(Q36011824)

https://www.ebi.ac.uk/europepmc/webservices/rest/search?query=EXT_ID:15654920%20AND%20SRC:MED&resulttype=core&format=json

7 January 2020

review article

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title

The brown adipose cell: a model for understanding the molecular mechanisms of insulin resistance (English)

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https://www.ebi.ac.uk/europepmc/webservices/rest/search?query=EXT_ID:15654920%20AND%20SRC:MED&resulttype=core&format=json

7 January 2020

1 reference

1 reference

2

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https://www.ebi.ac.uk/europepmc/webservices/rest/search?query=EXT_ID:15654920%20AND%20SRC:MED&resulttype=core&format=json

7 January 2020

author name string

Valverde AM

series ordinal

1

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https://www.ebi.ac.uk/europepmc/webservices/rest/search?query=EXT_ID:15654920%20AND%20SRC:MED&resulttype=core&format=json

7 January 2020

Lorenzo M

series ordinal

3

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https://www.ebi.ac.uk/europepmc/webservices/rest/search?query=EXT_ID:15654920%20AND%20SRC:MED&resulttype=core&format=json

7 January 2020

publication date

1 January 2005

1 reference

https://www.ebi.ac.uk/europepmc/webservices/rest/search?query=EXT_ID:15654920%20AND%20SRC:MED&resulttype=core&format=json

Acta Physiologica Scandinavica

7 January 2020

published in

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https://www.ebi.ac.uk/europepmc/webservices/rest/search?query=EXT_ID:15654920%20AND%20SRC:MED&resulttype=core&format=json

7 January 2020

volume

183

1 reference

https://www.ebi.ac.uk/europepmc/webservices/rest/search?query=EXT_ID:15654920%20AND%20SRC:MED&resulttype=core&format=json

7 January 2020

issue

1

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https://www.ebi.ac.uk/europepmc/webservices/rest/search?query=EXT_ID:15654920%20AND%20SRC:MED&resulttype=core&format=json

7 January 2020

page(s)

59-73

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https://www.ebi.ac.uk/europepmc/webservices/rest/search?query=EXT_ID:15654920%20AND%20SRC:MED&resulttype=core&format=json

Phosphorylation of Ser307 in insulin receptor substrate-1 blocks interactions with the insulin receptor and inhibits insulin action

7 January 2020

cites work

1 reference

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PD 098059 is a specific inhibitor of the activation of mitogen-activated protein kinase kinase in vitro and in vivo

21 January 2018

1 reference

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The adipocyte in insulin resistance: key molecules and the impact of the thiazolidinediones

21 January 2018

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Role of IRS-3 in the insulin signaling of IRS-1-deficient brown adipocytes.

21 January 2018

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Essential role of protein kinase C zeta in the impairment of insulin-induced glucose transport in IRS-2-deficient brown adipocytes

21 January 2018

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Absence of functional insulin receptor substrate-3 (IRS-3) gene in humans.

21 January 2018

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Brown adipose tissue: function and physiological significance

21 January 2018

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Insulin resistance and a diabetes mellitus-like syndrome in mice lacking the protein kinase Akt2 (PKB beta)

21 January 2018

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Tumor necrosis factor alpha produces insulin resistance in skeletal muscle by activation of inhibitor kappaB kinase in a p38 MAPK-dependent manner

21 January 2018

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Insulin resistance: a multifaceted syndrome responsible for NIDDM, obesity, hypertension, dyslipidaemia and atherosclerosis

21 January 2018

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PPARs and the complex journey to obesity

21 January 2018

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Essential role of insulin receptor substrate-2 in insulin stimulation of Glut4 translocation and glucose uptake in brown adipocytes

21 January 2018

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Essential role of insulin receptor substrate 1 in differentiation of brown adipocytes

21 January 2018

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Functional inactivation of the IGF-I and insulin receptors in skeletal muscle causes type 2 diabetes

21 January 2018

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Glucose utilization in vivo and insulin-sensitivity of rat brown adipose tissue in various physiological and pathological conditions

21 January 2018

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Three mitogen-activated protein kinases inhibit insulin signaling by different mechanisms in 3T3-L1 adipocytes

21 January 2018

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Serine phosphorylation of insulin receptor substrate 1 by inhibitor kappa B kinase complex.

