(Q36211460)

12 August 2017

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title

Protease-activated receptors: regulation of neuronal function (English)

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12 August 2017

Toshiyuki Saito

1

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12 August 2017

Nigel W Bunnett

series ordinal

2

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12 August 2017

publication date

1 January 2005

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12 August 2017

published in

NeuroMolecular Medicine

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12 August 2017

volume

7

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12 August 2017

issue

1-2

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12 August 2017

page(s)

79-99

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Activation of trigeminal nociceptive neurons by parotid PAR-2 activation in rats

12 August 2017

cites work

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12 December 2020

Mucosal pathophysiology and inflammatory changes in the late phase of the intestinal allergic reaction in the rat

1 reference

12 December 2020

Purification and characterization of a trypsin-like serine proteinase from rat brain slices that degrades laminin and type IV collagen and stimulates protease-activated receptor-2

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12 December 2020

Protease-activated receptor 3 is a second thrombin receptor in humans

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12 December 2020

Proteinase-activated receptor 2-mediated potentiation of transient receptor potential vanilloid subfamily 1 activity reveals a mechanism for proteinase-induced inflammatory pain.

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12 December 2020

PKA/AKAP/VR-1 module: A common link of Gs-mediated signaling to thermal hyperalgesia.

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12 December 2020

Co-existence of two types of [Ca2+]i-inducing protease-activated receptors (PAR-1 and PAR-2) in rat astrocytes and C6 glioma cells

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12 December 2020

Internalization and recycling of activated thrombin receptors

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12 December 2020

Proteinase-activated receptors: novel signals for peripheral nerves.

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12 December 2020

Thrombin receptor peptides induce shape change in neonatal murine astrocytes in culture

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12 December 2020

Release of the mucosal mast cell granule chymase, rat mast cell protease-II, during anaphylaxis is associated with the rapid development of paracellular permeability to macromolecules in rat jejunum

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12 December 2020

Proteinases and proteinase-activated receptor 2: a possible role to promote visceral hyperalgesia in rats

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12 December 2020

Proteinase-activated receptor-2 mediates hyperresponsiveness in isolated guinea pig bronchi

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12 December 2020

Peripheral PAR-2 triggers thermal hyperalgesia and nociceptive responses in rats

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12 December 2020

Characteristics of thrombin-induced calcium signals in rat astrocytes

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12 December 2020

Molecular mechanisms of nociception

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12 December 2020

In vivo functions of heterotrimeric G-proteins: studies in Galpha-deficient mice.

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12 December 2020

Modulation of capsaicin-evoked visceral pain and referred hyperalgesia by protease-activated receptors 1 and 2.

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12 December 2020

Proteinase-activated receptor-1 agonists attenuate nociception in response to noxious stimuli

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12 December 2020

G protein-coupled receptor kinase-5 regulates thrombin-activated signaling in endothelial cells

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12 December 2020

Agonists of proteinase-activated receptor 2 induce inflammation by a neurogenic mechanism

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12 December 2020

PAR-2 agonists induce contraction of murine small intestine through neurokinin receptors

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12 December 2020

Domains specifying thrombin–receptor interaction

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12 December 2020

The cloned platelet thrombin receptor couples to at least two distinct effectors to stimulate phosphoinositide hydrolysis and inhibit adenylyl cyclase

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12 December 2020

Activation of G12/G13 results in shape change and Rho/Rho-kinase-mediated myosin light chain phosphorylation in mouse platelets

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12 December 2020

Myocardial overexpression of GRK3 in transgenic mice: evidence for in vivo selectivity of GRKs

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12 December 2020

Proteinase-activated receptor-2 and hyperalgesia: A novel pain pathway

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12 December 2020

Proteinase-activated receptors.

