(Q36095561)

6 October 2017

A Pleiotropic Missense Variant in SLC39A8 Is Associated With Crohn's Disease and Human Gut Microbiome Composition (English)

1 reference

6 October 2017

0 references

0 references

1 reference

6

1 reference

6 October 2017

3

Talin Haritunians

1 reference

6 October 2017

18

Marla Dubinsky

1 reference

6 October 2017

Steven R Brant

34

0 references

Jonas Halfvarson

Jonas Halfvarson

9

0 references

John D. Rioux

John D Rioux

35

0 references

Richard Duerr

Richard H Duerr

40

0 references

Lambertus Klei

14

Lambertus Klei

1 reference

6 October 2017

Jonathan Braun

38

0 references

Mark Joseph Daly

33

Mark Daly

1 reference

6 October 2017

39

Dermot P B McGovern

1 reference

6 October 2017

26

Stephan R Targan

1 reference

6 October 2017

31

Hakon Hakonarson

1 reference

6 October 2017

32

Ramnik J Xavier

1 reference

6 October 2017

36

Mark S Silverberg

1 reference

6 October 2017

11

Subra Kugathasan

1 reference

6 October 2017

Ashwin N Ananthakrishnan

15

Ashwin Ananthakrishnan

1 reference

6 October 2017

37

Judy H Cho

1 reference

6 October 2017

2

Jean-Paul Achkar

1 reference

6 October 2017

22

Deborah D Proctor

1 reference

6 October 2017

23

Miguel Regueiro

1 reference

6 October 2017

13

L Philip Schumm

1 reference

6 October 2017

24

Lisa A Simms

1 reference

6 October 2017

Graham L Radford-Smith

8

Graham Radford-Smith

1 reference

6 October 2017

25

Joanne M Stempak

1 reference

6 October 2017

28

Yashoda Sharma

1 reference

6 October 2017

17

Leonard Baidoo

1 reference

6 October 2017

7

Stephan Brand

1 reference

6 October 2017

12

Carsten Büning

1 reference

6 October 2017

27

Leif Törkvist

1 reference

6 October 2017

16

Guy Aumais

1 reference

6 October 2017

21

Raquel Milgrom

1 reference

6 October 2017

30

James Borneman

1 reference

6 October 2017

5

Ken Y Hui

1 reference

6 October 2017

Dalin Li

1

1 reference

6 October 2017

Jonathan P Jacobs

4

1 reference

6 October 2017

Jan-Hendrik Niess

10

1 reference

6 October 2017

Claudio Fiocchi

19

1 reference

6 October 2017

Jürgen Glas

20

1 reference

6 October 2017

Bernie Devlin

29

1 reference

6 October 2017

language of work or name

English

0 references

publication date

1 August 2016

1 reference

6 October 2017

1 reference

6 October 2017

151

1 reference

6 October 2017

4

1 reference

6 October 2017

724-732

1 reference

Sub-clinical detection of gut microbial biomarkers of obesity and type 2 diabetes

6 October 2017

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=5037008

Chronic Zinc Deficiency Alters Chick Gut Microbiota Composition and Function

2 July 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=5037008

The global burden of IBD: from 2015 to 2025.

2 July 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=5037008

Association analyses identify 38 susceptibility loci for inflammatory bowel disease and highlight shared genetic risk across populations

2 July 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=5037008

IBD and the gut microbiota--from bench to personalized medicine

2 July 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=5037008

Complex host genetics influence the microbiome in inflammatory bowel disease

2 July 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=5037008

Moderated estimation of fold change and dispersion for RNA-seq data with DESeq2

2 July 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=5037008

Pediatric Crohn disease patients exhibit specific ileal transcriptome and microbiome signature

2 July 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=5037008

Pleiotropic genes for metabolic syndrome and inflammation

2 July 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=5037008

Activation of pattern recognition receptors up-regulates metallothioneins, thereby increasing intracellular accumulation of zinc, autophagy, and bacterial clearance by macrophages

2 July 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=5037008

Reprograming of gut microbiome energy metabolism by the FUT2 Crohn's disease risk polymorphism

2 July 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=5037008

IBD. Understanding gut microbiota in new-onset Crohn's disease

2 July 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=5037008

Systematic evaluation of coding variation identifies a candidate causal variant in TM6SF2 influencing total cholesterol and myocardial infarction risk

2 July 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=5037008

The treatment-naive microbiome in new-onset Crohn's disease

2 July 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=5037008

A general framework for estimating the relative pathogenicity of human genetic variants

2 July 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=5037008

SMAD3 gene variant is a risk factor for recurrent surgery in patients with Crohn's disease

2 July 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=5037008

Integrative analysis of the microbiome and metabolome of the human intestinal mucosal surface reveals exquisite inter-relationships

2 July 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=5037008

A modular organization of the human intestinal mucosal microbiota and its association with inflammatory bowel disease

2 July 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=5037008

Richness of human gut microbiome correlates with metabolic markers

2 July 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=5037008

Best practices and joint calling of the HumanExome BeadChip: the CHARGE Consortium

2 July 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=5037008

phyloseq: an R package for reproducible interactive analysis and graphics of microbiome census data

2 July 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=5037008

Diet, the human gut microbiota, and IBD.

