(Q36011649)

11 August 2017

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title

Assembly and function of RNA silencing complexes (English)

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11 August 2017

Erik J Sontheimer

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publication date

1 February 2005

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Nature Reviews Molecular Cell Biology

11 August 2017

published in

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11 August 2017

volume

6

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11 August 2017

issue

2

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11 August 2017

page(s)

127-138

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Potent and specific genetic interference by double-stranded RNA in Caenorhabditis elegans

11 August 2017

cites work

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Quelling in Neurospora crassa

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Duplexes of 21-nucleotide RNAs mediate RNA interference in cultured mammalian cells

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An RNA-directed nuclease mediates post-transcriptional gene silencing in Drosophila cells

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RNAi: double-stranded RNA directs the ATP-dependent cleavage of mRNA at 21 to 23 nucleotide intervals

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Single-stranded antisense siRNAs guide target RNA cleavage in RNAi

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The genetics of RNA silencing

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RNA interference is mediated by 21- and 22-nucleotide RNAs

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Role for a bidentate ribonuclease in the initiation step of RNA interference

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Argonaute2, a link between genetic and biochemical analyses of RNAi

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ATP requirements and small interfering RNA structure in the RNA interference pathway

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A microRNA in a multiple-turnover RNAi enzyme complex

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A Dicer-2-dependent 80s complex cleaves targeted mRNAs during RNAi in Drosophila

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The dsRNA binding protein RDE-4 interacts with RDE-1, DCR-1, and a DExH-box helicase to direct RNAi in C. elegans

31 March 2020

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Characterization of the interactions between mammalian PAZ PIWI domain proteins and Dicer

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R2D2, a Bridge Between the Initiation and Effector Steps of the Drosophila RNAi Pathway

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Distinct roles for Drosophila Dicer-1 and Dicer-2 in the siRNA/miRNA silencing pathways

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Functional anatomy of siRNAs for mediating efficient RNAi in Drosophila melanogaster embryo lysate

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Specific inhibition of gene expression by small double-stranded RNAs in invertebrate and vertebrate systems

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Short-interfering-RNA-mediated gene silencing in mammalian cells requires Dicer and eIF2C translation initiation factors

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Argonaute2 is the catalytic engine of mammalian RNAi

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Synthetic shRNAs as potent RNAi triggers.

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Synthetic dsRNA Dicer substrates enhance RNAi potency and efficacy.

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RISC assembly defects in the Drosophila RNAi mutant armitage.

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A protein sensor for siRNA asymmetry

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Distinct roles for Argonaute proteins in small RNA-directed RNA cleavage pathways

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microRNAs: runts of the genome assert themselves

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MicroRNAs: genomics, biogenesis, mechanism, and function

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MicroRNAs: small RNAs with a big role in gene regulation

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Cleavage of Scarecrow-like mRNA targets directed by a class of Arabidopsis miRNA

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The role of RNA interference in heterochromatic silencing

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RNAi-mediated targeting of heterochromatin by the RITS complex

31 March 2020

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Evidence that siRNAs function as guides, not primers, in the Drosophila and human RNAi pathways.

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DEAD-box proteins: the driving forces behind RNA metabolism

31 March 2020

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RNAi is activated during Drosophila oocyte maturation in a manner dependent on aubergine and spindle-E.

31 March 2020

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A Drosophila fragile X protein interacts with components of RNAi and ribosomal proteins

31 March 2020

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Functional siRNAs and miRNAs Exhibit Strand Bias

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Asymmetry in the assembly of the RNAi enzyme complex

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Rational siRNA design for RNA interference

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Improving the efficiency of RNA interference in mammals

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Structural basis for overhang-specific small interfering RNA recognition by the PAZ domain

31 March 2020

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Nucleic acid 3'-end recognition by the Argonaute2 PAZ domain

31 March 2020

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Human Dicer preferentially cleaves dsRNAs at their termini without a requirement for ATP

31 March 2020

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Single processing center models for human Dicer and bacterial RNase III

31 March 2020

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Endogenous trans-acting siRNAs regulate the accumulation of Arabidopsis mRNAs

31 March 2020

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Biochemical identification of Argonaute 2 as the sole protein required for RNA-induced silencing complex activity

31 March 2020

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31 March 2020

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A micrococcal nuclease homologue in RNAi effector complexes

31 March 2020

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RISC is a 5' phosphomonoester-producing RNA endonuclease

31 March 2020

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Sequence-specific inhibition of microRNA- and siRNA-induced RNA silencing

31 March 2020

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The crystal structure of the Argonaute2 PAZ domain reveals an RNA binding motif in RNAi effector complexes

31 March 2020

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Structure and nucleic-acid binding of the Drosophila Argonaute 2 PAZ domain

31 March 2020

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Crystal structure of Argonaute and its implications for RISC slicer activity

31 March 2020

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The RNA-induced silencing complex is a Mg2+-dependent endonuclease.

31 March 2020

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An siRNA ribonucleoprotein is found associated with polyribosomes in Trypanosoma brucei

31 March 2020

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The lin-4 regulatory RNA controls developmental timing in Caenorhabditis elegans by blocking LIN-14 protein synthesis after the initiation of translation

31 March 2020

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Kinetic analysis of the RNAi enzyme complex

31 March 2020

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Sequence-specific inhibition of small RNA function

31 March 2020

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The importance of being ribose at the cleavage site in the Tetrahymena ribozyme reaction

31 March 2020

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Human Argonaute2 mediates RNA cleavage targeted by miRNAs and siRNAs

31 March 2020

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Unlocking the potential of the human genome with RNA interference

31 March 2020

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Dicer functions in RNA interference and in synthesis of small RNA involved in developmental timing in C. elegans

31 March 2020

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Genes and mechanisms related to RNA interference regulate expression of the small temporal RNAs that control C. elegans developmental timing

31 March 2020

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A cellular function for the RNA-interference enzyme Dicer in the maturation of the let-7 small temporal RNA

31 March 2020

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MicroRNA-directed cleavage of HOXB8 mRNA

31 March 2020

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The rde-1 gene, RNA interference, and transposon silencing in C. elegans

31 March 2020

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Tethering of human Ago proteins to mRNA mimics the miRNA-mediated repression of protein synthesis

31 March 2020

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Analysis of a piwi-related gene implicates small RNAs in genome rearrangement in tetrahymena

31 March 2020

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RNA silencing genes control de novo DNA methylation

31 March 2020

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Heterochromatic silencing and HP1 localization in Drosophila are dependent on the RNAi machinery

31 March 2020

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31 March 2020

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Dicer is essential for formation of the heterochromatin structure in vertebrate cells

31 March 2020

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Induction of DNA methylation and gene silencing by short interfering RNAs in human cells

31 March 2020

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Small interfering RNA-induced transcriptional gene silencing in human cells

31 March 2020

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Establishment and maintenance of a heterochromatin domain

31 March 2020

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Regulation of heterochromatic silencing and histone H3 lysine-9 methylation by RNAi

31 March 2020

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Hairpin RNAs and retrotransposon LTRs effect RNAi and chromatin-based gene silencing

31 March 2020

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RITS acts in cis to promote RNA interference-mediated transcriptional and post-transcriptional silencing

31 March 2020

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RNase III enzymes and the initiation of gene silencing

31 March 2020

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Mechanisms of gene silencing by double-stranded RNA

31 March 2020

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ARGONAUTE1 is required for efficient RNA interference in Drosophila embryos

31 March 2020

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31 March 2020

Identifiers

DOI

10.1038/NRM1568

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11 August 2017

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