21 January 2018

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Ceramide impairs the insulin-dependent membrane recruitment of protein kinase B leading to a loss in downstream signalling in L6 skeletal muscle cells.

21 January 2018

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Akt mediates insulin induction of glucose uptake and up-regulation of GLUT4 gene expression in brown adipocytes

21 January 2018

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Insulin and dexamethasone induce GLUT4 gene expression in foetal brown adipocytes: synergistic effect through CCAAT/enhancer-binding protein alpha

21 January 2018

1 reference

https://api.crossref.org/works/10.1111%2FJ.1365-201X.2004.01384.X

Rosiglitazone produces insulin sensitisation by increasing expression of the insulin receptor and its tyrosine kinase activity in brown adipocytes

21 January 2018

1 reference

https://api.crossref.org/works/10.1111%2FJ.1365-201X.2004.01384.X

Rosiglitazone ameliorates insulin resistance in brown adipocytes of Wistar rats by impairing TNF-alpha induction of p38 and p42/p44 mitogen-activated protein kinases

21 January 2018

1 reference

https://api.crossref.org/works/10.1111%2FJ.1365-201X.2004.01384.X

A central role for JNK in obesity and insulin resistance

21 January 2018

1 reference

https://api.crossref.org/works/10.1111%2FJ.1365-201X.2004.01384.X

Rosiglitazone, an agonist of peroxisome-proliferator-activated receptor gamma (PPARgamma), decreases inhibitory serine phosphorylation of IRS1 in vitro and in vivo

21 January 2018

1 reference

https://api.crossref.org/works/10.1111%2FJ.1365-201X.2004.01384.X

Association of the insulin receptor with phospholipase C-gamma (PLCgamma) in 3T3-L1 adipocytes suggests a role for PLCgamma in metabolic signaling by insulin

21 January 2018

1 reference

https://api.crossref.org/works/10.1111%2FJ.1365-201X.2004.01384.X

Construction and characterization of a conditionally active version of the serine/threonine kinase Akt.

21 January 2018

1 reference

https://api.crossref.org/works/10.1111%2FJ.1365-201X.2004.01384.X

Aberrant p38 mitogen-activated protein kinase signalling in skeletal muscle from Type 2 diabetic patients.

21 January 2018

1 reference

https://api.crossref.org/works/10.1111%2FJ.1365-201X.2004.01384.X

IGF-I is a mitogen involved in differentiation-related gene expression in fetal rat brown adipocytes

21 January 2018

1 reference

https://api.crossref.org/works/10.1111%2FJ.1365-201X.2004.01384.X

PLCgamma participates in insulin stimulation of glucose uptake through activation of PKCzeta in brown adipocytes

21 January 2018

1 reference

https://api.crossref.org/works/10.1111%2FJ.1365-201X.2004.01384.X

PPARgamma: an essential regulator of adipogenesis and modulator of fat cell function

21 January 2018

1 reference

https://api.crossref.org/works/10.1111%2FJ.1365-201X.2004.01384.X

Minireview: Adiposity, Inflammation, and Atherogenesis

21 January 2018

1 reference

https://api.crossref.org/works/10.1111%2FJ.1365-201X.2004.01384.X

Activated phosphatidylinositol 3-kinase is sufficient to mediate actin rearrangement and GLUT4 translocation in 3T3-L1 adipocytes

21 January 2018

1 reference

https://api.crossref.org/works/10.1111%2FJ.1365-201X.2004.01384.X

Essential role of insulin receptor substrate 1 (IRS-1) and IRS-2 in adipocyte differentiation

21 January 2018

1 reference

https://api.crossref.org/works/10.1111%2FJ.1365-201X.2004.01384.X

A polymorphism in the 5' untranslated region and a Met229-->Leu variant in exon 5 of the human UCP1 gene are associated with susceptibility to type II diabetes mellitus

21 January 2018

1 reference

https://api.crossref.org/works/10.1111%2FJ.1365-201X.2004.01384.X

Essential role of insulin-like growth factor I receptor in insulin-induced fetal brown adipocyte differentiation

