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A single administration of low-dose varenicline saturates α4β2* nicotinic acetylcholine receptors in the human brain.
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Europe PubMed Central
PMC publication ID
3358744
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https://www.ebi.ac.uk/europepmc/webservices/rest/search?query=EXT_ID:22395733%20AND%20SRC:MED&resulttype=core&format=json
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25 January 2020
title
A single administration of low-dose varenicline saturates α4β2* nicotinic acetylcholine receptors in the human brain
(English)
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Europe PubMed Central
PMC publication ID
3358744
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25 January 2020
main subject
varenicline
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author
Shahrdad Lotfipour
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1
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Europe PubMed Central
PMC publication ID
3358744
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https://www.ebi.ac.uk/europepmc/webservices/rest/search?query=EXT_ID:22395733%20AND%20SRC:MED&resulttype=core&format=json
retrieved
25 January 2020
Mark Mandelkern
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Mark Mandelkern
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Europe PubMed Central
PMC publication ID
3358744
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25 January 2020
author name string
Miguel Alvarez-Estrada
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3
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Europe PubMed Central
PMC publication ID
3358744
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https://www.ebi.ac.uk/europepmc/webservices/rest/search?query=EXT_ID:22395733%20AND%20SRC:MED&resulttype=core&format=json
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25 January 2020
Arthur L Brody
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4
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Europe PubMed Central
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3358744
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https://www.ebi.ac.uk/europepmc/webservices/rest/search?query=EXT_ID:22395733%20AND%20SRC:MED&resulttype=core&format=json
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25 January 2020
language of work or name
English
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publication date
7 March 2012
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Europe PubMed Central
PMC publication ID
3358744
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https://www.ebi.ac.uk/europepmc/webservices/rest/search?query=EXT_ID:22395733%20AND%20SRC:MED&resulttype=core&format=json
retrieved
25 January 2020
published in
Neuropsychopharmacology
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PMC publication ID
3358744
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https://www.ebi.ac.uk/europepmc/webservices/rest/search?query=EXT_ID:22395733%20AND%20SRC:MED&resulttype=core&format=json
retrieved
25 January 2020
volume
37
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3358744
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https://www.ebi.ac.uk/europepmc/webservices/rest/search?query=EXT_ID:22395733%20AND%20SRC:MED&resulttype=core&format=json
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25 January 2020
issue
7
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Europe PubMed Central
PMC publication ID
3358744
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https://www.ebi.ac.uk/europepmc/webservices/rest/search?query=EXT_ID:22395733%20AND%20SRC:MED&resulttype=core&format=json
retrieved
25 January 2020
page(s)
1738-1748
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Europe PubMed Central
PMC publication ID
3358744
reference URL
https://www.ebi.ac.uk/europepmc/webservices/rest/search?query=EXT_ID:22395733%20AND%20SRC:MED&resulttype=core&format=json
retrieved
25 January 2020
exact match
https://scigraph.springernature.com/pub.10.1038/npp.2012.20
0 references
cites work
Quantitative Molecular Imaging of Neuronal Nicotinic Acetylcholine Receptors in the Human Brain with A-85380 Radiotracers
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PubMed Central
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2 October 2017
Effect of secondhand smoke on occupancy of nicotinic acetylcholine receptors in brain
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2 October 2017
Nicotine receptor partial agonists for smoking cessation
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PubMed Central
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2 October 2017
Effects of varenicline on smoking cue–triggered neural and craving responses
1 reference
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PubMed Central
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https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=3358744
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2 October 2017
Parallel anxiolytic-like effects and upregulation of neuronal nicotinic acetylcholine receptors following chronic nicotine and varenicline
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PubMed Central
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https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=3358744
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2 October 2017
Nicotine addiction and nicotinic receptors: lessons from genetically modified mice
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2 October 2017
Determination of volatile organic compounds for a systematic evaluation of third-hand smoking
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2 October 2017
Pre-clinical properties of the alpha4beta2 nicotinic acetylcholine receptor partial agonists varenicline, cytisine and dianicline translate to clinical efficacy for nicotine dependence
1 reference
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PubMed Central
reference URL
https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=3358744
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2 October 2017
The role of alpha6-containing nicotinic acetylcholine receptors in nicotine reward and withdrawal
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PubMed Central
reference URL
https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=3358744
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2 October 2017
Stimulation of dopamine release by nicotinic acetylcholine receptor ligands in rat brain slices correlates with the profile of high, but not low, sensitivity alpha4beta2 subunit combination
1 reference
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PubMed Central
reference URL
https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=3358744
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2 October 2017
Varenicline improves mood and cognition during smoking abstinence
1 reference
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PubMed Central
reference URL
https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=3358744
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2 October 2017
Varenicline ameliorates nicotine withdrawal-induced learning deficits in C57BL/6 mice
1 reference
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PubMed Central
reference URL
https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=3358744
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2 October 2017
Brain nicotinic acetylcholine receptor occupancy: effect of smoking a denicotinized cigarette
1 reference
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PubMed Central
reference URL
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2 October 2017
Subtypes of nicotinic acetylcholine receptors in nicotine reward, dependence, and withdrawal: evidence from genetically modified mice.
