(Q35956613)

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Activated protein C inhibits pancreatic islet inflammation, stimulates T regulatory cells, and prevents diabetes in non-obese diabetic (NOD) mice

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scholarly article

1 reference

Europe PubMed Central

PMC publication ID

11 August 2017

Activated protein C inhibits pancreatic islet inflammation, stimulates T regulatory cells, and prevents diabetes in non-obese diabetic (NOD) mice (English)

1 reference

Europe PubMed Central

PMC publication ID

11 August 2017

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drotrecogin alfa

1 reference

based on heuristic

inferred from title

Christopher J Jackson

object named as

Christopher J Jackson

5

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author name string

Meilang Xue

1

1 reference

Europe PubMed Central

PMC publication ID

11 August 2017

Suat Dervish

2

1 reference

Europe PubMed Central

PMC publication ID

11 August 2017

Leonard C Harrison

3

1 reference

Europe PubMed Central

PMC publication ID

11 August 2017

Gregory Fulcher

4

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Europe PubMed Central

PMC publication ID

11 August 2017

language of work or name

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publication date

23 March 2012

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Europe PubMed Central

PMC publication ID

11 August 2017

Journal of Biological Chemistry

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Europe PubMed Central

PMC publication ID

11 August 2017

287

1 reference

Europe PubMed Central

PMC publication ID

11 August 2017

20

1 reference

Europe PubMed Central

PMC publication ID

11 August 2017

16356-16364

1 reference

Europe PubMed Central

PMC publication ID

11 August 2017

Activated protein C targets CD8+ dendritic cells to reduce the mortality of endotoxemia in mice.

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=3351324

2 October 2017

Genetics, pathogenesis and clinical interventions in type 1 diabetes

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=3351324

2 October 2017

Severe congenital protein C deficiency: the use of protein C concentrates (human) as replacement therapy for life-threatening blood-clotting complications

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=3351324

2 October 2017

TGFbeta plasmid construction and delivery for the prevention of type 1 diabetes

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=3351324

2 October 2017

Regulatory T cells and immune tolerance

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=3351324

2 October 2017

Central role of defective interleukin-2 production in the triggering of islet autoimmune destruction

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=3351324

2 October 2017

Activated protein C--an anticoagulant that does more than stop clots

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=3351324

2 October 2017

Activated protein C protects against diabetic nephropathy by inhibiting endothelial and podocyte apoptosis

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=3351324

2 October 2017

Acute inflammation is exacerbated in mice genetically predisposed to a severe protein C deficiency

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=3351324

2 October 2017

Conditional and specific NF-kappaB blockade protects pancreatic beta cells from diabetogenic agents.

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=3351324

2 October 2017

The promise of protein C.

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=3351324

2 October 2017

Mechanisms of pancreatic beta-cell death in type 1 and type 2 diabetes: many differences, few similarities

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=3351324

2 October 2017

The effect of activated protein C on experimental acute necrotizing pancreatitis

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=3351324

2 October 2017

FOXP3 acts as a rheostat of the immune response

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=3351324

2 October 2017

Structure and functions of the endothelial cell protein C receptor

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=3351324

2 October 2017

CD4+CD25+ T regulatory cells control anti-islet CD8+ T cells through TGF-beta-TGF-beta receptor interactions in type 1 diabetes

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=3351324

2 October 2017

Matrix metalloproteinase processing of monocyte chemoattractant proteins generates CC chemokine receptor antagonists with anti-inflammatory properties in vivo

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=3351324

2 October 2017

Understanding autoimmune diabetes: insights from mouse models.

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=3351324

2 October 2017

Characterization of protein C receptor expression in monocytes

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=3351324

2 October 2017

X-linked neonatal diabetes mellitus, enteropathy and endocrinopathy syndrome is the human equivalent of mouse scurfy

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=3351324

2 October 2017

Neutrophil gelatinase B potentiates interleukin-8 tenfold by aminoterminal processing, whereas it degrades CTAP-III, PF-4, and GRO-alpha and leaves RANTES and MCP-2 intact.

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=3351324

2 October 2017

B7/CD28 costimulation is essential for the homeostasis of the CD4+CD25+ immunoregulatory T cells that control autoimmune diabetes

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=3351324

2 October 2017

Protein C prevents the coagulopathic and lethal effects of Escherichia coli infusion in the baboon

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=3351324

2 October 2017

Cytokine and lipid inflammatory mediator profile of human tears during contact lens associated inflammatory diseases

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=3351324

27 July 2018

Activated protein C resistance in type I diabetes.

