(Q36104480)

12 August 2017

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title

Proapoptotic regimes for HTLV-I-transformed cells: targeting Tax and the NF-kappaB pathway (English)

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Human T-lymphotropic virus 1

12 August 2017

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3

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12 August 2017

Kfoury Y

1

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12 August 2017

Nasr R

series ordinal

2

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12 August 2017

de Thé H

series ordinal

4

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12 August 2017

Bazarbachi A

series ordinal

5

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12 August 2017

1 August 2005

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Cell Death & Differentiation

12 August 2017

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12 August 2017

12 Suppl 1

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12 August 2017

871-877

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https://scigraph.springernature.com/pub.10.1038/sj.cdd.4401624

12 August 2017

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21 January 2018

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Human T-cell leukemia virus type 1 Tax shuttles between functionally discrete subcellular targets

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Multiple viral strategies of HTLV-1 for dysregulation of cell growth control

21 January 2018

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Down-regulation of the INK4 family of cyclin-dependent kinase inhibitors by tax protein of HTLV-1 through two distinct mechanisms

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Life, death, and tax: role of HTLV-I oncoprotein in genetic instability and cellular transformation

21 January 2018

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Human T-cell leukemia virus type 1 Tax and cell cycle progression: role of cyclin D-cdk and p110Rb

21 January 2018

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HTLV-I trans-activator protein, tax, is a trans-repressor of the human beta-polymerase gene

21 January 2018

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Inactivation of hTERT transcription by Tax.

21 January 2018

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Human T-cell leukemia virus type I tax protein induces the expression of anti-apoptotic gene Bcl-xL in human T-cells through nuclear factor-kappaB and c-AMP responsive element binding protein pathways

21 January 2018

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Repression of bax gene expression by the HTLV-1 Tax protein: implications for suppression of apoptosis in virally infected cells

21 January 2018

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Inactivation of p53 by HTLV type 1 and HTLV type 2 Tax trans-activators

21 January 2018

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Insights into the molecular mechanism of p53 inhibition by HTLV type 1 Tax.

21 January 2018

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Multiple control levels of cell proliferation by human T-cell leukemia virus type 1 Tax protein

21 January 2018

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Human T-cell lymphotropic virus oncoprotein Tax represses TGF-beta 1 signaling in human T cells via c-Jun activation: a potential mechanism of HTLV-I leukemogenesis.

21 January 2018

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Human T-cell lymphotropic virus type 1-transformed cells induce angiogenesis and establish functional gap junctions with endothelial cells

21 January 2018

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Human T-cell lymphotropic virus type I-infected cells extravasate through the endothelial barrier by a local angiogenesis-like mechanism

21 January 2018

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Transformation to continuous growth of primary human T lymphocytes by human T-cell leukemia virus type I X-region genes transduced by a Herpesvirus saimiri vector

21 January 2018

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Oncogenic transformation by the tax gene of human T-cell leukemia virus type I in vitro

21 January 2018

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The tat gene of human T-lymphotropic virus type 1 induces mesenchymal tumors in transgenic mice

21 January 2018

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Deregulation of NF-kappaB and its upstream kinases in cancer

21 January 2018

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The NF-kappa B and I kappa B proteins: new discoveries and insights

21 January 2018

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Function and activation of NF-kappa B in the immune system

21 January 2018

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RelB, a new Rel family transcription activator that can interact with p50-NF-kappa B.

21 January 2018

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Purified human I kappa B can rapidly dissociate the complex of the NF-kappa B transcription factor with its cognate DNA.