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PubMed Central
reference URL
https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=3358744
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2 October 2017
It is not "either/or": activation and desensitization of nicotinic acetylcholine receptors both contribute to behaviors related to nicotine addiction and mood
1 reference
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PubMed Central
reference URL
https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=3358744
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2 October 2017
Differential role of nicotinic acetylcholine receptor subunits in physical and affective nicotine withdrawal signs
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PubMed Central
reference URL
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2 October 2017
Measurement of the effects of abstinence from tobacco: a qualitative review
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PubMed Central
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https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=3358744
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2 October 2017
Consensus nomenclature for in vivo imaging of reversibly binding radioligands
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PubMed Central
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2 October 2017
Effects of abstinence from tobacco: valid symptoms and time course
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PubMed Central
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https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=3358744
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2 October 2017
Pharmacological profile of the alpha4beta2 nicotinic acetylcholine receptor partial agonist varenicline, an effective smoking cessation aid
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PubMed Central
reference URL
https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=3358744
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2 October 2017
Cigarette smoking saturates brain alpha 4 beta 2 nicotinic acetylcholine receptors
1 reference
stated in
PubMed Central
reference URL
https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=3358744
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2 October 2017
Desensitization of neuronal nicotinic receptors of human neuroblastoma SH-SY5Y cells during short or long exposure to nicotine
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PubMed Central
reference URL
https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=3358744
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2 October 2017
Metabolism and disposition of varenicline, a selective alpha4beta2 acetylcholine receptor partial agonist, in vivo and in vitro
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PubMed Central
reference URL
https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=3358744
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2 October 2017
Desensitization of neuronal nicotinic receptors
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PubMed Central
reference URL
https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=3358744
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2 October 2017
Neurobiology of the nicotine withdrawal syndrome
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2 October 2017
Evaluation of the brief questionnaire of smoking urges (QSU-brief) in laboratory and clinical settings
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PubMed Central
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https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=3358744
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2 October 2017
Chronic exposure to nicotine upregulates the human (alpha)4((beta)2 nicotinic acetylcholine receptor function.
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PubMed Central
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https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=3358744
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2 October 2017
Use of the Beck Depression Inventory for Primary Care to screen for major depression disorders
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PubMed Central
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https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=3358744
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2 October 2017
Measuring degree of physical dependence to tobacco smoking with reference to individualization of treatment
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PubMed Central
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https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=3358744
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2 October 2017
The monoamine oxidase (MAO) inhibitor tranylcypromine enhances nicotine self-administration in rats through a mechanism independent of MAO inhibition
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PubMed Central
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https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=3358744
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11 July 2018
Prenatal exposure to maternal cigarette smoking interacts with a polymorphism in the alpha6 nicotinic acetylcholine receptor gene to influence drug use and striatum volume in adolescence
1 reference
stated in
PubMed Central
reference URL
https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=3358744
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11 July 2018
Revealing the multidimensional framework of the Minnesota nicotine withdrawal scale.
1 reference
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PubMed Central
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https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=3358744
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11 July 2018
Signs and symptoms of tobacco withdrawal.
1 reference
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PubMed Central
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https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=3358744
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11 July 2018
Symptoms of tobacco withdrawal. A replication and extension.
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PubMed Central
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https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=3358744
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11 July 2018
Effects of nicotine gum on prevalence and severity of withdrawal in female cigarette smokers
1 reference
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PubMed Central
reference URL
https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=3358744
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11 July 2018
Unraveling the high- and low-sensitivity agonist responses of nicotinic acetylcholine receptors.
1 reference
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PubMed Central
reference URL
https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=3358744
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24 September 2018
Maternal smoking during pregnancy is associated with epigenetic modifications of the brain-derived neurotrophic factor-6 exon in adolescent offspring.
