(Q36207257)

https://www.ebi.ac.uk/europepmc/webservices/rest/search?query=EXT_ID:16043992%20AND%20SRC:MED&resulttype=core&format=json

4 January 2020

review article

1 reference

title

Stepwise regulation of TH1 responses in autoimmunity: IL-12-related cytokines and their receptors (English)

1 reference

https://www.ebi.ac.uk/europepmc/webservices/rest/search?query=EXT_ID:16043992%20AND%20SRC:MED&resulttype=core&format=json

4 January 2020

1

1 reference

https://www.ebi.ac.uk/europepmc/webservices/rest/search?query=EXT_ID:16043992%20AND%20SRC:MED&resulttype=core&format=json

4 January 2020

Stefan Wirtz

series ordinal

2

1 reference

https://www.ebi.ac.uk/europepmc/webservices/rest/search?query=EXT_ID:16043992%20AND%20SRC:MED&resulttype=core&format=json

4 January 2020

3

Markus F Neurath

1 reference

https://www.ebi.ac.uk/europepmc/webservices/rest/search?query=EXT_ID:16043992%20AND%20SRC:MED&resulttype=core&format=json

4 January 2020

publication date

1 August 2005

1 reference

https://www.ebi.ac.uk/europepmc/webservices/rest/search?query=EXT_ID:16043992%20AND%20SRC:MED&resulttype=core&format=json

Inflammatory Bowel Diseases

4 January 2020

published in

1 reference

https://www.ebi.ac.uk/europepmc/webservices/rest/search?query=EXT_ID:16043992%20AND%20SRC:MED&resulttype=core&format=json

4 January 2020

volume

11

1 reference

https://www.ebi.ac.uk/europepmc/webservices/rest/search?query=EXT_ID:16043992%20AND%20SRC:MED&resulttype=core&format=json

4 January 2020

issue

8

1 reference

https://www.ebi.ac.uk/europepmc/webservices/rest/search?query=EXT_ID:16043992%20AND%20SRC:MED&resulttype=core&format=json

4 January 2020

page(s)

755-764

1 reference

https://www.ebi.ac.uk/europepmc/webservices/rest/search?query=EXT_ID:16043992%20AND%20SRC:MED&resulttype=core&format=json

Genetically resistant mice lacking interleukin-12 are susceptible to infection with Leishmania major and mount a polarized Th2 cell response.

4 January 2020

cites work

1 reference

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Coexpression of two distinct genes is required to generate secreted bioactive cytotoxic lymphocyte maturation factor

21 January 2018

1 reference

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Identification and purification of natural killer cell stimulatory factor (NKSF), a cytokine with multiple biologic effects on human lymphocytes

21 January 2018

1 reference

https://api.crossref.org/works/10.1097%2F01.MIB.0000172808.03877.4D

Purification to homogeneity and partial characterization of cytotoxic lymphocyte maturation factor from human B-lymphoblastoid cells

21 January 2018

1 reference

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Homology of the p40 subunit of natural killer cell stimulatory factor (NKSF) with the extracellular domain of the interleukin-6 receptor

21 January 2018

1 reference

https://api.crossref.org/works/10.1097%2F01.MIB.0000172808.03877.4D

Regulation of interleukin-12 production in antigen-presenting cells

21 January 2018

1 reference

https://api.crossref.org/works/10.1097%2F01.MIB.0000172808.03877.4D

A functional interleukin 12 receptor complex is composed of two beta-type cytokine receptor subunits

21 January 2018

1 reference

https://api.crossref.org/works/10.1097%2F01.MIB.0000172808.03877.4D

Selective expression of an interleukin-12 receptor component by human T helper 1 cells

21 January 2018

1 reference

https://api.crossref.org/works/10.1097%2F01.MIB.0000172808.03877.4D

Biological function and distribution of human interleukin-12 receptor beta chain

21 January 2018

1 reference

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Identification of a STAT4 binding site in the interleukin-12 receptor required for signaling

21 January 2018

1 reference

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Interleukin 12 signaling in T helper type 1 (Th1) cells involves tyrosine phosphorylation of signal transducer and activator of transcription (Stat)3 and Stat4

21 January 2018

1 reference

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Interleukin 12 induces tyrosine phosphorylation and activation of STAT4 in human lymphocytes

21 January 2018

1 reference

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Interleukin 12 (IL-12) induces tyrosine phosphorylation of JAK2 and TYK2: differential use of Janus family tyrosine kinases by IL-2 and IL-12

21 January 2018

1 reference

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Toll-like receptor signalling

21 January 2018

1 reference

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Interleukin 12 (IL-12) is crucial to the development of protective immunity in mice intravenously infected with mycobacterium tuberculosis

21 January 2018

1 reference

https://api.crossref.org/works/10.1097%2F01.MIB.0000172808.03877.4D

Severe mycobacterial and Salmonella infections in interleukin-12 receptor-deficient patients

21 January 2018

1 reference

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Novel p19 protein engages IL-12p40 to form a cytokine, IL-23, with biological activities similar as well as distinct from IL-12

21 January 2018

1 reference

https://api.crossref.org/works/10.1097%2F01.MIB.0000172808.03877.4D

Commensal Gram-negative bacteria prime human dendritic cells for enhanced IL-23 and IL-27 expression and enhanced Th1 development

21 January 2018

1 reference

https://api.crossref.org/works/10.1097%2F01.MIB.0000172808.03877.4D

Human IL-23-producing type 1 macrophages promote but IL-10-producing type 2 macrophages subvert immunity to (myco)bacteria

21 January 2018

1 reference

https://api.crossref.org/works/10.1097%2F01.MIB.0000172808.03877.4D

IL-23 provides a limited mechanism of resistance to acute toxoplasmosis in the absence of IL-12.

