(Q36150816)

12 August 2017

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title

Lymphocyte trafficking to inflamed skin--molecular mechanisms and implications for therapeutic target molecules (English)

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12 August 2017

Michael P Schön

1

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Ralf J. Ludwig

object named as

Ralf J Ludwig

series ordinal

2

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language of work or name

English

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publication date

1 April 2005

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Expert Opinion on Therapeutic Targets

12 August 2017

published in

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12 August 2017

volume

9

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12 August 2017

issue

2

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12 August 2017

page(s)

225-243

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https://api.crossref.org/works/10.1517%2F14728222.9.2.225

12 August 2017

1 reference

Leukocyte and endothelial cell adhesion molecules as targets for therapeutic interventions in inflammatory disease

21 January 2018

1 reference

https://api.crossref.org/works/10.1517%2F14728222.9.2.225

Inflammatory skin diseases, T cells, and immune surveillance

21 January 2018

1 reference

https://api.crossref.org/works/10.1517%2F14728222.9.2.225

Spontaneous development of psoriasis in a new animal model shows an essential role for resident T cells and tumor necrosis factor-alpha

21 January 2018

1 reference

https://api.crossref.org/works/10.1517%2F14728222.9.2.225

Chemokines and the tissue-specific migration of lymphocytes

21 January 2018

1 reference

https://api.crossref.org/works/10.1517%2F14728222.9.2.225

Four molecular pathways of T cell adhesion to endothelial cells: roles of LFA-1, VCAM-1, and ELAM-1 and changes in pathway hierarchy under different activation conditions

21 January 2018

1 reference

https://api.crossref.org/works/10.1517%2F14728222.9.2.225

Two-step model of leukocyte-endothelial cell interaction in inflammation: distinct roles for LECAM-1 and the leukocyte beta 2 integrins in vivo

21 January 2018

1 reference

https://api.crossref.org/works/10.1517%2F14728222.9.2.225

Traffic signals for lymphocyte recirculation and leukocyte emigration: the multistep paradigm

21 January 2018

1 reference

https://api.crossref.org/works/10.1517%2F14728222.9.2.225

Lymphocyte homing and homeostasis

21 January 2018

1 reference

https://api.crossref.org/works/10.1517%2F14728222.9.2.225

21 January 2018

1 reference

https://api.crossref.org/works/10.1517%2F14728222.9.2.225

GMP-140, a platelet alpha-granule membrane protein, is also synthesized by vascular endothelial cells and is localized in Weibel-Palade bodies

21 January 2018

1 reference

https://api.crossref.org/works/10.1517%2F14728222.9.2.225

Endothelial leukocyte adhesion molecule 1: an inducible receptor for neutrophils related to complement regulatory proteins and lectins

21 January 2018

1 reference

https://api.crossref.org/works/10.1517%2F14728222.9.2.225

Induction and detection of a human endothelial activation antigen in vivo

21 January 2018

1 reference

https://api.crossref.org/works/10.1517%2F14728222.9.2.225

From rolling to arrest on blood vessels: leukocyte tap dancing on endothelial integrin ligands and chemokines at sub-second contacts.

21 January 2018

1 reference

https://api.crossref.org/works/10.1517%2F14728222.9.2.225

Characterization of E-selectin-deficient mice: demonstration of overlapping function of the endothelial selectins.

21 January 2018

1 reference

https://api.crossref.org/works/10.1517%2F14728222.9.2.225

Anti-E-selectin is ineffective in the treatment of psoriasis: a randomized trial

21 January 2018

1 reference

https://api.crossref.org/works/10.1517%2F14728222.9.2.225

Efomycine M, a new specific inhibitor of selectin, impairs leukocyte adhesion and alleviates cutaneous inflammation

21 January 2018

1 reference

https://api.crossref.org/works/10.1517%2F14728222.9.2.225

Characterization of the rapid proteolytic shedding of murine L-selectin

21 January 2018

1 reference

https://api.crossref.org/works/10.1517%2F14728222.9.2.225

ADAM17 but not ADAM10 mediates tumor necrosis factor-alpha and L-selectin shedding from leukocyte membranes

21 January 2018

1 reference

https://api.crossref.org/works/10.1517%2F14728222.9.2.225

Relevance of L-selectin shedding for leukocyte rolling in vivo

21 January 2018

1 reference

https://api.crossref.org/works/10.1517%2F14728222.9.2.225

L-selectin shedding regulates leukocyte recruitment

21 January 2018

1 reference

https://api.crossref.org/works/10.1517%2F14728222.9.2.225

Cutaneous lymphocyte antigen is a specialized form of PSGL-1 expressed on skin-homing T cells