21 January 2018

1 reference

https://api.crossref.org/works/10.1111%2FJ.1365-201X.2004.01384.X

Insulin/IGF-I rescues immortalized brown adipocytes from apoptosis down-regulating Bcl-xS expression, in a PI 3-kinase- and map kinase-dependent manner

21 January 2018

1 reference

https://api.crossref.org/works/10.1111%2FJ.1365-201X.2004.01384.X

p38 MAP kinases: beyond the stress response

21 January 2018

1 reference

https://api.crossref.org/works/10.1111%2FJ.1365-201X.2004.01384.X

PPAR gamma and the treatment of insulin resistance

21 January 2018

1 reference

https://api.crossref.org/works/10.1111%2FJ.1365-201X.2004.01384.X

Tumor necrosis factor (TNF)-alpha inhibits insulin signaling through stimulation of the p55 TNF receptor and activation of sphingomyelinase

21 January 2018

1 reference

https://api.crossref.org/works/10.1111%2FJ.1365-201X.2004.01384.X

p42/p44 mitogen-activated protein kinases activation is required for the insulin-like growth factor-I/insulin induced proliferation, but inhibits differentiation, in rat fetal brown adipocytes

21 January 2018

1 reference

https://api.crossref.org/works/10.1111%2FJ.1365-201X.2004.01384.X

Peroxisome proliferator-activated receptor-gamma coactivator 1 alpha (PGC-1 alpha): transcriptional coactivator and metabolic regulator

21 January 2018

1 reference

https://api.crossref.org/works/10.1111%2FJ.1365-201X.2004.01384.X

3',5'-cyclic adenosine monophosphate-response sequences of the uncoupling protein gene are sequentially recruited during darglitazone-induced brown adipocyte differentiation

21 January 2018

1 reference

https://api.crossref.org/works/10.1111%2FJ.1365-201X.2004.01384.X

Regulation of gene expression by activation of the peroxisome proliferator-activated receptor gamma with rosiglitazone (BRL 49653) in human adipocytes

21 January 2018

1 reference

https://api.crossref.org/works/10.1111%2FJ.1365-201X.2004.01384.X

Insulin receptor substrate (IRS) 1 is reduced and IRS-2 is the main docking protein for phosphatidylinositol 3-kinase in adipocytes from subjects with non-insulin-dependent diabetes mellitus

21 January 2018

1 reference

https://api.crossref.org/works/10.1111%2FJ.1365-201X.2004.01384.X

Transforming growth factor-alpha prevents detachment-induced inhibition of c-Src kinase activity, Bcl-XL down-regulation, and apoptosis of intestinal epithelial cells

21 January 2018

1 reference

https://api.crossref.org/works/10.1111%2FJ.1365-201X.2004.01384.X

Mapping of early signaling events in tumor necrosis factor-alpha -mediated lipolysis in human fat cells.

21 January 2018

1 reference

https://api.crossref.org/works/10.1111%2FJ.1365-201X.2004.01384.X

Ceramide generation is sufficient to account for the inhibition of the insulin-stimulated PKB pathway in C2C12 skeletal muscle cells pretreated with palmitate

21 January 2018

1 reference

https://api.crossref.org/works/10.1111%2FJ.1365-201X.2004.01384.X

Regulation of glucose transporter messenger RNA in insulin-deficient states

21 January 2018

1 reference

https://api.crossref.org/works/10.1111%2FJ.1365-201X.2004.01384.X

Thiazolidinediones (PPARgamma agonists) but not PPARalpha agonists increase IRS-2 gene expression in 3T3-L1 and human adipocytes

21 January 2018

1 reference

https://api.crossref.org/works/10.1111%2FJ.1365-201X.2004.01384.X

An inhibitor of p38 mitogen-activated protein kinase prevents insulin-stimulated glucose transport but not glucose transporter translocation in 3T3-L1 adipocytes and L6 myotubes

21 January 2018

1 reference

https://api.crossref.org/works/10.1111%2FJ.1365-201X.2004.01384.X

Differentiation of rat brown adipocytes during late foetal development: role of insulin-like growth factor I.

