(Q40056621)

16 September 2017

title

Activated protein C protects against diabetic nephropathy by inhibiting endothelial and podocyte apoptosis (English)

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16 September 2017

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Triantafyllos Chavakis

14

object named as

Triantafyllos Chavakis

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16 September 2017

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Peter P Nawroth

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Angelika Bierhaus

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Berend Isermann

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Thati Madhusudhan

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Stefanie Herzog

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Muhammed Kashif

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Janusch Blautzik

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Marcus A F Corat

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Martin Zeier

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Erwin Blessing

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Jun Oh

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Bruce Gerlitz

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David T Berg

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Brian W Grinnell

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Charles T Esmon

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Hartmut Weiler

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16 September 2017

language of work or name

English

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publication date

4 November 2007

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16 September 2017

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16 September 2017

volume

13

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issue

11

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16 September 2017

page(s)

1349-1358

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RAGE drives the development of glomerulosclerosis and implicates podocyte activation in the pathogenesis of diabetic nephropathy

16 September 2017

cites work

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Workshop: endothelial cell dysfunction leading to diabetic nephropathy : focus on nitric oxide

21 January 2018

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Is podocyte injury relevant in diabetic nephropathy? Studies in patients with type 2 diabetes

21 January 2018

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7 January 2021

Podocyte number predicts long-term urinary albumin excretion in Pima Indians with Type II diabetes and microalbuminuria

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7 January 2021

Inflammation and the activated protein C anticoagulant pathway

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7 January 2021

Activation of endothelial cell protease activated receptor 1 by the protein C pathway

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7 January 2021

Activated protein C blocks p53-mediated apoptosis in ischemic human brain endothelium and is neuroprotective

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7 January 2021

Endothelial barrier protection by activated protein C through PAR1-dependent sphingosine 1-phosphate receptor-1 crossactivation

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7 January 2021

Activated protein C mediates novel lung endothelial barrier enhancement: role of sphingosine 1-phosphate receptor transactivation

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7 January 2021

Influence of ramipril on the course of plasma thrombomodulin in patients with diabetes mellitus

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7 January 2021

Circulating thrombomodulin and hematological alterations in type 2 diabetic patients with retinopathy

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7 January 2021

A targeted point mutation in thrombomodulin generates viable mice with a prethrombotic state

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7 January 2021

Thrombin interacts with thrombomodulin, protein C, and thrombin-activatable fibrinolysis inhibitor via specific and distinct domains

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7 January 2021

Inflammation and microalbuminuria in nondiabetic and type 2 diabetic subjects: The Insulin Resistance Atherosclerosis Study.

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7 January 2021

The thrombomodulin-protein C system is essential for the maintenance of pregnancy.

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7 January 2021

Inhibition of staurosporine-induced apoptosis of endothelial cells by activated protein C requires protease-activated receptor-1 and endothelial cell protein C receptor

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7 January 2021

Yama/CPP32 beta, a mammalian homolog of CED-3, is a CrmA-inhibitable protease that cleaves the death substrate poly(ADP-ribose) polymerase

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7 January 2021

Minocycline up-regulates Bcl-2 and protects against cell death in mitochondria

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7 January 2021

Minocycline inhibits apoptosis and inflammation in a rat model of ischemic renal injury

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7 January 2021

Biochemistry and molecular cell biology of diabetic complications

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7 January 2021

High glucose via peroxynitrite causes tyrosine nitration and inactivation of prostacyclin synthase that is associated with thromboxane/prostaglandin H(2) receptor-mediated apoptosis and adhesion molecule expression in cultured human aortic endotheli

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7 January 2021

Activated protein C, a natural anticoagulant protein, has antioxidant properties and inhibits lipid peroxidation and advanced glycation end products formation.

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7 January 2021

Protease-activated receptor-1 signaling by activated protein C in cytokine-perturbed endothelial cells is distinct from thrombin signaling

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Endothelial dysfunction

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Apoptotic cell loss following cell proliferation in renal glomeruli of Otsuka Long-Evans Tokushima Fatty rats, a model of human type 2 diabetes

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7 January 2021

Evidence of apoptosis in human diabetic kidney

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7 January 2021

Involvement of apoptosis in patients with diabetic nephropathy: A study on plasma soluble Fas levels and pathological findings

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7 January 2021

Patients with severe sepsis vary markedly in their ability to generate activated protein C

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7 January 2021

New insights into the protein C pathway: potential implications for the biological activities of drotrecogin alfa (activated).

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7 January 2021

Oxidation of a specific methionine in thrombomodulin by activated neutrophil products blocks cofactor activity. A potential rapid mechanism for modulation of coagulation

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7 January 2021

Activated protein C variants with normal cytoprotective but reduced anticoagulant activity

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7 January 2021

Safety assessment of drotrecogin alfa (activated) in the treatment of adult patients with severe sepsis

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7 January 2021

Activated protein C in sepsis

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Constitutive expression of the S1P1 receptor in adult tissues.

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7 January 2021

The therapeutic potential of poly(ADP-ribose) polymerase inhibitors

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7 January 2021

Nuclear poly(ADP-ribose) polymerase-1 rapidly triggers mitochondrial dysfunction

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7 January 2021

Minocycline inhibits poly(ADP-ribose) polymerase-1 at nanomolar concentrations.

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7 January 2021

Poly(ADP-ribose) polymerase inhibitors ameliorate nephropathy of type 2 diabetic Leprdb/db mice.

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7 January 2021

The pathogenesis of diabetic complications: the role of DNA injury and poly(ADP-ribose) polymerase activation in peroxynitrite-mediated cytotoxicity

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7 January 2021

Enhancing protein C interaction with thrombin results in a clot-activated anticoagulant

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7 January 2021

Minocycline inhibits caspase-1 and caspase-3 expression and delays mortality in a transgenic mouse model of Huntington disease

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7 January 2021

Survival advantage associated with heterozygous factor V Leiden mutation in patients with severe sepsis and in mouse endotoxemia.

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7 January 2021

PPAR-alpha and -gamma agonists attenuate diabetic kidney disease in the apolipoprotein E knockout mouse.

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7 January 2021

Rearrangements of the cytoskeleton and cell contacts induce process formation during differentiation of conditionally immortalized mouse podocyte cell lines.

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7 January 2021

Identifiers

DOI

10.1038/NM1667

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16 September 2017

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