(Q36084498)

https://www.ebi.ac.uk/europepmc/webservices/rest/search?query=EXT_ID:22322857%20AND%20SRC:MED&resulttype=core&format=json

22 January 2020

title

Identification of an acetylation-dependant Ku70/FLIP complex that regulates FLIP expression and HDAC inhibitor-induced apoptosis (English)

1 reference

https://www.ebi.ac.uk/europepmc/webservices/rest/search?query=EXT_ID:22322857%20AND%20SRC:MED&resulttype=core&format=json

22 January 2020

7

1 reference

https://www.ebi.ac.uk/europepmc/webservices/rest/search?query=EXT_ID:22322857%20AND%20SRC:MED&resulttype=core&format=json

22 January 2020

Izabela Stasik

9

1 reference

https://www.ebi.ac.uk/europepmc/webservices/rest/search?query=EXT_ID:22322857%20AND%20SRC:MED&resulttype=core&format=json

22 January 2020

Rosemary O'Connor

13

1 reference

https://www.ebi.ac.uk/europepmc/webservices/rest/search?query=EXT_ID:22322857%20AND%20SRC:MED&resulttype=core&format=json

22 January 2020

author name string

E Kerr

1

1 reference

https://www.ebi.ac.uk/europepmc/webservices/rest/search?query=EXT_ID:22322857%20AND%20SRC:MED&resulttype=core&format=json

22 January 2020

C Holohan

2

1 reference

https://www.ebi.ac.uk/europepmc/webservices/rest/search?query=EXT_ID:22322857%20AND%20SRC:MED&resulttype=core&format=json

22 January 2020

K M McLaughlin

3

1 reference

https://www.ebi.ac.uk/europepmc/webservices/rest/search?query=EXT_ID:22322857%20AND%20SRC:MED&resulttype=core&format=json

22 January 2020

J Majkut

4

1 reference

https://www.ebi.ac.uk/europepmc/webservices/rest/search?query=EXT_ID:22322857%20AND%20SRC:MED&resulttype=core&format=json

22 January 2020

S Dolan

5

1 reference

https://www.ebi.ac.uk/europepmc/webservices/rest/search?query=EXT_ID:22322857%20AND%20SRC:MED&resulttype=core&format=json

22 January 2020

K Redmond

6

1 reference

https://www.ebi.ac.uk/europepmc/webservices/rest/search?query=EXT_ID:22322857%20AND%20SRC:MED&resulttype=core&format=json

22 January 2020

K McLaughlin

8

1 reference

https://www.ebi.ac.uk/europepmc/webservices/rest/search?query=EXT_ID:22322857%20AND%20SRC:MED&resulttype=core&format=json

22 January 2020

M Crudden

10

1 reference

https://www.ebi.ac.uk/europepmc/webservices/rest/search?query=EXT_ID:22322857%20AND%20SRC:MED&resulttype=core&format=json

22 January 2020

S Van Schaeybroeck

11

1 reference

https://www.ebi.ac.uk/europepmc/webservices/rest/search?query=EXT_ID:22322857%20AND%20SRC:MED&resulttype=core&format=json

22 January 2020

C Fenning

12

1 reference

https://www.ebi.ac.uk/europepmc/webservices/rest/search?query=EXT_ID:22322857%20AND%20SRC:MED&resulttype=core&format=json

22 January 2020

P Kiely

14

1 reference

https://www.ebi.ac.uk/europepmc/webservices/rest/search?query=EXT_ID:22322857%20AND%20SRC:MED&resulttype=core&format=json

22 January 2020

M Sgobba

15

1 reference

https://www.ebi.ac.uk/europepmc/webservices/rest/search?query=EXT_ID:22322857%20AND%20SRC:MED&resulttype=core&format=json

22 January 2020

D Haigh

16

1 reference

https://www.ebi.ac.uk/europepmc/webservices/rest/search?query=EXT_ID:22322857%20AND%20SRC:MED&resulttype=core&format=json