1 reference
stated in
PubMed Central
reference URL
https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=3358744
retrieved
24 September 2018
Effects of the alpha4beta2 partial agonist varenicline on brain activity and working memory in abstinent smokers
1 reference
stated in
PubMed Central
reference URL
https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=3358744
retrieved
24 September 2018
Orbitofrontal cortex and drug use during adolescence: role of prenatal exposure to maternal smoking and BDNF genotype.
1 reference
stated in
PubMed Central
reference URL
https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=3358744
retrieved
24 September 2018
Effect of varenicline and bupropion SR on craving, nicotine withdrawal symptoms, and rewarding effects of smoking during a quit attempt
1 reference
stated in
PubMed Central
reference URL
https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=3358744
retrieved
24 September 2018
A randomized, placebo-controlled trial of varenicline, a selective alpha4beta2 nicotinic acetylcholine receptor partial agonist, as a new therapy for smoking cessation in Asian smokers.
1 reference
stated in
PubMed Central
reference URL
https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=3358744
retrieved
24 September 2018
Measurement of the alpha4beta2* nicotinic acetylcholine receptor ligand 2-[(18)F]Fluoro-A-85380 and its metabolites in human blood during PET investigation: a methodological study.
1 reference
stated in
PubMed Central
reference URL
https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=3358744
retrieved
24 September 2018
Binding properties of the cerebral alpha4beta2 nicotinic acetylcholine receptor ligand 2-[18F]fluoro-A-85380 to plasma proteins.
1 reference
stated in
PubMed Central
reference URL
https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=3358744
retrieved
24 September 2018
alpha4beta2 nicotinic receptors with high and low acetylcholine sensitivity: pharmacology, stoichiometry, and sensitivity to long-term exposure to nicotine.
1 reference
stated in
PubMed Central
reference URL
https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=3358744
retrieved
24 September 2018
Nicotine blood levels and subjective craving for cigarettes.
1 reference
stated in
PubMed Central
reference URL
https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=3358744
retrieved
24 September 2018
Synthesis and nicotinic acetylcholine receptor in vivo binding properties of 2-fluoro-3-[2(S)-2-azetidinylmethoxy]pyridine: a new positron emission tomography ligand for nicotinic receptors.
1 reference
stated in
PubMed Central
reference URL
https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=3358744
retrieved
24 September 2018
Functional contributions of alpha5 subunit to neuronal acetylcholine receptor channels.
1 reference
stated in
PubMed Central
reference URL
https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=3358744
retrieved
24 September 2018
Nicotine and cotinine elimination pharmacokinetics in smokers and nonsmokers
1 reference
stated in
PubMed
reference URL
https://pubmed.ncbi.nlm.nih.gov/22395733
retrieved
12 December 2020
based on heuristic
inferred from PubMed ID database lookup
A simplified method for the measurement of nonmetabolized 2-[18F]F-A-85380 in blood plasma using solid-phase extraction
1 reference
stated in
PubMed
reference URL
https://pubmed.ncbi.nlm.nih.gov/22395733
retrieved
12 December 2020
based on heuristic
inferred from PubMed ID database lookup
Smoking withdrawal symptoms in two weeks of abstinence
1 reference
stated in
PubMed
reference URL
https://pubmed.ncbi.nlm.nih.gov/22395733
retrieved
12 December 2020
based on heuristic
inferred from PubMed ID database lookup
Identifiers
DOI
10.1038/NPP.2012.20
1 reference
stated in
Europe PubMed Central
PMC publication ID
3358744
reference URL
https://www.ebi.ac.uk/europepmc/webservices/rest/search?query=EXT_ID:22395733%20AND%20SRC:MED&resulttype=core&format=json
retrieved
25 January 2020
PMC publication ID
3358744
1 reference
stated in
Europe PubMed Central
PMC publication ID
3358744
reference URL
https://www.ebi.ac.uk/europepmc/webservices/rest/search?query=EXT_ID:22395733%20AND%20SRC:MED&resulttype=core&format=json
retrieved
25 January 2020
PubMed publication ID
22395733
1 reference
stated in
Europe PubMed Central
PMC publication ID
3358744
reference URL
https://www.ebi.ac.uk/europepmc/webservices/rest/search?query=EXT_ID:22395733%20AND%20SRC:MED&resulttype=core&format=json
retrieved
25 January 2020
ResearchGate publication ID
221682581
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