(Q36086330)

https://www.ebi.ac.uk/europepmc/webservices/rest/search?query=EXT_ID:22547613%20AND%20SRC:MED&resulttype=core&format=json

30 January 2020

title

HDQ, a potent inhibitor of Plasmodium falciparum proliferation, binds to the quinone reduction site of the cytochrome bc1 complex (English)

1 reference

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30 January 2020

main subject

Plasmodium falciparum

0 references

author

Neil G. Berry

6

1 reference

https://www.ebi.ac.uk/europepmc/webservices/rest/search?query=EXT_ID:22547613%20AND%20SRC:MED&resulttype=core&format=json

30 January 2020

Steve Ward

8

1 reference

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30 January 2020

Giancarlo Biagini

10

1 reference

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30 January 2020

Brigitte Meunier

11

1 reference

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30 January 2020

Alexandre S Lawrenson

7

object named as

Alexandre S Lawrenson

1 reference

https://www.ebi.ac.uk/europepmc/webservices/rest/search?query=EXT_ID:22547613%20AND%20SRC:MED&resulttype=core&format=json

30 January 2020

5

Paul Stocks

1 reference

https://www.ebi.ac.uk/europepmc/webservices/rest/search?query=EXT_ID:22547613%20AND%20SRC:MED&resulttype=core&format=json

30 January 2020

author name string

Cindy Vallières

1

1 reference

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30 January 2020

Nicholas Fisher

2

1 reference

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30 January 2020

Thomas Antoine

3

1 reference

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30 January 2020

Mohammed Al-Helal

4

1 reference

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30 January 2020

Paul M O'Neill

9

1 reference

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30 January 2020

language of work or name

English

0 references

publication date

30 April 2012

1 reference

https://www.ebi.ac.uk/europepmc/webservices/rest/search?query=EXT_ID:22547613%20AND%20SRC:MED&resulttype=core&format=json

30 January 2020

number of pages

9

1 reference

Antimicrobial Agents and Chemotherapy

inferred from page(s)

published in

1 reference

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30 January 2020

volume

56

1 reference

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30 January 2020

issue

7

1 reference

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30 January 2020

page(s)

3739-3747

1 reference

https://www.ebi.ac.uk/europepmc/webservices/rest/search?query=EXT_ID:22547613%20AND%20SRC:MED&resulttype=core&format=json

Two internal type II NADH dehydrogenases of Toxoplasma gondii are both required for optimal tachyzoite growth

30 January 2020

cites work

1 reference

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Arrested oocyst maturation in Plasmodium parasites lacking type II NADH:ubiquinone dehydrogenase

2 October 2017

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2 October 2017

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Inhibiting Plasmodium cytochrome bc1: a complex issue

2 October 2017

1 reference

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Ascochlorin is a novel, specific inhibitor of the mitochondrial cytochrome bc1 complex

2 October 2017

1 reference

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Chapter 17 Type II NADH: quinone oxidoreductases of Plasmodium falciparum and Mycobacterium tuberculosis kinetic and high-throughput assays.

2 October 2017

1 reference

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Type II NADH dehydrogenase inhibitor 1-hydroxy-2-dodecyl-4(1H)quinolone leads to collapse of mitochondrial inner-membrane potential and ATP depletion in Toxoplasma gondii

2 October 2017

1 reference

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Type II NADH dehydrogenase of the respiratory chain of Plasmodium falciparum and its inhibitors

2 October 2017

1 reference

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Network pharmacology: the next paradigm in drug discovery

2 October 2017

1 reference

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Structure of complex III with bound cytochrome c in reduced state and definition of a minimal core interface for electron transfer

2 October 2017

1 reference

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Acridinediones: selective and potent inhibitors of the malaria parasite mitochondrial bc1 complex

2 October 2017

1 reference

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Molecular basis of resistance to cytochrome bc1 inhibitors

2 October 2017

1 reference

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The malaria parasite type II NADH:quinone oxidoreductase: an alternative enzyme for an alternative lifestyle

2 October 2017

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=3393389

Specific role of mitochondrial electron transport in blood-stage Plasmodium falciparum

2 October 2017

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=3393389

Functional characterization and target validation of alternative complex I of Plasmodium falciparum mitochondria

2 October 2017

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=3393389

Binding of the respiratory chain inhibitor antimycin to the mitochondrial bc1 complex: a new crystal structure reveals an altered intramolecular hydrogen-bonding pattern

2 October 2017

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=3393389

Simple and inexpensive fluorescence-based technique for high-throughput antimalarial drug screening.

