(Q36079873)

12 August 2017

1 reference

title

CTLA4 gene polymorphism and autoimmunity (English)

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12 August 2017

2

Lucy S K Walker

1 reference

12 August 2017

David M Sansom

3

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author name string

Stephen C L Gough

series ordinal

1

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12 August 2017

publication date

1 April 2005

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12 August 2017

published in

Immunological Reviews

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12 August 2017

volume

204

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12 August 2017

page(s)

102-115

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A range of CD4 T cell tolerance: partial inactivation to organ-specific antigen allows nondestructive thyroiditis or insulitis.

12 August 2017

cites work

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21 January 2018

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A new member of the immunoglobulin superfamily--CTLA-4

21 January 2018

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Complete sequence determination of the mouse and human CTLA4 gene loci: cross-species DNA sequence similarity beyond exon borders

21 January 2018

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CD28, CTLA-4 and their ligands: who does what and to whom?

21 January 2018

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Structure and dimerization of a soluble form of B7-1

21 January 2018

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The interaction properties of costimulatory molecules revisited.

21 January 2018

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B7-1 and B7-2 selectively recruit CTLA-4 and CD28 to the immunological synapse

21 January 2018

1 reference

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Src kinases Fyn and Lck facilitate the accumulation of phosphorylated CTLA-4 and its association with PI-3 kinase in intracellular compartments of T-cells

21 January 2018

1 reference

https://api.crossref.org/works/10.1111%2FJ.0105-2896.2005.00249.X

CTLA-4 binding to the lipid kinase phosphatidylinositol 3-kinase in T cells

21 January 2018

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Src family tyrosine kinases associate with and phosphorylate CTLA-4 (CD152).

21 January 2018

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Molecular basis of T cell inactivation by CTLA-4

21 January 2018

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Tyrosine phosphatase SHP-2 binding to CTLA-4: absence of direct YVKM/YFIP motif recognition

21 January 2018

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Cytotoxic T lymphocyte antigen-4 accumulation in the immunological synapse is regulated by TCR signal strength

21 January 2018

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Searching for genetic determinants in the new millennium

21 January 2018

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Genomewide scans of complex human diseases: true linkage is hard to find

21 January 2018

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Genetic associations in large versus small studies: an empirical assessment

21 January 2018

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Meta-analysis of genetic association studies supports a contribution of common variants to susceptibility to common disease

21 January 2018

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A genome-wide search for human type 1 diabetes susceptibility genes

21 January 2018

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A second-generation screen of the human genome for susceptibility to insulin-dependent diabetes mellitus

21 January 2018

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Seven regions of the genome show evidence of linkage to type 1 diabetes in a consensus analysis of 767 multiplex families

21 January 2018

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Linkage disequilibrium mapping of a type 1 diabetes susceptibility gene (IDDM7) to chromosome 2q31-q33.

21 January 2018

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A Genome-Wide Scan for Autoimmune Thyroiditis in the Old Order Amish: Replication of Genetic Linkage on Chromosome 5q11.2-q14.3

21 January 2018

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Common and unique susceptibility loci in Graves and Hashimoto diseases: results of whole-genome screening in a data set of 102 multiplex families

21 January 2018

1 reference

https://api.crossref.org/works/10.1111%2FJ.0105-2896.2005.00249.X

The cytotoxic T lymphocyte antigen-4 is a major Graves' disease locus.

21 January 2018

1 reference

https://api.crossref.org/works/10.1111%2FJ.0105-2896.2005.00249.X

CTLA4 alanine-17 confers genetic susceptibility to Graves' disease and to type 1 diabetes mellitus.

21 January 2018

1 reference

https://api.crossref.org/works/10.1111%2FJ.0105-2896.2005.00249.X

CTLA-4 gene polymorphisms in Tunisian patients with Graves' disease

21 January 2018

1 reference

https://api.crossref.org/works/10.1111%2FJ.0105-2896.2005.00249.X

A CTLA-4 gene polymorphism is associated with both Graves disease and autoimmune hypothyroidism

21 January 2018

1 reference

https://api.crossref.org/works/10.1111%2FJ.0105-2896.2005.00249.X

CTLA-4 gene A-G polymorphism and childhood Graves' disease

21 January 2018

1 reference

https://api.crossref.org/works/10.1111%2FJ.0105-2896.2005.00249.X

The 3' untranslated region of messenger RNA: A molecular 'hotspot' for pathology?

21 January 2018

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https://api.crossref.org/works/10.1111%2FJ.0105-2896.2005.00249.X

A conserved AU sequence from the 3' untranslated region of GM-CSF mRNA mediates selective mRNA degradation

21 January 2018

1 reference

https://api.crossref.org/works/10.1111%2FJ.0105-2896.2005.00249.X

Evidence for CTLA4 as a susceptibility gene for systemic lupus erythematosus

21 January 2018

1 reference

https://api.crossref.org/works/10.1111%2FJ.0105-2896.2005.00249.X

Association of CTLA4 gene A-G polymorphism with rheumatoid arthritis in Chinese

21 January 2018

1 reference

https://api.crossref.org/works/10.1111%2FJ.0105-2896.2005.00249.X

No evidence for allelic association of a human CTLA-4 promoter polymorphism with autoimmune thyroid disease in either population-based case-control or family-based studies.

