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8 February 2021

Insulin resistance and cancer risk: an overview of the pathogenetic mechanisms (English)

1 reference

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inferred from abstract

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20 August 2019

neoplastic gene expression regulation

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4 November 2020

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8 February 2021

6

1 reference

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Daniela Foti

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Eusebio Chiefari

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Antonio Brunetti

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Biagio Arcidiacono

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Stefania Iiritano

2

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Aurora Nocera

3

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Katiuscia Possidente

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Maria T Nevolo

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4 June 2012

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Experimental Diabetes Research

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20 June 2019

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Banting Lecture. From the triumvirate to the ominous octet: a new paradigm for the treatment of type 2 diabetes mellitus

2 October 2017

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Phosphorylated insulin-like growth factor-i/insulin receptor is present in all breast cancer subtypes and is related to poor survival.

2 October 2017

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Type 2 diabetes mellitus and risk of non-Hodgkin lymphoma: a systematic review and meta-analysis

2 October 2017

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Forkhead box transcription factor FOXO3a suppresses estrogen-dependent breast cancer cell proliferation and tumorigenesis

2 October 2017

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2 October 2017

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2 October 2017

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2 October 2017

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2 October 2017

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2 October 2017

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2 October 2017

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2 October 2017

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Diabetes mellitus and risk of bladder cancer: a meta-analysis

2 October 2017

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Adipocytokines: mediators linking adipose tissue, inflammation and immunity

2 October 2017

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The role of the IGF system in cancer growth and metastasis: overview and recent insights

2 October 2017

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Functional in vivo interactions between JNK1 and JNK2 isoforms in obesity and insulin resistance

2 October 2017

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Diabetes, insulin, and risk of cancer

2 October 2017

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Activator protein-2 overexpression accounts for increased insulin receptor expression in human breast cancer.

2 October 2017

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MCP-1 contributes to macrophage infiltration into adipose tissue, insulin resistance, and hepatic steatosis in obesity

2 October 2017

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MAPK signal specificity: the right place at the right time

2 October 2017

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The association between diabetes and hepatocellular carcinoma: a systematic review of epidemiologic evidence

2 October 2017

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From mice to men: insights into the insulin resistance syndromes

2 October 2017

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Diabetes mellitus and risk of colorectal cancer: a meta-analysis

2 October 2017

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Growing roles for the mTOR pathway

2 October 2017

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Type-II diabetes and pancreatic cancer: a meta-analysis of 36 studies

2 October 2017

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Adipose tissue, adipokines, and inflammation

2 October 2017

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FoxO proteins in insulin action and metabolism

2 October 2017

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Increased oxidative stress in obesity and its impact on metabolic syndrome

2 October 2017

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Upstream and downstream of mTOR

2 October 2017

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Overweight, obesity and cancer: epidemiological evidence and proposed mechanisms

2 October 2017

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Control of cell size through phosphorylation of upstream binding factor 1 by nuclear phosphatidylinositol 3-kinase

2 October 2017

1 reference

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ERK and p38 MAPK-activated protein kinases: a family of protein kinases with diverse biological functions

2 October 2017

1 reference

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Adipose tissue as an endocrine organ

2 October 2017

1 reference

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The insulin receptor isoform exon 11- (IR-A) in cancer and other diseases: a review.

2 October 2017

1 reference

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A nucleoprotein complex containing Sp1, C/EBP beta, and HMGI-Y controls human insulin receptor gene transcription

2 October 2017

1 reference

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TSC2 is phosphorylated and inhibited by Akt and suppresses mTOR signalling

2 October 2017

1 reference

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The phosphoinositide 3-kinase pathway

2 October 2017

1 reference

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HMGI/Y proteins: flexible regulators of transcription and chromatin structure

2 October 2017

1 reference

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Energy balance and cancer: the role of insulin and insulin-like growth factor-I.

2 October 2017

1 reference

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Insulin resistance syndrome.

