(Q38302095)

English

Indole-3-carbinol inhibits CDK6 expression in human MCF-7 breast cancer cells by disrupting Sp1 transcription factor interactions with a composite element in the CDK6 gene promoter

scientific article published on 10 April 2001

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scholarly article

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Europe PubMed Central

1 September 2017

Indole-3-carbinol inhibits CDK6 expression in human MCF-7 breast cancer cells by disrupting Sp1 transcription factor interactions with a composite element in the CDK6 gene promoter (English)

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Europe PubMed Central

1 September 2017

indole-3-carbinol

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author name string

Cram EJ

1

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Europe PubMed Central

1 September 2017

Liu BD

2

1 reference

Europe PubMed Central

1 September 2017

Bjeldanes LF

3

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Europe PubMed Central

1 September 2017

Firestone GL

4

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Europe PubMed Central

1 September 2017

language of work or name

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publication date

10 April 2001

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Europe PubMed Central

1 September 2017

Journal of Biological Chemistry

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Europe PubMed Central

1 September 2017

276

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Europe PubMed Central

1 September 2017

22332-22340

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Europe PubMed Central

1 September 2017

25

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Europe PubMed Central

1 September 2017

Indole-3-carbinol. A novel approach to breast cancer prevention.

1 reference

https://api.crossref.org/works/10.1074%2FJBC.M010539200

21 January 2018

Aromatic hydrocarbon responsiveness-receptor agonists generated from indole-3-carbinol in vitro and in vivo: comparisons with 2,3,7,8-tetrachlorodibenzo-p-dioxin

1 reference

https://api.crossref.org/works/10.1074%2FJBC.M010539200

21 January 2018

Aryl hydrocarbon receptor-mediated antiestrogenic and antitumorigenic activity of diindolylmethane

1 reference

https://api.crossref.org/works/10.1074%2FJBC.M010539200

21 January 2018

Indole-3-carbinol inhibits the expression of cyclin-dependent kinase-6 and induces a G1 cell cycle arrest of human breast cancer cells independent of estrogen receptor signaling.

1 reference

https://api.crossref.org/works/10.1074%2FJBC.M010539200

21 January 2018

G1 cyclins and control of the cell division cycle in normal and transformed cells

1 reference

https://api.crossref.org/works/10.1074%2FJBC.M010539200

21 January 2018

The retinoblastoma protein and cell cycle control

1 reference

https://api.crossref.org/works/10.1074%2FJBC.M010539200

21 January 2018

Distinct roles for cyclin-dependent kinases in cell cycle control

1 reference

https://api.crossref.org/works/10.1074%2FJBC.M010539200

21 January 2018

Principles of CDK regulation

1 reference

https://api.crossref.org/works/10.1074%2FJBC.M010539200

21 January 2018

Cancer cell cycles

1 reference

https://api.crossref.org/works/10.1074%2FJBC.M010539200

21 January 2018

Cell cycle control of DNA replication.

1 reference

https://api.crossref.org/works/10.1074%2FJBC.M010539200

21 January 2018

Rb function in cell-cycle regulation and apoptosis

1 reference

https://api.crossref.org/works/10.1074%2FJBC.M010539200

21 January 2018

RB kinases and RB-binding proteins: new points of view

1 reference

https://api.crossref.org/works/10.1074%2FJBC.M010539200

21 January 2018

Genetic aberrations in hypodiploid breast cancer: frequent loss of chromosome 4 and amplification of cyclin D1 oncogene

1 reference

https://api.crossref.org/works/10.1074%2FJBC.M010539200

21 January 2018

Characterization of the murine cyclin-dependent kinase inhibitor gene p27Kip1.

1 reference

https://api.crossref.org/works/10.1074%2FJBC.M010539200

21 January 2018

Characterization of the human cyclin-dependent kinase 2 gene. Promoter analysis and gene structure

1 reference

https://api.crossref.org/works/10.1074%2FJBC.M010539200

21 January 2018

Repression of CDK1 and other genes with CDE and CHR promoter elements during DNA damage-induced G(2)/M arrest in human cells

1 reference

https://api.crossref.org/works/10.1074%2FJBC.M010539200

21 January 2018

Isolation of biologically active ribonucleic acid from sources enriched in ribonuclease

1 reference

https://api.crossref.org/works/10.1074%2FJBC.M010539200

21 January 2018

Accurate transcription initiation by RNA polymerase II in a soluble extract from isolated mammalian nuclei

1 reference

https://api.crossref.org/works/10.1074%2FJBC.M010539200

21 January 2018

A rapid and sensitive method for the quantitation of microgram quantities of protein utilizing the principle of protein-dye binding

1 reference

https://api.crossref.org/works/10.1074%2FJBC.M010539200

21 January 2018

Structural basis for inhibition of the cyclin-dependent kinase Cdk6 by the tumour suppressor p16INK4a

1 reference

https://api.crossref.org/works/10.1074%2FJBC.M010539200

21 January 2018

Human-mouse comparative mapping of the genomic region containing CDK6: localization of an evolutionary breakpoint

1 reference

https://api.crossref.org/works/10.1074%2FJBC.M010539200

21 January 2018

MatInd and MatInspector: new fast and versatile tools for detection of consensus matches in nucleotide sequence data

1 reference

https://api.crossref.org/works/10.1074%2FJBC.M010539200

21 January 2018

Cloning of the cyclin A1 genomic structure and characterization of the promoter region. GC boxes are essential for cell cycle-regulated transcription of the cyclin A1 gene.