2 October 2017

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=3393389

Human disease-related mutations in cytochrome b studied in yeast

2 October 2017

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=3393389

Recapitulation in Saccharomyces cerevisiae of cytochrome b mutations conferring resistance to atovaquone in Pneumocystis jiroveci

2 October 2017

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=3393389

Improved protein-ligand docking using GOLD

2 October 2017

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=3393389

Structural basis for the quinone reduction in the bc1 complex: a comparative analysis of crystal structures of mitochondrial cytochrome bc1 with bound substrate and inhibitors at the Qi site

2 October 2017

1 reference

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Genetic confirmation of atovaquone-proguanil-resistant Plasmodium falciparum malaria acquired by a nonimmune traveler to East Africa

2 October 2017

1 reference

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Protonmotive pathways and mechanisms in the cytochrome bc1 complex

2 October 2017

1 reference

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Malarone treatment failure and in vitro confirmation of resistance of Plasmodium falciparum isolate from Lagos, Nigeria

2 October 2017

1 reference

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Structure at 2.3 A resolution of the cytochrome bc(1) complex from the yeast Saccharomyces cerevisiae co-crystallized with an antibody Fv fragment

2 October 2017

1 reference

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Resistance mutations reveal the atovaquone-binding domain of cytochrome b in malaria parasites

2 October 2017

1 reference

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A compilation of mutations located in the cytochrome b subunit of the bacterial and mitochondrial bc1 complex

2 October 2017

1 reference

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Human malaria parasites in continuous culture

2 October 2017

1 reference

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Synchronization of Plasmodium falciparum Erythrocytic Stages in Culture

2 October 2017

1 reference

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Growth inhibition of Toxoplasma gondii and Plasmodium falciparum by nanomolar concentrations of 1-hydroxy-2-dodecyl-4(1H)quinolone, a high-affinity inhibitor of alternative (type II) NADH dehydrogenases

2 October 2017

1 reference

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Atovaquone, a broad spectrum antiparasitic drug, collapses mitochondrial membrane potential in a malarial parasite

11 July 2018

1 reference

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Molecular basis for resistance to antimycin and diuron, Q-cycle inhibitors acting at the Qi site in the mitochondrial ubiquinol-cytochrome c reductase in Saccharomyces cerevisiae.

11 July 2018

1 reference

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The Toxoplasma gondii type-II NADH dehydrogenase TgNDH2-I is inhibited by 1-hydroxy-2-alkyl-4(1H)quinolones.

11 July 2018

1 reference

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Preparation of respiratory chain complexes from Saccharomyces cerevisiae wild-type and mutant mitochondria : activity measurement and subunit composition analysis

23 September 2018

1 reference

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Investigating the Qn site of the cytochrome bc1 complex in Saccharomyces cerevisiae with mutants resistant to ilicicolin H, a novel Qn site inhibitor.

23 September 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=3393389

Clinical atovaquone-proguanil resistance of Plasmodium falciparum associated with cytochrome b codon 268 mutations

23 September 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=3393389

Prevalence of Plasmodium falciparum cytochrome b gene mutations in isolates imported from Africa, and implications for atovaquone resistance

23 September 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=3393389

Re-examination of inhibitor resistance conferred by Qo-site mutations in cytochrome b using yeast as a model system.

23 September 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=3393389

Cytochrome b mutations that modify the ubiquinol-binding pocket of the cytochrome bc1 complex and confer anti-malarial drug resistance in Saccharomyces cerevisiae

23 September 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=3393389

HDQ (1-hydroxy-2-dodecyl-4(1H)quinolone), a high affinity inhibitor for mitochondrial alternative NADH dehydrogenase: evidence for a ping-pong mechanism

23 September 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=3393389

Crystallographic studies of quinol oxidation site inhibitors: a modified classification of inhibitors for the cytochrome bc(1) complex

23 September 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=3393389

Mechanism of ubiquinol oxidation by the bc(1) complex: different domains of the quinol binding pocket and their role in the mechanism and binding of inhibitors

23 September 2018

1 reference

12 December 2020

Site of action of the antimalarial hydroxynaphthoquinone, 2-[trans-4-(4'-chlorophenyl) cyclohexyl]-3- hydroxy-1,4-naphthoquinone (566C80)

1 reference

12 December 2020

Non-native intragenic reversions selected from Saccharomyces cerevisiae cytochrome b-deficient mutants. Structural and functional features of the catalytic center N domain

1 reference

12 December 2020

Characterization of Mutations in the Mitochondrial Cytochrome b Gene of Saccharomyces Cerevisiae Affecting the Quinone Reductase Site (QN)

1 reference

12 December 2020

Structure-function relationships of the mitochondrial bc1 complex in temperature-sensitive mutants of the cytochrome b gene, impaired in the catalytic center N

1 reference

12 December 2020

Identifiers

DOI

10.1128/AAC.00486-12

1 reference

https://www.ebi.ac.uk/europepmc/webservices/rest/search?query=EXT_ID:22547613%20AND%20SRC:MED&resulttype=core&format=json

30 January 2020

1 reference

https://www.ebi.ac.uk/europepmc/webservices/rest/search?query=EXT_ID:22547613%20AND%20SRC:MED&resulttype=core&format=json

30 January 2020

PubMed publication ID

22547613

1 reference