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12 December 2020

The protease thrombin is an endogenous mediator of hippocampal neuroprotection against ischemia at low concentrations but causes degeneration at high concentrations

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12 December 2020

Trypsin mediates nociception via the proteinase-activated receptor 2: a potentially novel role in pancreatic pain

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12 December 2020

Mechanisms of desensitization and resensitization of proteinase-activated receptor-2.

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12 December 2020

Protease-activated receptor-1 down-regulation: a mutant HeLa cell line suggests novel requirements for PAR1 phosphorylation and recruitment to clathrin-coated pits

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12 December 2020

Molecular cloning, expression and potential functions of the human proteinase-activated receptor-2

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12 December 2020

Intestinal mucosal mast cells in normal and nematode-infected rat intestines are in intimate contact with peptidergic nerves

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12 December 2020

Cathepsin G activates protease-activated receptor-4 in human platelets

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12 December 2020

Thrombin, its receptor and protease nexin I, its potent serpin, in the nervous system

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12 December 2020

Interactions of mast cell tryptase with thrombin receptors and PAR-2.

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12 December 2020

Potentiation of capsaicin receptor activity by metabotropic ATP receptors as a possible mechanism for ATP-evoked pain and hyperalgesia

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12 December 2020

Thrombin accumulation in brains of patients with Alzheimer's disease

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12 December 2020

Enhanced GFAP expression in astrocytes of transgenic mice expressing the human brain-specific trypsinogen IV.

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12 December 2020

Desensitization of Capsaicin-activated Currents in the Vanilloid Receptor TRPV1 Is Decreased by the Cyclic AMP-dependent Protein Kinase Pathway

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12 December 2020

Rab5a and rab11a mediate agonist-induced trafficking of protease-activated receptor 2.

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12 December 2020

Protease-activated receptors in inflammation, neuronal signaling and pain

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12 December 2020

Proteinase-activated receptor 2 (PAR2)-activating peptides: identification of a receptor distinct from PAR2 that regulates intestinal transport

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12 December 2020

Cloning of the cDNA encoding human brain trypsinogen and characterization of its product

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12 December 2020

Thrombin induces apoptosis in cultured neurons and astrocytes via a pathway requiring tyrosine kinase and RhoA activities.

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12 December 2020

Prothrombin mRNA is expressed by cells of the nervous system.

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12 December 2020

Serine proteases excite myenteric neurons through protease-activated receptors in guinea pig small intestine

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12 December 2020

Glycosylation and the activation of proteinase-activated receptor 2 (PAR(2)) by human mast cell tryptase

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12 December 2020

Regulation of the actin cytoskeleton by thrombin in human endothelial cells: role of Rho proteins in endothelial barrier function

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12 December 2020

Thrombin induces nigral dopaminergic neurodegeneration in vivo by altering expression of death-related proteins

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12 December 2020

Opposing Actions of Thrombin and Protease Nexin‐1 on Amyloid β‐Peptide Toxicity and on Accumulation of Peroxides and Calcium in Hippocampal Neurons

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12 December 2020

Down-regulation of protease-activated receptor-1 is regulated by sorting nexin 1

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12 December 2020

Agonists of proteinase-activated receptor 1 induce plasma extravasation by a neurogenic mechanism

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12 December 2020

EGF receptor transactivation by G-protein-coupled receptors requires metalloproteinase cleavage of proHB-EGF

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12 December 2020

Specific expression of spinal Fos after PAR-2 stimulation in mast cell-depleted rats

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12 December 2020

The proteinase-activated receptor 2 is involved in nociception.