2 October 2017

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2 October 2017

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PTEN: life as a tumor suppressor

2 October 2017

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Transcriptional regulation of human insulin receptor gene by the high-mobility group protein HMGI(Y).

2 October 2017

1 reference

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Mechanism of transmembrane signaling: insulin binding and the insulin receptor

2 October 2017

1 reference

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Insulin receptor isoform A, a newly recognized, high-affinity insulin-like growth factor II receptor in fetal and cancer cells.

2 October 2017

1 reference

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Deconstructing type 2 diabetes

2 October 2017

1 reference

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Nuclear translocation of p42/p44 mitogen-activated protein kinase is required for growth factor-induced gene expression and cell cycle entry

2 October 2017

1 reference

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Negative regulation of PKB/Akt-dependent cell survival by the tumor suppressor PTEN

2 October 2017

1 reference

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High-mobility-group chromosomal proteins: architectural components that facilitate chromatin function.

2 October 2017

1 reference

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IRS-1-mediated inhibition of insulin receptor tyrosine kinase activity in TNF-alpha- and obesity-induced insulin resistance

2 October 2017

1 reference

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Identification of unique nuclear regulatory proteins for the insulin receptor gene, which appear during myocyte and adipocyte differentiation

2 October 2017

1 reference

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Nutritional regulation of hormones and growth factors that control mammalian growth.

2 October 2017

1 reference

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The insulin signaling system

2 October 2017

1 reference

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Nutritional regulation of the insulin-like growth factors

2 October 2017

2 references

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2 October 2017

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Nonenzymatic glycosylation in vitro and in bovine endothelial cells alters basic fibroblast growth factor activity. A model for intracellular glycosylation in diabetes

23 September 2018

1 reference

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Molecular basis of thyroid cancer

2 October 2017

1 reference

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Stimulation of adipogenesis in fibroblasts by PPAR gamma 2, a lipid-activated transcription factor

2 October 2017

1 reference

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Insulin-like growth factors and their binding proteins: biological actions

2 October 2017

1 reference

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Adipose expression of tumor necrosis factor-alpha: direct role in obesity-linked insulin resistance

2 October 2017

1 reference

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Characterization of the promoter region of the human insulin receptor gene. Evidence for promoter activity

2 October 2017

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=3372318

The insulin receptor: molecular biology and transmembrane signaling

2 October 2017

1 reference

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Banting lecture 1988. Role of insulin resistance in human disease

2 October 2017

1 reference

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Human insulin receptor and its relationship to the tyrosine kinase family of oncogenes

2 October 2017

1 reference

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Structure of the human insulin receptor gene and characterization of its promoter

2 October 2017

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=3372318

Insulin-like growth factor I receptor primary structure: comparison with insulin receptor suggests structural determinants that define functional specificity

2 October 2017

1 reference

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Banting lecture 1989. Structure and function of insulin receptors

2 October 2017

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=3372318

Regulating insulin-receptor-gene expression by differentiation and hormones

2 October 2017

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=3372318

Elevated insulin receptor content in human breast cancer

2 October 2017

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=3372318

Aminoguanidine treatment inhibits the development of experimental diabetic retinopathy

2 October 2017

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=3372318

Nutritional regulation of IGF-I and IGF binding proteins

2 October 2017

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=3372318

Hormone responsive human breast cancer in long-term tissue culture: effect of insulin

2 October 2017

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=3372318

Correlation among insulin binding, degradation, and biological activity in human breast cancer cells in long-term tissue culture

2 October 2017

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=3372318

Insulin-like growth factors and insulin control a multifunctional signalling network of significant importance in cancer

2 October 2017

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=3372318

New target genes for the peroxisome proliferator-activated receptor-γ (PPARγ) antitumour activity: Perspectives from the insulin receptor

11 July 2018

1 reference

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The insulin receptor: a new anticancer target for peroxisome proliferator-activated receptor-gamma (PPARgamma) and thiazolidinedione-PPARgamma agonists.

