(Q36118204)

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Tumor necrosis factor-α synthesis inhibitor 3,6'-dithiothalidomide attenuates markers of inflammation, Alzheimer pathology and behavioral deficits in animal models of neuroinflammation and Alzheimer's disease

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2 February 2020

Tumor necrosis factor-α synthesis inhibitor 3,6'-dithiothalidomide attenuates markers of inflammation, Alzheimer pathology and behavioral deficits in animal models of neuroinflammation and Alzheimer's disease (English)

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2 February 2020

Alzheimer's disease

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Henriette van Praag

5

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2 February 2020

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2 February 2020

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David Tweedie

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2 February 2020

Ryan A Ferguson

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2 February 2020

Kelly Fishman

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2 February 2020

Kathryn A Frankola

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2 February 2020

Harold W Holloway

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2 February 2020

Weiming Luo

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2 February 2020

Yazhou Li

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2 February 2020

Luca Caracciolo

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2 February 2020

Sergio Barlati

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2 February 2020

Balmiki Ray

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2 February 2020

Debomoy K Lahiri

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2 February 2020

Francesca Bosetti

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2 February 2020

Nigel H Greig

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2 February 2020

Susanna Rosi

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2 February 2020

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29 May 2012

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2 February 2020

Journal of Neuroinflammation

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2 February 2020

9

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2 February 2020

106

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2 February 2020

https://scigraph.springernature.com/pub.10.1186/1742-2094-9-106

0 references

TNF-α protein synthesis inhibitor restores neuronal function and reverses cognitive deficits induced by chronic neuroinflammation.

1 reference

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2 October 2017

Deciphering the physiology underlying the rapid clinical effects of perispinal etanercept in Alzheimer's disease

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2 October 2017

Arc in synaptic plasticity: from gene to behavior

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2 October 2017

Ablation of TNF-RI/RII expression in Alzheimer's disease mice leads to an unexpected enhancement of pathology: implications for chronic pan-TNF-α suppressive therapeutic strategies in the brain

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2 October 2017

A role for tumor necrosis factor-α in ischemia and ischemic preconditioning

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2 October 2017

Rivastigmine lowers Aβ and increases sAPPα levels, which parallel elevated synaptic markers and metabolic activity in degenerating primary rat neurons

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2 October 2017

Thalidomide Analogues Suppress Lipopolysaccharide-Induced Synthesis of TNF-α and Nitrite, an Intermediate of Nitric Oxide, in a Cellular Model of Inflammation

1 reference

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2 October 2017

Chronic neuroinflammation impacts the recruitment of adult-born neurons into behaviorally relevant hippocampal networks

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2 October 2017

Tumor necrosis factor-α synthesis inhibitor, 3,6'-dithiothalidomide, reverses behavioral impairments induced by minimal traumatic brain injury in mice

1 reference

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2 October 2017

Inflammatory risk factors and pathologies associated with Alzheimer's disease

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2 October 2017

Neuroinflammation and the plasticity-related immediate-early gene Arc.

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2 October 2017

Targeting TNF-α to elucidate and ameliorate neuroinflammation in neurodegenerative diseases

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2 October 2017

Mechanisms of TNFα regulation in uveitis: focus on RNA-binding proteins

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2 October 2017

Probing the biology of Alzheimer's disease in mice

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2 October 2017

GLP-1 receptor stimulation reduces amyloid-beta peptide accumulation and cytotoxicity in cellular and animal models of Alzheimer's disease.

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2 October 2017

Posttranscriptional regulation of TNF mRNA: a paradigm of signal-dependent mRNA utilization and its relevance to pathology

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2 October 2017

Cyclooxygenase-1 null mice show reduced neuroinflammation in response to beta-amyloid

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2 October 2017

Tumor necrosis factor-alpha mediated signaling in neuronal homeostasis and dysfunction

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2 October 2017

Tumour Necrosis Factor Modulation for Treatment of Alzheimerʼs Disease

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2 October 2017

A cellular model of inflammation for identifying TNF-alpha synthesis inhibitors

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2 October 2017

Treatment with a C5aR antagonist decreases pathology and enhances behavioral performance in murine models of Alzheimer's disease

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2 October 2017

Accuracy of hippocampal network activity is disrupted by neuroinflammation: rescue by memantine

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2 October 2017

Inhibition of soluble TNF signaling in a mouse model of Alzheimer's disease prevents pre-plaque amyloid-associated neuropathology

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2 October 2017

Chronic neuron-specific tumor necrosis factor-alpha expression enhances the local inflammatory environment ultimately leading to neuronal death in 3xTg-AD mice

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2 October 2017

The brain expression of genes involved in inflammatory response, the ribosome, and learning and memory is altered by centrally injected lipopolysaccharide in mice