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12 December 2020

G proteins of the G12 family are activated via thromboxane A2 and thrombin receptors in human platelets

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12 December 2020

Mast cell tryptase and proteinase-activated receptor 2 induce hyperexcitability of guinea-pig submucosal neurons

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12 December 2020

Interaction of mite allergens Der p3 and Der p9 with protease-activated receptor-2 expressed by lung epithelial cells

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12 December 2020

Characterisation of immune mediator release during the immediate response to segmental mucosal challenge in the jejunum of patients with food allergy

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12 December 2020

Protease-activated receptors in vascular biology

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12 December 2020

Glycosylation of human proteinase-activated receptor-2 (hPAR2): role in cell surface expression and signalling

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12 December 2020

Mitogenic responses mediated through the proteinase-activated receptor-2 are induced by expressed forms of mast cell alpha- or beta-tryptases

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12 December 2020

Potentiation of NMDA receptor function by the serine protease thrombin

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12 December 2020

Thrombin responses in human endothelial cells. Contributions from receptors other than PAR1 include the transactivation of PAR2 by thrombin-cleaved PAR1.

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12 December 2020

Prostaglandin and protein kinase A-dependent modulation of vanilloid receptor function by metabotropic glutamate receptor 5: potential mechanism for thermal hyperalgesia.

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12 December 2020

Tissue factor- and factor X-dependent activation of protease-activated receptor 2 by factor VIIa

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12 December 2020

Neutrophil serine proteinases activate human nonepithelial cells to produce inflammatory cytokines through protease-activated receptor 2.

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12 December 2020

Four subtypes of protease-activated receptors, co-expressed in rat astrocytes, evoke different physiological signaling

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12 December 2020

Activity of protein kinase C is necessary for sustained thrombin-induced [Ca2+]i oscillations in rat glioma cells.

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12 December 2020

Ethanol elicits and potentiates nociceptor responses via the vanilloid receptor-1.

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12 December 2020

PAR3 is a cofactor for PAR4 activation by thrombin

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12 December 2020

Basolateral PAR-2 receptors mediate KCl secretion and inhibition of Na+ absorption in the mouse distal colon

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12 December 2020

A genomic perspective on human proteases

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12 December 2020

beta-arrestin-dependent endocytosis of proteinase-activated receptor 2 is required for intracellular targeting of activated ERK1/2

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12 December 2020

Luminal trypsin may regulate enterocytes through proteinase-activated receptor 2.

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12 December 2020

G12 requirement for thrombin-stimulated gene expression and DNA synthesis in 1321N1 astrocytoma cells

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12 December 2020

Thrombin induced inhibition of neurite outgrowth from dorsal root ganglion neurons

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12 December 2020

The protease-activated receptor-2 agonist induces gastric mucus secretion and mucosal cytoprotection

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12 December 2020

G protein coupling to the thrombin receptor in Chinese hamster lung fibroblasts

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12 December 2020

Agonists of proteinase-activated receptor 2 excite guinea pig ileal myenteric neurons

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12 December 2020

Changes in the expression of protease-activated receptor 1 and protease nexin-1 mRNA during rat nervous system development and after nerve lesion

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12 December 2020

Induction of intestinal inflammation in mouse by activation of proteinase-activated receptor-2

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12 December 2020

Stimulation of PAR-2 excites and sensitizes rat cutaneous C-nociceptors to heat

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12 December 2020

Cloning and characterization of human protease-activated receptor 4

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12 December 2020

Mitogen-activated protein kinase: conservation of a three-kinase module from yeast to human

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12 December 2020

Activated protein C blocks p53-mediated apoptosis in ischemic human brain endothelium and is neuroprotective

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12 December 2020

Thrombin and mast cell tryptase regulate guinea-pig myenteric neurons through proteinase-activated receptors-1 and -2.

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12 December 2020

Activation of proteinase-activated receptor 1 stimulates epithelial chloride secretion through a unique MAP kinase- and cyclo-oxygenase-dependent pathway

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12 December 2020

Mast cell tryptase regulates rat colonic myocytes through proteinase-activated receptor 2.

