(Q36203193)

12 August 2017

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title

Mechanism of action of bisphosphonates (English)

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12 August 2017

Alfred A Reszka

1

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12 August 2017

Gideon A Rodan

series ordinal

2

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12 August 2017

publication date

1 September 2003

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Current osteoporosis reports

12 August 2017

published in

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12 August 2017

volume

1

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12 August 2017

issue

2

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12 August 2017

page(s)

45-52

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Rac-GTPase, osteoclast cytoskeleton and bone resorption

12 August 2017

cites work

1 reference

Crossref

https://api.crossref.org/works/10.1007%2FS11914-003-0008-5

The small GTP-binding protein, rho p21, is involved in bone resorption by regulating cytoskeletal organization in osteoclasts.

21 January 2018

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12 December 2020

Bisphosphonate mechanism of action

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12 December 2020

Protein geranylgeranylation is required for osteoclast formation, function, and survival: inhibition by bisphosphonates and GGTI-298.

1 reference

12 December 2020

Heterocycle-containing bisphosphonates cause apoptosis and inhibit bone resorption by preventing protein prenylation: evidence from structure-activity relationships in J774 macrophages.

1 reference

12 December 2020

Structural requirements for bisphosphonate actions in vitro

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12 December 2020

The molecular mechanism of action of the antiresorptive and antiinflammatory drug clodronate: evidence for the formation in vivo of a metabolite that inhibits bone resorption and causes osteoclast and macrophage apoptosis

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12 December 2020

Farnesol and geranylgeraniol prevent activation of caspases by aminobisphosphonates: biochemical evidence for two distinct pharmacological classes of bisphosphonate drugs

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12 December 2020

Alendronate disturbs vesicular trafficking in osteoclasts

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12 December 2020

Alendronate distributed on bone surfaces inhibits osteoclastic bone resorption in vitro and in experimental hypercalcemia models

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12 December 2020

Further insight into mechanism of action of clodronate: inhibition of mitochondrial ADP/ATP translocase by a nonhydrolyzable, adenine-containing metabolite.

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12 December 2020

Antagonistic effects of different classes of bisphosphonates in osteoclasts and macrophages in vitro.

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12 December 2020

In vivo effects of bisphosphonates on the osteoclast mevalonate pathway

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12 December 2020

Acid extrusion is induced by osteoclast attachment to bone. Inhibition by alendronate and calcitonin

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12 December 2020

Removal of osteoclast bone resorption products by transcytosis

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12 December 2020

The effects of bisphosphonates on the resorption cycle of isolated osteoclasts

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12 December 2020

Rho-A is critical for osteoclast podosome organization, motility, and bone resorption

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12 December 2020

Isoprenoid (phosphinylmethyl)phosphonates as inhibitors of squalene synthetase

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12 December 2020

Mapping of MST1 kinase sites of phosphorylation. Activation and autophosphorylation

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12 December 2020

A possible mechanism of the specific action of bisphosphonates on osteoclasts: tiludronate preferentially affects polarized osteoclasts having ruffled borders

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12 December 2020

Clodronate and liposome-encapsulated clodronate are metabolized to a toxic ATP analog, adenosine 5'-(beta, gamma-dichloromethylene) triphosphate, by mammalian cells in vitro.

1 reference

12 December 2020

Structure-activity relationships for inhibition of farnesyl diphosphate synthase in vitro and inhibition of bone resorption in vivo by nitrogen-containing bisphosphonates.

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12 December 2020

An ultrastructural study of the effects of bisphosphonate administration on osteoclastic bone resorption during relapse of experimentally moved rat molars

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12 December 2020

Caspase-mediated activation and induction of apoptosis by the mammalian Ste20-like kinase Mst1

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12 December 2020

Farnesyl pyrophosphate synthase is the molecular target of nitrogen-containing bisphosphonates

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12 December 2020

Bisphosphonate mechanism of action

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12 December 2020

Effect of ethane-1-hydroxy-1,1-diphosphonate (EHDP) and dichloromethylene diphosphonate (Cl 2 MDP) on the calcification and resorption of cartilage and bone in the tibial epiphysis and metaphysis of rats

1 reference

12 December 2020

Post-translational processing of RhoA. Carboxyl methylation of the carboxyl-terminal prenylcysteine increases the half-life of Rhoa

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12 December 2020

Bisphosphonates promote apoptosis in murine osteoclasts in vitro and in vivo

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12 December 2020

Nitrogen-containing bisphosphonates inhibit the mevalonate pathway and prevent post-translational prenylation of GTP-binding proteins, including Ras.

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12 December 2020

Bisphosphonates suppress bone resorption by a direct effect on early osteoclast precursors without affecting the osteoclastogenic capacity of osteogenic cells: the role of protein geranylgeranylation in the action of nitrogen-containing bisphosphona

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12 December 2020

Compactin suppresses bone resorption by inhibiting the fusion of prefusion osteoclasts and disrupting the actin ring in osteoclasts.

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12 December 2020

Alendronate is a specific, nanomolar inhibitor of farnesyl diphosphate synthase

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12 December 2020

Bisphosphonates act directly on the osteoclast to induce caspase cleavage of mst1 kinase during apoptosis. A link between inhibition of the mevalonate pathway and regulation of an apoptosis-promoting kinase

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12 December 2020

Characteristics of clodronate-induced apoptosis in osteoclasts and macrophages.

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12 December 2020

The role of geranylgeranylation in bone resorption and its suppression by bisphosphonates in fetal bone explants in vitro: A clue to the mechanism of action of nitrogen-containing bisphosphonates

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12 December 2020

Bisphosphonate acts on osteoclasts independent of ruffled borders in osteosclerotic (oc/oc) mice.

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12 December 2020

Intracellular membrane trafficking pathways in bone-resorbing osteoclasts revealed by cloning and subcellular localization studies of small GTP-binding rab proteins

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12 December 2020

Comparison of the distribution of 3H-alendronate and 3H-etidronate in rat and mouse bones

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12 December 2020

Inhibition of bone resorption by alendronate and risedronate does not require osteoclast apoptosis

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12 December 2020

Identification of adenine nucleotide-containing metabolites of bisphosphonate drugs using ion-pair liquid chromatography-electrospray mass spectrometry.

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12 December 2020

Alendronate mechanism of action: geranylgeraniol, an intermediate in the mevalonate pathway, prevents inhibition of osteoclast formation, bone resorption, and kinase activation in vitro

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12 December 2020

Downregulation of small GTPase Rab7 impairs osteoclast polarization and bone resorption

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12 December 2020

Bisphosphonate action. Alendronate localization in rat bone and effects on osteoclast ultrastructure

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12 December 2020

10.1007/S11914-003-0008-5

Identifiers

DOI

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12 August 2017

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