(Q52549296)

3 May 2018

title

The thrombomodulin-protein C system is essential for the maintenance of pregnancy. (English)

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3 May 2018

author name string

Berend Isermann

1

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3 May 2018

Rashmi Sood

2

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3 May 2018

Rafal Pawlinski

3

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3 May 2018

Mark Zogg

4

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3 May 2018

Shawn Kalloway

5

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3 May 2018

Jay L Degen

6

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3 May 2018

Nigel Mackman

7

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3 May 2018

Hartmut Weiler

8

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3 May 2018

language of work or name

English

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publication date

10 February 2003

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3 May 2018

published in

Nature Medicine

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3 May 2018

volume

9

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3 May 2018

issue

3

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3 May 2018

page(s)

331-337

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3 May 2018

https://scigraph.springernature.com/pub.10.1038/nm825

exact match

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cites work

Regulation of blood coagulation

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7 January 2021

Endothelial cell protein C receptor plays an important role in protein C activation in vivo

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7 January 2021

Absence of the blood-clotting regulator thrombomodulin causes embryonic lethality in mice before development of a functional cardiovascular system

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7 January 2021

Targeting of transgene expression to the vascular endothelium of mice by homologous recombination at the thrombomodulin locus

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7 January 2021

A targeted point mutation in thrombomodulin generates viable mice with a prethrombotic state

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7 January 2021

Thrombomodulin modulates growth of tumor cells independent of its anticoagulant activity

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7 January 2021

Elements of the primary structure of thrombomodulin required for efficient thrombin-activable fibrinolysis inhibitor activation

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7 January 2021

Clot-bound thrombin is protected from inhibition by heparin-antithrombin III but is susceptible to inactivation by antithrombin III-independent inhibitors

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7 January 2021

Mechanism of the anticoagulant effect of warfarin as evaluated in rabbits by selective depression of individual procoagulant vitamin K-dependent clotting factors

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7 January 2021

Role of tissue factor in embryonic blood vessel development.

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7 January 2021

Fatal embryonic bleeding events in mice lacking tissue factor, the cell-associated initiator of blood coagulation

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7 January 2021

Low levels of tissue factor are compatible with development and hemostasis in mice.

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7 January 2021

Tissue factor is required for uterine hemostasis and maintenance of the placental labyrinth during gestation

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7 January 2021

Resolution of spontaneous bleeding events but failure of pregnancy in fibrinogen-deficient mice

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7 January 2021

Promotion of trophoblast stem cell proliferation by FGF4

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7 January 2021

Expression of BCL-2, BAX and BAK in the Trophoblast Layer of the Term Human Placenta: a Unique Model of Apoptosis within a Syncytium

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7 January 2021

Inverse relationship between apoptosis and Bcl-2 expression in syncytiotrophoblast and fibrin-type fibrinoid in early gestation

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7 January 2021

Effects of fibrinogen degradation products on glomerular mesangial cells in culture

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7 January 2021

RGD peptides induce apoptosis by direct caspase-3 activation.

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7 January 2021

Invasion of the trophoblasts

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7 January 2021

Expression of tissue type and urokinase type plasminogen activators as well as plasminogen activator inhibitor type-1 and type-2 in human and rhesus monkey placenta.

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7 January 2021

Activation of endothelial cell protease activated receptor 1 by the protein C pathway

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7 January 2021

Role of the thrombin receptor in development and evidence for a second receptor.

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7 January 2021

Disruption of the endothelial cell protein C receptor gene in mice causes placental thrombosis and early embryonic lethality.

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7 January 2021

Thrombin signalling and protease-activated receptors

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7 January 2021

Implantation and the placenta: key pieces of the development puzzle

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7 January 2021

Increase in expression and activity of thrombomodulin in term human syncytiotrophoblast microvilli.

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7 January 2021

Thrombin receptor overexpression in malignant and physiological invasion processes

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7 January 2021

Increased fetal loss in women with heritable thrombophilia.

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7 January 2021

Thrombosis in pregnancy: maternal and fetal issues

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7 January 2021

Increased frequency of genetic thrombophilia in women with complications of pregnancy

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7 January 2021

Thrombophilia-associated pregnancy wastage

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7 January 2021

Histopathological findings in placentae from patients with intra-uterine fetal death and anti-phospholipid antibodies

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7 January 2021

Identifiers

DOI

10.1038/NM825

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3 May 2018

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3 May 2018