(Q73011879)

https://www.ebi.ac.uk/europepmc/webservices/rest/search?query=EXT_ID:12590887%20AND%20SRC:MED&resulttype=core&format=json

31 October 2019

review article

1 reference

title

Bisphosphonate mechanism of action (English)

1 reference

https://www.ebi.ac.uk/europepmc/webservices/rest/search?query=EXT_ID:12590887%20AND%20SRC:MED&resulttype=core&format=json

31 October 2019

author name string

Alfred A Reszka

series ordinal

1

1 reference

https://www.ebi.ac.uk/europepmc/webservices/rest/search?query=EXT_ID:12590887%20AND%20SRC:MED&resulttype=core&format=json

31 October 2019

Gideon A Rodan

series ordinal

2

1 reference

https://www.ebi.ac.uk/europepmc/webservices/rest/search?query=EXT_ID:12590887%20AND%20SRC:MED&resulttype=core&format=json

31 October 2019

publication date

1 February 2003

1 reference

https://www.ebi.ac.uk/europepmc/webservices/rest/search?query=EXT_ID:12590887%20AND%20SRC:MED&resulttype=core&format=json

Current Rheumatology Reports

31 October 2019

published in

1 reference

https://www.ebi.ac.uk/europepmc/webservices/rest/search?query=EXT_ID:12590887%20AND%20SRC:MED&resulttype=core&format=json

31 October 2019

volume

5

1 reference

https://www.ebi.ac.uk/europepmc/webservices/rest/search?query=EXT_ID:12590887%20AND%20SRC:MED&resulttype=core&format=json

31 October 2019

issue

1

1 reference

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31 October 2019

page(s)

65-74

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https://www.ebi.ac.uk/europepmc/webservices/rest/search?query=EXT_ID:12590887%20AND%20SRC:MED&resulttype=core&format=json

The small GTP-binding protein rho regulates the assembly of focal adhesions and actin stress fibers in response to growth factors

31 October 2019

cites work

1 reference

12 December 2020

Time-dependent changes in biochemical bone markers and serum cholesterol in ovariectomized rats: effects of raloxifene HCl, tamoxifen, estrogen, and alendronate

1 reference

12 December 2020

An enzyme inhibition assay for the quantitative determination of the new bisphosphonate zoledronate in plasma

1 reference

12 December 2020

The small GTP-binding protein, rho p21, is involved in bone resorption by regulating cytoskeletal organization in osteoclasts.

1 reference

12 December 2020

Protein geranylgeranylation is required for osteoclast formation, function, and survival: inhibition by bisphosphonates and GGTI-298.

1 reference

12 December 2020

Preclinical pharmacology of CGP 42'446, a new, potent, heterocyclic bisphosphonate compound

1 reference

12 December 2020

Heterocycle-containing bisphosphonates cause apoptosis and inhibit bone resorption by preventing protein prenylation: evidence from structure-activity relationships in J774 macrophages.

1 reference

12 December 2020

Integrin-mediated signals regulated by members of the rho family of GTPases

1 reference

12 December 2020

Esophagitis associated with the use of alendronate

1 reference

12 December 2020

Alendronate increases bone strength by increasing the mean degree of mineralization of bone tissue in osteoporotic women

1 reference

12 December 2020

Direct stereological estimation of three-dimensional connectivity in rat vertebrae: effect of estrogen, etidronate and risedronate following ovariectomy

1 reference

12 December 2020

The small GTP-binding protein rac regulates growth factor-induced membrane ruffling

1 reference

12 December 2020

Protein prenylation: molecular mechanisms and functional consequences

1 reference

12 December 2020

The bisphosphonate tiludronate is a potent inhibitor of the osteoclast vacuolar H(+)-ATPase

1 reference

12 December 2020

How does alendronate inhibit protein-tyrosine phosphatases?

1 reference

12 December 2020

Alendronate increases skeletal mass of growing rats during unloading by inhibiting resorption of calcified cartilage.

