(Q40597763)

https://www.ebi.ac.uk/europepmc/webservices/rest/search?query=EXT_ID:14732719%20AND%20SRC:MED&resulttype=core&format=json

17 November 2019

title

Amelioration of radiation-induced fibrosis: inhibition of transforming growth factor-beta signaling by halofuginone (English)

1 reference

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17 November 2019

4

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17 November 2019

Alain Mauviel

5

1 reference

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17 November 2019

13

Anita B Roberts

1 reference

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17 November 2019

author name string

Sandhya Xavier

1

1 reference

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17 November 2019

Ester Piek

2

1 reference

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17 November 2019

Makiko Fujii

3

1 reference

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17 November 2019

Kathy C Flanders

6

1 reference

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17 November 2019

Ayelet M Samuni

7

1 reference

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17 November 2019

Angelina Felici

8

1 reference

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17 November 2019

Michael Reiss

9

1 reference

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17 November 2019

Shai Yarkoni

10

1 reference

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17 November 2019

Anastasia Sowers

11

1 reference

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17 November 2019

James B Mitchell

12

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17 November 2019

Angelo Russo

14

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17 November 2019

language of work or name

English

0 references

publication date

19 January 2004

1 reference

https://www.ebi.ac.uk/europepmc/webservices/rest/search?query=EXT_ID:14732719%20AND%20SRC:MED&resulttype=core&format=json

Journal of Biological Chemistry

17 November 2019

published in

1 reference

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17 November 2019

volume

279

1 reference

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17 November 2019

issue

15

1 reference

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17 November 2019

page(s)

15167-15176

1 reference

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The role of DNA double strand breaks in lonizing radiation-induced killing of eukaryotic cells

17 November 2019

cites work

1 reference

https://api.crossref.org/works/10.1074%2FJBC.M309798200

The role of repair in radiobiology

21 January 2018

1 reference

https://api.crossref.org/works/10.1074%2FJBC.M309798200

Growth factors: biological and clinical aspects.

21 January 2018

1 reference

https://api.crossref.org/works/10.1074%2FJBC.M309798200

Pathogenesis of fibrosis: role of TGF-beta and CTGF.

21 January 2018

1 reference

https://api.crossref.org/works/10.1074%2FJBC.M309798200

Stress and radiation-induced activation of multiple intracellular signaling pathways

21 January 2018

1 reference

https://api.crossref.org/works/10.1074%2FJBC.M309798200

TGF-beta1 and radiation fibrosis: a master switch and a specific therapeutic target?

21 January 2018

1 reference

https://api.crossref.org/works/10.1074%2FJBC.M309798200

TGF-beta signaling from receptors to the nucleus

21 January 2018

1 reference

https://api.crossref.org/works/10.1074%2FJBC.M309798200

Signal transduction by the TGF-beta superfamily

21 January 2018

1 reference

https://api.crossref.org/works/10.1074%2FJBC.M309798200

How cells read TGF-beta signals

21 January 2018

1 reference

https://api.crossref.org/works/10.1074%2FJBC.M309798200

Mice lacking Smad3 are protected against cutaneous injury induced by ionizing radiation

21 January 2018

1 reference

https://api.crossref.org/works/10.1074%2FJBC.M309798200

Halofuginone: an inhibitor of collagen type I synthesis

21 January 2018

1 reference

https://api.crossref.org/works/10.1074%2FJBC.M309798200

Halofuginone, an inhibitor of type-I collagen synthesis and skin sclerosis, blocks transforming-growth-factor-beta-mediated Smad3 activation in fibroblasts.

21 January 2018

1 reference

https://api.crossref.org/works/10.1074%2FJBC.M309798200

Halofuginone to prevent and treat thioacetamide-induced liver fibrosis in rats

21 January 2018

1 reference

https://api.crossref.org/works/10.1074%2FJBC.M309798200

Use of vanadate as protein-phosphotyrosine phosphatase inhibitor

21 January 2018

1 reference

https://api.crossref.org/works/10.1074%2FJBC.M309798200

Normal keratinization in a spontaneously immortalized aneuploid human keratinocyte cell line

21 January 2018

1 reference

https://api.crossref.org/works/10.1074%2FJBC.M309798200

Heterogeneity of hematopoietic cells immortalized by v-myc/v-raf recombinant retrovirus infection of bone marrow or fetal liver

21 January 2018

1 reference

https://api.crossref.org/works/10.1074%2FJBC.M309798200

Functional characterization of transforming growth factor beta signaling in Smad2- and Smad3-deficient fibroblasts

21 January 2018

1 reference

https://api.crossref.org/works/10.1074%2FJBC.M309798200

NEMO/IKK gamma-deficient mice model incontinentia pigmenti.

21 January 2018

1 reference

https://api.crossref.org/works/10.1074%2FJBC.M309798200

Defective neural tube morphogenesis and altered apoptosis in the absence of both JNK1 and JNK2.

