(Q36004703)

English

Disrupted Signaling through the Fanconi Anemia Pathway Leads to Dysfunctional Hematopoietic Stem Cell Biology: Underlying Mechanisms and Potential Therapeutic Strategies

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scholarly article

1 reference

Europe PubMed Central

PMC publication ID

11 August 2017

Disrupted Signaling through the Fanconi Anemia Pathway Leads to Dysfunctional Hematopoietic Stem Cell Biology: Underlying Mechanisms and Potential Therapeutic Strategies (English)

1 reference

Europe PubMed Central

PMC publication ID

11 August 2017

1 reference

based on heuristic

inferred from title

1 reference

based on heuristic

inferred from title

author name string

Anja Geiselhart

1

1 reference

Europe PubMed Central

PMC publication ID

11 August 2017

Amelie Lier

2

1 reference

Europe PubMed Central

PMC publication ID

11 August 2017

Dagmar Walter

3

1 reference

Europe PubMed Central

PMC publication ID

11 August 2017

Michael D Milsom

4

1 reference

Europe PubMed Central

PMC publication ID

11 August 2017

publication date

23 May 2012

1 reference

Europe PubMed Central

PMC publication ID

11 August 2017

1 reference

Europe PubMed Central

PMC publication ID

11 August 2017

2012

1 reference

Europe PubMed Central

PMC publication ID

11 August 2017

265790

1 reference

Europe PubMed Central

PMC publication ID

11 August 2017

copyright license

Creative Commons Attribution 3.0 Unported

1 January 2012

1 reference

April 2022 Public Data File from Crossref

copyright status

1 reference

April 2022 Public Data File from Crossref

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Genetic disruption of both Fancc and Fancg in mice recapitulates the hematopoietic manifestations of Fanconi anemia.

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Large animal models of hematopoietic stem cell gene therapy

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Haematopoeitic cell transplantation for Fanconi anaemia - when and how?

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Update on gene therapy for immunodeficiencies

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Oxidative stress-specific interaction between FANCD2 and FOXO3a

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Fanca-/- hematopoietic stem cells demonstrate a mobilization defect which can be overcome by administration of the Rac inhibitor NSC23766.

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Disease-corrected haematopoietic progenitors from Fanconi anaemia induced pluripotent stem cells.

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1 reference

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2 October 2017

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2 October 2017

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2 October 2017

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2 October 2017

TNF-alpha and IFN-gamma are overexpressed in the bone marrow of Fanconi anemia patients and TNF-alpha suppresses erythropoiesis in vitro.

1 reference

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2 October 2017

Reverse mosaicism in Fanconi anemia: natural gene therapy via molecular self-correction

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2 October 2017

Cancer in Fanconi anemia, 1927-2001

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2 October 2017

The Fanconi anaemia/BRCA pathway

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2 October 2017

Generation and initial analysis of more than 15,000 full-length human and mouse cDNA sequences

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In vitro phenotypic correction of hematopoietic progenitors from Fanconi anemia group A knockout mice

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2 October 2017

Phenotypic correction of primary Fanconi anemia T cells with retroviral vectors as a diagnostic tool.

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2 October 2017

Reduced fertility and hypersensitivity to mitomycin C characterize Fancg/Xrcc9 null mice

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Targeted disruption of the murine Fanconi anemia gene, Fancg/Xrcc9

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FANCC interacts with Hsp70 to protect hematopoietic cells from IFN-gamma/TNF-alpha-mediated cytotoxicity

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Defective hematopoiesis and hepatic steatosis in mice with combined deficiencies of the genes encoding Fancc and Cu/Zn superoxide dismutase

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2 October 2017

Interaction of the Fanconi anemia proteins and BRCA1 in a common pathway

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Mice with a targeted disruption of the Fanconi anemia homolog Fanca

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The Fanconi anemia protein FANCC binds to and facilitates the activation of STAT1 by gamma interferon and hematopoietic growth factors