1 reference

12 December 2020

The molecular mechanism of action of the antiresorptive and antiinflammatory drug clodronate: evidence for the formation in vivo of a metabolite that inhibits bone resorption and causes osteoclast and macrophage apoptosis

1 reference

12 December 2020

Farnesol and geranylgeraniol prevent activation of caspases by aminobisphosphonates: biochemical evidence for two distinct pharmacological classes of bisphosphonate drugs

1 reference

12 December 2020

The bisphosphonate alendronate (MK-217) inhibits bone loss due to ovariectomy in rats

1 reference

12 December 2020

An endoscopic comparison of the effects of alendronate and risedronate on upper gastrointestinal mucosae

1 reference

12 December 2020

1,1-Bisphosphonate Squalene Synthase Inhibitors: Interplay Between the Isoprenoid Subunit and the Diphosphate Surrogate

1 reference

12 December 2020

1-Hydroxy-3-(methylpentylamino)-propylidene-1,1-bisphosphonic acid as a potent inhibitor of squalene synthase

1 reference

12 December 2020

Alendronate disturbs vesicular trafficking in osteoclasts

1 reference

12 December 2020

Alendronate distributed on bone surfaces inhibits osteoclastic bone resorption in vitro and in experimental hypercalcemia models

1 reference

12 December 2020

Further insight into mechanism of action of clodronate: inhibition of mitochondrial ADP/ATP translocase by a nonhydrolyzable, adenine-containing metabolite.

1 reference

12 December 2020

Human osteoclast formation and activity in vitro: effects of alendronate.

1 reference

12 December 2020

Bisphosphonates used for the treatment of bone disorders inhibit squalene synthase and cholesterol biosynthesis.

1 reference

12 December 2020

Bisphosphonates directly inhibit the bone resorption activity of isolated avian osteoclasts in vitro

1 reference

12 December 2020

Effects of bisphosphonates on isolated rat osteoclasts as examined by reflected light microscopy

1 reference

12 December 2020

In vivo effects of bisphosphonates on the osteoclast mevalonate pathway

1 reference

12 December 2020

Lipophilic 1,1-bisphosphonates are potent squalene synthase inhibitors and orally active cholesterol lowering agents in vivo

1 reference

12 December 2020

Lovastatin, an inhibitor of cholesterol synthesis, induces hydroxymethylglutaryl-coenzyme A reductase directly on membranes of expanded smooth endoplasmic reticulum in rat hepatocytes

1 reference

12 December 2020

The effects of bisphosphonates on the resorption cycle of isolated osteoclasts

1 reference

12 December 2020

Nitrogen-bisphosphonates block retinoblastoma phosphorylation and cell growth by inhibiting the cholesterol biosynthetic pathway in a keratinocyte model for esophageal irritation.

1 reference

12 December 2020

Human protein tyrosine phosphatase-sigma: alternative splicing and inhibition by bisphosphonates

1 reference

12 December 2020

Isoprenoid (phosphinylmethyl)phosphonates as inhibitors of squalene synthetase

1 reference

12 December 2020

Binding and antiresorptive properties of heterocycle-containing bisphosphonate analogs: structure-activity relationships

1 reference

12 December 2020

A possible mechanism of the specific action of bisphosphonates on osteoclasts: tiludronate preferentially affects polarized osteoclasts having ruffled borders

1 reference

12 December 2020

Clodronate and liposome-encapsulated clodronate are metabolized to a toxic ATP analog, adenosine 5'-(beta, gamma-dichloromethylene) triphosphate, by mammalian cells in vitro.

1 reference

12 December 2020

Tiludronate inhibits protein tyrosine phosphatase activity in osteoclasts.

1 reference

12 December 2020

Structure-activity relationships for inhibition of farnesyl diphosphate synthase in vitro and inhibition of bone resorption in vivo by nitrogen-containing bisphosphonates.

1 reference

12 December 2020

Nitrogen-containing bisphosphonates inhibit isopentenyl pyrophosphate isomerase/farnesyl pyrophosphate synthase activity with relative potencies corresponding to their antiresorptive potencies in vitro and in vivo

1 reference

12 December 2020

Nonclinical model for assessing gastric effects of bisphosphonates

1 reference

12 December 2020

Caspase-mediated activation and induction of apoptosis by the mammalian Ste20-like kinase Mst1

1 reference

12 December 2020

Risedronate reverses bone loss in postmenopausal women with low bone mass: results from a multinational, double-blind, placebo-controlled trial. BMD-MN Study Group

1 reference

12 December 2020

Alendronate induces gastric injury and delays ulcer healing in rodents

1 reference

12 December 2020

Bone mineral density reflects bone mass but also the degree of mineralization of bone: therapeutic implications

1 reference

12 December 2020

Both phosphorylation and caspase-mediated cleavage contribute to regulation of the Ste20-like protein kinase Mst1 during CD95/Fas-induced apoptosis.

