of C3a anaphylatoxin

2 October 2017

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=3349770

Automated computational framework for the analysis of electrostatic similarities of proteins

11 July 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=3349770

Selective hexapeptide agonists and antagonists for human complement C3a receptor

24 September 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=3349770

Bio3d: an R package for the comparative analysis of protein structures.

24 September 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=3349770

Prediction of beta-sheet topology and disulfide bridges in polypeptides.

24 September 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=3349770

Ab initio prediction of helical segments in polypeptides.

24 September 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=3349770

Both C3a and C3a(desArg) regulate interleukin-6 synthesis in human peripheral blood mononuclear cells.

24 September 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=3349770

Integrated Computational and Experimental Approach for Lead Optimization and Design of Compstatin Variants with Improved Activity

24 September 2018

1 reference

12 December 2020

Crystal structure analysis and molecular model of human C3a anaphylatoxin

1 reference

12 December 2020

C3a activates reactive oxygen radical species production and intracellular calcium transients in human eosinophils

1 reference

12 December 2020

Degranulation from human eosinophils stimulated with C3a and C5a

1 reference

12 December 2020

C5a stimulus-secretion coupling in rat basophilic leukaemia (RBL-2H3) cells transfected with the human C5a receptor is mediated by pertussis and cholera toxin-sensitive G proteins

1 reference

12 December 2020

A new biologic role for C3a and C3a desArg: regulation of TNF-alpha and IL-1 beta synthesis

1 reference

12 December 2020

Differential regulation of the C3a and C5a receptors (CD88) by IFN-gamma and PMA in U937 cells and related myeloblastic cell lines

1 reference

12 December 2020

Regulation of IL-6 synthesis in human peripheral blood mononuclear cells by C3a and C3a(desArg)

1 reference

12 December 2020

Transdermal Pharmacology of Small Molecule Cyclic C5a Antagonists

1 reference

12 December 2020

Identifiers

DOI

10.1021/JM201609K

1 reference

11 August 2017

1 reference

11 August 2017

1 reference