(Q35538490)

8 August 2017

title

Seven novel modulators of the analgesic target NaV 1.7 uncovered using a high-throughput venom-based discovery approach (English)

1 reference

8 August 2017

0 references

Sebastian Senff

6

0 references

Jennifer J. Smith

Jennifer J Smith

2

0 references

Volker Herzig

Volker Herzig

7

0 references

Frank Bosmans

Frank Bosmans

10

0 references

Irina Vetter

Irina Vetter

3

0 references

Mehdi Mobli

Mehdi Mobli

8

0 references

Glenn F King

Glenn F King

11

0 references

Richard J. Lewis

Richard J Lewis

9

0 references

Julie Klint

1

Julie K Klint

1 reference

8 August 2017

5

Sing Yan Er

1 reference

8 August 2017

author name string

Darshani B Rupasinghe

4

1 reference

8 August 2017

language of work or name

English

0 references

publication date

4 March 2015

1 reference

British Journal of Pharmacology

8 August 2017

published in

1 reference

8 August 2017

volume

172

1 reference

8 August 2017

issue

10

1 reference

8 August 2017

page(s)

2445-2458

1 reference

No gain, no pain: NaV1.7 as an analgesic target

8 August 2017

cites work

1 reference

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A Tarantula-Venom Peptide Antagonizes the TRPA1 Nociceptor Ion Channel by Binding to the S1–S4 Gating Domain

12 July 2018

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12 July 2018

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12 July 2018

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Analysis of the Structural and Molecular Basis of Voltage-sensitive Sodium Channel Inhibition by the Spider Toxin Huwentoxin-IV ( -TRTX-Hh2a)

12 July 2018

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Production of recombinant disulfide-rich venom peptides for structural and functional analysis via expression in the periplasm of E. coli.

12 July 2018

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Expression and pharmacology of endogenous Cav channels in SH-SY5Y human neuroblastoma cells

12 July 2018

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12 July 2018

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Polymorphism in the SCN9A voltage-gated sodium channel gene associated with interstitial cystitis/bladder pain syndrome.

12 July 2018

1 reference

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Chemical punch packed in venoms makes centipedes excellent predators

12 July 2018

1 reference

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Spider-venom peptides that target voltage-gated sodium channels: pharmacological tools and potential therapeutic leads.

12 July 2018

1 reference

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Characterisation of Na(v) types endogenously expressed in human SH-SY5Y neuroblastoma cells

12 July 2018

1 reference

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Functional properties and toxin pharmacology of a dorsal root ganglion sodium channel viewed through its voltage sensors

12 July 2018

1 reference

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Common molecular determinants of tarantula huwentoxin-IV inhibition of Na+ channel voltage sensors in domains II and IV

12 July 2018

1 reference

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Macromolecular NMR spectroscopy for the non-spectroscopist.

12 July 2018

1 reference

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ArachnoServer 2.0, an updated online resource for spider toxin sequences and structures

12 July 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=4409898

A non-uniformly sampled 4D HCC(CO)NH-TOCSY experiment processed using maximum entropy for rapid protein sidechain assignment

12 July 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=4409898

Pain perception is altered by a nucleotide polymorphism in SCN9A

12 July 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=4409898

Venomics: a new paradigm for natural products-based drug discovery.

12 July 2018

1 reference

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Targeting voltage sensors in sodium channels with spider toxins.

12 July 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=4409898

MolProbity: all-atom structure validation for macromolecular crystallography

12 July 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=4409898

TALOS+: a hybrid method for predicting protein backbone torsion angles from NMR chemical shifts

12 July 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=4409898

Deconstructing voltage sensor function and pharmacology in sodium channels

12 July 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=4409898

Peptide toxins that selectively target insect Na(V) and Ca(V) channels

12 July 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=4409898

Tarantula huwentoxin-IV inhibits neuronal sodium channels by binding to receptor site 4 and trapping the domain ii voltage sensor in the closed configuration

12 July 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=4409898

Portability of paddle motif function and pharmacology in voltage sensors

12 July 2018

1 reference

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Voltage-gated ion channels and gating modifier toxins.

12 July 2018

1 reference

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The insecticidal potential of scorpion beta-toxins

12 July 2018

1 reference

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Modulation of insect Ca(v) channels by peptidic spider toxins.