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2 October 2017

TNF signaling inhibition in the CNS: implications for normal brain function and neurodegenerative disease

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2 October 2017

Targeting mRNA stability arrests inflammatory bone loss

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2 October 2017

Amyloid-beta protein dimers isolated directly from Alzheimer's brains impair synaptic plasticity and memory

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2 October 2017

Toll-like receptor 4-dependent upregulation of cytokines in a transgenic mouse model of Alzheimer's disease

1 reference

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2 October 2017

Rapid cognitive improvement in Alzheimer's disease following perispinal etanercept administration

1 reference

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2 October 2017

Posttranscriptional gene regulation by RNA-binding proteins during oxidative stress: implications for cellular senescence

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2 October 2017

Neuroinflammation in Parkinson's disease: is there sufficient evidence for mechanism-based interventional therapy?

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2 October 2017

TNFalpha blockade in human diseases: an overview of efficacy and safety

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2 October 2017

TNF-alpha inhibition as a treatment strategy for neurodegenerative disorders: new drug candidates and targets.

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2 October 2017

Deletion of tumor necrosis factor death receptor inhibits amyloid beta generation and prevents learning and memory deficits in Alzheimer's mice

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2 October 2017

A Oligomer-Induced Aberrations in Synapse Composition, Shape, and Density Provide a Molecular Basis for Loss of Connectivity in Alzheimer's Disease

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2 October 2017

Arc/Arg3.1 is essential for the consolidation of synaptic plasticity and memories.

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2 October 2017

Role of cytokines in inflammatory process in Parkinson's disease.

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2 October 2017

Synaptic scaling mediated by glial TNF-alpha

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2 October 2017

Early correlation of microglial activation with enhanced tumor necrosis factor-alpha and monocyte chemoattractant protein-1 expression specifically within the entorhinal cortex of triple transgenic Alzheimer's disease mice

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2 October 2017

Tumor necrosis factor-alpha, interleukin-1beta, and interferon-gamma stimulate gamma-secretase-mediated cleavage of amyloid precursor protein through a JNK-dependent MAPK pathway

1 reference

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2 October 2017

Chronic brain inflammation leads to a decline in hippocampal NMDA-R1 receptors

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2 October 2017

Thalidomide in cancer medicine

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2 October 2017

Tumor necrosis factor (TNF)-mediated neuroprotection against glutamate-induced excitotoxicity is enhanced by N-methyl-D-aspartate receptor activation. Essential role of a TNF receptor 2-mediated phosphatidylinositol 3-kinase-dependent NF-kappa B pat

1 reference

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2 October 2017

Thiothalidomides: Novel Isosteric Analogues of Thalidomide with Enhanced TNF-α Inhibitory Activity

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2 October 2017

Intrathecal inflammation precedes development of Alzheimer's disease

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2 October 2017

Triple-transgenic model of Alzheimer's disease with plaques and tangles: intracellular Abeta and synaptic dysfunction

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2 October 2017

The role of glial reaction and inflammation in Parkinson's disease.

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2 October 2017

Tumor necrosis factor signaling.

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2 October 2017

Role of microglia in inflammation-mediated neurodegenerative diseases: mechanisms and strategies for therapeutic intervention.

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2 October 2017

The many faces of tumor necrosis factor in stroke

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2 October 2017

Advances in the cellular and molecular biology of the beta-amyloid protein in Alzheimer's disease

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2 October 2017

The role of TNF and its receptors in Alzheimer's disease

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2 October 2017

The pathogenesis of Alzheimer's disease. Is amyloid beta-protein the beginning or the end?

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2 October 2017

Cytokines in Parkinson's disease

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2 October 2017

The type 1 receptor (CD120a) is the high-affinity receptor for soluble tumor necrosis factor

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2 October 2017

Tumor necrosis factor (TNF) receptors in cellular signaling of soluble and membrane-expressed TNF.

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2 October 2017

The transmembrane form of tumor necrosis factor is the prime activating ligand of the 80 kDa tumor necrosis factor receptor

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2 October 2017

Reactive microglia are positive for HLA-DR in the substantia nigra of Parkinson's and Alzheimer's disease brains

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2 October 2017

Neuropathological stageing of Alzheimer-related changes

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2 October 2017

Tumor necrosis factor-alpha modulates survival, proliferation, and neuronal differentiation in neonatal subventricular zone cell cultures

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2 July 2018

Memantine protects against LPS-induced neuroinflammation, restores behaviorally-induced gene expression and spatial learning in the rat.

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2 July 2018

Tumor necrosis factor receptor 1 is a negative regulator of progenitor proliferation in adult hippocampal neurogenesis.