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https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=3366203

2 October 2017

Engraftment of hematopoietic progenitor cells transduced with the Fanconi anemia group C gene (FANCC)

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=3366203

2 October 2017

The Fanconi anemia group C gene product modulates apoptotic responses to tumor necrosis factor-alpha and Fas ligand but does not suppress expression of receptors of the tumor necrosis factor receptor superfamily

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=3366203

2 October 2017

Prolonged administration of granulocyte colony-stimulating factor (filgrastim) to patients with Fanconi anemia: a pilot study

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=3366203

2 October 2017

Germ cell defects and hematopoietic hypersensitivity to gamma-interferon in mice with a targeted disruption of the Fanconi anemia C gene

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=3366203

2 October 2017

Inactivation of Fac in mice produces inducible chromosomal instability and reduced fertility reminiscent of Fanconi anaemia

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=3366203

2 October 2017

Hematologic abnormalities in Fanconi anemia: an International Fanconi Anemia Registry study.

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=3366203

2 October 2017

Repression of Fanconi anemia gene (FACC) expression inhibits growth of hematopoietic progenitor cells

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=3366203

2 October 2017

Flow cytometric characterization of the response of Fanconi's anemia cells to mitomycin C treatment

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=3366203

2 October 2017

Bone marrow transplantation for Fanconi anemia

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=3366203

2 October 2017

Endogenous blockage and delay of the chromosome cycle despite normal recruitment and growth phase explain poor proliferation and frequent edomitosis in Fanconi anemia cells

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=3366203

2 October 2017

An in vitro limiting-dilution assay of long-term repopulating hematopoietic stem cells in the mouse

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=3366203

2 October 2017

Leukemia and preleukemia in Fanconi anemia patients. A review of the literature and report of the International Fanconi Anemia Registry

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=3366203

2 October 2017

Molecular Analysis of Primitive Hematopoietic Cell Proliferation Control Mechanisms

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=3366203

2 October 2017

Conditions controlling the proliferation of haemopoietic stem cells in vitro

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=3366203

2 October 2017

Tumor necrosis factor restricts hematopoietic stem cell activity in mice: involvement of two distinct receptors

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=3366203

11 July 2018

Correction of Fanconi Anemia Group C Hematopoietic Stem Cells Following Intrafemoral Gene Transfer

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=3366203

11 July 2018

AMD3100 synergizes with G-CSF to mobilize repopulating stem cells in Fanconi anemia knockout mice

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=3366203

11 July 2018

Inflammatory reactive oxygen species-mediated hemopoietic suppression in Fancc-deficient mice

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=3366203

11 July 2018

SLAM family markers are conserved among hematopoietic stem cells from old and reconstituted mice and markedly increase their purity

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=3366203

11 July 2018

Ex vivo culture of Fancc-/- stem/progenitor cells predisposes cells to undergo apoptosis, and surviving stem/progenitor cells display cytogenetic abnormalities and an increased risk of malignancy

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=3366203

11 July 2018

Knockdown of zebrafish Fancd2 causes developmental abnormalities via p53-dependent apoptosis

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=3366203

11 July 2018

Retroviral-mediated expression of recombinant Fancc enhances the repopulating ability of Fancc-/- hematopoietic stem cells and decreases the risk of clonal evolution

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=3366203

11 July 2018

Analysis of human hematopoietic stem cell populations

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=3366203

11 July 2018

A functionally active retrovirus vector for gene therapy in Fanconi anemia group C.

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=3366203

11 July 2018

Fanconi anemia mutation causes cellular susceptibility to ambient oxygen.

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=3366203

11 July 2018

Increased ratio of targeted to random integration after transfection of chicken B cell lines.

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=3366203

11 July 2018

Abnormal lymphokine production: a novel feature of the genetic disease Fanconi anemia. I. Involvement of interleukin-6

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=3366203

11 July 2018

A 20-year perspective on the International Fanconi Anemia Registry (IFAR).