12 July 2018

1 reference

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An SCN9A channelopathy causes congenital inability to experience pain

12 July 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=4409898

SCN9A mutations in paroxysmal extreme pain disorder: allelic variants underlie distinct channel defects and phenotypes

12 July 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=4409898

Venom landscapes: mining the complexity of spider venoms via a combined cDNA and mass spectrometric approach

12 July 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=4409898

A family of E. coli expression vectors for laboratory scale and high throughput soluble protein production

12 July 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=4409898

International Union of Pharmacology. XLVII. Nomenclature and structure-function relationships of voltage-gated sodium channels

12 July 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=4409898

Overview of scorpion toxins specific for Na+ channels and related peptides: biodiversity, structure-function relationships and evolution

12 July 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=4409898

Four novel tarantula toxins as selective modulators of voltage-gated sodium channel subtypes

12 July 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=4409898

Automated NMR structure calculation with CYANA

12 July 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=4409898

Mutations in SCN9A, encoding a sodium channel alpha subunit, in patients with primary erythermalgia

12 July 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=4409898

Tracking voltage-dependent conformational changes in skeletal muscle sodium channel during activation.

12 July 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=4409898

The P1' specificity of tobacco etch virus protease

12 July 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=4409898

Immobilizing the moving parts of voltage-gated ion channels

12 July 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=4409898

The Na channel voltage sensor associated with inactivation is localized to the external charged residues of domain IV, S4.

12 July 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=4409898

Voltage sensor-trapping: enhanced activation of sodium channels by beta-scorpion toxin bound to the S3-S4 loop in domain II.

12 July 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=4409898

Hanatoxin modifies the gating of a voltage-dependent K+ channel through multiple binding sites.

12 July 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=4409898

Contribution of the S4 segment to gating charge in the Shaker K+ channel.

12 July 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=4409898

Purification and characterization of three inhibitors of voltage-dependent K+ channels from Leiurus quinquestriatus var. hebraeus venom

12 July 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=4409898

A common structural motif incorporating a cystine knot and a triple-stranded beta-sheet in toxic and inhibitory polypeptides

12 July 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=4409898

A novel potassium channel with delayed rectifier properties isolated from rat brain by expression cloning

12 July 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=4409898

A single-nucleotide polymorphism in SCN9A may decrease postoperative pain sensitivity in the general population

12 July 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=4409898

The economic costs of pain in the United States

26 September 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=4409898

Deletion mutation of sodium channel Na(V)1.7 in inherited erythromelalgia: enhanced slow inactivation modulates dorsal root ganglion neuron hyperexcitability.

26 September 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=4409898

NaV1.7 gain-of-function mutations as a continuum: A1632E displays physiological changes associated with erythromelalgia and paroxysmal extreme pain disorder mutations and produces symptoms of both disorders.

26 September 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=4409898

A rational nomenclature for naming peptide toxins from spiders and other venomous animals.

26 September 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=4409898

Voltage-sensing residues in the S2 and S4 segments of the Shaker K+ channel

26 September 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=4409898

An automated tool for maximum entropy reconstruction of biomolecular NMR spectra

26 September 2018

1 reference

Crossref

https://api.crossref.org/works/10.1111%2FBPH.13081

Potency optimization of Huwentoxin-IV on hNav1.7: A neurotoxin TTX-S sodium-channel antagonist from the venom of the Chinese bird-eating spider Selenocosmia huwena

21 January 2018

1 reference

Crossref

https://api.crossref.org/works/10.1111%2FBPH.13081

Nav1.7 mutations associated with paroxysmal extreme pain disorder, but not erythromelalgia, enhance Navbeta4 peptide-mediated resurgent sodium currents

21 January 2018

1 reference

PubMed

https://pubmed.ncbi.nlm.nih.gov/25754331

inferred from PubMed ID database lookup

12 December 2020

based on heuristic

A positively charged surface patch is important for hainantoxin-IV binding to voltage-gated sodium channels

1 reference

PubMed

https://pubmed.ncbi.nlm.nih.gov/25754331

inferred from PubMed ID database lookup

12 December 2020

based on heuristic

Localization of the voltage-sensor toxin receptor on KvAP

1 reference

PubMed

https://pubmed.ncbi.nlm.nih.gov/25754331

inferred from PubMed ID database lookup

12 December 2020

based on heuristic

Identifiers

DOI

10.1111/BPH.13081

1 reference

8 August 2017

1 reference

8 August 2017

1 reference