2 July 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=5037008

ZIP8 regulates host defense through zinc-mediated inhibition of NF-κB.

2 July 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=5037008

NOD2-mediated dysbiosis predisposes mice to transmissible colitis and colorectal cancer.

2 July 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=5037008

Host-microbe interactions have shaped the genetic architecture of inflammatory bowel disease

2 July 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=5037008

Dysfunction of the intestinal microbiome in inflammatory bowel disease and treatment

2 July 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=5037008

The gut microbiota in IBD.

2 July 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=5037008

ZIP8 is an iron and zinc transporter whose cell-surface expression is up-regulated by cellular iron loading

2 July 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=5037008

ZIP8 zinc transporter: indispensable role for both multiple-organ organogenesis and hematopoiesis in utero

2 July 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=5037008

Genetic variants in novel pathways influence blood pressure and cardiovascular disease risk

2 July 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=5037008

Differential expression analysis for sequence count data

2 July 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=5037008

Association analyses of 249,796 individuals reveal 18 new loci associated with body mass index

2 July 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=5037008

Genetic variants influencing circulating lipid levels and risk of coronary artery disease

2 July 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=5037008

A method and server for predicting damaging missense mutations

2 July 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=5037008

Inflammatory bowel disease

2 July 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=5037008

Common variants at five new loci associated with early-onset inflammatory bowel disease

2 July 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=5037008

Regulation of inflammatory responses by gut microbiota and chemoattractant receptor GPR43

2 July 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=5037008

Zinc transporter ZIP8 (SLC39A8) and zinc influence IFN-gamma expression in activated human T cells

2 July 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=5037008

Mammalian zinc transporters: nutritional and physiologic regulation

2 July 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=5037008

Faecalibacterium prausnitzii is an anti-inflammatory commensal bacterium identified by gut microbiota analysis of Crohn disease patients

2 July 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=5037008

Spatial organization and composition of the mucosal flora in patients with inflammatory bowel disease

2 July 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=5037008

Mycobacterium bovis BCG cell wall and lipopolysaccharide induce a novel gene, BIGM103, encoding a 7-TM protein: identification of a new protein family having Zn-transporter and Zn-metalloprotease signatures

2 July 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=5037008

Activation of Paneth cell alpha-defensins in mouse small intestine

2 July 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=5037008

Modulation of mouse Paneth cell alpha-defensin secretion by mIKCa1, a Ca2+-activated, intermediate conductance potassium channel

2 July 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=5037008

G protein-coupled receptor 43 moderates gut inflammation through cytokine regulation from mononuclear cells.

2 July 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=5037008

Pleiotropic effects of obesity-susceptibility loci on metabolic traits: a meta-analysis of up to 37,874 individuals.

23 September 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=5037008

Dysbiosis of the faecal microbiota in patients with Crohn's disease and their unaffected relatives.

23 September 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=5037008

The human zinc transporter SLC39A8 (Zip8) is critical in zinc-mediated cytoprotection in lung epithelia

23 September 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=5037008

Monocyte-derived dendritic cells from Crohn patients show differential NOD2/CARD15-dependent immune responses to bacteria.

23 September 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=5037008

Missense mutations in transmembrane domains of proteins: phenotypic propensity of polar residues for human disease

23 September 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=5037008

Association Study of Nonsynonymous Single Nucleotide Polymorphisms in Schizophrenia

23 September 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=5037008

Mucolytic Bacteria With Increased Prevalence in IBD Mucosa Augment In Vitro Utilization of Mucin by Other Bacteria

21 October 2018

1 reference

PubMed

https://pubmed.ncbi.nlm.nih.gov/27492617

inferred from PubMed ID database lookup

12 December 2020

based on heuristic

IFN Regulatory Factor 3-Dependent Induction of Type I IFNs by Intracellular Bacteria Is Mediated by a TLR- and Nod2-Independent Mechanism

1 reference

PubMed

https://pubmed.ncbi.nlm.nih.gov/27492617

inferred from PubMed ID database lookup

12 December 2020

based on heuristic

Zinc homeostasis and immunity

1 reference

PubMed

https://pubmed.ncbi.nlm.nih.gov/27492617

inferred from PubMed ID database lookup

12 December 2020

based on heuristic

Identifiers

DOI

10.1053/J.GASTRO.2016.06.051

1 reference

6 October 2017

1 reference

6 October 2017

1 reference