(Q36211191)

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Molecular dynamics and functional studies define a hot spot of crystal contacts essential for PcTx1 inhibition of acid-sensing ion channel 1a.

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scholarly article

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Europe PubMed Central

PMC publication ID

12 August 2017

Molecular dynamics and functional studies define a hot spot of crystal contacts essential for PcTx1 inhibition of acid-sensing ion channel 1a. (English)

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Europe PubMed Central

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12 August 2017

1

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31 May 2020

Evelyne Deplazes

2

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31 May 2020

Ben Cristofori-Armstrong

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31 May 2020

Irène R Chassagnon

4

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31 May 2020

6

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31 May 2020

7

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31 May 2020

Lachlan D. Rash

8

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31 May 2020

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31 May 2020

author name string

Xiaozhen Lin

5

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31 May 2020

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6 August 2015

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12 August 2017

British Journal of Pharmacology

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31 May 2020

172

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31 May 2020

20

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31 May 2020

4985-4995

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31 May 2020

Seven novel modulators of the analgesic target NaV 1.7 uncovered using a high-throughput venom-based discovery approach

1 reference

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1 October 2017

ASICs as therapeutic targets for migraine

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=4621980

1 October 2017

Acid-sensing ion channels: a novel therapeutic target for pain and anxiety

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=4621980

1 October 2017

The Concise Guide to PHARMACOLOGY 2013/14: ligand-gated ion channels.

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1 October 2017

The IUPHAR/BPS Guide to PHARMACOLOGY: an expert-driven knowledgebase of drug targets and their ligands

1 reference

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1 October 2017

Proton-mediated conformational changes in an acid-sensing ion channel.

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=4621980

1 October 2017

Acid-sensing ion channels in pain and disease.

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=4621980

1 October 2017

Production of recombinant disulfide-rich venom peptides for structural and functional analysis via expression in the periplasm of E. coli.

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=4621980

1 October 2017

Acid-sensing ion channels in pathological conditions

1 reference

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1 October 2017

Structural plasticity and dynamic selectivity of acid-sensing ion channel–spider toxin complexes

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=4621980

1 October 2017

Structure of the acid-sensing ion channel 1 in complex with the gating modifier Psalmotoxin 1

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=4621980

1 October 2017

Molecular dynamics simulations and drug discovery

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=4621980

1 October 2017

A dynamic pharmacophore drives the interaction between Psalmotoxin-1 and the putative drug target acid-sensing ion channel 1a

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=4621980

1 October 2017

Heteromeric acid-sensing ion channels (ASICs) composed of ASIC2b and ASIC1a display novel channel properties and contribute to acidosis-induced neuronal death

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=4621980

1 October 2017

Structure, function, and pharmacology of acid-sensing ion channels (ASICs): focus on ASIC1a.

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=4621980

1 October 2017

Identification of a calcium permeable human acid-sensing ion channel 1 transcript variant

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=4621980

1 October 2017

Acid-sensing ion channels (ASICs): pharmacology and implication in pain

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=4621980

1 October 2017

Animal research: reporting in vivo experiments: the ARRIVE guidelines

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=4621980

1 October 2017

Guidelines for reporting experiments involving animals: the ARRIVE guidelines

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=4621980

1 October 2017

Identification of protein domains that control proton and calcium sensitivity of ASIC1a

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=4621980

1 October 2017

Acid-sensing ion channel-1a in the amygdala, a novel therapeutic target in depression-related behavior

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=4621980

1 October 2017

Native and recombinant ASIC1a receptors conduct negligible Ca2+ entry

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=4621980

1 October 2017

Seizure termination by acidosis depends on ASIC1a

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=4621980

1 October 2017

A one-step PCR-based method for rapid and efficient site-directed fragment deletion, insertion, and substitution mutagenesis

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=4621980

1 October 2017

Structure of acid-sensing ion channel 1 at 1.9 A resolution and low pH

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=4621980

1 October 2017

Interaction of acid-sensing ion channel (ASIC) 1 with the tarantula toxin psalmotoxin 1 is state dependent

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=4621980

1 October 2017

The receptor site of the spider toxin PcTx1 on the proton-gated cation channel ASIC1a

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=4621980

1 October 2017

Very fast empirical prediction and rationalization of protein pKa values

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=4621980

1 October 2017

GROMACS: fast, flexible, and free

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=4621980

1 October 2017

The tarantula toxin psalmotoxin 1 inhibits acid-sensing ion channel (ASIC) 1a by increasing its apparent H+ affinity

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=4621980

1 October 2017

Neuroprotection in ischemia: blocking calcium-permeable acid-sensing ion channels.

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=4621980

1 October 2017

Recombinant production and solution structure of PcTx1, the specific peptide inhibitor of ASIC1a proton-gated cation channels

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=4621980

1 October 2017

A simple physical model for binding energy hot spots in protein-protein complexes

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=4621980

1 October 2017

Close-range electrostatic interactions in proteins

1 reference

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1 October 2017

Epithelial sodium channel/degenerin family of ion channels: a variety of functions for a shared structure.

1 reference

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1 October 2017

Isolation of a tarantula toxin specific for a class of proton-gated Na+ channels.

1 reference

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1 October 2017

Anatomy of hot spots in protein interfaces

1 reference

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1 October 2017

A proton-gated cation channel involved in acid-sensing

1 reference

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1 October 2017

Toxin binding reveals two open state structures for one acid-sensing ion channel

1 reference

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29 June 2018

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1 reference

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1 reference

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29 June 2018

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1 reference

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22 September 2018

pH Dependency and desensitization kinetics of heterologously expressed combinations of acid-sensing ion channel subunits

1 reference

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22 September 2018

Zn2+ and H+ are coactivators of acid-sensing ion channels

1 reference

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Molecular dynamics with coupling to an external bath

1 reference

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1 reference

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10.1111/BPH.13267

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31 May 2020

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31 May 2020

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Europe PubMed Central

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31 May 2020

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