1 reference

https://api.crossref.org/works/10.1155%2F2012%2F265790

21 January 2018

Mutation of the RAD51C gene in a Fanconi anemia-like disorder

1 reference

https://api.crossref.org/works/10.1155%2F2012%2F265790

21 January 2018

SLX4, a coordinator of structure-specific endonucleases, is mutated in a new Fanconi anemia subtype

1 reference

https://api.crossref.org/works/10.1155%2F2012%2F265790

21 January 2018

Matched sibling donor haematopoietic stem cell transplantation in Fanconi anaemia: an update of the Cincinnati Children's experience.

1 reference

https://api.crossref.org/works/10.1155%2F2012%2F265790

21 January 2018

Successful engraftment without radiation after fludarabine-based regimen in Fanconi anemia patients undergoing genotypically identical donor hematopoietic cell transplantation

1 reference

https://api.crossref.org/works/10.1155%2F2012%2F265790

21 January 2018

Effects of lethal irradiation in zebrafish and rescue by hematopoietic cell transplantation

1 reference

https://api.crossref.org/works/10.1155%2F2012%2F265790

21 January 2018

Fancm-deficient mice reveal unique features of Fanconi anemia complementation group M.

1 reference

https://api.crossref.org/works/10.1155%2F2012%2F265790

21 January 2018

Genotype-phenotype correlations in Fanconi anemia

1 reference

https://api.crossref.org/works/10.1155%2F2012%2F265790

21 January 2018

Hematopoietic compartment of Fanconi anemia group C null mice contains fewer lineage-negative CD34+ primitive hematopoietic cells and shows reduced reconstruction ability.

1 reference

https://api.crossref.org/works/10.1155%2F2012%2F265790

21 January 2018

Phenotype correction of Fanconi anemia group A hematopoietic stem cells using lentiviral vector

1 reference

https://api.crossref.org/works/10.1155%2F2012%2F265790

21 January 2018

Fancd2-/- mice have hematopoietic defects that can be partially corrected by resveratrol.

1 reference

https://api.crossref.org/works/10.1155%2F2012%2F265790

21 January 2018

In vivo proliferation advantage of genetically corrected hematopoietic stem cells in a mouse model of Fanconi anemia FA-D1.

1 reference

https://api.crossref.org/works/10.1155%2F2012%2F265790

21 January 2018

Fanconi anemia proteins and endogenous stresses

1 reference

https://api.crossref.org/works/10.1155%2F2012%2F265790

21 January 2018

Oxidant hypersensitivity of Fanconi anemia type C-deficient cells is dependent on a redox-regulated apoptotic pathway

1 reference

https://api.crossref.org/works/10.1155%2F2012%2F265790

21 January 2018

Regulation of reactive oxygen species by Atm is essential for proper response to DNA double-strand breaks in lymphocytes.

1 reference

https://api.crossref.org/works/10.1155%2F2012%2F265790

21 January 2018

Accumulation of oxidative DNA damage restricts the self-renewal capacity of human hematopoietic stem cells.

1 reference

https://api.crossref.org/works/10.1155%2F2012%2F265790

21 January 2018

Continuous in vivo infusion of interferon-gamma (IFN-gamma) preferentially reduces myeloid progenitor numbers and enhances engraftment of syngeneic wild-type cells in Fancc-/- mice

1 reference

https://api.crossref.org/works/10.1155%2F2012%2F265790

21 January 2018

Rapid myeloerythroid repopulation after intrafemoral transplantation of NOD-SCID mice reveals a new class of human stem cells

1 reference

https://api.crossref.org/works/10.1155%2F2012%2F265790

21 January 2018

Rapid Lentiviral Transduction Preserves the Engraftment Potential of Fanca-/- Hematopoietic Stem Cells

1 reference

https://api.crossref.org/works/10.1155%2F2012%2F265790

21 January 2018

In vivo selection of wild-type hematopoietic stem cells in a murine model of Fanconi anemia

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=3366203

23 September 2018

Loss of FancC function results in decreased hematopoietic stem cell repopulating ability.

