(Q36067741)

12 August 2017

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title

Scleroderma, fibroblasts, signaling, and excessive extracellular matrix (English)

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12 August 2017

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Hironobu Ihn

1

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12 August 2017

publication date

1 April 2005

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Current Rheumatology Reports

12 August 2017

published in

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12 August 2017

volume

7

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12 August 2017

issue

2

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12 August 2017

page(s)

156-162

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https://scigraph.springernature.com/pub.10.1007/s11926-005-0069-9

12 August 2017

exact match

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cites work

Mice lacking Smad3 are protected against cutaneous injury induced by ionizing radiation

1 reference

https://api.crossref.org/works/10.1007%2FS11926-005-0069-9

Regulation of connective tissue growth factor gene expression in human skin fibroblasts and during wound repair

21 January 2018

1 reference

https://api.crossref.org/works/10.1007%2FS11926-005-0069-9

Phosphatidylinositol 3-kinase is involved in alpha2(I) collagen gene expression in normal and scleroderma fibroblasts

21 January 2018

1 reference

https://api.crossref.org/works/10.1007%2FS11926-005-0069-9

Smad3 and PKCdelta mediate TGF-beta1-induced collagen I expression in human mesangial cells

21 January 2018

1 reference

https://api.crossref.org/works/10.1007%2FS11926-005-0069-9

Persistent down-regulation of Fli1, a suppressor of collagen transcription, in fibrotic scleroderma skin

21 January 2018

1 reference

https://api.crossref.org/works/10.1007%2FS11926-005-0069-9

IL-4 up-regulates the expression of tissue inhibitor of metalloproteinase-2 in dermal fibroblasts via the p38 mitogen-activated protein kinase dependent pathway

21 January 2018

1 reference

https://api.crossref.org/works/10.1007%2FS11926-005-0069-9

Increased expression levels of integrin alphavbeta5 on scleroderma fibroblasts

21 January 2018

1 reference

https://api.crossref.org/works/10.1007%2FS11926-005-0069-9

An increased transforming growth factor beta receptor type I:type II ratio contributes to elevated collagen protein synthesis that is resistant to inhibition via a kinase-deficient transforming growth factor beta receptor type II in scleroderma

21 January 2018

1 reference

12 December 2020

Transcriptional activation of the type I collagen genes COL1A1 and COL1A2 in fibroblasts by interleukin‐4: Analysis of the functional collagen promoter sequences

1 reference

12 December 2020

Transforming growth factor-beta repression of matrix metalloproteinase-1 in dermal fibroblasts involves Smad3.

1 reference

12 December 2020

Oncostatin M Stimulates Transcription of the Human α2(I) Collagen Gene via the Sp1/Sp3-binding Site

1 reference

12 December 2020

Sp3 is a transcriptional activator of the human alpha2(I) collagen gene

1 reference

12 December 2020

Role of protein kinase C-delta in the regulation of collagen gene expression in scleroderma fibroblasts

1 reference

12 December 2020

Role of p38 MAPK in Transforming Growth Factor β Stimulation of Collagen Production by Scleroderma and Healthy Dermal Fibroblasts

1 reference

12 December 2020

Smad-dependent stimulation of type I collagen gene expression in human skin fibroblasts by TGF-beta involves functional cooperation with p300/CBP transcriptional coactivators

1 reference

12 December 2020

Interferon-gamma interferes with transforming growth factor-beta signaling through direct interaction of YB-1 with Smad3.

1 reference

12 December 2020

Amelioration of radiation-induced fibrosis: inhibition of transforming growth factor-beta signaling by halofuginone.

1 reference

12 December 2020

Blockade of endogenous transforming growth factor beta signaling prevents up-regulated collagen synthesis in scleroderma fibroblasts: association with increased expression of transforming growth factor beta receptors

1 reference

12 December 2020

Competition analysis of the human alpha2(I) collagen promoter using synthetic oligonucleotides

1 reference

12 December 2020

Tumor necrosis factor alpha inhibits type I collagen synthesis through repressive CCAAT/enhancer-binding proteins

1 reference

12 December 2020

Significant correlation between connective tissue growth factor gene expression and skin sclerosis in tissue sections from patients with systemic sclerosis

1 reference

12 December 2020

Distinct involvement of the Jun-N-terminal kinase and NF-kappaB pathways in the repression of the human COL1A2 gene by TNF-alpha.

