(Q36160691)

https://www.ebi.ac.uk/europepmc/webservices/rest/search?query=EXT_ID:26384421%20AND%20SRC:MED&resulttype=core&format=json

24 February 2020

title

Structure and specificity of the RNA-guided endonuclease Cas9 during DNA interrogation, target binding and cleavage (English)

1 reference

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24 February 2020

0 references

1

1 reference

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24 February 2020

6

Piotr E Marszalek

1 reference

https://www.ebi.ac.uk/europepmc/webservices/rest/search?query=EXT_ID:26384421%20AND%20SRC:MED&resulttype=core&format=json

24 February 2020

author name string

D Dewran Kocak

2

1 reference

https://www.ebi.ac.uk/europepmc/webservices/rest/search?query=EXT_ID:26384421%20AND%20SRC:MED&resulttype=core&format=json

24 February 2020

Christopher J Fitzgibbon

3

1 reference

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24 February 2020

Joshua McMenemy

4

1 reference

https://www.ebi.ac.uk/europepmc/webservices/rest/search?query=EXT_ID:26384421%20AND%20SRC:MED&resulttype=core&format=json

24 February 2020

Charles A Gersbach

5

1 reference

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24 February 2020

language of work or name

English

0 references

publication date

17 September 2015

1 reference

https://www.ebi.ac.uk/europepmc/webservices/rest/search?query=EXT_ID:26384421%20AND%20SRC:MED&resulttype=core&format=json

24 February 2020

published in

Nucleic Acids Research

1 reference

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24 February 2020

volume

43

1 reference

https://www.ebi.ac.uk/europepmc/webservices/rest/search?query=EXT_ID:26384421%20AND%20SRC:MED&resulttype=core&format=json

24 February 2020

issue

18

1 reference

https://www.ebi.ac.uk/europepmc/webservices/rest/search?query=EXT_ID:26384421%20AND%20SRC:MED&resulttype=core&format=json

24 February 2020

page(s)

8924-8941

1 reference

https://www.ebi.ac.uk/europepmc/webservices/rest/search?query=EXT_ID:26384421%20AND%20SRC:MED&resulttype=core&format=json

Creative Commons Attribution 4.0 International

24 February 2020

copyright license

start time

7 November 2016

1 reference

April 2022 Public Data File from Crossref

copyright status

copyrighted

0 references

cites work

STRUCTURAL BIOLOGY. A Cas9-guide RNA complex preorganized for target DNA recognition

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=4605321

Engineered CRISPR-Cas9 nucleases with altered PAM specificities

2 October 2017

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=4605321

CRISPR immunity drives rapid phage genome evolution in Streptococcus thermophilus

2 October 2017

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=4605321

Epigenome editing by a CRISPR-Cas9-based acetyltransferase activates genes from promoters and enhancers.

2 October 2017

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=4605321

Protected DNA strand displacement for enhanced single nucleotide discrimination in double-stranded DNA.

2 October 2017

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=4605321

GUIDE-seq enables genome-wide profiling of off-target cleavage by CRISPR-Cas nucleases

2 October 2017

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=4605321

Genome editing. The new frontier of genome engineering with CRISPR-Cas9

2 October 2017

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=4605321

Protospacer adjacent motif (PAM)-distal sequences engage CRISPR Cas9 DNA target cleavage.

2 October 2017

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=4605321

Rational design of highly active sgRNAs for CRISPR-Cas9-mediated gene inactivation.

2 October 2017

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=4605321

Structural basis of PAM-dependent target DNA recognition by the Cas9 endonuclease

2 October 2017

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=4605321

Direct observation of R-loop formation by single RNA-guided Cas9 and Cascade effector complexes.

2 October 2017

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=4605321

Development and applications of CRISPR-Cas9 for genome engineering

2 October 2017

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=4605321

Genome-wide analysis reveals characteristics of off-target sites bound by the Cas9 endonuclease.

2 October 2017

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=4605321

Genome-wide binding of the CRISPR endonuclease Cas9 in mammalian cells

2 October 2017

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=4605321

Crystal Structure of Cas9 in Complex with Guide RNA and Target DNA

2 October 2017

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=4605321

Structures of Cas9 Endonucleases Reveal RNA-Mediated Conformational Activation

2 October 2017

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=4605321

DNA interrogation by the CRISPR RNA-guided endonuclease Cas9.