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=3351324

27 July 2018

Secretion of metalloproteinases by stimulated capillary endothelial cells. II. Expression of collagenase and stromelysin activities is regulated by endogenous inhibitors.

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=3351324

27 July 2018

Suppression of development of diabetes in NOD mice by lactate dehydrogenase virus infection

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=3351324

27 July 2018

Activated protein C preserves functional islet mass after intraportal transplantation: a novel link between endothelial cell activation, thrombosis, inflammation, and islet cell death

1 reference

https://api.crossref.org/works/10.1074%2FJBC.M111.325951

21 January 2018

Treatment of chronic leg ulcers with topical activated protein C.

1 reference

https://api.crossref.org/works/10.1074%2FJBC.M111.325951

21 January 2018

Gene expression profile of antithrombotic protein c defines new mechanisms modulating inflammation and apoptosis

1 reference

https://api.crossref.org/works/10.1074%2FJBC.M111.325951

21 January 2018

Endothelial protein C receptor-dependent inhibition of migration of human lymphocytes by protein C involves epidermal growth factor receptor

1 reference

https://api.crossref.org/works/10.1074%2FJBC.M111.325951

21 January 2018

Activated protein C stimulates proliferation, migration and wound closure, inhibits apoptosis and upregulates MMP-2 activity in cultured human keratinocytes.

1 reference

https://api.crossref.org/works/10.1074%2FJBC.M111.325951

21 January 2018

IL-2 is essential for TGF-beta to convert naive CD4+CD25- cells to CD25+Foxp3+ regulatory T cells and for expansion of these cells

1 reference

https://api.crossref.org/works/10.1074%2FJBC.M111.325951

21 January 2018

Activated protein C attenuates acute lung injury and apoptosis in a hyperoxic animal model

1 reference

https://pubmed.ncbi.nlm.nih.gov/22447930

12 December 2020

based on heuristic

inferred from PubMed ID database lookup

A protocol for islet isolation from mouse pancreas

1 reference

https://pubmed.ncbi.nlm.nih.gov/22447930

12 December 2020

based on heuristic

inferred from PubMed ID database lookup

The role of matrix metalloproteinase-2 and matrix metalloproteinase-9 in antibody-induced arthritis

1 reference

https://pubmed.ncbi.nlm.nih.gov/22447930

12 December 2020

based on heuristic

inferred from PubMed ID database lookup

Selective inhibitory effects of the anticoagulant activated protein C on the responses of human mononuclear phagocytes to LPS, IFN-gamma, or phorbol ester

1 reference

https://pubmed.ncbi.nlm.nih.gov/22447930

12 December 2020

based on heuristic

inferred from PubMed ID database lookup

New therapeutic applications for the anticoagulant, activated protein C

1 reference

https://pubmed.ncbi.nlm.nih.gov/22447930

12 December 2020

based on heuristic

inferred from PubMed ID database lookup

Activated protein C directly activates human endothelial gelatinase A

1 reference

https://pubmed.ncbi.nlm.nih.gov/22447930

12 December 2020

based on heuristic

inferred from PubMed ID database lookup

Differential regulation of matrix metalloproteinase 2 and matrix metalloproteinase 9 by activated protein C: relevance to inflammation in rheumatoid arthritis

1 reference

https://pubmed.ncbi.nlm.nih.gov/22447930

12 December 2020

based on heuristic

inferred from PubMed ID database lookup

[Detection of soluble endothelial protein C receptor (sEPCR) in patients with CHD, DM and SLE]

1 reference

https://pubmed.ncbi.nlm.nih.gov/22447930

12 December 2020

based on heuristic

inferred from PubMed ID database lookup

Decreased protein C levels in patients with insulin-dependent type I diabetes mellitus

1 reference

https://pubmed.ncbi.nlm.nih.gov/22447930

12 December 2020

based on heuristic

inferred from PubMed ID database lookup

Identifiers

10.1074/JBC.M111.325951

1 reference

Europe PubMed Central

PMC publication ID

11 August 2017

PMC publication ID

1 reference

Europe PubMed Central

PMC publication ID

11 August 2017

PubMed publication ID

1 reference

Europe PubMed Central

PMC publication ID

11 August 2017

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