(Q36044790)

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In vivo screening of modified siRNAs for non-specific antiviral effect in a small fish model: number and localization in the strands are important

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21 January 2020

In vivo screening of modified siRNAs for non-specific antiviral effect in a small fish model: number and localization in the strands are important (English)

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21 January 2020

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21 January 2020

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21 January 2020

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Niels Lorenzen

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Brian Dall Schyth

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21 January 2020

Jesper Bertram Bramsen

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21 January 2020

Malgorzata Maria Pakula

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21 January 2020

Sekar Larashati

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21 January 2020

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28 January 2012

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21 January 2020

Nucleic Acids Research

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21 January 2020

40

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21 January 2020

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21 January 2020

4653-4665

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21 January 2020

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Creative Commons Attribution-NonCommercial 3.0 Unported

7 November 2016

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April 2022 Public Data File from Crossref

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0 references

Utilization of unlocked nucleic acid (UNA) to enhance siRNA performance in vitro and in vivo

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=3378874

2 October 2017

A screen of chemical modifications identifies position-specific modification by UNA to most potently reduce siRNA off-target effects

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=3378874

2 October 2017

Distinct and complementary functions of MDA5 and TLR3 in poly(I:C)-mediated activation of mouse NK cells

1 reference

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2 October 2017

Understanding how the crowded interior of cells stabilizes DNA/DNA and DNA/RNA hybrids-in silico predictions and in vitro evidence

1 reference

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2 October 2017

Alternating 2'-O-ribose methylation is a universal approach for generating non-stimulatory siRNA by acting as TLR7 antagonist

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=3378874

2 October 2017

Identification, characterization and genetic mapping of TLR7, TLR8a1 and TLR8a2 genes in rainbow trout (Oncorhynchus mykiss).

1 reference

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2 October 2017

Sequence determinants of innate immune activation by short interfering RNAs.

1 reference

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2 October 2017

A cell biological view of Toll-like receptor function: regulation through compartmentalization.

1 reference

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2 October 2017

siRNA and innate immunity

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=3378874

2 October 2017

Biological effects of hexitol and altritol-modified siRNAs targeting B-Raf

1 reference

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2 October 2017

Small interfering RNA-induced TLR3 activation inhibits blood and lymphatic vessel growth

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=3378874

2 October 2017

A large-scale chemical modification screen identifies design rules to generate siRNAs with high activity, high stability and low toxicity

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=3378874

2 October 2017

Chemical modification of siRNAs for in vivo use.

1 reference

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2 October 2017

Misinterpreting the therapeutic effects of small interfering RNA caused by immune stimulation

1 reference

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2 October 2017

Sequence- and target-independent angiogenesis suppression by siRNA via TLR3

1 reference

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2 October 2017

Improved silencing properties using small internally segmented interfering RNAs

1 reference

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2 October 2017

Conservation of Toll-Like Receptor Signaling Pathways in Teleost Fish

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=3378874

2 October 2017

siRNA and isRNA: two edges of one sword

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=3378874

2 October 2017

Induction of the interferon response by siRNA is cell type- and duplex length-dependent

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=3378874

2 October 2017

RNA interference: its use as antiviral therapy.

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=3378874

2 October 2017

Innate sensing of self and non-self RNAs by Toll-like receptors

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=3378874

2 October 2017

Antiviral activity of small interfering RNAs: specificity testing using heterologous virus reveals interferon-related effects overlooked by conventional mismatch controls

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=3378874

2 October 2017

Cleavage of the siRNA passenger strand during RISC assembly in human cells

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=3378874

2 October 2017

Activation of the mammalian immune system by siRNAs.

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=3378874

2 October 2017

Human RISC couples microRNA biogenesis and posttranscriptional gene silencing

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=3378874

2 October 2017

Passenger-strand cleavage facilitates assembly of siRNA into Ago2-containing RNAi enzyme complexes

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=3378874

2 October 2017

Argonaute2 cleaves the anti-guide strand of siRNA during RISC activation

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=3378874

2 October 2017

Characterization of Toll-like receptor 3 gene in rainbow trout (Oncorhynchus mykiss).

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=3378874

2 October 2017

Potent and persistent in vivo anti-HBV activity of chemically modified siRNAs

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=3378874

2 October 2017

Innate immunity of fish (overview).

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=3378874

2 October 2017

The interferon system of teleost fish.

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=3378874

2 October 2017

Sequence-specific potent induction of IFN-alpha by short interfering RNA in plasmacytoid dendritic cells through TLR7

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=3378874

2 October 2017

Locked nucleic acid (LNA) mediated improvements in siRNA stability and functionality

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=3378874

2 October 2017

LNA-antisense rivals siRNA for gene silencing

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=3378874

2 October 2017

Exogenous siRNA mediates sequence-independent gene suppression by signaling through toll-like receptor 3.