21 January 2018

1 reference

https://api.crossref.org/works/10.1517%2F14728222.9.2.225

ELAM-1 is an adhesion molecule for skin-homing T cells

21 January 2018

1 reference

https://api.crossref.org/works/10.1517%2F14728222.9.2.225

alpha 4 integrins mediate lymphocyte attachment and rolling under physiologic flow

21 January 2018

1 reference

https://api.crossref.org/works/10.1517%2F14728222.9.2.225

Role of blood platelets in infection and inflammation

21 January 2018

1 reference

https://api.crossref.org/works/10.1517%2F14728222.9.2.225

CCL27-CCR10 interactions regulate T cell-mediated skin inflammation

21 January 2018

1 reference

https://api.crossref.org/works/10.1517%2F14728222.9.2.225

Cell adhesion and polarity during immune interactions

21 January 2018

1 reference

https://api.crossref.org/works/10.1517%2F14728222.9.2.225

Beta2 integrins are required for skin homing of primed T cells but not for priming naive T cells

21 January 2018

1 reference

https://api.crossref.org/works/10.1517%2F14728222.9.2.225

Marked synergism between tumor necrosis factor-alpha and interferon-gamma in regulation of keratinocyte-derived adhesion molecules and chemotactic factors

21 January 2018

1 reference

https://api.crossref.org/works/10.1517%2F14728222.9.2.225

Inducibility and expression of microvascular endothelial adhesion molecules in lesional, perilesional, and uninvolved skin of psoriatic patients

21 January 2018

1 reference

https://api.crossref.org/works/10.1517%2F14728222.9.2.225

PECAM-1 (CD31) Cloning and Relation to Adhesion Molecules of the Immunoglobulin Gene Superfamily

21 January 2018

1 reference

https://api.crossref.org/works/10.1517%2F14728222.9.2.225

Monoclonal antibody to murine PECAM-1 (CD31) blocks acute inflammation in vivo

21 January 2018

1 reference

https://api.crossref.org/works/10.1517%2F14728222.9.2.225

Migration of monocytes across endothelium and passage through extracellular matrix involve separate molecular domains of PECAM-1

21 January 2018

1 reference

https://api.crossref.org/works/10.1517%2F14728222.9.2.225

Leukocyte recruitment in the cerebrospinal fluid of mice with experimental meningitis is inhibited by an antibody to junctional adhesion molecule (JAM).

21 January 2018

1 reference

https://api.crossref.org/works/10.1517%2F14728222.9.2.225

Junctional adhesion molecule, a novel member of the immunoglobulin superfamily that distributes at intercellular junctions and modulates monocyte transmigration

21 January 2018

1 reference

https://api.crossref.org/works/10.1517%2F14728222.9.2.225

Antibodies to the junctional adhesion molecule cause disruption of endothelial cells and do not prevent leukocyte influx into the meninges after viral or bacterial infection.

21 January 2018

1 reference

https://api.crossref.org/works/10.1517%2F14728222.9.2.225

Heterogeneity of endothelial junctions is reflected by differential expression and specific subcellular localization of the three JAM family members

21 January 2018

1 reference

https://api.crossref.org/works/10.1517%2F14728222.9.2.225

JAM2 interacts with alpha4beta1. Facilitation by JAM3

21 January 2018

1 reference

https://api.crossref.org/works/10.1517%2F14728222.9.2.225

VLA proteins in the integrin family: structures, functions, and their role on leukocytes

21 January 2018

1 reference

https://api.crossref.org/works/10.1517%2F14728222.9.2.225

Integrins: versatility, modulation, and signaling in cell adhesion

21 January 2018

1 reference

https://api.crossref.org/works/10.1517%2F14728222.9.2.225

CD44 is necessary for optimal contact allergic responses but is not required for normal leukocyte extravasation

21 January 2018

1 reference

https://api.crossref.org/works/10.1517%2F14728222.9.2.225

Epiligrin, a component of epithelial basement membranes, is an adhesive ligand for alpha 3 beta 1 positive T lymphocytes

21 January 2018

1 reference

https://api.crossref.org/works/10.1517%2F14728222.9.2.225

A family of beta 7 integrins on human mucosal lymphocytes

21 January 2018

1 reference

https://api.crossref.org/works/10.1517%2F14728222.9.2.225

Adhesion between epithelial cells and T lymphocytes mediated by E-cadherin and the alpha E beta 7 integrin

21 January 2018

1 reference

https://api.crossref.org/works/10.1517%2F14728222.9.2.225

Recognition of E-cadherin on epithelial cells by the mucosal T cell integrin alpha M290 beta 7 (alpha E beta 7).

