(Q36072102)

English

Interspecies differences in the metabolism of methotrexate: An insight into the active site differences between human and rabbit aldehyde oxidase

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scholarly article

1 reference

Europe PubMed Central

PMC publication ID

12 August 2017

Interspecies differences in the metabolism of methotrexate: An insight into the active site differences between human and rabbit aldehyde oxidase (English)

1 reference

Europe PubMed Central

PMC publication ID

12 August 2017

1 reference

based on heuristic

inferred from title

author name string

Kanika V Choughule

1

1 reference

Europe PubMed Central

PMC publication ID

12 August 2017

Carolyn A Joswig-Jones

2

1 reference

Europe PubMed Central

PMC publication ID

12 August 2017

Jeffrey P Jones

3

1 reference

Europe PubMed Central

PMC publication ID

12 August 2017

language of work or name

0 references

publication date

29 May 2015

1 reference

Europe PubMed Central

PMC publication ID

12 August 2017

Biochemical Pharmacology

1 reference

Europe PubMed Central

PMC publication ID

12 August 2017

96

1 reference

Europe PubMed Central

PMC publication ID

12 August 2017

3

1 reference

Europe PubMed Central

PMC publication ID

12 August 2017

288-295

1 reference

Europe PubMed Central

PMC publication ID

12 August 2017

Absolute quantification of aldehyde oxidase protein in human liver using liquid chromatography-tandem mass spectrometry

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=4574636

2 October 2017

Evaluation of rhesus monkey and guinea pig hepatic cytosol fractions as models for human aldehyde oxidase

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=4574636

2 October 2017

Predicting intrinsic clearance for drugs and drug candidates metabolized by aldehyde oxidase

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=4574636

2 October 2017

The First Mammalian Aldehyde Oxidase Crystal Structure: INSIGHTS INTO SUBSTRATE SPECIFICITY

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=4574636

2 October 2017

Evidence for substrate-dependent inhibition profiles for human liver aldehyde oxidase

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=4574636

2 October 2017

The role of aldehyde oxidase in drug metabolism

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=4574636

2 October 2017

The impact of single nucleotide polymorphisms on human aldehyde oxidase

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=4574636

2 October 2017

Inhibition of human liver aldehyde oxidase: implications for potential drug-drug interactions

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=4574636

2 October 2017

Increasing recognition of the importance of aldehyde oxidase in drug development and discovery

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=4574636

2 October 2017

Aldehyde oxidase: an enzyme of emerging importance in drug discovery

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=4574636

2 October 2017

In vitro-in vivo correlation for intrinsic clearance for drugs metabolized by human aldehyde oxidase

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=4574636

2 October 2017

Purification and mechanism of human aldehyde oxidase expressed in Escherichia coli

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=4574636

2 October 2017

Site directed mutagenesis of amino acid residues at the active site of mouse aldehyde oxidase AOX1

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=4574636

2 October 2017

The crystal structure of xanthine oxidoreductase during catalysis: implications for reaction mechanism and enzyme inhibition

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=4574636

2 October 2017

Ziprasidone metabolism, aldehyde oxidase, and clinical implications

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=4574636

2 October 2017

7-Hydroxymethotrexate as a urinary metabolite in human subjects and rhesus monkeys receiving high dose methotrexate

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=4574636

2 October 2017

Studies on the mechanism of aldehyde oxidase and xanthine oxidase

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=4574636

27 July 2018

An in vitro study on methotrexate hydroxylation in rat and human liver

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=4574636

27 July 2018

Interspecies variation in the metabolism of zoniporide by aldehyde oxidase.

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=4574636

23 September 2018

Species-specific metabolism of SGX523 by aldehyde oxidase and the toxicological implications

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=4574636

23 September 2018

A single amino acid substitution confers high cinchonidine oxidation activity comparable with that of rabbit to monkey aldehyde oxidase 1.

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=4574636

23 September 2018

Zebularine metabolism by aldehyde oxidase in hepatic cytosol from humans, monkeys, dogs, rats, and mice: influence of sex and inhibitors

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=4574636

23 September 2018

Aldehyde oxidase-catalysed oxidation of methotrexate in the liver of guinea-pig, rabbit and man.

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=4574636

23 September 2018

Design of a novel P450: a functional bacterial-human cytochrome P450 chimera

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=4574636

23 September 2018

Variation of hepatic methotrexate 7-hydroxylase activity in animals and humans

1 reference

https://pubmed.ncbi.nlm.nih.gov/26032640

12 December 2020

based on heuristic

inferred from PubMed ID database lookup

The identity of rabbit-liver methotrexate oxidase

1 reference

https://pubmed.ncbi.nlm.nih.gov/26032640

12 December 2020

based on heuristic

inferred from PubMed ID database lookup

The role of 7-hydroxymethotrexate during methotrexate anti-cancer therapy

1 reference

https://pubmed.ncbi.nlm.nih.gov/26032640

12 December 2020

based on heuristic

inferred from PubMed ID database lookup

Pharmacokinetics of methotrexate and 7-hydroxymethotrexate following infusions of high-dose methotrexate

1 reference

https://pubmed.ncbi.nlm.nih.gov/26032640

12 December 2020

based on heuristic

inferred from PubMed ID database lookup

Tissue metabolism and distribution of methotrexate in rabbits

1 reference

https://pubmed.ncbi.nlm.nih.gov/26032640

12 December 2020

based on heuristic

inferred from PubMed ID database lookup

Involvement of the narJ and mob gene products in distinct steps in the biosynthesis of the molybdoenzyme nitrate reductase in Escherichia coli

1 reference

https://pubmed.ncbi.nlm.nih.gov/26032640

12 December 2020

based on heuristic

inferred from PubMed ID database lookup

In vitro oxidation of famciclovir and 6-deoxypenciclovir by aldehyde oxidase from human, guinea pig, rabbit, and rat liver

1 reference

https://pubmed.ncbi.nlm.nih.gov/26032640

12 December 2020

based on heuristic

inferred from PubMed ID database lookup

Aldehyde oxidase-dependent marked species difference in hepatic metabolism of the sedative-hypnotic, zaleplon, between monkeys and rats

1 reference

https://pubmed.ncbi.nlm.nih.gov/26032640

12 December 2020

based on heuristic

inferred from PubMed ID database lookup

Use of density functional calculations to predict the regioselectivity of drugs and molecules metabolized by aldehyde oxidase

1 reference

https://pubmed.ncbi.nlm.nih.gov/26032640

12 December 2020

based on heuristic

inferred from PubMed ID database lookup

Identifiers

10.1016/J.BCP.2015.05.010

1 reference

Europe PubMed Central

PMC publication ID

12 August 2017

PMC publication ID

1 reference

Europe PubMed Central

PMC publication ID

12 August 2017

PubMed publication ID

1 reference

Europe PubMed Central

PMC publication ID

12 August 2017

ResearchGate publication ID

0 references

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