22 January 2020

P G Johnston

17

1 reference

https://www.ebi.ac.uk/europepmc/webservices/rest/search?query=EXT_ID:22322857%20AND%20SRC:MED&resulttype=core&format=json

22 January 2020

D B Longley

18

1 reference

https://www.ebi.ac.uk/europepmc/webservices/rest/search?query=EXT_ID:22322857%20AND%20SRC:MED&resulttype=core&format=json

22 January 2020

language of work or name

1 reference

10 February 2012

1 reference

https://www.ebi.ac.uk/europepmc/webservices/rest/search?query=EXT_ID:22322857%20AND%20SRC:MED&resulttype=core&format=json

Cell Death & Differentiation

22 January 2020

published in

1 reference

https://www.ebi.ac.uk/europepmc/webservices/rest/search?query=EXT_ID:22322857%20AND%20SRC:MED&resulttype=core&format=json

22 January 2020

volume

19

1 reference

https://www.ebi.ac.uk/europepmc/webservices/rest/search?query=EXT_ID:22322857%20AND%20SRC:MED&resulttype=core&format=json

22 January 2020

page(s)

1317-1327

1 reference

https://www.ebi.ac.uk/europepmc/webservices/rest/search?query=EXT_ID:22322857%20AND%20SRC:MED&resulttype=core&format=json

22 January 2020

issue

8

1 reference

https://www.ebi.ac.uk/europepmc/webservices/rest/search?query=EXT_ID:22322857%20AND%20SRC:MED&resulttype=core&format=json

https://scigraph.springernature.com/pub.10.1038/cdd.2012.8

22 January 2020

exact match

0 references

cites work

HDAC6 deacetylates Ku70 and regulates Ku70-Bax binding in neuroblastoma

1 reference

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2 October 2017

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Vorinostat: A novel therapy for the treatment of cutaneous T-cell lymphoma

2 October 2017

1 reference

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A phase I, pharmacokinetic, and pharmacodynamic study of two schedules of vorinostat in combination with 5-fluorouracil and leucovorin in patients with refractory solid tumors

2 October 2017

1 reference

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c-FLIP degradation mediates sensitization of pancreatic cancer cells to TRAIL-induced apoptosis by the histone deacetylase inhibitor LBH589.

2 October 2017

1 reference

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Chemical phylogenetics of histone deacetylases

2 October 2017

1 reference

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A phase I/II trial of vorinostat in combination with 5-fluorouracil in patients with metastatic colorectal cancer who previously failed 5-FU-based chemotherapy

2 October 2017

1 reference

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Selective inhibition of histone deacetylases sensitizes malignant cells to death receptor ligands

2 October 2017

1 reference

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A phase I, pharmacokinetic and pharmacodynamic study on vorinostat in combination with 5-fluorouracil, leucovorin, and oxaliplatin in patients with refractory colorectal cancer

2 October 2017

1 reference

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p53 acetylation is crucial for its transcription-independent proapoptotic functions

2 October 2017

1 reference

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Combined inhibition of FLIP and XIAP induces Bax-independent apoptosis in type II colorectal cancer cells

2 October 2017

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=3392639

Combination therapy of established cancer using a histone deacetylase inhibitor and a TRAIL receptor agonist

2 October 2017

1 reference

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Tyrosine 302 in RACK1 is essential for insulin-like growth factor-I-mediated competitive binding of PP2A and beta1 integrin and for tumor cell proliferation and migration

2 October 2017

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=3392639

Regulation of the proapoptotic factor Bax by Ku70-dependent deubiquitylation

2 October 2017

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=3392639

Improved synthesis of histone deacetylase inhibitors (HDIs) (MS-275 and CI-994) and inhibitory effects of HDIs alone or in combination with RAMBAs or retinoids on growth of human LNCaP prostate cancer cells and tumor xenografts

2 October 2017

1 reference

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Phase II trial of the histone deacetylase inhibitor vorinostat (Zolinza, suberoylanilide hydroxamic acid, SAHA) in patients with recurrent and/or metastatic head and neck cancer

2 October 2017

1 reference

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Design, synthesis, structure--selectivity relationship, and effect on human cancer cells of a novel series of histone deacetylase 6-selective inhibitors

2 October 2017

1 reference

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HDAC6, at the crossroads between cytoskeleton and cell signaling by acetylation and ubiquitination

2 October 2017

1 reference

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c-FLIP: a key regulator of colorectal cancer cell death

2 October 2017

1 reference

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HDAC inhibitor treatment of hepatoma cells induces both TRAIL-independent apoptosis and restoration of sensitivity to TRAIL.