1 reference

12 December 2020

The hepatitis B virus encoded oncoprotein pX amplifies TGF-beta family signaling through direct interaction with Smad4: potential mechanism of hepatitis B virus-induced liver fibrosis

1 reference

12 December 2020

Tenascin-C upregulation by transforming growth factor-beta in human dermal fibroblasts involves Smad3, Sp1, and Ets1

1 reference

12 December 2020

Transcriptional Regulation of the Human α2(I) Collagen Gene

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12 December 2020

Controlling TGF-beta signaling

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12 December 2020

5-fluorouracil blocks transforming growth factor-beta-induced alpha 2 type I collagen gene (COL1A2) expression in human fibroblasts via c-Jun NH2-terminal kinase/activator protein-1 activation

1 reference

12 December 2020

Ets1 is an effector of the transforming growth factor beta (TGF-beta ) signaling pathway and an antagonist of the profibrotic effects of TGF-beta

1 reference

12 December 2020

The tumor suppressor p53 abrogates Smad-dependent collagen gene induction in mesenchymal cells

1 reference

12 December 2020

B-Myb acts as a repressor of human COL1A1 collagen gene expression by interacting with Sp1 and CBF factors in scleroderma fibroblasts

1 reference

12 December 2020

Iloprost suppresses connective tissue growth factor production in fibroblasts and in the skin of scleroderma patients

1 reference

12 December 2020

Selective stimulation of collagen synthesis in the presence of costimulatory insulin signaling by connective tissue growth factor in scleroderma fibroblasts

1 reference

12 December 2020

Epidermal growth factor induces fibronectin expression in human dermal fibroblasts via protein kinase C delta signaling pathway

1 reference

12 December 2020

Increased phosphorylation of transcription factor Sp1 in scleroderma fibroblasts: association with increased expression of the type I collagen gene

1 reference

12 December 2020

Interaction of smad3 with a proximal smad-binding element of the human alpha2(I) procollagen gene promoter required for transcriptional activation by TGF-beta

1 reference

12 December 2020

Serum levels of tissue inhibitor of metalloproteinase-1 and 2 in patients with eosinophilic fasciitis

1 reference

12 December 2020

Transforming growth factor-beta: selective increase in glycosaminoglycan synthesis by cultures of fibroblasts from patients with progressive systemic sclerosis

1 reference

12 December 2020

Deficient Smad7 expression: a putative molecular defect in scleroderma

1 reference

12 December 2020

Sp1 is required for the early response of alpha2(I) collagen to transforming growth factor-beta1.

1 reference

12 December 2020

Transforming growth factor beta induces fibroblast fibrillin-1 matrix formation

1 reference

12 December 2020

Interleukin-13 stimulates the transcription of the human alpha2(I) collagen gene in human dermal fibroblasts

1 reference

12 December 2020

Endothelin-1 promotes myofibroblast induction through the ETA receptor via a rac/phosphoinositide 3-kinase/Akt-dependent pathway and is essential for the enhanced contractile phenotype of fibrotic fibroblasts.

1 reference

12 December 2020

Antagonistic regulation of type I collagen gene expression by interferon-gamma and transforming growth factor-beta. Integration at the level of p300/CBP transcriptional coactivators

1 reference

12 December 2020

Constitutive connective tissue growth factor expression in scleroderma fibroblasts is dependent on Sp1

1 reference

12 December 2020

The transforming growth factor-beta family

1 reference

12 December 2020

Fibroblast matrix gene expression and connective tissue remodeling: role of endothelin-1.

1 reference

12 December 2020

Secretion and binding of transforming growth factor beta by scleroderma and normal dermal fibroblasts.

1 reference

12 December 2020

Expression and regulation of intracellular SMAD signaling in scleroderma skin fibroblasts

1 reference

12 December 2020

Up-regulated expression of transforming growth factor beta receptors in dermal fibroblasts in skin sections from patients with localized scleroderma

1 reference

12 December 2020

TGF-beta induces fibronectin synthesis through a c-Jun N-terminal kinase-dependent, Smad4-independent pathway

1 reference

12 December 2020

Co-localization of transforming growth factor beta 2 with alpha 1(I) procollagen mRNA in tissue sections of patients with systemic sclerosis

1 reference

12 December 2020

A strategy for determining the pathogenesis of systemic sclerosis. Is transforming growth factor beta the answer?

1 reference

12 December 2020

Synergistic cooperation between Sp1 and Smad3/Smad4 mediates transforming growth factor beta1 stimulation of alpha 2(I)-collagen (COL1A2) transcription

1 reference

12 December 2020

Halofuginone inhibition of COL1A2 promoter activity via a c-Jun-dependent mechanism.

1 reference

12 December 2020

Gene transfer of Smad7 using electroporation of adenovirus prevents renal fibrosis in post-obstructed kidney

1 reference

12 December 2020

Pathogenesis of fibrosis: role of TGF-beta and CTGF.