21 January 2018

1 reference

https://api.crossref.org/works/10.1097%2F01.MIB.0000172808.03877.4D

Interleukin-23 rather than interleukin-12 is the critical cytokine for autoimmune inflammation of the brain

21 January 2018

1 reference

https://api.crossref.org/works/10.1097%2F01.MIB.0000172808.03877.4D

Divergent pro- and antiinflammatory roles for IL-23 and IL-12 in joint autoimmune inflammation

21 January 2018

1 reference

https://api.crossref.org/works/10.1097%2F01.MIB.0000172808.03877.4D

IL-23 up-regulates IL-10 and induces IL-17 synthesis by polyclonally activated naive T cells in human.

21 January 2018

1 reference

https://api.crossref.org/works/10.1097%2F01.MIB.0000172808.03877.4D

Interleukin-23 promotes a distinct CD4 T cell activation state characterized by the production of interleukin-17

21 January 2018

1 reference

https://api.crossref.org/works/10.1097%2F01.MIB.0000172808.03877.4D

IL-23 drives a pathogenic T cell population that induces autoimmune inflammation

21 January 2018

1 reference

https://api.crossref.org/works/10.1097%2F01.MIB.0000172808.03877.4D

Phagocytosis of apoptotic neutrophils regulates granulopoiesis via IL-23 and IL-17.

21 January 2018

1 reference

https://api.crossref.org/works/10.1097%2F01.MIB.0000172808.03877.4D

Interleukin-17 family members and inflammation

21 January 2018

1 reference

https://api.crossref.org/works/10.1097%2F01.MIB.0000172808.03877.4D

T cell interleukin-17 induces stromal cells to produce proinflammatory and hematopoietic cytokines

21 January 2018

1 reference

https://api.crossref.org/works/10.1097%2F01.MIB.0000172808.03877.4D

IL-17 is increased in asthmatic airways and induces human bronchial fibroblasts to produce cytokines

21 January 2018

1 reference

https://api.crossref.org/works/10.1097%2F01.MIB.0000172808.03877.4D

Distinct lineages of T(H)1 cells have differential capacities for memory cell generation in vivo.

21 January 2018

1 reference

https://api.crossref.org/works/10.1097%2F01.MIB.0000172808.03877.4D

IL-27, a heterodimeric cytokine composed of EBI3 and p28 protein, induces proliferation of naive CD4+ T cells

21 January 2018

1 reference

https://api.crossref.org/works/10.1097%2F01.MIB.0000172808.03877.4D

Epstein-Barr virus-induced gene 3 and the p35 subunit of interleukin 12 form a novel heterodimeric hematopoietin

21 January 2018

1 reference

https://api.crossref.org/works/10.1097%2F01.MIB.0000172808.03877.4D

Frequent expression of the Epstein-Barr virus (EBV)-induced gene, EBI3, an IL-12 p40-related cytokine, in Hodgkin and Reed-Sternberg cells

21 January 2018

1 reference

https://api.crossref.org/works/10.1097%2F01.MIB.0000172808.03877.4D

An interleukin 12-related cytokine is up-regulated in ulcerative colitis but not in Crohn's disease

21 January 2018

1 reference

https://api.crossref.org/works/10.1097%2F01.MIB.0000172808.03877.4D

Disruption of T helper 2-immune responses in Epstein-Barr virus-induced gene 3-deficient mice

21 January 2018

1 reference

https://api.crossref.org/works/10.1097%2F01.MIB.0000172808.03877.4D

Cloning and characterization of a novel class I cytokine receptor

21 January 2018

1 reference

https://api.crossref.org/works/10.1097%2F01.MIB.0000172808.03877.4D

WSX-1 and glycoprotein 130 constitute a signal-transducing receptor for IL-27

21 January 2018

1 reference

https://api.crossref.org/works/10.1097%2F01.MIB.0000172808.03877.4D

Impaired Th1 responses in mice deficient in Epstein-Barr virus-induced gene 3 and challenged with physiological doses of Leishmania major

21 January 2018

1 reference

https://api.crossref.org/works/10.1097%2F01.MIB.0000172808.03877.4D

Development of Th1-type immune responses requires the type I cytokine receptor TCCR

21 January 2018

1 reference

https://api.crossref.org/works/10.1097%2F01.MIB.0000172808.03877.4D

IL-27 regulates IL-12 responsiveness of naive CD4+ T cells through Stat1-dependent and -independent mechanisms

21 January 2018

1 reference

https://api.crossref.org/works/10.1097%2F01.MIB.0000172808.03877.4D

Potent antitumor activity of interleukin-27.

