(Q36029828)

11 August 2017

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title

Drugs, QT interval prolongation and ICH E14: the need to get it right (English)

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11 August 2017

Rashmi R Shah

1

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11 August 2017

publication date

1 January 2005

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11 August 2017

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11 August 2017

volume

28

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11 August 2017

issue

2

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11 August 2017

page(s)

115-125

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Excessive increase in QT interval and dispersion of repolarization predict recurrent ventricular tachyarrhythmia after amiodarone

11 August 2017

cites work

1 reference

12 December 2020

Sudden death associated with short-QT syndrome linked to mutations in HERG.

1 reference

12 December 2020

Preclinical strategies to assess QT liability and torsadogenic potential of new drugs: the role of experimental models

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12 December 2020

The significance of QT interval in drug development

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12 December 2020

Mechanisms of arsenic-induced prolongation of cardiac repolarization

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12 December 2020

Ventricular tachycardia with 2 variable opposing foci

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12 December 2020

Drug-induced torsades de pointes and implications for drug development.

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12 December 2020

The impact of drug-induced QT interval prolongation on drug discovery and development

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12 December 2020

Amplified transmural dispersion of repolarization as the basis for arrhythmogenesis in a canine ventricular-wedge model of short-QT syndrome

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12 December 2020

The price of innovation: new estimates of drug development costs

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12 December 2020

Rank power of metrics used to assess QTc interval prolongation by clinical trial simulation

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12 December 2020

Idiopathic long QT syndrome with early afterdepolarization induced by epinephrine. Acase report

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12 December 2020

A molecular basis for cardiac arrhythmia: HERG mutations cause long QT syndrome

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12 December 2020

Drug-induced prolongation of the QT interval

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12 December 2020

Cisapride-induced transmural dispersion of repolarization and torsade de pointes in the canine left ventricular wedge preparation during epicardial stimulation

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12 December 2020

Idiopathic short QT interval: a new clinical syndrome?

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12 December 2020

Exploring the hidden danger of noncardiac drugs.

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12 December 2020

Mutation in the KCNQ1 gene leading to the short QT-interval syndrome

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12 December 2020

Pentamidine-induced long QT syndrome and block of hERG trafficking

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12 December 2020

Torsades de pointes associated with drugs and toxins: recognition and management

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12 December 2020

Developmental changes in IKr and IKs contribute to age-related expression of dofetilide effects on repolarization and proarrhythmia

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12 December 2020

Short QT Syndrome: a familial cause of sudden death

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12 December 2020

Transmural dispersion of repolarization and ventricular tachyarrhythmias

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12 December 2020

A mechanistic approach to assess the proarrhythmic risk of QT-prolonging drugs in preclinical pharmacologic studies

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12 December 2020

Arrhythmogenic mechanisms of QT prolonging drugs: is QT prolongation really the problem?

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12 December 2020

Alpha-adrenoceptor stimulation and blockade modulates cesium-induced early afterdepolarizations and ventricular tachyarrhythmias in dogs

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12 December 2020

Induction of torsades de pointes by dobutamine infusion in a patient with idiopathic long QT syndrome

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12 December 2020

Electrophysiologic parameters and predisposing factors in the generation of drug-induced Torsade de Pointes arrhythmias

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12 December 2020

Drug block of I(kr): model systems and relevance to human arrhythmias

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12 December 2020

Terminology of torsades de pointes

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12 December 2020

Electrophysiological effects of ranolazine, a novel antianginal agent with antiarrhythmic properties

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12 December 2020

A family of potassium channel genes related to eag in Drosophila and mammals

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12 December 2020

Relationships between preclinical cardiac electrophysiology, clinical QT interval prolongation and torsade de pointes for a broad range of drugs: evidence for a provisional safety margin in drug development

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12 December 2020

Polymorphic ventricular tachycardia, long Q-T syndrome, and torsades de pointes

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12 December 2020

Relations of QTc prolongation on the electrocardiogram to torsades de pointes: definitions and mechanisms

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12 December 2020

Effects of imidapril on heterogeneity of action potential and calcium current of ventricular myocytes in infarcted rabbits

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12 December 2020

Nonselective I(Kr)-blockers do not induce torsades de pointes in the anesthetized rabbit during alpha1-adrenoceptor stimulation.

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12 December 2020

A definitive or thorough phase 1 QT ECG trial as a requirement for drug safety assessment

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12 December 2020

Drug-induced QT dispersion: does it predict the risk of torsade de pointes?

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12 December 2020

QT interval shortening in families with history of sudden death at young age

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12 December 2020

Gene-specific response of dynamic ventricular repolarization to sympathetic stimulation in LQT1, LQT2 and LQT3 forms of congenital long QT syndrome

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12 December 2020

10.2165/00002018-200528020-00003

Identifiers

DOI

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Dimensions Publication ID

11 August 2017

1002233188

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