(Q36104021)

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A method for prediction of the locations of linker regions within large multifunctional proteins, and application to a type I polyketide synthase.

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13 December 2019

A method for prediction of the locations of linker regions within large multifunctional proteins, and application to a type I polyketide synthase (English)

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13 December 2019

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13 December 2019

Daniel W Udwary

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Daniel W Udwary

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13 December 2019

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Craig A Townsend

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13 December 2019

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1 October 2002

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13 December 2019

Journal of Molecular Biology

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13 December 2019

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13 December 2019

585-598

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13 December 2019

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13 December 2019

Combinatorial biosynthesis of antibiotics: challenges and opportunities

1 reference

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Modular Peptide Synthetases Involved in Nonribosomal Peptide Synthesis

1 reference

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Quaternary structure of human fatty acid synthase by electron cryomicroscopy

1 reference

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Crystal structure of the macrocycle-forming thioesterase domain of the erythromycin polyketide synthase: Versatility from a unique substrate channel

1 reference

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CDD: a database of conserved domain alignments with links to domain three-dimensional structure

1 reference

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Domain alternation switches B(12)-dependent methionine synthase to the activation conformation

1 reference

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Review: protein secondary structure prediction continues to rise.

1 reference

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Polyketide biosynthesis: a millennium review

1 reference

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2 October 2017

Mapping the functional topology of the animal fatty acid synthase by mutant complementation in vitro

1 reference

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Exploring the domain structure of modular nonribosomal peptide synthetases

1 reference

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Human fatty acid synthase: role of interdomain in the formation of catalytically active synthase dimer

1 reference

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2 October 2017

Molecular cloning and characterization of WdPKS1, a gene involved in dihydroxynaphthalene melanin biosynthesis and virulence in Wangiella (Exophiala) dermatitidis

1 reference

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Natural product biosynthesis: a new interface between enzymology and medicine

1 reference

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Control of directionality in nonribosomal peptide synthesis: role of the condensation domain in preventing misinitiation and timing of epimerization

1 reference

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2 October 2017

Construction of hybrid peptide synthetases by module and domain fusions

1 reference

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2 October 2017

Evidence for the transfer of sulfane sulfur from IscS to ThiI during the in vitro biosynthesis of 4-thiouridine in Escherichia coli tRNA

1 reference

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The specificity-conferring code of adenylation domains in nonribosomal peptide synthetases

1 reference

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2 October 2017

A comprehensive comparison of multiple sequence alignment programs

1 reference

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2 October 2017

Twilight zone of protein sequence alignments

1 reference

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2 October 2017

Identification of a polyketide synthase gene (pksP) of Aspergillus fumigatus involved in conidial pigment biosynthesis and virulence.

1 reference

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2 October 2017

Carbamoyl phosphate synthetase: caught in the act of glutamine hydrolysis

1 reference

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2 October 2017

The developmentally regulated alb1 gene of Aspergillus fumigatus: its role in modulation of conidial morphology and virulence

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=3400148

2 October 2017

Identification of a gene involved in the generation of 4-thiouridine in tRNA

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=3400148

2 October 2017

Structural principles for the inhibition of the 3'-5' exonuclease activity of Escherichia coli DNA polymerase I by phosphorothioates

1 reference

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2 October 2017

Structural basis for the activation of phenylalanine in the non-ribosomal biosynthesis of gramicidin S

1 reference

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Characterization of thiI, a new gene involved in thiazole biosynthesis in Salmonella typhimurium

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Solution structure of the actinorhodin polyketide synthase acyl carrier protein from Streptomyces coelicolor A3(2)

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=3400148

2 October 2017

Animal fatty acid synthase: functional mapping and cloning and expression of the domain I constituent activities

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=3400148

2 October 2017

The structure of the C-terminal domain of methionine synthase: presenting S-adenosylmethionine for reductive methylation of B12

1 reference

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PHD: predicting one-dimensional protein structure by profile-based neural networks

1 reference

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2 October 2017

Twenty-five coregulated transcripts define a sterigmatocystin gene cluster in Aspergillus nidulans

1 reference

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2 October 2017

Structure of DNA polymerase I Klenow fragment bound to duplex DNA

1 reference

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2 October 2017

Improved prediction of protein secondary structure by use of sequence profiles and neural networks

1 reference

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2 October 2017

How a protein binds B12: A 3.0 A X-ray structure of B12-binding domains of methionine synthase

1 reference

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2 October 2017

CLUSTAL W: improving the sensitivity of progressive multiple sequence alignment through sequence weighting, position-specific gap penalties and weight matrix choice

1 reference

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Modular binding domains in signal transduction proteins

1 reference

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2 October 2017

Refined solution structure of 8,9-dihydro-8-(N7-guanyl)-9-hydroxyaflatoxin B1 opposite CpA in the complementary strand of an oligodeoxynucleotide duplex as determined by 1H NMR

1 reference

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2 October 2017

A simple method for displaying the hydropathic character of a protein

1 reference

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2 October 2017

Selective Elimination of the Exonuclease Activity of the Deoxyribonucleic Acid Polymerase from Escherichia coli B by Limited Proteolysis

1 reference

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2 October 2017

Structure of large fragment of Escherichia coli DNA polymerase I complexed with dTMP

1 reference

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2 October 2017

Chelating peptide-immobilized metal ion affinity chromatography. A new concept in affinity chromatography for recombinant proteins

1 reference

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2 October 2017

Vectors that facilitate the expression and purification of foreign peptides in Escherichia coli by fusion to maltose-binding protein

1 reference

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2 October 2017

Basic local alignment search tool

1 reference

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2 October 2017

Dominant forces in protein folding

1 reference

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2 October 2017

Nonribosomal biosynthesis of peptide antibiotics

1 reference

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Amino acid substitution matrices from protein blocks

1 reference

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2 October 2017

6 Statistical analysis of enzyme kinetic data

1 reference

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2 October 2017

Multifunctional Peptide Synthetases.