21 January 2018

1 reference

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The IL-27R (WSX-1) is required to suppress T cell hyperactivity during infection

21 January 2018

1 reference

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WSX-1 is required for resistance to Trypanosoma cruzi infection by regulation of proinflammatory cytokine production

21 January 2018

1 reference

https://api.crossref.org/works/10.1097%2F01.MIB.0000172808.03877.4D

Hyperproduction of proinflammatory cytokines by WSX-1-deficient NKT cells in concanavalin A-induced hepatitis

21 January 2018

1 reference

https://api.crossref.org/works/10.1097%2F01.MIB.0000172808.03877.4D

Mouse interleukin-12 (IL-12) p40 homodimer: a potent IL-12 antagonist

21 January 2018

1 reference

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Induction of tumor necrosis factor-alpha (TNF-alpha) by interleukin-12 p40 monomer and homodimer in microglia and macrophages

21 January 2018

1 reference

https://api.crossref.org/works/10.1097%2F01.MIB.0000172808.03877.4D

Interleukin-12 induces tyrosine phosphorylation of an 85-kDa protein associated with the interleukin-12 receptor beta 1 subunit

21 January 2018

1 reference

https://api.crossref.org/works/10.1097%2F01.MIB.0000172808.03877.4D

T-bet is rapidly induced by interferon-gamma in lymphoid and myeloid cells

21 January 2018

1 reference

https://api.crossref.org/works/10.1097%2F01.MIB.0000172808.03877.4D

Role of T-bet in commitment of TH1 cells before IL-12-dependent selection.

21 January 2018

1 reference

https://api.crossref.org/works/10.1097%2F01.MIB.0000172808.03877.4D

A novel transcription factor, T-bet, directs Th1 lineage commitment

21 January 2018

1 reference

https://api.crossref.org/works/10.1097%2F01.MIB.0000172808.03877.4D

Blocking the CD40L-CD40 interaction in vivo specifically prevents the priming of T helper 1 cells through the inhibition of interleukin 12 secretion

21 January 2018

1 reference

https://api.crossref.org/works/10.1097%2F01.MIB.0000172808.03877.4D

Antibodies to interleukin 12 abrogate established experimental colitis in mice

21 January 2018

1 reference

https://api.crossref.org/works/10.1097%2F01.MIB.0000172808.03877.4D

T cell-mediated pathology in two models of experimental colitis depends predominantly on the interleukin 12/Signal transducer and activator of transcription (Stat)-4 pathway, but is not conditional on interferon gamma expression by T cells

21 January 2018

1 reference

https://api.crossref.org/works/10.1097%2F01.MIB.0000172808.03877.4D

Anti-interleukin-12 antibody for active Crohn's disease

21 January 2018

1 reference

https://api.crossref.org/works/10.1097%2F01.MIB.0000172808.03877.4D

Constitutive p40 promoter activation and IL-23 production in the terminal ileum mediated by dendritic cells

21 January 2018

1 reference

https://api.crossref.org/works/10.1097%2F01.MIB.0000172808.03877.4D

Cytokine/chemokine transcript profiles reflect mucosal inflammation in Crohn?s disease

21 January 2018

1 reference

https://api.crossref.org/works/10.1097%2F01.MIB.0000172808.03877.4D

Expression of interleukin-12-related cytokine transcripts in inflammatory bowel disease: elevated interleukin-23p19 and interleukin-27p28 in Crohn's disease but not in ulcerative colitis

21 January 2018

1 reference

https://api.crossref.org/works/10.1097%2F01.MIB.0000172808.03877.4D

Increased expression of interleukin 17 in inflammatory bowel disease

21 January 2018

1 reference

https://api.crossref.org/works/10.1097%2F01.MIB.0000172808.03877.4D

Porphyria cutanea tarda as a predictor of poor response to interferon alfa therapy in chronic hepatitis C.

21 January 2018

1 reference

https://api.crossref.org/works/10.1097%2F01.MIB.0000172808.03877.4D

Inhibition of Thl responses prevents inflammatory bowel disease in scid mice reconstituted with CD45RBhi CD4+ T cells

21 January 2018

1 reference

https://api.crossref.org/works/10.1097%2F01.MIB.0000172808.03877.4D

CD45RBhigh CD4+ T cells from IFN-gamma knockout mice do not induce wasting disease

21 January 2018

1 reference

https://api.crossref.org/works/10.1097%2F01.MIB.0000172808.03877.4D

Enterocolitis and colon cancer in interleukin-10-deficient mice are associated with aberrant cytokine production and CD4(+) TH1-like responses

21 January 2018

1 reference

https://api.crossref.org/works/10.1097%2F01.MIB.0000172808.03877.4D

10.1097/01.MIB.0000172808.03877.4D

21 January 2018

Identifiers

DOI

1 reference

https://www.ebi.ac.uk/europepmc/webservices/rest/search?query=EXT_ID:16043992%20AND%20SRC:MED&resulttype=core&format=json

4 January 2020

1 reference