(Q40777493)

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Identification of a novel phosphonocarboxylate inhibitor of Rab geranylgeranyl transferase that specifically prevents Rab prenylation in osteoclasts and macrophages.

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scholarly article

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Europe PubMed Central

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https://www.ebi.ac.uk/europepmc/webservices/rest/search?query=EXT_ID:11581260%20AND%20SRC:MED&resulttype=core&format=json

11 November 2019

Identification of a novel phosphonocarboxylate inhibitor of Rab geranylgeranyl transferase that specifically prevents Rab prenylation in osteoclasts and macrophages (English)

1 reference

Europe PubMed Central

PubMed publication ID

https://www.ebi.ac.uk/europepmc/webservices/rest/search?query=EXT_ID:11581260%20AND%20SRC:MED&resulttype=core&format=json

11 November 2019

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Banafshé Larijani

3

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Europe PubMed Central

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https://www.ebi.ac.uk/europepmc/webservices/rest/search?query=EXT_ID:11581260%20AND%20SRC:MED&resulttype=core&format=json

11 November 2019

James E. Dunford

5

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Europe PubMed Central

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https://www.ebi.ac.uk/europepmc/webservices/rest/search?query=EXT_ID:11581260%20AND%20SRC:MED&resulttype=core&format=json

11 November 2019

Miguel C. Seabra

10

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11 November 2019

Michael J. Rogers

12

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11 November 2019

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Coxon FP

1

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11 November 2019

Helfrich MH

2

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11 November 2019

Muzylak M

4

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11 November 2019

Marshall D

6

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11 November 2019

McKinnon AD

7

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11 November 2019

Nesbitt SA

8

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11 November 2019

Horton MA

9

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11 November 2019

Ebetino FH

11

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11 November 2019

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publication date

1 October 2001

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11 November 2019

number of pages

10

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Journal of Biological Chemistry

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11 November 2019

276

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11 November 2019

51

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11 November 2019

48213-48222

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11 November 2019

Membrane association and targeting of prenylated Ras-like GTPases

1 reference

https://api.crossref.org/works/10.1074%2FJBC.M106473200

21 January 2018

Mechanism of Rab geranylgeranylation: formation of the catalytic ternary complex

1 reference

https://api.crossref.org/works/10.1074%2FJBC.M106473200

21 January 2018

Ras CAAX Peptidomimetic FTI-277 Selectively Blocks Oncogenic Ras Signaling by Inducing Cytoplasmic Accumulation of Inactive Ras-Raf Complexes

1 reference

https://api.crossref.org/works/10.1074%2FJBC.M106473200

21 January 2018

Platelet-derived growth factor receptor tyrosine phosphorylation requires protein geranylgeranylation but not farnesylation

1 reference

https://api.crossref.org/works/10.1074%2FJBC.M106473200

21 January 2018

Inhibition of type I and type II geranylgeranyl-protein transferases by the monoterpene perillyl alcohol in NIH3T3 cells

1 reference

https://api.crossref.org/works/10.1074%2FJBC.M106473200

21 January 2018

Inhibition of protein prenylation by metabolites of limonene

1 reference

https://api.crossref.org/works/10.1074%2FJBC.M106473200

21 January 2018

Nitrogen-containing bisphosphonates inhibit the mevalonate pathway and prevent post-translational prenylation of GTP-binding proteins, including Ras.

1 reference

https://api.crossref.org/works/10.1074%2FJBC.M106473200

21 January 2018

Bisphosphonates: from the laboratory to the clinic and back again

1 reference

https://api.crossref.org/works/10.1074%2FJBC.M106473200

21 January 2018

Farnesyl pyrophosphate synthase is the molecular target of nitrogen-containing bisphosphonates

1 reference

https://api.crossref.org/works/10.1074%2FJBC.M106473200

21 January 2018

Alendronate is a specific, nanomolar inhibitor of farnesyl diphosphate synthase

1 reference

https://api.crossref.org/works/10.1074%2FJBC.M106473200

21 January 2018

Alendronate mechanism of action: geranylgeraniol, an intermediate in the mevalonate pathway, prevents inhibition of osteoclast formation, bone resorption, and kinase activation in vitro

1 reference

https://api.crossref.org/works/10.1074%2FJBC.M106473200

21 January 2018

The role of geranylgeranylation in bone resorption and its suppression by bisphosphonates in fetal bone explants in vitro: A clue to the mechanism of action of nitrogen-containing bisphosphonates

1 reference

https://api.crossref.org/works/10.1074%2FJBC.M106473200

21 January 2018

Protein geranylgeranylation is required for osteoclast formation, function, and survival: inhibition by bisphosphonates and GGTI-298.

1 reference

https://api.crossref.org/works/10.1074%2FJBC.M106473200

21 January 2018

Phosphonate and bisphosphonate analogues of farnesyl pyrophosphate as potential inhibitors of farnesyl protein transferase

1 reference

https://api.crossref.org/works/10.1074%2FJBC.M106473200

21 January 2018

Binding and antiresorptive properties of heterocycle-containing bisphosphonate analogs: structure-activity relationships

1 reference

https://api.crossref.org/works/10.1074%2FJBC.M106473200

21 January 2018

Heterocycle-containing bisphosphonates cause apoptosis and inhibit bone resorption by preventing protein prenylation: evidence from structure-activity relationships in J774 macrophages.

1 reference

https://api.crossref.org/works/10.1074%2FJBC.M106473200

21 January 2018

Rac-GTPase, osteoclast cytoskeleton and bone resorption

1 reference

https://api.crossref.org/works/10.1074%2FJBC.M106473200

21 January 2018

Bone resorption by osteoclasts

1 reference

https://api.crossref.org/works/10.1074%2FJBC.M106473200

21 January 2018

Rab7: a key to lysosome biogenesis

1 reference

https://api.crossref.org/works/10.1074%2FJBC.M106473200

21 January 2018

Deficient geranylgeranylation of Ram/Rab27 in choroideremia.

1 reference

https://api.crossref.org/works/10.1074%2FJBC.M106473200

21 January 2018

Rab geranylgeranyl transferase alpha mutation in the gunmetal mouse reduces Rab prenylation and platelet synthesis

1 reference

https://api.crossref.org/works/10.1074%2FJBC.M106473200

21 January 2018

Expression and Regulation of RAB3 Proteins in Osteoclasts and Their Precursors

1 reference

https://api.crossref.org/works/10.1074%2FJBC.M106473200

21 January 2018

Low levels of Ypt protein prenylation cause vesicle polarization defects and thermosensitive growth that can be suppressed by genes involved in cell wall maintenance

1 reference

https://api.crossref.org/works/10.1074%2FJBC.M106473200

21 January 2018

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