21 January 2018

1 reference

https://api.crossref.org/works/10.1517%2F14728222.9.2.225

T-lymphocyte-epithelial-cell interactions: integrin alpha(E)(CD103)beta(7), LEEP-CAM and chemokines.

21 January 2018

1 reference

https://api.crossref.org/works/10.1517%2F14728222.9.2.225

Mechanisms of binding of cutaneous lymphocyte-associated antigen-positive and alphaebeta7-positive lymphocytes to oral and skin keratinocytes

21 January 2018

1 reference

https://api.crossref.org/works/10.1517%2F14728222.9.2.225

Adhesion of T lymphoblasts to epidermal keratinocytes is regulated by interferon gamma and is mediated by intercellular adhesion molecule 1 (ICAM-1).

21 January 2018

1 reference

https://api.crossref.org/works/10.1517%2F14728222.9.2.225

The state of differentiation of cultured human keratinocytes determines the level of intercellular adhesion molecule-1 (ICAM-1) expression induced by gamma interferon

21 January 2018

1 reference

https://api.crossref.org/works/10.1517%2F14728222.9.2.225

Epidermal expression of intercellular adhesion molecule 1 is not a primary inducer of cutaneous inflammation in transgenic mice

21 January 2018

1 reference

https://api.crossref.org/works/10.1517%2F14728222.9.2.225

Investigation of epidermotropism in canine mycosis fungoides: expression of intercellular adhesion molecule-1 (ICAM-1) and beta-2 integrins.

21 January 2018

1 reference

https://api.crossref.org/works/10.1517%2F14728222.9.2.225

The ICAM-3/LFA-1 interaction is critical for epidermal Langerhans cell alloantigen presentation to CD4+ T cells

21 January 2018

1 reference

https://api.crossref.org/works/10.1517%2F14728222.9.2.225

21 January 2018

Chemokines and disease

1 reference

https://api.crossref.org/works/10.1517%2F14728222.9.2.225

Molecular mechanisms that control leukocyte extravasation: the selectins and the chemokines.

21 January 2018

1 reference

https://api.crossref.org/works/10.1517%2F14728222.9.2.225

Chemokines: a new classification system and their role in immunity

21 January 2018

1 reference

https://api.crossref.org/works/10.1517%2F14728222.9.2.225

Subsecond induction of alpha4 integrin clustering by immobilized chemokines stimulates leukocyte tethering and rolling on endothelial vascular cell adhesion molecule 1 under flow conditions

21 January 2018

1 reference

https://api.crossref.org/works/10.1517%2F14728222.9.2.225

Chemokines and the arrest of lymphocytes rolling under flow conditions.

21 January 2018

1 reference

https://api.crossref.org/works/10.1517%2F14728222.9.2.225

Chemokines: immunology's high impact factors

21 January 2018

1 reference

https://api.crossref.org/works/10.1517%2F14728222.9.2.225

The alpha 4-integrin supports leukocyte rolling and adhesion in chronically inflamed postcapillary venules in vivo

21 January 2018

1 reference

https://api.crossref.org/works/10.1517%2F14728222.9.2.225

Distinct roles of L-selectin and integrins alpha 4 beta 7 and LFA-1 in lymphocyte homing to Peyer's patch-HEV in situ: the multistep model confirmed and refined

21 January 2018

1 reference

https://api.crossref.org/works/10.1517%2F14728222.9.2.225

Mutational evidence for control of cell adhesion through integrin diffusion/clustering, independent of ligand binding

21 January 2018

1 reference

https://api.crossref.org/works/10.1517%2F14728222.9.2.225

Adapters in lymphocyte signaling

21 January 2018

1 reference

https://api.crossref.org/works/10.1517%2F14728222.9.2.225

Integrin-associated protein (CD47/IAP) contributes to T cell arrest on inflammatory vascular endothelium under flow

21 January 2018

1 reference

https://api.crossref.org/works/10.1517%2F14728222.9.2.225

Leukocyte polarization in cell migration and immune interactions

21 January 2018

1 reference

https://api.crossref.org/works/10.1517%2F14728222.9.2.225

CC chemokine receptor (CCR)4 and the CCR10 ligand cutaneous T cell-attracting chemokine (CTACK) in lymphocyte trafficking to inflamed skin

