(Q36100503)

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Model-based global sensitivity analysis as applied to identification of anti-cancer drug targets and biomarkers of drug resistance in the ErbB2/3 network

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Europe PubMed Central

PMC publication ID

12 August 2017

Model-based global sensitivity analysis as applied to identification of anti-cancer drug targets and biomarkers of drug resistance in the ErbB2/3 network (English)

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Europe PubMed Central

PMC publication ID

12 August 2017

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drug resistance

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based on heuristic

inferred from title

5

object named as

Alexey Goltsov

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Europe PubMed Central

PMC publication ID

12 August 2017

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David J Harrison

7

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Igor Goryanin

8

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Anatoly A. Sorokin

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Anatoly Sorokin

2

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author name string

Galina Lebedeva

1

1 reference

Europe PubMed Central

PMC publication ID

12 August 2017

Dana Faratian

3

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Europe PubMed Central

PMC publication ID

12 August 2017

Peter Mullen

4

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Europe PubMed Central

PMC publication ID

12 August 2017

Simon P Langdon

6

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Europe PubMed Central

PMC publication ID

12 August 2017

language of work or name

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publication date

9 November 2011

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Europe PubMed Central

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12 August 2017

European Journal of Pharmaceutical Sciences

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Europe PubMed Central

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12 August 2017

46

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Europe PubMed Central

PMC publication ID

12 August 2017

4

1 reference

Europe PubMed Central

PMC publication ID

12 August 2017

244-258

1 reference

Europe PubMed Central

PMC publication ID

12 August 2017

A comprehensive functional analysis of PTEN mutations: implications in tumor- and autism-related syndromes

1 reference

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Time-resolved fluorescence resonance energy transfer (TR-FRET) to analyze the disruption of EGFR/HER2 dimers: a new method to evaluate the efficiency of targeted therapy using monoclonal antibodies

1 reference

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Compensatory effects in the PI3K/PTEN/AKT signaling network following receptor tyrosine kinase inhibition.

1 reference

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Approaches and limitations of phosphatidylinositol-3-kinase pathway activation status as a predictive biomarker in the clinical development of targeted therapy

1 reference

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DBSolve Optimum: a software package for kinetic modeling which allows dynamic visualization of simulation results

1 reference

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Diverse somatic mutation patterns and pathway alterations in human cancers

1 reference

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Systematic calibration of a cell signaling network model

1 reference

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An ErbB3 antibody, MM-121, is active in cancers with ligand-dependent activation

1 reference

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Signal transduction networks in cancer: quantitative parameters influence network topology

1 reference

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An iterative identification procedure for dynamic modeling of biochemical networks

1 reference

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Cancer systems biology: a network modeling perspective

1 reference

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1 reference

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The Systems Biology Graphical Notation

1 reference

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1 reference

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Systems medicine: the future of medical genomics and healthcare

1 reference

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Investigating differential dynamics of the MAPK signaling cascade using a multi-parametric global sensitivity analysis

1 reference

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Input-output behavior of ErbB signaling pathways as revealed by a mass action model trained against dynamic data

1 reference

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New anti-cancer role for PDK1 inhibitors: preventing resistance to tamoxifen

1 reference

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Parallel RNAi and compound screens identify the PDK1 pathway as a target for tamoxifen sensitization

1 reference

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Reverse-phase protein lysate microarrays for cell signaling analysis

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Small-molecule inhibitors of PDK1.

1 reference

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2 October 2017

SBML-SAT: a systems biology markup language (SBML) based sensitivity analysis tool

1 reference

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A methodology for performing global uncertainty and sensitivity analysis in systems biology.

1 reference

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1 reference

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Topological analysis of MAPK cascade for kinetic ErbB signaling

1 reference

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1 reference

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New insights into PTEN.

1 reference

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Ligand-dependent responses of the ErbB signaling network: experimental and modeling analyses

1 reference

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PTEN, more than the AKT pathway

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1 reference

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1 reference

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Identifiers

10.1016/J.EJPS.2011.10.026

1 reference

Europe PubMed Central

PMC publication ID

12 August 2017

PMC publication ID

1 reference

Europe PubMed Central

PMC publication ID

12 August 2017

PubMed publication ID

1 reference

Europe PubMed Central

PMC publication ID

12 August 2017

ResearchGate publication ID

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