(Q36000813)

English

Targeting the LOX/hypoxia axis reverses many of the features that make pancreatic cancer deadly: inhibition of LOX abrogates metastasis and enhances drug efficacy.

scientific article published on 15 June 2015

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17 February 2020

Targeting the LOX/hypoxia axis reverses many of the features that make pancreatic cancer deadly: inhibition of LOX abrogates metastasis and enhances drug efficacy (English)

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17 February 2020

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pancreatic cancer

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inferred from title

Jennifer P. Morton

2

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17 February 2020

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17 February 2020

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17 February 2020

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17 February 2020

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17 February 2020

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17 February 2020

Caroline J Springer

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17 February 2020

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17 February 2020

Janine T. Erler

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17 February 2020

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Saadia Karim

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17 February 2020

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17 February 2020

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Colin McKay

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17 February 2020

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Ewan McGhee

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17 February 2020

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Paul Timpson

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17 February 2020

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Colin Steele

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17 February 2020

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Bryan W Miller

1

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17 February 2020

Grazia Saturno

4

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17 February 2020

Lynn McGarry

9

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17 February 2020

Peter Bailey

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17 February 2020

David Chang

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17 February 2020

Amy Au

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17 February 2020

Christopher Ross Carter

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17 February 2020

Thomas R Jeffry Evans

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17 February 2020

Richard Marais

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17 February 2020

publication date

1 August 2015

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17 February 2020

EMBO Molecular Medicine

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17 February 2020

7

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17 February 2020

8

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17 February 2020

1063-1076

1 reference

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17 February 2020

describes a project that uses

1 reference

Europe PubMed Central

11 June 2022

https://www.ebi.ac.uk/europepmc/webservices/rest/PMC4551344/fullTextXML

based on heuristic

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Stromal response to Hedgehog signaling restrains pancreatic cancer progression

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=4551344

2 October 2017

Depletion of carcinoma-associated fibroblasts and fibrosis induces immunosuppression and accelerates pancreas cancer with reduced survival

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=4551344

2 October 2017

Stromal elements act to restrain, rather than support, pancreatic ductal adenocarcinoma

1 reference

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2 October 2017

Mutant p53 drives pancreatic cancer metastasis through cell-autonomous PDGF receptor β signaling

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Lysyl oxidase activity regulates oncogenic stress response and tumorigenesis.

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2 October 2017

Lysyl oxidase in colorectal cancer

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Clinical and molecular characterization of HER2 amplified-pancreatic cancer.

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2 October 2017

LOX-mediated collagen crosslinking is responsible for fibrosis-enhanced metastasis

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Pancreatic cancer genomes reveal aberrations in axon guidance pathway genes

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Clinical implications of biological markers in Pancreatic Ductal Adenocarcinoma.

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The rationale for targeting the LOX family in cancer

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Organotypic collagen I assay: a malleable platform to assess cell behaviour in a 3-dimensional context

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Tissue biomarkers for prognosis in pancreatic ductal adenocarcinoma: a systematic review and meta-analysis

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The role of lysyl oxidase in SRC-dependent proliferation and metastasis of colorectal cancer

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Spatial regulation of RhoA activity during pancreatic cancer cell invasion driven by mutant p53

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Mutant p53 drives invasion by promoting integrin recycling

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Validation of lysyl oxidase as a prognostic marker for metastasis and survival in head and neck squamous cell carcinoma: Radiation Therapy Oncology Group trial 90-03.

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Inhibition of Hedgehog signaling enhances delivery of chemotherapy in a mouse model of pancreatic cancer

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A Mutant-p53/Smad complex opposes p63 to empower TGFbeta-induced metastasis

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Hypoxia-induced lysyl oxidase is a critical mediator of bone marrow cell recruitment to form the premetastatic niche

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Molecular Pathways: Connecting Fibrosis and Solid Tumor Metastasis

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A Phase II Randomized, Double-Blind, Placebo-Controlled Study of Simtuzumab or Placebo in Combination with Gemcitabine for the First-Line Treatment of Pancreatic Adenocarcinoma

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based on heuristic

inferred from PubMed ID database lookup

Identifiers

10.15252/EMMM.201404827

1 reference

Europe PubMed Central

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https://www.ebi.ac.uk/europepmc/webservices/rest/search?query=EXT_ID:26077591%20AND%20SRC:MED&resulttype=core&format=json

17 February 2020

PMC publication ID

1 reference

Europe PubMed Central

PMC publication ID

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17 February 2020

PubMed publication ID

1 reference

Europe PubMed Central

PMC publication ID

https://www.ebi.ac.uk/europepmc/webservices/rest/search?query=EXT_ID:26077591%20AND%20SRC:MED&resulttype=core&format=json

17 February 2020

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