1 reference

12 December 2020

Immunologic aspects of scleroderma

1 reference

12 December 2020

CTGF and SMADs, maintenance of scleroderma phenotype is independent of SMAD signaling

1 reference

12 December 2020

Transcriptional inhibition of type I collagen gene expression in scleroderma fibroblasts by the antineoplastic drug ecteinascidin 743.

1 reference

12 December 2020

Disruption of transforming growth factor beta signaling and profibrotic responses in normal skin fibroblasts by peroxisome proliferator-activated receptor gamma

1 reference

12 December 2020

Spl phosphorylation induced by serum stimulates the human alpha2(I) collagen gene expression.

1 reference

12 December 2020

Increased transcriptional activities of transforming growth factor beta receptors in scleroderma fibroblasts

1 reference

12 December 2020

Mutant fibrillin 1 from tight skin mice increases extracellular matrix incorporation of microfibril-associated glycoprotein 2 and type I collagen

1 reference

12 December 2020

Fibronectin release by systemic sclerosis and normal dermal fibroblasts in response to TGF-beta

1 reference

12 December 2020

Nuclear factor-kappa B mediates TNF-alpha inhibitory effect on alpha 2(I) collagen (COL1A2) gene transcription in human dermal fibroblasts

1 reference

12 December 2020

Epidermal growth factor up-regulates expression of transforming growth factor beta receptor type II in human dermal fibroblasts by phosphoinositide 3-kinase/Akt signaling pathway: Resistance to epidermal growth factor stimulation in scleroderma fibr

1 reference

12 December 2020

Overlapping pathways mediate the opposing actions of tumor necrosis factor-alpha and transforming growth factor-beta on alpha 2(I) collagen gene transcription

1 reference

12 December 2020

Interferon gamma repression of collagen (COL1A2) transcription is mediated by the RFX5 complex

1 reference

12 December 2020

Oncostatin M stimulates the growth of dermal fibroblasts via a mitogen-activated protein kinase-dependent pathway

1 reference

12 December 2020

Mammalian target of rapamycin positively regulates collagen type I production via a phosphatidylinositol 3-kinase-independent pathway

1 reference

12 December 2020

Circulating intercellular adhesion molecule-1 in the sera of patients with systemic sclerosis: enhancement by inflammatory cytokines

1 reference

12 December 2020

The role of TGF-beta signaling in the pathogenesis of fibrosis in scleroderma.

1 reference

12 December 2020

Increased Expression of TGF-β Receptors by Scleroderma Fibroblasts: Evidence for Contribution of Autocrine TGF-β Signaling to Scleroderma Phenotype

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12 December 2020

Myofibroblasts from scleroderma skin synthesize elevated levels of collagen and tissue inhibitor of metalloproteinase (TIMP-1) with two forms of TIMP-1.

1 reference

12 December 2020

Increased collagen synthesis by scleroderma skin fibroblasts in vitro: a possible defect in the regulation or activation of the scleroderma fibroblast

1 reference

12 December 2020

Characterization of the c-Myb-responsive region and regulation of the human type I collagen alpha 2 chain gene by c-Myb.

1 reference

12 December 2020

Sustained activation of fibroblast transforming growth factor-beta/Smad signaling in a murine model of scleroderma

1 reference

12 December 2020

Upregulated expression of transforming growth factor-beta receptors in dermal fibroblasts of skin sections from patients with systemic sclerosis.

1 reference

12 December 2020

Mechanism of activation of the TGF-beta receptor

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12 December 2020

Antagonistic Effects of TNF-α on TGF-β Signaling Through Down-Regulation of TGF-β Receptor Type II in Human Dermal Fibroblasts

1 reference

12 December 2020

An AP-1 binding sequence is essential for regulation of the human alpha2(I) collagen (COL1A2) promoter activity by transforming growth factor-beta.

1 reference

12 December 2020

Activation of tissue inhibitor of metalloproteinases-3 (TIMP-3) mRNA expression in scleroderma skin fibroblasts

1 reference

12 December 2020

Impaired Smad7-Smurf-mediated negative regulation of TGF-beta signaling in scleroderma fibroblasts

1 reference

12 December 2020

Modulation of transforming growth factor-beta (TGF-beta) signaling by endogenous sphingolipid mediators.

1 reference

12 December 2020

Angiotensin II in the lesional skin of systemic sclerosis patients contributes to tissue fibrosis via angiotensin II type 1 receptors

1 reference

12 December 2020

10.1007/S11926-005-0069-9

Identifiers

DOI

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12 August 2017

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