21 January 2018

1 reference

https://api.crossref.org/works/10.1111%2FJ.0105-2896.2005.00249.X

Unifying concepts in CD28, ICOS and CTLA4 co-receptor signalling

21 January 2018

1 reference

https://api.crossref.org/works/10.1111%2FJ.0105-2896.2005.00249.X

Association of the T-cell regulatory gene CTLA4 with susceptibility to autoimmune disease

21 January 2018

1 reference

https://api.crossref.org/works/10.1111%2FJ.0105-2896.2005.00249.X

Polymorphisms in the cytotoxic T lymphocyte antigen-4 gene region confer susceptibility to Addison's disease

21 January 2018

1 reference

https://api.crossref.org/works/10.1111%2FJ.0105-2896.2005.00249.X

Association of the T-cell regulatory gene CTLA4 with Graves' disease and autoimmune thyroid disease in the Japanese

21 January 2018

1 reference

https://api.crossref.org/works/10.1111%2FJ.0105-2896.2005.00249.X

A unified stepwise regression procedure for evaluating the relative effects of polymorphisms within a gene using case/control or family data: application to HLA in type 1 diabetes

21 January 2018

1 reference

https://api.crossref.org/works/10.1111%2FJ.0105-2896.2005.00249.X

CTLA-4 gene polymorphism at position 49 in exon 1 reduces the inhibitory function of CTLA-4 and contributes to the pathogenesis of Graves' disease

21 January 2018

1 reference

https://api.crossref.org/works/10.1111%2FJ.0105-2896.2005.00249.X

Abnormal expression of CTLA-4 by T cells from patients with myasthenia gravis: effect of an AT-rich gene sequence

21 January 2018

1 reference

https://api.crossref.org/works/10.1111%2FJ.0105-2896.2005.00249.X

CTLA-4 gene expression is influenced by promoter and exon 1 polymorphisms

21 January 2018

1 reference

https://api.crossref.org/works/10.1111%2FJ.0105-2896.2005.00249.X

Cytotoxic T lymphocyte antigen-4 (CTLA-4) limits the expansion of encephalitogenic T cells in experimental autoimmune encephalomyelitis (EAE)-resistant BALB/c mice

21 January 2018

1 reference

https://api.crossref.org/works/10.1111%2FJ.0105-2896.2005.00249.X

Pinpointing when T cell costimulatory receptor CTLA-4 must be engaged to dampen diabetogenic T cells

21 January 2018

1 reference

https://api.crossref.org/works/10.1111%2FJ.0105-2896.2005.00249.X

Cytotoxic T lymphocyte-associated antigen 4 (CTLA-4) regulates the unfolding of autoimmune diabetes

21 January 2018

1 reference

https://api.crossref.org/works/10.1111%2FJ.0105-2896.2005.00249.X

CTLA-4 differentially regulates T cell responses to endogenous tissue protein versus exogenous immunogen

21 January 2018

1 reference

https://api.crossref.org/works/10.1111%2FJ.0105-2896.2005.00249.X

Cooperative roles of CTLA-4 and regulatory T cells in tolerance to an islet cell antigen

21 January 2018

1 reference

https://api.crossref.org/works/10.1111%2FJ.0105-2896.2005.00249.X

A soluble form of CTLA-4 generated by alternative splicing is expressed by nonstimulated human T cells

21 January 2018

1 reference

https://api.crossref.org/works/10.1111%2FJ.0105-2896.2005.00249.X

Fine mapping, gene content, comparative sequencing, and expression analyses support Ctla4 and Nramp1 as candidates for Idd5.1 and Idd5.2 in the nonobese diabetic mouse.

21 January 2018

1 reference

https://api.crossref.org/works/10.1111%2FJ.0105-2896.2005.00249.X

A CD45 polymorphism associated with multiple sclerosis disrupts an exonic splicing silencer

21 January 2018

1 reference

https://api.crossref.org/works/10.1111%2FJ.0105-2896.2005.00249.X

Loss of CTLA-4 leads to massive lymphoproliferation and fatal multiorgan tissue destruction, revealing a critical negative regulatory role of CTLA-4

21 January 2018

1 reference

https://api.crossref.org/works/10.1111%2FJ.0105-2896.2005.00249.X

Structural analysis of CTLA-4 function in vivo

21 January 2018

1 reference

https://api.crossref.org/works/10.1111%2FJ.0105-2896.2005.00249.X

Cytotoxic T lymphocyte antigen 4 (CTLA-4) engagement delivers an inhibitory signal through the membrane-proximal region in the absence of the tyrosine motif in the cytoplasmic tail

21 January 2018

1 reference

https://api.crossref.org/works/10.1111%2FJ.0105-2896.2005.00249.X

B7-1 engagement of cytotoxic T lymphocyte antigen 4 inhibits T cell activation in the absence of CD28.