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=3366203

23 September 2018

Multiple inhibitory cytokines induce deregulated progenitor growth and apoptosis in hematopoietic cells from Fac-/- mice.

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=3366203

23 September 2018

Fanconi anemia diagnosis and the diepoxybutane (DEB) test.

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=3366203

23 September 2018

Mitomycin C test for diagnostic differentiation of idiopathic aplastic anemia and Fanconi anemia

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=3366203

23 September 2018

Spontaneous functional correction of homozygous Fanconi anaemia alleles reveals novel mechanistic basis for reverse mosaicism

1 reference

https://api.crossref.org/works/10.1155%2F2012%2F265790

21 January 2018

Oxygen-dependence of chromosomal aberrations in Fanconi's anaemia

1 reference

https://api.crossref.org/works/10.1155%2F2012%2F265790

21 January 2018

Aberrant activation of stress-response pathways leads to TNF-alpha oversecretion in Fanconi anemia

1 reference

https://pubmed.ncbi.nlm.nih.gov/22675615

12 December 2020

based on heuristic

inferred from PubMed ID database lookup

Abnormal lymphokine production: a novel feature of the genetic disease Fanconi anemia. II. In vitro and in vivo spontaneous overproduction of tumor necrosis factor alpha

1 reference

https://pubmed.ncbi.nlm.nih.gov/22675615

12 December 2020

based on heuristic

inferred from PubMed ID database lookup

Long-term proliferation in vitro of hematopoietic progenitor cells from children with congenital bone marrow failure: effect of rhGM-CSF and rhEPO

1 reference

https://pubmed.ncbi.nlm.nih.gov/22675615

12 December 2020

based on heuristic

inferred from PubMed ID database lookup

Cytokine stimulation of multilineage hematopoiesis from immature human cells engrafted in SCID mice

1 reference

https://pubmed.ncbi.nlm.nih.gov/22675615

12 December 2020

based on heuristic

inferred from PubMed ID database lookup

A high susceptibility of Fanconi's anemia to chromosome breakage by DNA cross-linking agents

1 reference

https://pubmed.ncbi.nlm.nih.gov/22675615

12 December 2020

based on heuristic

inferred from PubMed ID database lookup

Database of mouse strains carrying targeted mutations in genes affecting biological responses to DNA damage Version 7

1 reference

https://pubmed.ncbi.nlm.nih.gov/22675615

12 December 2020

based on heuristic

inferred from PubMed ID database lookup

Treatment of aplastic anemia in children

1 reference

https://pubmed.ncbi.nlm.nih.gov/22675615

12 December 2020

based on heuristic

inferred from PubMed ID database lookup

Modulation of hematopoietic stem cell homing and engraftment by CD26

1 reference

https://pubmed.ncbi.nlm.nih.gov/22675615

12 December 2020

based on heuristic

inferred from PubMed ID database lookup

SCID mice as an in vivo model of human cord blood hematopoiesis

1 reference

https://pubmed.ncbi.nlm.nih.gov/22675615

12 December 2020

based on heuristic

inferred from PubMed ID database lookup

Nonobese diabetic/severe combined immunodeficiency (NOD/SCID) mouse as a model system to study the engraftment and mobilization of human peripheral blood stem cells

1 reference

https://pubmed.ncbi.nlm.nih.gov/22675615

12 December 2020

based on heuristic

inferred from PubMed ID database lookup

A simple diagnostic test for Fanconi anemia by flow cytometry

1 reference

https://pubmed.ncbi.nlm.nih.gov/22675615

12 December 2020

based on heuristic

inferred from PubMed ID database lookup

Transplantation of umbilical cord blood in Fanconi's anemia

1 reference

https://pubmed.ncbi.nlm.nih.gov/22675615

12 December 2020

based on heuristic

inferred from PubMed ID database lookup

Bone marrow failure in the Fanconi anemia group C mouse model after DNA damage

1 reference

https://pubmed.ncbi.nlm.nih.gov/22675615

12 December 2020

based on heuristic

inferred from PubMed ID database lookup

Tumor necrosis factor-alpha overproduction in Fanconi's anemia

1 reference

https://pubmed.ncbi.nlm.nih.gov/22675615

12 December 2020

based on heuristic

inferred from PubMed ID database lookup

Myeloid and erythroid colony growth in non-anaemic patients with Fanconi's anaemia