1 reference

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Structural studies of natural product biosynthetic proteins

1 reference

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Cobalamin-dependent methionine synthase is a modular protein with distinct regions for binding homocysteine, methyltetrahydrofolate, cobalamin, and adenosylmethionine.

1 reference

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Electrospray mass spectrometric analysis of the domains of a large enzyme: observation of the occupied cobalamin-binding domain and redefinition of the carboxyl terminus of methionine synthase

1 reference

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2 July 2018

The architecture of the animal fatty acid synthetase. III. Isolation and characterization of beta-ketoacyl reductase.

1 reference

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2 July 2018

Isolation and mapping of the beta-hydroxyacyl dehydratase activity of chicken liver fatty acid synthase

1 reference

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2 July 2018

Hexanoate synthase, a specialized type I fatty acid synthase in aflatoxin B1 biosynthesis

1 reference

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23 September 2018

Initial characterization of a type I fatty acid synthase and polyketide synthase multienzyme complex NorS in the biosynthesis of aflatoxin B(1).

1 reference

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23 September 2018

Synthesis of 11-hydroxyl O-methylsterigmatocystin and the role of a cytochrome P-450 in the final step of aflatoxin biosynthesis.

1 reference

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23 September 2018

Generation of multiple bioactive macrolides by hybrid modular polyketide synthases in Streptomyces venezuelae

1 reference

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23 September 2018

The role of the cysteine residues of ThiI in the generation of 4-thiouridine in tRNA.

1 reference

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23 September 2018

Selective protein-protein interactions direct channeling of intermediates between polyketide synthase modules

1 reference

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23 September 2018

Identification of Claisen cyclase domain in fungal polyketide synthase WA, a naphthopyrone synthase of Aspergillus nidulans

1 reference

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23 September 2018

Iterative sequence/secondary structure search for protein homologs: comparison with amino acid sequence alignments and application to fold recognition in genome databases.

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=3400148

23 September 2018

Evidence that ThiI, an enzyme shared between thiamin and 4-thiouridine biosynthesis, may be a sulfurtransferase that proceeds through a persulfide intermediate

1 reference

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23 September 2018

A melanin polyketide synthase (PKS) gene from Nodulisporium sp. that shows homology to the pks1 gene of Colletotrichum lagenarium.

1 reference

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23 September 2018

DIALIGN: finding local similarities by multiple sequence alignment.

1 reference

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23 September 2018

Demonstration of the catalytic roles and evidence for the physical association of type I fatty acid synthases and a polyketide synthase in the biosynthesis of aflatoxin B1.

1 reference

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23 September 2018

Location of domains in globular proteins

1 reference

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23 September 2018

Predictive, structure-based model of amino acid recognition by nonribosomal peptide synthetase adenylation domains

2 references

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21 October 2018

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7 January 2021

The architecture of the animal fatty acid synthetase complex. IV. Mapping of active centers and model for the mechanism of action

1 reference

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21 October 2018

The architecture of the animal fatty acid synthetase. II. Separation of the core and thioesterase functions and determination of the N-C orientation of the subunit

1 reference

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21 October 2018

The architecture of the animal fatty acid synthetase. I. Proteolytic dissection and peptide mapping

1 reference

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21 October 2018

Bioengineering. Working outside the protein-synthesis rules

1 reference

https://api.crossref.org/works/10.1016%2FS0022-2836%2802%2900972-5

7 January 2021

Mechanism and specificity of the terminal thioesterase domain from the erythromycin polyketide synthase

1 reference

https://api.crossref.org/works/10.1016%2FS0022-2836%2802%2900972-5

7 January 2021

Enzymology and Molecular Biology of Aflatoxin Biosynthesis

1 reference

https://api.crossref.org/works/10.1016%2FS0022-2836%2802%2900972-5

7 January 2021

Hexanoate as a starter unit in polyketide biosynthesis

1 reference

https://api.crossref.org/works/10.1016%2FS0022-2836%2802%2900972-5

7 January 2021

Product identification of polyketide synthase coded by Aspergillus nidulans wA gene

1 reference

https://api.crossref.org/works/10.1016%2FS0022-2836%2802%2900972-5

7 January 2021

Do aligned sequences share the same fold?

1 reference

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7 January 2021

Identifiers

10.1016/S0022-2836(02)00972-5

1 reference

Europe PubMed Central

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13 December 2019

1 reference

Europe PubMed Central

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13 December 2019

1 reference

Europe PubMed Central

https://www.ebi.ac.uk/europepmc/webservices/rest/search?query=EXT_ID:12381311%20AND%20SRC:MED&resulttype=core&format=json

13 December 2019

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