21 January 2018

1 reference

https://api.crossref.org/works/10.1074%2FJBC.M309798200

Interference with transforming growth factor-beta/ Smad3 signaling results in accelerated healing of wounds in previously irradiated skin

21 January 2018

1 reference

https://api.crossref.org/works/10.1074%2FJBC.M309798200

Smads 2 and 3 are differentially activated by transforming growth factor-beta (TGF-beta ) in quiescent and activated hepatic stellate cells. Constitutive nuclear localization of Smads in activated cells is TGF-beta-independent.

21 January 2018

1 reference

https://api.crossref.org/works/10.1074%2FJBC.M309798200

Human Smad3 and Smad4 are sequence-specific transcription activators

21 January 2018

1 reference

https://api.crossref.org/works/10.1074%2FJBC.M309798200

A transcriptional partner for MAD proteins in TGF-beta signalling

21 January 2018

1 reference

https://api.crossref.org/works/10.1074%2FJBC.M309798200

TGF beta signals through a heteromeric protein kinase receptor complex

21 January 2018

1 reference

https://api.crossref.org/works/10.1074%2FJBC.M309798200

Role of glutathione S-transferases in protection against lipid peroxidation. Overexpression of hGSTA2-2 in K562 cells protects against hydrogen peroxide-induced apoptosis and inhibits JNK and caspase 3 activation

21 January 2018

1 reference

https://api.crossref.org/works/10.1074%2FJBC.M309798200

Targeted deletion of Smad4 shows it is required for transforming growth factor beta and activin signaling in colorectal cancer cells

21 January 2018

1 reference

https://api.crossref.org/works/10.1074%2FJBC.M309798200

The Smad4 activation domain (SAD) is a proline-rich, p300-dependent transcriptional activation domain

21 January 2018

1 reference

https://api.crossref.org/works/10.1074%2FJBC.M309798200

Inhibition of transforming growth factor-beta/SMAD signalling by the interferon-gamma/STAT pathway.

21 January 2018

1 reference

https://api.crossref.org/works/10.1074%2FJBC.M309798200

Phosphatidylinositol 3-kinase function is required for transforming growth factor beta-mediated epithelial to mesenchymal transition and cell migration.

21 January 2018

1 reference

https://api.crossref.org/works/10.1074%2FJBC.M309798200

The therapeutic advantage of combined heat and X rays on a mouse fibrosarcoma

21 January 2018

1 reference

https://api.crossref.org/works/10.1074%2FJBC.M309798200

Halofuginone to treat fibrosis in chronic graft-versus-host disease and scleroderma

21 January 2018

1 reference

https://api.crossref.org/works/10.1074%2FJBC.M309798200

Effect of halofuginone on the development of tight skin (TSK) syndrome

21 January 2018

1 reference

https://api.crossref.org/works/10.1074%2FJBC.M309798200

Fibroblast-specific Expression of a Kinase-deficient Type II Transforming Growth Factor β (TGFβ) Receptor Leads to Paradoxical Activation of TGFβ Signaling Pathways with Fibrosis in Transgenic Mice

21 January 2018

1 reference

https://api.crossref.org/works/10.1074%2FJBC.M309798200

Smad7 prevents activation of hepatic stellate cells and liver fibrosis in rats

21 January 2018

1 reference

https://api.crossref.org/works/10.1074%2FJBC.M309798200

Regulation of Smad3 expression in bleomycin-induced pulmonary fibrosis: a negative feedback loop of TGF-beta signaling

21 January 2018

1 reference

https://api.crossref.org/works/10.1074%2FJBC.M309798200

The role of Smad3 in mediating mouse hepatic stellate cell activation

21 January 2018

1 reference

https://api.crossref.org/works/10.1074%2FJBC.M309798200

Identification of novel TGF-beta /Smad gene targets in dermal fibroblasts using a combined cDNA microarray/promoter transactivation approach.

21 January 2018

1 reference

https://api.crossref.org/works/10.1074%2FJBC.M309798200

Hierarchical model of gene regulation by transforming growth factor beta

21 January 2018

1 reference

https://api.crossref.org/works/10.1074%2FJBC.M309798200

Transforming growth factor-beta in breast cancer: a working hypothesis

21 January 2018

1 reference

https://api.crossref.org/works/10.1074%2FJBC.M309798200

TGF-beta3 regulates the blood-testis barrier dynamics via the p38 mitogen activated protein (MAP) kinase pathway: an in vivo study

21 January 2018

1 reference

https://api.crossref.org/works/10.1074%2FJBC.M309798200

Connective tissue growth factor gene regulation. Requirements for its induction by transforming growth factor-beta 2 in fibroblasts

21 January 2018

1 reference

https://api.crossref.org/works/10.1074%2FJBC.M309798200

Transforming growth factor-beta1 potentiates renal tubular epithelial cell death by a mechanism independent of Smad signaling

21 January 2018

1 reference

https://api.crossref.org/works/10.1074%2FJBC.M309798200

21 January 2018

Identifiers

DOI

10.1074/JBC.M309798200

1 reference

https://www.ebi.ac.uk/europepmc/webservices/rest/search?query=EXT_ID:14732719%20AND%20SRC:MED&resulttype=core&format=json

17 November 2019

1 reference