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=3378874

2 October 2017

Human Argonaute2 mediates RNA cleavage targeted by miRNAs and siRNAs

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=3378874

2 October 2017

Structural variations and stabilising modifications of synthetic siRNAs in mammalian cells

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=3378874

2 October 2017

Type I-interferon signalling in fish

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=3378874

2 October 2017

Functional anatomy of siRNAs for mediating efficient RNAi in Drosophila melanogaster embryo lysate

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=3378874

2 October 2017

Specific inhibition of gene expression by small double-stranded RNAs in invertebrate and vertebrate systems

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=3378874

2 October 2017

Duplexes of 21-nucleotide RNAs mediate RNA interference in cultured mammalian cells

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=3378874

2 October 2017

Role for a bidentate ribonuclease in the initiation step of RNA interference

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=3378874

2 October 2017

An RNA-directed nuclease mediates post-transcriptional gene silencing in Drosophila cells

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=3378874

2 October 2017

Isolation of viral haemorrhagic septicaemia virus (VHSV) from wild marine fish species in the Baltic Sea, Kattegat, Skagerrak and the North Sea

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=3378874

2 October 2017

Potent and specific genetic interference by double-stranded RNA in Caenorhabditis elegans

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=3378874

2 October 2017

Interferon action: two distinct pathways for inhibition of protein synthesis by double-stranded RNA

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=3378874

2 October 2017

Interferon-induced inhibition of protein synthesis in L-cell extracts: an ATP-dependent step in the activation of an inhibitor by double-stranded RNA

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=3378874

2 October 2017

Inhibition of MDR1 expression with altritol-modified siRNAs

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=3378874

11 July 2018

Induction of inflammatory cytokines and interferon responses by double-stranded and single-stranded siRNAs is sequence-dependent and requires endosomal localization

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=3378874

11 July 2018

Functional characterization of full-length TLR3, IRAK-4, and TRAF6 in zebrafish (Danio rerio).

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=3378874

11 July 2018

Prediction of the prototype of the human Toll-like receptor gene family from the pufferfish, Fugu rubripes, genome

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=3378874

11 July 2018

Molecular cloning and expression in Escherichia coli of the glycoprotein gene of VHS virus, and immunization of rainbow trout with the recombinant protein

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=3378874

11 July 2018

Design of noninflammatory synthetic siRNA mediating potent gene silencing in vivo

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=3378874

23 September 2018

Therapeutic silencing of an endogenous gene by systemic administration of modified siRNAs

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=3378874

23 September 2018

Cationic liposome-mediated delivery of siRNAs in adult mice

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=3378874

23 September 2018

Gene Expression Analysis in Blood Cells in Response to Unmodified and 2′-Modified siRNAs Reveals TLR-dependent and Independent Effects

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=3378874

5 December 2018

A high throughput in vivo model for testing delivery and antiviral effects of siRNAs in vertebrates

1 reference

https://pubmed.ncbi.nlm.nih.gov/22287630

12 December 2020

based on heuristic

inferred from PubMed ID database lookup

Single-stranded small interfering RNA are more immunostimulatory than their double-stranded counterparts: a central role for 2'-hydroxyl uridines in immune responses

1 reference

https://pubmed.ncbi.nlm.nih.gov/22287630

12 December 2020

based on heuristic

inferred from PubMed ID database lookup

2'-O-methyl-modified RNAs act as TLR7 antagonists

1 reference

https://pubmed.ncbi.nlm.nih.gov/22287630

12 December 2020

based on heuristic

inferred from PubMed ID database lookup

Sequence-dependent stimulation of the mammalian innate immune response by synthetic siRNA

1 reference

https://pubmed.ncbi.nlm.nih.gov/22287630

12 December 2020

based on heuristic

inferred from PubMed ID database lookup

Identifiers

10.1093/NAR/GKS033

1 reference

Europe PubMed Central

https://www.ebi.ac.uk/europepmc/webservices/rest/search?query=EXT_ID:22287630%20AND%20SRC:MED&resulttype=core&format=json

21 January 2020

1 reference

Europe PubMed Central

https://www.ebi.ac.uk/europepmc/webservices/rest/search?query=EXT_ID:22287630%20AND%20SRC:MED&resulttype=core&format=json

21 January 2020

1 reference

Europe PubMed Central

https://www.ebi.ac.uk/europepmc/webservices/rest/search?query=EXT_ID:22287630%20AND%20SRC:MED&resulttype=core&format=json

21 January 2020

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