21 January 2018

1 reference

https://api.crossref.org/works/10.1111%2FJ.0105-2896.2005.00249.X

CD28 and CTLA-4 have opposing effects on the response of T cells to stimulation

21 January 2018

1 reference

https://api.crossref.org/works/10.1111%2FJ.0105-2896.2005.00249.X

CTLA-4 engagement inhibits IL-2 accumulation and cell cycle progression upon activation of resting T cells

21 January 2018

1 reference

https://api.crossref.org/works/10.1111%2FJ.0105-2896.2005.00249.X

CTLA-4 ligation blocks CD28-dependent T cell activation

21 January 2018

1 reference

https://api.crossref.org/works/10.1111%2FJ.0105-2896.2005.00249.X

Surface cytotoxic T lymphocyte-associated antigen 4 partitions within lipid rafts and relocates to the immunological synapse under conditions of inhibition of T cell activation

21 January 2018

1 reference

https://api.crossref.org/works/10.1111%2FJ.0105-2896.2005.00249.X

Cytotoxic T lymphocyte antigen 4 and CD28 modulate cell surface raft expression in their regulation of T cell function

21 January 2018

1 reference

https://api.crossref.org/works/10.1111%2FJ.0105-2896.2005.00249.X

An autoimmune disease-associated CTLA-4 splice variant lacking the B7 binding domain signals negatively in T cells

21 January 2018

1 reference

https://api.crossref.org/works/10.1111%2FJ.0105-2896.2005.00249.X

Regulatory T cells: key controllers of immunologic self-tolerance

21 January 2018

1 reference

https://api.crossref.org/works/10.1111%2FJ.0105-2896.2005.00249.X

Immunologic self-tolerance maintained by CD25(+)CD4(+) regulatory T cells constitutively expressing cytotoxic T lymphocyte-associated antigen 4.

21 January 2018

1 reference

https://api.crossref.org/works/10.1111%2FJ.0105-2896.2005.00249.X

Cytotoxic T lymphocyte-associated antigen 4 plays an essential role in the function of CD25(+)CD4(+) regulatory cells that control intestinal inflammation

21 January 2018

1 reference

https://api.crossref.org/works/10.1111%2FJ.0105-2896.2005.00249.X

Direct expansion of functional CD25+ CD4+ regulatory T cells by antigen-processing dendritic cells

21 January 2018

1 reference

https://api.crossref.org/works/10.1111%2FJ.0105-2896.2005.00249.X

Antigen-dependent proliferation of CD4+ CD25+ regulatory T cells in vivo

21 January 2018

1 reference

https://api.crossref.org/works/10.1111%2FJ.0105-2896.2005.00249.X

CD86 and CD80 differentially modulate the suppressive function of human regulatory T cells

21 January 2018

1 reference

https://api.crossref.org/works/10.1111%2FJ.0105-2896.2005.00249.X

Cutting Edge: CD28 Controls Peripheral Homeostasis of CD4+CD25+ Regulatory T Cells

21 January 2018

1 reference

https://api.crossref.org/works/10.1111%2FJ.0105-2896.2005.00249.X

CTLA-4-Ig regulates tryptophan catabolism in vivo.

21 January 2018

1 reference

https://api.crossref.org/works/10.1111%2FJ.0105-2896.2005.00249.X

Prevention of allogeneic fetal rejection by tryptophan catabolism

21 January 2018

1 reference

https://api.crossref.org/works/10.1111%2FJ.0105-2896.2005.00249.X

Normal human pregnancy is associated with an elevation in the immune suppressive CD25+ CD4+ regulatory T-cell subset.

21 January 2018

1 reference

https://api.crossref.org/works/10.1111%2FJ.0105-2896.2005.00249.X

The CTLA-4 gene region of chromosome 2q33 is linked to, and associated with, type 1 diabetes. Belgian Diabetes Registry

21 January 2018

1 reference

https://api.crossref.org/works/10.1111%2FJ.0105-2896.2005.00249.X

A polymorphism in the human cytotoxic T-lymphocyte antigen 4 ( CTLA4) gene (exon 1 +49) alters T-cell activation

21 January 2018

1 reference

https://api.crossref.org/works/10.1111%2FJ.0105-2896.2005.00249.X

A common autoimmunity predisposing signal peptide variant of the cytotoxic T-lymphocyte antigen 4 results in inefficient glycosylation of the susceptibility allele

21 January 2018

1 reference

https://api.crossref.org/works/10.1111%2FJ.0105-2896.2005.00249.X

Polymorphism of the CTLA-4 gene is associated with autoimmune hypothyroidism in the United Kingdom

21 January 2018

1 reference

https://api.crossref.org/works/10.1111%2FJ.0105-2896.2005.00249.X

Tyrosine phosphorylation controls internalization of CTLA-4 by regulating its interaction with clathrin-associated adaptor complex AP-2

21 January 2018

1 reference

https://api.crossref.org/works/10.1111%2FJ.0105-2896.2005.00249.X

10.1111/J.0105-2896.2005.00249.X

21 January 2018

Identifiers

DOI

1 reference

12 August 2017

1 reference