(Q36104754)

English

Indole-3-carbinol inhibits MDA-MB-231 breast cancer cell motility and induces stress fibers and focal adhesion formation by activation of Rho kinase activity

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scholarly article

1 reference

Europe PubMed Central

PMC publication ID

12 August 2017

Indole-3-carbinol inhibits MDA-MB-231 breast cancer cell motility and induces stress fibers and focal adhesion formation by activation of Rho kinase activity (English)

1 reference

Europe PubMed Central

PMC publication ID

12 August 2017

indole-3-carbinol

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author name string

Christine T Brew

1

1 reference

Europe PubMed Central

PMC publication ID

12 August 2017

Ida Aronchik

2

1 reference

Europe PubMed Central

PMC publication ID

12 August 2017

Karena Kosco

3

1 reference

Europe PubMed Central

PMC publication ID

12 August 2017

Jasmine McCammon

4

1 reference

Europe PubMed Central

PMC publication ID

12 August 2017

Leonard F Bjeldanes

5

1 reference

Europe PubMed Central

PMC publication ID

12 August 2017

Gary L Firestone

6

1 reference

Europe PubMed Central

PMC publication ID

12 August 2017

language of work or name

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publication date

1 May 2009

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Europe PubMed Central

PMC publication ID

12 August 2017

number of pages

9

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based on heuristic

inferred from page(s)

International Journal of Cancer

1 reference

Europe PubMed Central

PMC publication ID

12 August 2017

124

1 reference

Europe PubMed Central

PMC publication ID

12 August 2017

10

1 reference

Europe PubMed Central

PMC publication ID

12 August 2017

2294-2302

1 reference

Europe PubMed Central

PMC publication ID

12 August 2017

describes a project that uses

1 reference

Europe PubMed Central

11 June 2022

https://www.ebi.ac.uk/europepmc/webservices/rest/PMC3400502/fullTextXML

based on heuristic

inferred from PubMed Central ID database lookup

Rho GTPases in PC-3 prostate cancer cell morphology, invasion and tumor cell diapedesis

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=3400502

2 October 2017

Indole-3-carbinol as a chemopreventive and anti-cancer agent

1 reference

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2 October 2017

Vinculin controls focal adhesion formation by direct interactions with talin and actin.

1 reference

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2 October 2017

Actin stress fibres

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=3400502

2 October 2017

Cruciferous vegetables and human cancer risk: epidemiologic evidence and mechanistic basis

1 reference

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2 October 2017

Therapeutic intervention of experimental breast cancer bone metastasis by indole-3-carbinol in SCID-human mouse model

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=3400502

2 October 2017

Indole-3-carbinol mediated cell cycle arrest of LNCaP human prostate cancer cells requires the induced production of activated p53 tumor suppressor protein

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=3400502

2 October 2017

Inhibition of transendothelial migration and invasion of human breast cancer cells by preventing geranylgeranylation of Rho.

1 reference

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2 October 2017

Estrogen receptor alpha as a target for indole-3-carbinol

1 reference

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2 October 2017

Rac1 and Rac3 isoform activation is involved in the invasive and metastatic phenotype of human breast cancer cells

1 reference

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2 October 2017

Indole-3-carbinol activates the ATM signaling pathway independent of DNA damage to stabilize p53 and induce G1 arrest of human mammary epithelial cells

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=3400502

2 October 2017

Molecular targets and anticancer potential of indole-3-carbinol and its derivatives

1 reference

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2 October 2017

Targets for indole-3-carbinol in cancer prevention

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=3400502

2 October 2017

Anti-RhoA and anti-RhoC siRNAs inhibit the proliferation and invasiveness of MDA-MB-231 breast cancer cells in vitro and in vivo.

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=3400502

2 October 2017

Indole-3-carbinol (I3C) inhibits cyclin-dependent kinase-2 function in human breast cancer cells by regulating the size distribution, associated cyclin E forms, and subcellular localization of the CDK2 protein complex.

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=3400502

2 October 2017

Focal adhesion regulation of cell behavior.

