(Q36033313)

11 August 2017

Protein kinase G and focal adhesion kinase converge on Src/Akt/β-catenin signaling module in osteoblast mechanotransduction (English)

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11 August 2017

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Raphaela Schwappacher

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object named as

Raphaela Schwappacher

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author name string

Hema Rangaswami

1

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11 August 2017

Raphaela Schwappacher

2

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11 August 2017

Trish Tran

3

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11 August 2017

Geraldine C Chan

4

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11 August 2017

Shunhui Zhuang

5

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11 August 2017

Gerry R Boss

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11 August 2017

Renate B Pilz

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11 August 2017

language of work or name

English

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publication date

4 May 2012

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Journal of Biological Chemistry

11 August 2017

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11 August 2017

287

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11 August 2017

25

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11 August 2017

21509-21519

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describes a project that uses

11 August 2017

ImageJ

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11 June 2022

https://www.ebi.ac.uk/europepmc/webservices/rest/PMC3375572/fullTextXML

inferred from PubMed Central ID database lookup

cites work

Primary human osteoblast cultures.

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=3375572

Focal adhesion kinase signaling pathway is involved in mechanotransduction in MG-63 cells

2 October 2017

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=3375572

Effect of nitroglycerin ointment on bone density and strength in postmenopausal women: a randomized trial

2 October 2017

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=3375572

Non-overlapping functions for Pyk2 and FAK in osteoblasts during fluid shear stress-induced mechanotransduction

2 October 2017

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=3375572

Cyclic GMP and protein kinase G control a Src-containing mechanosome in osteoblasts

2 October 2017

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=3375572

Activation of β-catenin signaling in MLO-Y4 osteocytic cells versus 2T3 osteoblastic cells by fluid flow shear stress and PGE2: Implications for the study of mechanosensation in bone

2 October 2017

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=3375572

Osteocytes and WNT: the mechanical control of bone formation.

2 October 2017

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=3375572

Mechanical signals as anabolic agents in bone

2 October 2017

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=3375572

Molecular mechanisms underlying the activation of eNOS.

2 October 2017

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=3375572

Oscillatory flow-induced proliferation of osteoblast-like cells is mediated by alphavbeta3 and beta1 integrins through synergistic interactions of focal adhesion kinase and Shc with phosphatidylinositol 3-kinase and the Akt/mTOR/p70S6K pathway

2 October 2017

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=3375572

Tumor necrosis factor alpha and interleukin-1beta modulate calcium and nitric oxide signaling in mechanically stimulated osteocytes.

2 October 2017

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=3375572

The role of Akt1 in terminal stages of endochondral bone formation: angiogenesis and ossification

2 October 2017

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=3375572

Signaling networks and transcription factors regulating mechanotransduction in bone

2 October 2017

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=3375572

Lef1 haploinsufficient mice display a low turnover and low bone mass phenotype in a gender- and age-specific manner

2 October 2017

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=3375572

Mechanobiology of the skeleton.

2 October 2017

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=3375572

Type II cGMP-dependent protein kinase mediates osteoblast mechanotransduction

2 October 2017

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=3375572

Environmental sensing through focal adhesions

2 October 2017

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=3375572

Cell biology. The force is with us.

2 October 2017

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=3375572

From streaming-potentials to shear stress: 25 years of bone cell mechanotransduction

2 October 2017

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=3375572

Activation of extracellular-signal regulated kinase (ERK1/2) by fluid shear is Ca(2+)- and ATP-dependent in MC3T3-E1 osteoblasts

2 October 2017

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=3375572

Rationale for using nitric oxide donor therapy for prevention of bone loss and treatment of osteoporosis in humans.

2 October 2017

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=3375572

AKT/PKB signaling: navigating downstream

2 October 2017

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=3375572

Wnt/beta-catenin signaling is a component of osteoblastic bone cell early responses to load-bearing and requires estrogen receptor alpha

2 October 2017

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=3375572

Lifelong accumulation of bone in mice lacking Pten in osteoblasts

2 October 2017

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=3375572

Phosphorylation of beta-catenin by AKT promotes beta-catenin transcriptional activity

2 October 2017

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=3375572

Integrin-regulated FAK-Src signaling in normal and cancer cells

2 October 2017

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=3375572

Fluid shear stress induces less calcium response in a single primary osteocyte than in a single osteoblast: implication of different focal adhesion formation.

2 October 2017

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=3375572

Wnt proteins prevent apoptosis of both uncommitted osteoblast progenitors and differentiated osteoblasts by beta-catenin-dependent and -independent signaling cascades involving Src/ERK and phosphatidylinositol 3-kinase/AKT.

2 October 2017

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=3375572

Cyclic GMP-dependent protein kinase regulates CCAAT enhancer-binding protein beta functions through inhibition of glycogen synthase kinase-3.

2 October 2017

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=3375572

Canonical Wnt signaling in differentiated osteoblasts controls osteoclast differentiation

2 October 2017

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=3375572

Src kinase regulation by phosphorylation and dephosphorylation

2 October 2017

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=3375572

Fluid shear stress induces beta-catenin signaling in osteoblasts.