21 January 2018

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I kappa B epsilon, a novel member of the I kappa B family, controls RelA and cRel NF-kappa B activity

21 January 2018

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I kappa B gamma, a 70 kd protein identical to the C-terminal half of p110 NF-kappa B: a new member of the I kappa B family

21 January 2018

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Rel/NF-kappa B/I kappa B family: intimate tales of association and dissociation

21 January 2018

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Intramolecular masking of the nuclear location signal and dimerization domain in the precursor for the p50 NF-kappa B subunit

21 January 2018

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The bcl-3 proto-oncogene encodes a nuclear I kappa B-like molecule that preferentially interacts with NF-kappa B p50 and p52 in a phosphorylation-dependent manner

21 January 2018

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Constitutive expression of Bc1-3 in thymocytes increases the DNA binding of NF-kappaB1 (p50) homodimers in vivo

21 January 2018

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Activators and target genes of Rel/NF-kappaB transcription factors

21 January 2018

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Site-specific phosphorylation of IkappaBalpha by a novel ubiquitination-dependent protein kinase activity

21 January 2018

1 reference

https://api.crossref.org/works/10.1038%2FSJ.CDD.4401624

Complementation cloning of NEMO, a component of the IkappaB kinase complex essential for NF-kappaB activation

21 January 2018

1 reference

https://api.crossref.org/works/10.1038%2FSJ.CDD.4401624

IKK-gamma is an essential regulatory subunit of the IkappaB kinase complex

21 January 2018

1 reference

https://api.crossref.org/works/10.1038%2FSJ.CDD.4401624

NAK is an IkappaB kinase-activating kinase

21 January 2018

1 reference

https://api.crossref.org/works/10.1038%2FSJ.CDD.4401624

Differential regulation of IkappaB kinase alpha and beta by two upstream kinases, NF-kappaB-inducing kinase and mitogen-activated protein kinase/ERK kinase kinase-1

21 January 2018

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p105 and p98 precursor proteins play an active role in NF-kappa B-mediated signal transduction

21 January 2018

1 reference

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The ubiquitin-proteasome pathway is required for processing the NF-kappa B1 precursor protein and the activation of NF-kappa B

21 January 2018

1 reference

https://api.crossref.org/works/10.1038%2FSJ.CDD.4401624

The tax oncoprotein of human T-cell leukemia virus type 1 associates with and persistently activates IkappaB kinases containing IKKalpha and IKKbeta

21 January 2018

1 reference

https://api.crossref.org/works/10.1038%2FSJ.CDD.4401624

Human T-cell leukemia virus type I Tax activation of NF-kappa B/Rel involves phosphorylation and degradation of I kappa B alpha and RelA (p65)-mediated induction of the c-rel gene

21 January 2018

1 reference

https://api.crossref.org/works/10.1038%2FSJ.CDD.4401624

Persistent activation of NF-kappaB by the tax transforming protein of HTLV-1: hijacking cellular IkappaB kinases

21 January 2018

1 reference

https://api.crossref.org/works/10.1038%2FSJ.CDD.4401624

Activation of IKKalpha and IKKbeta through their fusion with HTLV-I tax protein

21 January 2018

1 reference

https://api.crossref.org/works/10.1038%2FSJ.CDD.4401624

Stimulation of IKK-gamma oligomerization by the human T-cell leukemia virus oncoprotein Tax.

21 January 2018

1 reference

https://api.crossref.org/works/10.1038%2FSJ.CDD.4401624

HTLV-I Tax protein binds to MEKK1 to stimulate IkappaB kinase activity and NF-kappaB activation.

21 January 2018

1 reference

https://api.crossref.org/works/10.1038%2FSJ.CDD.4401624

NF-kappaB-inducing kinase and IkappaB kinase participate in human T-cell leukemia virus I Tax-mediated NF-kappaB activation

21 January 2018

1 reference

https://api.crossref.org/works/10.1038%2FSJ.CDD.4401624

Regulation of Ikappa B kinase (IKK)gamma /NEMO function by IKKbeta -mediated phosphorylation

21 January 2018

1 reference

https://api.crossref.org/works/10.1038%2FSJ.CDD.4401624

Human T-lymphotropic virus type I tax activates I-kappa B kinase by inhibiting I-kappa B kinase-associated serine/threonine protein phosphatase 2A.