1 reference

https://api.crossref.org/works/10.1074%2FJBC.M010539200

21 January 2018

Sp1 elements protect a CpG island from de novo methylation

1 reference

https://api.crossref.org/works/10.1074%2FJBC.M010539200

21 January 2018

Suppression of breast cancer invasion and migration by indole-3-carbinol: associated with up-regulation of BRCA1 and E-cadherin/catenin complexes

1 reference

https://api.crossref.org/works/10.1074%2FJBC.M010539200

21 January 2018

Transcriptional regulation by the Sp family proteins.

1 reference

https://api.crossref.org/works/10.1074%2FJBC.M010539200

21 January 2018

Functional analysis of surfactant protein B (SP-B) promoter. Sp1, Sp3, TTF-1, and HNF-3alpha transcription factors are necessary for lung cell-specific activation of SP-B gene transcription

1 reference

https://api.crossref.org/works/10.1074%2FJBC.M010539200

21 January 2018

Context-dependent transcriptional regulation

1 reference

https://api.crossref.org/works/10.1074%2FJBC.M010539200

21 January 2018

Cooperative interaction between AhR.Arnt and Sp1 for the drug-inducible expression of CYP1A1 gene.

1 reference

https://api.crossref.org/works/10.1074%2FJBC.M010539200

21 January 2018

Functional and physical interactions between the estrogen receptor Sp1 and nuclear aryl hydrocarbon receptor complexes

1 reference

https://api.crossref.org/works/10.1074%2FJBC.M010539200

21 January 2018

Transcriptional activation of E2F1 gene expression by 17beta-estradiol in MCF-7 cells is regulated by NF-Y-Sp1/estrogen receptor interactions

1 reference

https://api.crossref.org/works/10.1074%2FJBC.M010539200

21 January 2018

The transcription factor E2F-1 is a downstream target of RB action

1 reference

https://api.crossref.org/works/10.1074%2FJBC.M010539200

21 January 2018

Estrogen induces adenosine deaminase gene expression in MCF-7 human breast cancer cells: role of estrogen receptor-Sp1 interactions

1 reference

https://api.crossref.org/works/10.1074%2FJBC.M010539200

21 January 2018

Ligand-, cell-, and estrogen receptor subtype (alpha/beta)-dependent activation at GC-rich (Sp1) promoter elements

1 reference

https://api.crossref.org/works/10.1074%2FJBC.M010539200

21 January 2018

Androgen induction of cyclin-dependent kinase inhibitor p21 gene: role of androgen receptor and transcription factor Sp1 complex

1 reference

https://api.crossref.org/works/10.1074%2FJBC.M010539200

21 January 2018

Ets transcription factors: nuclear effectors of the Ras-MAP-kinase signaling pathway

1 reference

https://api.crossref.org/works/10.1074%2FJBC.M010539200

21 January 2018

The ETS-domain transcription factor family

1 reference

https://api.crossref.org/works/10.1074%2FJBC.M010539200

21 January 2018

The human tissue inhibitor of metalloproteinases (TIMP)-1 gene contains repressive elements within the promoter and intron 1.

1 reference

https://api.crossref.org/works/10.1074%2FJBC.M010539200

21 January 2018

Sp1 cooperates with the ets transcription factor, GABP, to activate the CD18 (beta2 leukocyte integrin) promoter

1 reference

https://api.crossref.org/works/10.1074%2FJBC.M010539200

21 January 2018

Co-activators and co-repressors in the integration of transcriptional responses

1 reference

https://api.crossref.org/works/10.1074%2FJBC.M010539200

21 January 2018

Regulation and regulatory parameters of histone modifications.

1 reference

https://api.crossref.org/works/10.1074%2FJBC.M010539200

21 January 2018

The transcriptional cofactor complex CRSP is required for activity of the enhancer-binding protein Sp1

1 reference

https://api.crossref.org/works/10.1074%2FJBC.M010539200

21 January 2018

Increasing the complexity of coactivation in nuclear receptor signaling

1 reference

https://api.crossref.org/works/10.1074%2FJBC.M010539200

21 January 2018

The many HATs of transcription coactivators

1 reference

https://api.crossref.org/works/10.1074%2FJBC.M010539200

21 January 2018

Identifiers

10.1074/JBC.M010539200

1 reference

Europe PubMed Central

1 September 2017

1 reference

Europe PubMed Central

1 September 2017

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