21 January 2018

1 reference

https://api.crossref.org/works/10.1517%2F14728222.9.2.225

Endothelial chemokines destabilize L-selectin-mediated lymphocyte rolling without inducing selectin shedding

21 January 2018

1 reference

https://api.crossref.org/works/10.1517%2F14728222.9.2.225

Chemoattractants induce a rapid and transient upregulation of monocyte alpha4 integrin affinity for vascular cell adhesion molecule 1 which mediates arrest: an early step in the process of emigration

21 January 2018

1 reference

https://api.crossref.org/works/10.1517%2F14728222.9.2.225

The BBXB motif of RANTES is the principal site for heparin binding and controls receptor selectivity

21 January 2018

1 reference

https://api.crossref.org/works/10.1517%2F14728222.9.2.225

T cell adhesion to endothelium: the FRC conduit system and other anatomic and molecular features which facilitate the adhesion cascade in lymph node

21 January 2018

1 reference

https://api.crossref.org/works/10.1517%2F14728222.9.2.225

The CCR7 ligand elc (CCL19) is transcytosed in high endothelial venules and mediates T cell recruitment

21 January 2018

1 reference

https://api.crossref.org/works/10.1517%2F14728222.9.2.225

Glycosaminoglycans interact selectively with chemokines and modulate receptor binding and cellular responses

21 January 2018

1 reference

https://api.crossref.org/works/10.1517%2F14728222.9.2.225

Multistep navigation and the combinatorial control of leukocyte chemotaxis

21 January 2018

1 reference

https://api.crossref.org/works/10.1517%2F14728222.9.2.225

Differential regulation of thymus- and activation-regulated chemokine induced by IL-4, IL-13, TNF-alpha and IFN-gamma in human keratinocyte and fibroblast

21 January 2018

1 reference

https://api.crossref.org/works/10.1517%2F14728222.9.2.225

The molecular basis of lymphocyte recruitment to the skin: clues for pathogenesis and selective therapies of inflammatory disorders

21 January 2018

1 reference

https://api.crossref.org/works/10.1517%2F14728222.9.2.225

The alpha(1,3)fucosyltransferases FucT-IV and FucT-VII exert collaborative control over selectin-dependent leukocyte recruitment and lymphocyte homing

21 January 2018

1 reference

https://api.crossref.org/works/10.1517%2F14728222.9.2.225

High-level expression and purification of a recombinant human alpha-1, 3-fucosyltransferase in baculovirus-infected insect cells.

21 January 2018

1 reference

https://api.crossref.org/works/10.1517%2F14728222.9.2.225

Chemokines, chemokine receptors and small-molecule antagonists: recent developments

21 January 2018

1 reference

https://api.crossref.org/works/10.1517%2F14728222.9.2.225

Chemokine receptors in airway disease: which receptors to target?

21 January 2018

1 reference

https://api.crossref.org/works/10.1517%2F14728222.9.2.225

Therapeutic intervention with inhibitors of co-stimulatory pathways in autoimmune disease

21 January 2018

1 reference

https://api.crossref.org/works/10.1517%2F14728222.9.2.225

The cutaneous lymphocyte antigen is a skin lymphocyte homing receptor for the vascular lectin endothelial cell-leukocyte adhesion molecule 1

21 January 2018

1 reference

https://api.crossref.org/works/10.1517%2F14728222.9.2.225

L-selectin dimerization enhances tether formation to properly spaced ligand

21 January 2018

1 reference

https://api.crossref.org/works/10.1517%2F14728222.9.2.225

Platelet-mediated lymphocyte delivery to high endothelial venules

21 January 2018

1 reference

https://api.crossref.org/works/10.1517%2F14728222.9.2.225

Circulating activated platelets reconstitute lymphocyte homing and immunity in L-selectin-deficient mice.

21 January 2018

1 reference

https://api.crossref.org/works/10.1517%2F14728222.9.2.225

Activated, not resting, platelets increase leukocyte rolling in murine skin utilizing a distinct set of adhesion molecules

21 January 2018

1 reference

https://api.crossref.org/works/10.1517%2F14728222.9.2.225

Lymphocyte traffic control by chemokines

21 January 2018

1 reference

https://api.crossref.org/works/10.1517%2F14728222.9.2.225

The ligands of CXC chemokine receptor 3, I-TAC, Mig, and IP10, are natural antagonists for CCR3

21 January 2018

1 reference

https://api.crossref.org/works/10.1517%2F14728222.9.2.225

Therapeutic potential of a novel synthetic selectin blocker, OJ-R9188, in allergic dermatitis