21 January 2018

1 reference

https://api.crossref.org/works/10.1038%2FSJ.CDD.4401624

Retroviral oncoprotein Tax induces processing of NF-kappaB2/p100 in T cells: evidence for the involvement of IKKalpha

21 January 2018

1 reference

https://api.crossref.org/works/10.1038%2FSJ.CDD.4401624

Effects on NF-kappa B1/p105 processing of the interaction between the HTLV-1 transactivator Tax and the proteasome

21 January 2018

1 reference

https://api.crossref.org/works/10.1038%2FSJ.CDD.4401624

Tax protein of human T-cell leukemia virus type I binds to the ankyrin motifs of inhibitory factor kappa B and induces nuclear translocation of transcription factor NF-kappa B proteins for transcriptional activation

21 January 2018

1 reference

https://api.crossref.org/works/10.1038%2FSJ.CDD.4401624

Differential transcriptional activation by human T-cell leukemia virus type 1 Tax mutants is mediated by distinct interactions with CREB binding protein and p300

21 January 2018

1 reference

https://api.crossref.org/works/10.1038%2FSJ.CDD.4401624

The contribution of NF-kappa B activity to spontaneous proliferation and resistance to apoptosis in human T-cell leukemia virus type 1 Tax-induced tumors

21 January 2018

1 reference

https://api.crossref.org/works/10.1038%2FSJ.CDD.4401624

HTLV-I tax induces cellular proteins that activate the kappa B element in the IL-2 receptor alpha gene

21 January 2018

1 reference

https://api.crossref.org/works/10.1038%2FSJ.CDD.4401624

Pathways of retinoic acid- or arsenic trioxide-induced PML/RARalpha catabolism, role of oncogene degradation in disease remission

21 January 2018

1 reference

https://api.crossref.org/works/10.1038%2FSJ.CDD.4401624

Arsenic/interferon specifically reverses 2 distinct gene networks critical for the survival of HTLV-1-infected leukemic cells

21 January 2018

1 reference

https://api.crossref.org/works/10.1038%2FSJ.CDD.4401624

Interaction of HTLV-I Tax with the human proteasome: implications for NF-kappa B induction

21 January 2018

1 reference

https://api.crossref.org/works/10.1038%2FSJ.CDD.4401624

Human T-cell leukemia virus type 1 Tax protein binds to assembled nuclear proteasomes and enhances their proteolytic activity

21 January 2018

1 reference

https://api.crossref.org/works/10.1038%2FSJ.CDD.4401624

The 26S proteasome is required for estrogen receptor-alpha and coactivator turnover and for efficient estrogen receptor-alpha transactivation

21 January 2018

1 reference

https://api.crossref.org/works/10.1038%2FSJ.CDD.4401624

Interferon gamma stimulation modulates the proteolytic activity and cleavage site preference of 20S mouse proteasomes

21 January 2018

1 reference

https://api.crossref.org/works/10.1038%2FSJ.CDD.4401624

Properties of the hybrid form of the 26S proteasome containing both 19S and PA28 complexes.

21 January 2018

1 reference

https://api.crossref.org/works/10.1038%2FSJ.CDD.4401624

Role of promyelocytic leukemia (PML) sumolation in nuclear body formation, 11S proteasome recruitment, and As2O3-induced PML or PML/retinoic acid receptor alpha degradation

21 January 2018

1 reference

https://api.crossref.org/works/10.1038%2FSJ.CDD.4401624

Presentation of a new H-2D(k)-restricted epitope in the Tax protein of human T-lymphotropic virus type I is enhanced by the proteasome inhibitor lactacystin

21 January 2018

1 reference

https://api.crossref.org/works/10.1038%2FSJ.CDD.4401624

The immune response to HTLV-I.