1 reference

12 December 2020

Farnesyl pyrophosphate synthase is the molecular target of nitrogen-containing bisphosphonates

1 reference

12 December 2020

The novel cholesterol-lowering drug SR-12813 inhibits cholesterol synthesis via an increased degradation of 3-hydroxy-3-methylglutaryl-coenzyme A reductase

1 reference

12 December 2020

The bisphosphonate incadronate (YM175) causes apoptosis of human myeloma cells in vitro by inhibiting the mevalonate pathway

1 reference

12 December 2020

Nitrogen-containing bisphosphonates induce apoptosis of Caco-2 cells in vitro by inhibiting the mevalonate pathway: a model of bisphosphonate-induced gastrointestinal toxicity.

1 reference

12 December 2020

Effect of ethane-1-hydroxy-1,1-diphosphonate (EHDP) and dichloromethylene diphosphonate (Cl 2 MDP) on the calcification and resorption of cartilage and bone in the tibial epiphysis and metaphysis of rats

1 reference

12 December 2020

Bisphosphonates promote apoptosis in murine osteoclasts in vitro and in vivo

1 reference

12 December 2020

Identification of a novel phosphonocarboxylate inhibitor of Rab geranylgeranyl transferase that specifically prevents Rab prenylation in osteoclasts and macrophages.

1 reference

12 December 2020

Nitrogen-containing bisphosphonates inhibit the mevalonate pathway and prevent post-translational prenylation of GTP-binding proteins, including Ras.

1 reference

12 December 2020

Skeletal benefits of alendronate: 7-year treatment of postmenopausal osteoporotic women. Phase III Osteoporosis Treatment Study Group

1 reference

12 December 2020

Zoledronic acid versus pamidronate in the treatment of skeletal metastases in patients with breast cancer or osteolytic lesions of multiple myeloma: a phase III, double-blind, comparative trial

1 reference

12 December 2020

Alendronate is a specific, nanomolar inhibitor of farnesyl diphosphate synthase

1 reference

12 December 2020

Protein-tyrosine phosphatase activity regulates osteoclast formation and function: inhibition by alendronate

1 reference

12 December 2020

Bisphosphonates act directly on the osteoclast to induce caspase cleavage of mst1 kinase during apoptosis. A link between inhibition of the mevalonate pathway and regulation of an apoptosis-promoting kinase

1 reference

12 December 2020

Comparative study of potential for bisphosphonates to damage gastric mucosa of rats

1 reference

12 December 2020

The role of geranylgeranylation in bone resorption and its suppression by bisphosphonates in fetal bone explants in vitro: A clue to the mechanism of action of nitrogen-containing bisphosphonates

1 reference

12 December 2020

Alendronate increases degree and uniformity of mineralization in cancellous bone and decreases the porosity in cortical bone of osteoporotic women

1 reference

12 December 2020

MST, a physiological caspase substrate, highly sensitizes apoptosis both upstream and downstream of caspase activation

1 reference

12 December 2020

Endoscopic comparison of esophageal and gastroduodenal effects of risedronate and alendronate in postmenopausal women

1 reference

12 December 2020

Protein synthesis is required for caspase activation and induction of apoptosis by bisphosphonate drugs.

1 reference

12 December 2020

Dose-response relationships for alendronate treatment in osteoporotic elderly women. Alendronate Elderly Osteoporosis Study Centers

1 reference

12 December 2020

Comparison of the distribution of 3H-alendronate and 3H-etidronate in rat and mouse bones

1 reference

12 December 2020

Inhibition of bone resorption by alendronate and risedronate does not require osteoclast apoptosis

1 reference

12 December 2020

Alendronate mechanism of action: geranylgeraniol, an intermediate in the mevalonate pathway, prevents inhibition of osteoclast formation, bone resorption, and kinase activation in vitro

1 reference

12 December 2020

SR-12813 lowers plasma cholesterol in beagle dogs by decreasing cholesterol biosynthesis

1 reference

12 December 2020

Nitrogen-containing bisphosphonates as carbocation transition state analogs for isoprenoid biosynthesis

1 reference

12 December 2020

Recent advances in the study of prenylated proteins

1 reference

12 December 2020

Alendronate inhibition of protein-tyrosine-phosphatase-meg1

1 reference

12 December 2020

Bisphosphonate action. Alendronate localization in rat bone and effects on osteoclast ultrastructure

1 reference

12 December 2020