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=3400502

2 October 2017

Thy-1 regulates fibroblast focal adhesions, cytoskeletal organization and migration through modulation of p190 RhoGAP and Rho GTPase activity

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=3400502

2 October 2017

p27Kip1 modulates cell migration through the regulation of RhoA activation.

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=3400502

2 October 2017

Cell shape, cytoskeletal tension, and RhoA regulate stem cell lineage commitment

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=3400502

2 October 2017

Rho-family GTPases: it's not only Rac and Rho (and I like it).

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=3400502

2 October 2017

The tumor invasion inhibitor dihydromotuporamine C activates RHO, remodels stress fibers and focal adhesions, and stimulates sodium-proton exchange

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=3400502

2 October 2017

Cell migration: integrating signals from front to back

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=3400502

2 October 2017

Illuminating adhesion complexes in migrating cells: moving toward a bright future

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=3400502

2 October 2017

Indole-3-carbinol and 3-3'-diindolylmethane antiproliferative signaling pathways control cell-cycle gene transcription in human breast cancer cells by regulating promoter-Sp1 transcription factor interactions

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=3400502

2 October 2017

RhoE binds to ROCK I and inhibits downstream signaling

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=3400502

2 October 2017

Differential regulation of cell motility and invasion by FAK

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=3400502

2 October 2017

Molecular mechanism of the anti-cancer activity of cerivastatin, an inhibitor of HMG-CoA reductase, on aggressive human breast cancer cells

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=3400502

2 October 2017

Indole-3-carbinol inhibits protein kinase B/Akt and induces apoptosis in the human breast tumor cell line MDA MB468 but not in the nontumorigenic HBL100 line.

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=3400502

2 October 2017

Rho GTPases in transformation and metastasis.

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=3400502

2 October 2017

Rho GTPases and cell migration

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=3400502

2 October 2017

RhoA inactivation by p190RhoGAP regulates cell spreading and migration by promoting membrane protrusion and polarity

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=3400502

2 October 2017

Cerivastatin, an inhibitor of HMG-CoA reductase, inhibits the signaling pathways involved in the invasiveness and metastatic properties of highly invasive breast cancer cell lines: an in vitro study

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=3400502

2 October 2017

Indole-3-carbinol (I3C) induced cell growth inhibition, G1 cell cycle arrest and apoptosis in prostate cancer cells

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=3400502

2 October 2017

Brassica vegetables and breast cancer risk

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=3400502

2 October 2017

Indole-3-carbinol inhibits CDK6 expression in human MCF-7 breast cancer cells by disrupting Sp1 transcription factor interactions with a composite element in the CDK6 gene promoter

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=3400502

2 October 2017

Integrin-mediated adhesion regulates cell polarity and membrane protrusion through the Rho family of GTPases

1 reference

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Cross-talk between Ras and Rho signalling pathways in transformation favours proliferation and increased motility

1 reference

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2 October 2017

Focal adhesion kinase: a regulator of focal adhesion dynamics and cell movement

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=3400502

2 October 2017

Focal adhesions: a nexus for intracellular signaling and cytoskeletal dynamics

1 reference

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2 October 2017

Rho family proteins in cell adhesion and cell migration.

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=3400502

2 October 2017

Suppression of breast cancer invasion and migration by indole-3-carbinol: associated with up-regulation of BRCA1 and E-cadherin/catenin complexes

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=3400502

2 October 2017

Brassica vegetables and cancer prevention. Epidemiology and mechanisms.

1 reference

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2 October 2017

Focal adhesions - the cytoskeletal connection

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=3400502

2 October 2017

Indole-3-carbinol and tamoxifen cooperate to arrest the cell cycle of MCF-7 human breast cancer cells.