2 October 2017

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=4605321

Improving CRISPR-Cas nuclease specificity using truncated guide RNAs

2 October 2017

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=4605321

Cas9 as a versatile tool for engineering biology

2 October 2017

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=4605321

Double nicking by RNA-guided CRISPR Cas9 for enhanced genome editing specificity

2 October 2017

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=4605321

CRISPR RNA-guided activation of endogenous human genes

2 October 2017

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=4605321

RNA-guided gene activation by CRISPR-Cas9-based transcription factors

2 October 2017

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=4605321

DNA targeting specificity of RNA-guided Cas9 nucleases

2 October 2017

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=4605321

CRISPR-mediated modular RNA-guided regulation of transcription in eukaryotes

2 October 2017

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=4605321

Repurposing CRISPR as an RNA-guided platform for sequence-specific control of gene expression

2 October 2017

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=4605321

RNA-guided human genome engineering via Cas9

2 October 2017

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=4605321

Multiplex genome engineering using CRISPR/Cas systems

2 October 2017

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=4605321

Phage mutations in response to CRISPR diversification in a bacterial population

2 October 2017

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=4605321

Cas9-crRNA ribonucleoprotein complex mediates specific DNA cleavage for adaptive immunity in bacteria

2 October 2017

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=4605321

A Programmable Dual-RNA-Guided DNA Endonuclease in Adaptive Bacterial Immunity

2 October 2017

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=4605321

Thermodynamic contributions of single internal rA·dA, rC·dC, rG·dG and rU·dT mismatches in RNA/DNA duplexes

2 October 2017

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=4605321

Programming biomolecular self-assembly pathways

2 October 2017

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=4605321

CRISPR Provides Acquired Resistance Against Viruses in Prokaryotes

2 October 2017

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=4605321

A monovalent streptavidin with a single femtomolar biotin binding site

2 October 2017

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=4605321

Determination of protein-DNA binding constants and specificities from statistical analyses of single molecules: MutS-DNA interactions

2 October 2017

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=4605321

Monte Carlo simulation for single RNA unfolding by force

2 October 2017

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=4605321

Triggered amplification by hybridization chain reaction

2 October 2017

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=4605321

RNA folding at elementary step resolution

2 October 2017

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=4605321

DNA hairpins destabilize duplexes primarily by promoting melting rather than by inhibiting hybridization.

2 October 2017

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=4605321

Unbiased detection of off-target cleavage by CRISPR-Cas9 and TALENs using integrase-defective lentiviral vectors.

2 July 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=4605321

Genome-wide identification of CRISPR/Cas9 off-targets in human genome

2 July 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=4605321

Silatrane-based surface chemistry for immobilization of DNA, protein-DNA complexes and other biological materials

2 July 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=4605321

Three-dimensional reconstruction of single particles embedded in ice

2 July 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=4605321

Flexible guide-RNA design for CRISPR applications using Protospacer Workbench.

2 July 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=4605321

Directional R-Loop Formation by the CRISPR-Cas Surveillance Complex Cascade Provides Efficient Off-Target Site Rejection.

23 September 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=4605321

Programmable energy landscapes for kinetic control of DNA strand displacement.

23 September 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=4605321

Guide RNA functional modules direct Cas9 activity and orthogonality

23 September 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=4605321

Machine learning. Clustering by fast search and find of density peaks.

23 September 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=4605321

High flexibility of DNA on short length scales probed by atomic force microscopy.

23 September 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=4605321

Relative thermodynamic stability of DNA, RNA, and DNA:RNA hybrid duplexes: relationship with base composition and structure.

23 September 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=4605321

A general method for numerically simulating the stochastic time evolution of coupled chemical reactions

23 September 2018

1 reference

Crossref

https://api.crossref.org/works/10.1093%2FNAR%2FGKV892

Improved nearest-neighbor parameters for predicting DNA duplex stability

21 January 2018

1 reference

PubMed

https://pubmed.ncbi.nlm.nih.gov/26384421

inferred from PubMed ID database lookup

12 December 2020

based on heuristic

Thermodynamic parameters to predict stability of RNA/DNA hybrid duplexes

1 reference

PubMed

https://pubmed.ncbi.nlm.nih.gov/26384421

inferred from PubMed ID database lookup

12 December 2020

based on heuristic

Thermodynamics-structure relationship of single mismatches in RNA/DNA duplexes

1 reference

PubMed

https://pubmed.ncbi.nlm.nih.gov/26384421

inferred from PubMed ID database lookup

12 December 2020

based on heuristic

Identifiers

DOI

10.1093/NAR/GKV892

1 reference

https://www.ebi.ac.uk/europepmc/webservices/rest/search?query=EXT_ID:26384421%20AND%20SRC:MED&resulttype=core&format=json

24 February 2020

1 reference

https://www.ebi.ac.uk/europepmc/webservices/rest/search?query=EXT_ID:26384421%20AND%20SRC:MED&resulttype=core&format=json

24 February 2020

PubMed publication ID

26384421

1 reference

https://www.ebi.ac.uk/europepmc/webservices/rest/search?query=EXT_ID:26384421%20AND%20SRC:MED&resulttype=core&format=json