1 reference

https://pubmed.ncbi.nlm.nih.gov/22675615

12 December 2020

based on heuristic

inferred from PubMed ID database lookup

Lack of self-renewal capacity in Fancc-/- stem cells after ex vivo expansion

1 reference

https://pubmed.ncbi.nlm.nih.gov/22675615

12 December 2020

based on heuristic

inferred from PubMed ID database lookup

Rapid lentiviral transduction preserves the engraftment potential of Fanca(-/-) hematopoietic stem cells

1 reference

https://pubmed.ncbi.nlm.nih.gov/22675615

12 December 2020

based on heuristic

inferred from PubMed ID database lookup

Testosterone-induced remission in aplastic anemia of both acquired and congenital types. Further observations in 24 cases

1 reference

https://pubmed.ncbi.nlm.nih.gov/22675615

12 December 2020

based on heuristic

inferred from PubMed ID database lookup

Inactivation of the Fanconi anemia group C gene augments interferon-gamma-induced apoptotic responses in hematopoietic cells

1 reference

https://pubmed.ncbi.nlm.nih.gov/22675615

12 December 2020

based on heuristic

inferred from PubMed ID database lookup

Long-term bone marrow culture in persons with Fanconi anemia and bone marrow failure

1 reference

https://pubmed.ncbi.nlm.nih.gov/22675615

12 December 2020

based on heuristic

inferred from PubMed ID database lookup

A trial of recombinant human superoxide dismutase in patients with Fanconi anaemia

1 reference

https://pubmed.ncbi.nlm.nih.gov/22675615

12 December 2020

based on heuristic

inferred from PubMed ID database lookup

Evaluation of granulocyte-macrophage colony-stimulating factor for treatment of pancytopenia in children with fanconi anemia

1 reference

https://pubmed.ncbi.nlm.nih.gov/22675615

12 December 2020

based on heuristic

inferred from PubMed ID database lookup

Tumor necrosis factor-alpha and CD95 ligation suppress erythropoiesis in Fanconi anemia C gene knockout mice

1 reference

https://pubmed.ncbi.nlm.nih.gov/22675615

12 December 2020

based on heuristic

inferred from PubMed ID database lookup

Prenatal identification of potential donors for umbilical cord blood transplantation for Fanconi anemia

1 reference

https://pubmed.ncbi.nlm.nih.gov/22675615

12 December 2020

based on heuristic

inferred from PubMed ID database lookup

Effect of procarbazine and cyclophosphamide on chromosome breakage in Fanconi anemia cells: Relevance to bone marrow transplantation

1 reference

https://pubmed.ncbi.nlm.nih.gov/22675615

12 December 2020

based on heuristic

inferred from PubMed ID database lookup

Effect of stem cell factor on colony growth from acquired and constitutional (Fanconi) aplastic anemia

1 reference

https://pubmed.ncbi.nlm.nih.gov/22675615

12 December 2020

based on heuristic

inferred from PubMed ID database lookup

Identifiers

10.1155/2012/265790

1 reference

Europe PubMed Central

PMC publication ID

11 August 2017

PMC publication ID

1 reference

Europe PubMed Central

PMC publication ID

11 August 2017

PubMed publication ID

1 reference

Europe PubMed Central

PMC publication ID

11 August 2017

ResearchGate publication ID

0 references

Sitelinks

Wikipedia(0 entries)

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Wikiquote(0 entries)

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