21 January 2018

1 reference

https://api.crossref.org/works/10.1038%2FSJ.CDD.4401624

Phase II trial of arsenic trioxide and alpha interferon in patients with relapsed/refractory adult T-cell leukemia/lymphoma

21 January 2018

1 reference

https://api.crossref.org/works/10.1038%2FSJ.CDD.4401624

Bay 11-7082 inhibits transcription factor NF-kappaB and induces apoptosis of HTLV-I-infected T-cell lines and primary adult T-cell leukemia cells

21 January 2018

1 reference

https://api.crossref.org/works/10.1038%2FSJ.CDD.4401624

Rapid Tumor Formation of Human T-Cell Leukemia Virus Type 1-Infected Cell Lines in Novel NOD-SCID/γcnullMice: Suppression by an Inhibitor against NF-κB

21 January 2018

1 reference

https://api.crossref.org/works/10.1038%2FSJ.CDD.4401624

The proteasome: structure, function, and role in the cell

21 January 2018

1 reference

https://api.crossref.org/works/10.1038%2FSJ.CDD.4401624

Selective protein degradation: a journey's end within the proteasome

21 January 2018

1 reference

https://api.crossref.org/works/10.1038%2FSJ.CDD.4401624

21 January 2018

1 reference

https://api.crossref.org/works/10.1038%2FSJ.CDD.4401624

N-terminal ubiquitination: more protein substrates join in.

21 January 2018

1 reference

https://api.crossref.org/works/10.1038%2FSJ.CDD.4401624

Recognition of the polyubiquitin proteolytic signal

21 January 2018

1 reference

https://api.crossref.org/works/10.1038%2FSJ.CDD.4401624

Stable ubiquitination of human T-cell leukemia virus type 1 tax is required for proteasome binding

21 January 2018

1 reference

https://api.crossref.org/works/10.1038%2FSJ.CDD.4401624

Effects of the proteasome inhibitor PS-341 on tumor growth in HTLV-1 Tax transgenic mice and Tax tumor transplants

21 January 2018

1 reference

https://api.crossref.org/works/10.1038%2FSJ.CDD.4401624

Proteasome inhibitor, bortezomib, potently inhibits the growth of adult T-cell leukemia cells both in vivo and in vitro.

21 January 2018

1 reference

https://api.crossref.org/works/10.1038%2FSJ.CDD.4401624

Efficacy and mechanism of action of the proteasome inhibitor PS-341 in T-cell lymphomas and HTLV-I associated adult T-cell leukemia/lymphoma

21 January 2018

1 reference

https://api.crossref.org/works/10.1038%2FSJ.CDD.4401624

Adult T-cell leukemia cells over-express the multidrug-resistance-protein (MRP) and lung-resistance-protein (LRP) genes

21 January 2018

1 reference

https://api.crossref.org/works/10.1038%2FSJ.CDD.4401624

Geographic and molecular epidemiology of primate T lymphotropic retroviruses: HTLV-I, HTLV-II, STLV-I, STLV-PP, and PTLV-L.

21 January 2018

1 reference

https://api.crossref.org/works/10.1038%2FSJ.CDD.4401624

7 January 2021

Persistent activation of NF-kappa B/Rel by human T-cell leukemia virus type 1 tax involves degradation of I kappa B beta.

1 reference

https://api.crossref.org/works/10.1038%2FSJ.CDD.4401624

7 January 2021

Subcellular redistribution of HTLV-1 Tax protein by NF-kappa B/Rel transcription factors

1 reference

https://api.crossref.org/works/10.1038%2FSJ.CDD.4401624

7 January 2021

The human T-cell leukemia virus type 1 transactivator protein Tax colocalizes in unique nuclear structures with NF-kappaB proteins

1 reference

https://api.crossref.org/works/10.1038%2FSJ.CDD.4401624

7 January 2021

Immortalization of CD4(+) and CD8(+) T lymphocytes by human T-cell leukemia virus type 1 Tax mutants expressed in a functional molecular clone

1 reference

https://api.crossref.org/works/10.1038%2FSJ.CDD.4401624

7 January 2021

Identifiers

DOI

10.1038/SJ.CDD.4401624

1 reference

12 August 2017

1 reference