21 January 2018

1 reference

https://api.crossref.org/works/10.1111%2FJ.1365-201X.2004.01384.X

Insulin-like growth factor I and insulin induce adipogenic-related gene expression in fetal brown adipocyte primary cultures.

21 January 2018

1 reference

https://api.crossref.org/works/10.1111%2FJ.1365-201X.2004.01384.X

Inhibition of PI 3-kinase and RAS blocks IGF-I and insulin-induced uncoupling protein 1 gene expression in brown adipocytes

21 January 2018

1 reference

https://api.crossref.org/works/10.1111%2FJ.1365-201X.2004.01384.X

PPARalpha activation by Wy 14643 induces transactivation of the rat UCP-1 promoter without increasing UCP-1 mRNA levels and attenuates PPARgamma-mediated increases in UCP-1 mRNA levels induced by rosiglitazone in fetal rat brown adipocytes

21 January 2018

1 reference

https://api.crossref.org/works/10.1111%2FJ.1365-201X.2004.01384.X

Rosiglitazone and retinoic acid induce uncoupling protein-1 (UCP-1) in a p38 mitogen-activated protein kinase-dependent manner in fetal primary brown adipocytes.

21 January 2018

1 reference

https://api.crossref.org/works/10.1111%2FJ.1365-201X.2004.01384.X

C2C12 myocytes lack an insulin-responsive vesicular compartment despite dexamethasone-induced GLUT4 expression.

21 January 2018

1 reference

https://api.crossref.org/works/10.1111%2FJ.1365-201X.2004.01384.X

Protection from obesity-induced insulin resistance in mice lacking TNF-alpha function

21 January 2018

1 reference

https://api.crossref.org/works/10.1111%2FJ.1365-201X.2004.01384.X

Alterations in the insulin signaling pathway induced by immortalization and H-ras transformation of brown adipocytes

21 January 2018

1 reference

https://api.crossref.org/works/10.1111%2FJ.1365-201X.2004.01384.X

Insulin receptor substrate (IRS) proteins IRS-1 and IRS-2 differential signaling in the insulin/insulin-like growth factor-I pathways in fetal brown adipocytes

21 January 2018

1 reference

https://api.crossref.org/works/10.1111%2FJ.1365-201X.2004.01384.X

H-ras induces glucose uptake in brown adipocytes in an insulin- and phosphatidylinositol 3-kinase-independent manner

21 January 2018

1 reference

https://api.crossref.org/works/10.1111%2FJ.1365-201X.2004.01384.X

Insulin and insulin-like growth factor I up-regulate GLUT4 gene expression in fetal brown adipocytes, in a phosphoinositide 3-kinase-dependent manner.

21 January 2018

1 reference

https://api.crossref.org/works/10.1111%2FJ.1365-201X.2004.01384.X

Association of insulin receptor substrate 1 (IRS-1) y895 with Grb-2 mediates the insulin signaling involved in IRS-1-deficient brown adipocyte mitogenesis.

21 January 2018

1 reference

https://api.crossref.org/works/10.1111%2FJ.1365-201X.2004.01384.X

Subcellular compartmentalization and trafficking of the insulin-responsive glucose transporter, GLUT4.

21 January 2018

1 reference

https://api.crossref.org/works/10.1111%2FJ.1365-201X.2004.01384.X

Perspective: The insulin signaling system--a common link in the pathogenesis of type 2 diabetes

21 January 2018

1 reference

https://api.crossref.org/works/10.1111%2FJ.1365-201X.2004.01384.X

Reversal of obesity- and diet-induced insulin resistance with salicylates or targeted disruption of Ikkbeta

21 January 2018

1 reference

https://api.crossref.org/works/10.1111%2FJ.1365-201X.2004.01384.X

Targeted disruption of the glucose transporter 4 selectively in muscle causes insulin resistance and glucose intolerance.

21 January 2018

1 reference

https://api.crossref.org/works/10.1111%2FJ.1365-201X.2004.01384.X

10.1111/J.1365-201X.2004.01384.X

21 January 2018

Identifiers

DOI

1 reference

https://www.ebi.ac.uk/europepmc/webservices/rest/search?query=EXT_ID:15654920%20AND%20SRC:MED&resulttype=core&format=json

7 January 2020

1 reference