2 October 2017

1 reference

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Identification of small molecules that sensitize resistant tumor cells to tumor necrosis factor-family death receptors

2 October 2017

1 reference

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Histone deacetylase inhibitors and the promise of epigenetic (and more) treatments for cancer

2 October 2017

1 reference

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Crystal structure of MC159 reveals molecular mechanism of DISC assembly and FLIP inhibition

2 October 2017

1 reference

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Effect of p53 status and STAT1 on chemotherapy-induced, Fas-mediated apoptosis in colorectal cancer

2 October 2017

1 reference

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Phase I study of an oral histone deacetylase inhibitor, suberoylanilide hydroxamic acid, in patients with advanced cancer

2 October 2017

1 reference

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Sensitization of osteosarcoma cells to death receptor-mediated apoptosis by HDAC inhibitors through downregulation of cellular FLIP.

2 October 2017

1 reference

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Cotreatment with histone deacetylase inhibitor LAQ824 enhances Apo-2L/tumor necrosis factor-related apoptosis inducing ligand-induced death inducing signaling complex activity and apoptosis of human acute leukemia cells

2 October 2017

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=3392639

Phase I clinical trial of histone deacetylase inhibitor: suberoylanilide hydroxamic acid administered intravenously.

2 October 2017

1 reference

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Domain-selective small-molecule inhibitor of histone deacetylase 6 (HDAC6)-mediated tubulin deacetylation

2 October 2017

1 reference

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Ku, a DNA repair protein with multiple cellular functions?

2 October 2017

1 reference

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The role of c-FLIP in modulation of CD95-induced apoptosis

2 October 2017

1 reference

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2 October 2017

1 reference

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Inhibition of death receptor signals by cellular FLIP

2 October 2017

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=3392639

Mutational analyses of c-FLIPR, the only murine short FLIP isoform, reveal requirements for DISC recruitment

2 October 2017

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=3392639

Histone deacetylase inhibitors sensitize prostate cancer cells to agents that produce DNA double-strand breaks by targeting Ku70 acetylation.

11 July 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=3392639

In situ trapping of activated initiator caspases reveals a role for caspase-2 in heat shock-induced apoptosis.

23 September 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=3392639

Histone deacetylase inhibition by valproic acid down-regulates c-FLIP/CASH and sensitizes hepatoma cells towards CD95- and TRAIL receptor-mediated apoptosis and chemotherapy.

23 September 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=3392639

c-FLIP inhibits chemotherapy-induced colorectal cancer cell death

23 September 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=3392639

Acetylation of the C terminus of Ku70 by CBP and PCAF controls Bax-mediated apoptosis

23 September 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=3392639

Identification of two domains of the p70 Ku protein mediating dimerization with p80 and DNA binding

23 September 2018

1 reference

PubMed

https://pubmed.ncbi.nlm.nih.gov/22322857

inferred from PubMed ID database lookup

12 December 2020

based on heuristic

Identifiers

DOI

10.1038/CDD.2012.8

1 reference

https://www.ebi.ac.uk/europepmc/webservices/rest/search?query=EXT_ID:22322857%20AND%20SRC:MED&resulttype=core&format=json

22 January 2020

1 reference

https://www.ebi.ac.uk/europepmc/webservices/rest/search?query=EXT_ID:22322857%20AND%20SRC:MED&resulttype=core&format=json

22 January 2020

1 reference

https://www.ebi.ac.uk/europepmc/webservices/rest/search?query=EXT_ID:22322857%20AND%20SRC:MED&resulttype=core&format=json