21 January 2018

1 reference

https://api.crossref.org/works/10.1517%2F14728222.9.2.225

Identification and characterization of small molecule functional antagonists of the CCR1 chemokine receptor

21 January 2018

1 reference

https://api.crossref.org/works/10.1517%2F14728222.9.2.225

CCR2B receptor antagonists: conversion of a weak HTS hit to a potent lead compound

21 January 2018

1 reference

https://api.crossref.org/works/10.1517%2F14728222.9.2.225

Identification of the binding site for a novel class of CCR2b chemokine receptor antagonists: binding to a common chemokine receptor motif within the helical bundle

21 January 2018

1 reference

https://api.crossref.org/works/10.1517%2F14728222.9.2.225

Chemokines in pathology and medicine

21 January 2018

1 reference

https://api.crossref.org/works/10.1517%2F14728222.9.2.225

Emerging drugs in psoriasis

21 January 2018

1 reference

https://api.crossref.org/works/10.1517%2F14728222.9.2.225

Potential therapeutic role for cytokine or adhesion molecule manipulation in Crohn's disease: in the shadow of infliximab?

21 January 2018

1 reference

https://api.crossref.org/works/10.1517%2F14728222.9.2.225

Novel mimics of sialyl Lewis X: design, synthesis and biological activity of a series of 2- and 3-malonate substituted galactoconjugates

21 January 2018

1 reference

https://api.crossref.org/works/10.1517%2F14728222.9.2.225

Synthesis of sialyl Lewis(x) mimics. Modifications of the 6-position of galactose

21 January 2018

1 reference

https://api.crossref.org/works/10.1517%2F14728222.9.2.225

Multiple selectin blockade with a small-molecule selectin inhibitor does not affect survival after a second inflammatory challenge with nonlethal LPS.

21 January 2018

1 reference

https://api.crossref.org/works/10.1517%2F14728222.9.2.225

The kinetics and shear threshold of transient and rolling interactions of L-selectin with its ligand on leukocytes

21 January 2018

1 reference

https://api.crossref.org/works/10.1517%2F14728222.9.2.225

Adhesion molecules as therapeutic targets for autoimmune diseases and transplant rejection

21 January 2018

1 reference

https://api.crossref.org/works/10.1517%2F14728222.9.2.225

Inhibition of LFA-1/ICAM-1 and VLA-4/VCAM-1 as a therapeutic approach to inflammation and autoimmune diseases

21 January 2018

1 reference

https://api.crossref.org/works/10.1517%2F14728222.9.2.225

The effect of blockade of the CD11/CD18 integrin receptor on infarct size in patients with acute myocardial infarction treated with direct angioplasty: the results of the HALT-MI study

21 January 2018

1 reference

https://api.crossref.org/works/10.1517%2F14728222.9.2.225

21 January 2018

1 reference

https://api.crossref.org/works/10.1517%2F14728222.9.2.225

Double blind, placebo controlled trial of the remission inducing and steroid sparing properties of an ICAM-1 antisense oligodeoxynucleotide, alicaforsen (ISIS 2302), in active steroid dependent Crohn's disease

21 January 2018

1 reference

https://api.crossref.org/works/10.1517%2F14728222.9.2.225

Pulmonary eosinophilia in a murine model of allergic inflammation is attenuated by small molecule alpha4beta1 antagonists

21 January 2018

1 reference

https://api.crossref.org/works/10.1517%2F14728222.9.2.225

Antiadhesion molecule therapy in inflammatory bowel disease

21 January 2018

1 reference

https://api.crossref.org/works/10.1517%2F14728222.9.2.225

VLA-4 antagonists: potent inhibitors of lymphocyte migration

21 January 2018

1 reference

https://api.crossref.org/works/10.1517%2F14728222.9.2.225

Selective, tight-binding inhibitors of integrin alpha4beta1 that inhibit allergic airway responses

21 January 2018

1 reference

https://api.crossref.org/works/10.1517%2F14728222.9.2.225

Transcytosis and Surface Presentation of IL-8 by Venular Endothelial Cells

21 January 2018

1 reference

https://api.crossref.org/works/10.1517%2F14728222.9.2.225

Glycosaminoglycans Mediate Cell Surface Oligomerization of Chemokines

21 January 2018

1 reference

https://api.crossref.org/works/10.1517%2F14728222.9.2.225

21 January 2018

Identifiers

DOI

10.1517/14728222.9.2.225

1 reference

12 August 2017

1 reference