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=3400502

2 October 2017

Ral-specific guanine nucleotide exchange factor activity opposes other Ras effectors in PC12 cells by inhibiting neurite outgrowth

1 reference

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2 October 2017

A role for Cdc42 in macrophage chemotaxis

1 reference

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2 October 2017

Focal adhesions, contractility, and signaling

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=3400502

2 October 2017

Rho-stimulated contractility drives the formation of stress fibers and focal adhesions

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=3400502

2 October 2017

Regulation of myosin phosphatase by Rho and Rho-associated kinase (Rho-kinase)

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=3400502

2 October 2017

Rho-associated kinase, a novel serine/threonine kinase, as a putative target for small GTP binding protein Rho

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=3400502

2 October 2017

Tyrosine phosphorylation and cytoskeletal tension regulate the release of fibroblast adhesions

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=3400502

2 October 2017

Reduced cell motility and enhanced focal adhesion contact formation in cells from FAK-deficient mice

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=3400502

2 October 2017

Inhibition of polycyclic aromatic hydrocarbon-induced neoplasia by naturally occurring indoles

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=3400502

2 October 2017

Use and properties of ROCK-specific inhibitor Y-27632.

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=3400502

2 July 2018

Effects of dietary indole-3-carbinol on estradiol metabolism and spontaneous mammary tumors in mice.

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=3400502

2 July 2018

Association of increased basement membrane invasiveness with absence of estrogen receptor and expression of vimentin in human breast cancer cell lines

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=3400502

2 July 2018

Indole-3-carbinol selectively uncouples expression and activity of estrogen receptor subtypes in human breast cancer cells

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=3400502

23 September 2018

Indole-3-carbinol induces a G1 cell cycle arrest and inhibits prostate-specific antigen production in human LNCaP prostate carcinoma cells

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=3400502

23 September 2018

Rho GTPases are over-expressed in human tumors.

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=3400502

23 September 2018

Indole-3-carbinol inhibits the expression of cyclin-dependent kinase-6 and induces a G1 cell cycle arrest of human breast cancer cells independent of estrogen receptor signaling.

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=3400502

23 September 2018

Chemoprevention of chemically-induced mammary carcinogenesis by indole-3-carbinol.

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=3400502

23 September 2018

Reduction in mammary tumorigenesis in the rat by cabbage and cabbage residue.

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=3400502

23 September 2018

Breast and prostate cancer: an analysis of common epidemiological, genetic, and biochemical features

1 reference

https://pubmed.ncbi.nlm.nih.gov/19173291

12 December 2020

based on heuristic

inferred from PubMed ID database lookup

Induction of apoptosis in MCF-7 cells by indole-3-carbinol is independent of p53 and bax

1 reference

https://pubmed.ncbi.nlm.nih.gov/19173291

12 December 2020

based on heuristic

inferred from PubMed ID database lookup

Purification and in vitro activity of Rho-associated kinase

1 reference

https://pubmed.ncbi.nlm.nih.gov/19173291

12 December 2020

based on heuristic

inferred from PubMed ID database lookup

Inhibitory effects of Indole-3-carbinol on invasion and migration in human breast cancer cells

1 reference

https://pubmed.ncbi.nlm.nih.gov/19173291

12 December 2020

based on heuristic

inferred from PubMed ID database lookup

Indole-3-carbinol and diindolylmethane induce apoptosis of human cervical cancer cells and in murine HPV16-transgenic preneoplastic cervical epithelium

1 reference

https://pubmed.ncbi.nlm.nih.gov/19173291

12 December 2020

based on heuristic

inferred from PubMed ID database lookup

ERK-MAPK signaling coordinately regulates activity of Rac1 and RhoA for tumor cell motility

1 reference

https://pubmed.ncbi.nlm.nih.gov/19173291

12 December 2020

based on heuristic

inferred from PubMed ID database lookup

Screening of potential chemopreventive agents using biochemical markers of carcinogenesis

1 reference

https://pubmed.ncbi.nlm.nih.gov/19173291

12 December 2020

based on heuristic

inferred from PubMed ID database lookup

Long-term responses of women to indole-3-carbinol or a high fiber diet

1 reference

https://pubmed.ncbi.nlm.nih.gov/19173291

12 December 2020

based on heuristic

inferred from PubMed ID database lookup

Identifiers

10.1002/IJC.24210

1 reference

Europe PubMed Central

PMC publication ID

12 August 2017

PMC publication ID

1 reference

Europe PubMed Central

PMC publication ID

12 August 2017

PubMed publication ID

1 reference

Europe PubMed Central

PMC publication ID

12 August 2017

ResearchGate publication ID

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