11 July 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=3372318

Terminal differentiation of human breast cancer through PPAR gamma

11 July 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=3372318

Receptors for insulin and insulin-like growth factor-I can form hybrid dimers. Characterisation of hybrid receptors in transfected cells

11 July 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=3372318

Obesity, inflammation, and postmenopausal breast cancer: therapeutic implications.

11 July 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=3372318

Risk of esophageal cancer in diabetes mellitus: a meta-analysis of observational studies.

23 September 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=3372318

Diabetes mellitus and increased risk of cholangiocarcinoma: a meta-analysis.

23 September 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=3372318

Chronic intermittent hypoxia is a major trigger for non-alcoholic fatty liver disease in morbid obese

23 September 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=3372318

Functional variants of the HMGA1 gene and type 2 diabetes mellitus

23 September 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=3372318

Fen1 mutations result in autoimmunity, chronic inflammation and cancers

23 September 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=3372318

Diabetes mellitus and risk of endometrial cancer: a meta-analysis

23 September 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=3372318

Relation between insulin resistance and serum concentrations of IL-6 and TNF-alpha in overweight or obese women with early stage breast cancer

23 September 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=3372318

Lack of the architectural factor HMGA1 causes insulin resistance and diabetes in humans and mice

23 September 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=3372318

From blood monocytes to adipose tissue-resident macrophages: induction of diapedesis by human mature adipocytes.

23 September 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=3372318

Adipocyte-secreted factors synergistically promote mammary tumorigenesis through induction of anti-apoptotic transcriptional programs and proto-oncogene stabilization

23 September 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=3372318

Enhancement of BRCA1 gene expression by the peroxisome proliferator-activated receptor gamma in the MCF-7 breast cancer cell line

23 September 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=3372318

The Gordon Wilson Lecture. Lessons about the control of glucose homeostasis and the pathogenesis of diabetes from knockout mice.

23 September 2018

1 reference

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Insulin resistance, the metabolic syndrome, and risk of incident cardiovascular disease in nondiabetic american indians: the Strong Heart Study

23 September 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=3372318

Components of the "metabolic syndrome" and incidence of type 2 diabetes.

23 September 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=3372318

Functional insulin receptors on human epithelial ovarian carcinoma cells: implications for IGF-II mitogenic signaling

23 September 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=3372318

Circulating interleukin-6 in relation to adiposity, insulin action, and insulin secretion

23 September 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=3372318

Insulin regulation of the Ras activation/inactivation cycle

23 September 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=3372318

Genetic and environmental influences on insulin levels and the insulin resistance syndrome: an analysis of women twins

23 September 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=3372318

Hepatic and peripheral insulin resistance: a common feature of type 2 (non-insulin-dependent) and type 1 (insulin-dependent) diabetes mellitus.

23 September 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=3372318

A Comparison of the Relative Effects of Obesity and Non-insulin-dependent Diabetes Mellitus on In Vivo Insulin-stimulated Glucose Utilization

23 September 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=3372318

Insulin receptor expression and function in human breast cancer cell lines.

23 September 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=3372318

The role of insulin receptors and IGF-I receptors in cancer and other diseases

23 September 2018

1 reference

PubMed

12 December 2020

Reinventing type 2 diabetes: pathogenesis, treatment, and prevention

1 reference

PubMed

12 December 2020

Inflammation and necrosis promote tumour growth

1 reference

PubMed

12 December 2020

1 reference

12 December 2020

Identifiers

DOI

10.1155/2012/789174

1 reference

https://www.ebi.ac.uk/europepmc/webservices/rest/search?query=EXT_ID:22701472%20AND%20SRC:MED&resulttype=core&format=json

5 February 2020

1 reference

https://www.ebi.ac.uk/europepmc/webservices/rest/search?query=EXT_ID:22701472%20AND%20SRC:MED&resulttype=core&format=json

5 February 2020

PubMed publication ID

22701472

1 reference

https://www.ebi.ac.uk/europepmc/webservices/rest/search?query=EXT_ID:22701472%20AND%20SRC:MED&resulttype=core&format=json