2 October 2017

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=3375572

Wnt signaling in osteoblasts and bone diseases

2 October 2017

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=3375572

Signal transduction and mechanical stress

2 October 2017

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=3375572

Calcium rises locally trigger focal adhesion disassembly and enhance residency of focal adhesion kinase at focal adhesions

2 October 2017

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=3375572

Formation of focal adhesions on fibronectin promotes fluid shear stress induction of COX-2 and PGE2 release in MC3T3-E1 osteoblasts

2 October 2017

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=3375572

Role of integrins in endothelial mechanosensing of shear stress

2 October 2017

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=3375572

Anchorage-dependent ERK signaling--mechanisms and consequences

2 October 2017

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=3375572

Differential effect of steady versus oscillating flow on bone cells

2 October 2017

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=3375572

Fluid shear stress activation of focal adhesion kinase. Linking to mitogen-activated protein kinases

2 October 2017

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=3375572

Osteoblasts and osteocytes respond differently to oscillatory and unidirectional fluid flow profiles

2 October 2017

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=3375572

Osteopontin gene regulation by oscillatory fluid flow via intracellular calcium mobilization and activation of mitogen-activated protein kinase in MC3T3-E1 osteoblasts

11 July 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=3375572

Ca(2+) regulates fluid shear-induced cytoskeletal reorganization and gene expression in osteoblasts

11 July 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=3375572

Steady and transient fluid shear stress stimulate NO release in osteoblasts through distinct biochemical pathways

11 July 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=3375572

Interaction between nitric oxide synthase and cyclooxygenase pathways in osteoblastic MC3T3-E1 cells

11 July 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=3375572

Involvement of different ion channels in osteoblasts' and osteocytes' early responses to mechanical strain

11 July 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=3375572

Distinct responses of different populations of bone cells to mechanical stress

11 July 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=3375572

Role of inducible nitric oxide synthase in skeletal adaptation to acute increases in mechanical loading

11 July 2018

1 reference

https://api.crossref.org/works/10.1074%2FJBC.M112.347245

Venous ligation-mediated bone adaptation is NOS 3 dependent

21 January 2018

1 reference

https://api.crossref.org/works/10.1074%2FJBC.M112.347245

Focal adhesion kinase is important for fluid shear stress-induced mechanotransduction in osteoblasts

21 January 2018

1 reference

https://api.crossref.org/works/10.1074%2FJBC.M112.347245

Fluid shear stress inhibits TNF-alpha-induced apoptosis in osteoblasts: a role for fluid shear stress-induced activation of PI3-kinase and inhibition of caspase-3.

21 January 2018

1 reference

https://api.crossref.org/works/10.1074%2FJBC.M112.347245

Up-regulation of the Wnt, estrogen receptor, insulin-like growth factor-I, and bone morphogenetic protein pathways in C57BL/6J osteoblasts as opposed to C3H/HeJ osteoblasts in part contributes to the differential anabolic response to fluid shear

21 January 2018

1 reference

https://api.crossref.org/works/10.1074%2FJBC.M112.347245

A novel role for FAK as a protease-targeting adaptor protein: regulation by p42 ERK and Src.

21 January 2018

1 reference

https://api.crossref.org/works/10.1074%2FJBC.M112.347245

Mechanotransduction in response to shear stress. Roles of receptor tyrosine kinases, integrins, and Shc.

21 January 2018

1 reference

https://api.crossref.org/works/10.1074%2FJBC.M112.347245

A mechanosensory complex that mediates the endothelial cell response to fluid shear stress

21 January 2018

1 reference

https://api.crossref.org/works/10.1074%2FJBC.M112.347245

The role of Src kinase in insulin-like growth factor-dependent mitogenic signaling in vascular smooth muscle cells.

21 January 2018

1 reference

https://api.crossref.org/works/10.1074%2FJBC.M112.347245

Wnt/beta-catenin signaling is a normal physiological response to mechanical loading in bone

21 January 2018

1 reference

12 December 2020

Bone Cell Responses to Fluid Flow

1 reference

12 December 2020

Nitric oxide is an early mediator of the increase in bone formation by mechanical stimulation

1 reference

12 December 2020

Intracellular Ca2+ stores and extracellular Ca2+ are required in the real-time Ca2+ response of bone cells experiencing fluid flow

1 reference

12 December 2020

Role of nitric oxide and prostaglandins in mechanically induced bone formation

1 reference

12 December 2020

Nitric oxide response to shear stress by human bone cell cultures is endothelial nitric oxide synthase dependent

1 reference

12 December 2020

Shear stress stimulation of p130(cas) tyrosine phosphorylation requires calcium-dependent c-Src activation

1 reference

12 December 2020

Identifiers

DOI

10.1074/JBC.M112.347245

1 reference

release_vwq5khuwxjfnhpgkspag64awh4

11 August 2017

1 reference

Fatcat

https://api.fatcat.wiki/v0/release/vwq5khuwxjfnhpgkspag64awh4

24 November 2022

mapped directly with Wikidata item

1 reference

11 August 2017

1 reference