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2 July 2018

Neuroinflammation alters the hippocampal pattern of behaviorally induced Arc expression.

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2 July 2018

Inhibition of activity-dependent arc protein expression in the rat hippocampus impairs the maintenance of long-term potentiation and the consolidation of long-term memory.

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2 July 2018

Thalidomide exerts its inhibitory action on tumor necrosis factor alpha by enhancing mRNA degradation

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2 July 2018

Reactive microglia in patients with senile dementia of the Alzheimer type are positive for the histocompatibility glycoprotein HLA-DR.

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2 July 2018

Involvement of rat hippocampal astrocytes in β-amyloid-induced angiogenesis and neuroinflammation.

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23 September 2018

Females exhibit more extensive amyloid, but not tau, pathology in an Alzheimer transgenic model.

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23 September 2018

Pro-inflammatory cytokines modulate glial apolipoprotein E secretion.

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23 September 2018

Ccr2 deficiency impairs microglial accumulation and accelerates progression of Alzheimer-like disease.

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23 September 2018

Tumor necrosis factor alpha and interleukin 10 promoter region polymorphisms and risk of late-onset Alzheimer disease.

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23 September 2018

Implanted cannula-mediated repetitive administration of Abeta25-35 into the mouse cerebral ventricle effectively impairs spatial working memory.

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23 September 2018

TNF polymorphisms in Alzheimer disease and functional implications on CSF beta-amyloid levels.

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23 September 2018

Intraneuronal Abeta causes the onset of early Alzheimer's disease-related cognitive deficits in transgenic mice

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=3405480

23 September 2018

Thalidomide-based TNF-alpha inhibitors for neurodegenerative diseases

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=3405480

23 September 2018

Involvement of tumor necrosis factor alpha in hippocampal development and function.

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=3405480

23 September 2018

Role of cytokines in the gene expression of amyloid β–protein precursor: Identification of a 5'-UTR-Binding nuclear factor and its implications in Alzheimer's disease

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=3405480

23 September 2018

Chronic brain inflammation results in cell loss in the entorhinal cortex and impaired LTP in perforant path-granule cell synapses

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=3405480

23 September 2018

Non-steroidal anti-inflammatory drugs stimulate secretion of non-amyloidogenic precursor protein

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=3405480

23 September 2018

Target depletion of distinct tumor necrosis factor receptor subtypes reveals hippocampal neuron death and survival through different signal transduction pathways.

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=3405480

23 September 2018

Neurodegenerative and neuroprotective effects of tumor Necrosis factor (TNF) in retinal ischemia: opposite roles of TNF receptor 1 and TNF receptor 2.

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=3405480

23 September 2018

Neuroinflammation-induced acceleration of amyloid deposition in the APPV717F transgenic mouse

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=3405480

23 September 2018

Intracerebral production of tumor necrosis factor-alpha, a local neuroprotective agent, in Alzheimer disease and vascular dementia.

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=3405480

23 September 2018

Amnesia induced in mice by centrally administered beta-amyloid peptides involves cholinergic dysfunction.

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=3405480

23 September 2018

Transforming growth factor beta mediates increase of mature transmembrane amyloid precursor protein in microglial cells

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=3405480

23 September 2018

Fluoro-Jade: novel fluorochromes for detecting toxicant-induced neuronal degeneration

1 reference

https://pubmed.ncbi.nlm.nih.gov/22642825

12 December 2020

based on heuristic

inferred from PubMed ID database lookup

Glial cells and inflammation in Parkinson's disease: a role in neurodegeneration?

1 reference

https://pubmed.ncbi.nlm.nih.gov/22642825

12 December 2020

based on heuristic

inferred from PubMed ID database lookup

Unresponsiveness of MyD88-deficient mice to endotoxin

1 reference

https://pubmed.ncbi.nlm.nih.gov/22642825

12 December 2020

based on heuristic

inferred from PubMed ID database lookup

Identifiers

10.1186/1742-2094-9-106

1 reference

Europe PubMed Central

https://www.ebi.ac.uk/europepmc/webservices/rest/search?query=EXT_ID:22642825%20AND%20SRC:MED&resulttype=core&format=json

2 February 2020

Dimensions Publication ID

0 references

1 reference

Europe PubMed Central

https://www.ebi.ac.uk/europepmc/webservices/rest/search?query=EXT_ID:22642825%20AND%20SRC:MED&resulttype=core&format=json

2 February 2020

1 reference

Europe PubMed Central

https://www.ebi.ac.uk/europepmc/webservices/rest/search?query=EXT_ID:22642825%20AND%20SRC:MED&resulttype=core&format=json

2 February 2020

ResearchGate publication ID

0 references

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