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12 December 2020

Involvement of nitric oxide and tachykinins in the effects induced by protease-activated receptors in rat colon longitudinal muscle

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12 December 2020

Inhibition of thrombin receptor signaling by a G-protein coupled receptor kinase. Functional specificity among G-protein coupled receptor kinases

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12 December 2020

Activation of endothelial cell protease activated receptor 1 by the protein C pathway

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12 December 2020

Expression of a mutant Gi2 alpha subunit inhibits ATP and thrombin stimulation of cytoplasmic phospholipase A2-mediated arachidonic acid release independent of Ca2+ and mitogen-activated protein kinase regulation

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12 December 2020

Persistent protease-activated receptor 4 signaling mediates thrombin-induced microglial activation

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12 December 2020

Evidence for the presence of a protease-activated receptor distinct from the thrombin receptor in human keratinocytes

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12 December 2020

Activated mast cells in proximity to colonic nerves correlate with abdominal pain in irritable bowel syndrome.

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12 December 2020

Inhibition of lysophosphatidate- and thrombin-induced neurite retraction and neuronal cell rounding by ADP ribosylation of the small GTP-binding protein Rho.

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12 December 2020

Protease-activated receptors: contribution to physiology and disease

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12 December 2020

Thrombin is an extracellular signal that activates intracellular death protease pathways inducing apoptosis in model motor neurons

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12 December 2020

Cellular localization of thrombin receptor mRNA in rat brain: expression by mesencephalic dopaminergic neurons and codistribution with prothrombin mRNA.

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12 December 2020

Protease nexin-1 and thrombin modulate neuronal Ca2+ homeostasis and sensitivity to glucose deprivation-induced injury

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12 December 2020

Protease-activated receptor-1 in human brain: localization and functional expression in astrocytes

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12 December 2020

Nerve growth factor acutely sensitizes the response of adult rat sensory neurons to capsaicin

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12 December 2020

Protease-activated receptor-2 (PAR-2) in the pancreas and parotid gland: Immunolocalization and involvement of nitric oxide in the evoked amylase secretion

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12 December 2020

Evidence for the presence of functional protease activated receptor 4 (PAR4) in the rat colon

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12 December 2020

Mechanistic coupling of protease signaling and initiation of coagulation by tissue factor

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12 December 2020

Proteinase-activated receptors: novel mechanisms of signaling by serine proteases.

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12 December 2020

Protease-activated receptor 2 sensitizes the capsaicin receptor transient receptor potential vanilloid receptor 1 to induce hyperalgesia.

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12 December 2020

Protease nexin-1, a potent thrombin inhibitor, is reduced around cerebral blood vessels in Alzheimer's disease

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12 December 2020

Neuroprotective signal transduction in model motor neurons exposed to thrombin: G-protein modulation effects on neurite outgrowth, Ca(2+) mobilization, and apoptosis

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12 December 2020

Reciprocal Modulation of Astrocyte Stellation by Thrombin and Protease Nexin-1

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12 December 2020

The two-receptor system PAR-1/PAR-4 mediates alpha-thrombin-induced [Ca(2+)](i) mobilization in human astrocytoma cells.

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12 December 2020

c-Cbl mediates ubiquitination, degradation, and down-regulation of human protease-activated receptor 2

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12 December 2020

The PAR-1-activating peptide attenuates carrageenan-induced hyperalgesia in rats

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12 December 2020

Thrombin induces NO release from cultured rat microglia via protein kinase C, mitogen-activated protein kinase, and NF-kappa B

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12 December 2020

Characterization of protease-activated receptor-2 immunoreactivity in normal human tissues

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12 December 2020

Thrombin-induced microglial activation produces degeneration of nigral dopaminergic neurons in vivo.

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12 December 2020

Trypsin IV, a novel agonist of protease-activated receptors 2 and 4.

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12 December 2020

Cleavage and activation of proteinase-activated receptor-2 on human neutrophils by gingipain-R from Porphyromonas gingivalis

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12 December 2020

Thrombin receptor activation protects neurons and astrocytes from cell death produced by environmental insults.

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12 December 2020

Vascular system defects and impaired cell chemokinesis as a result of Galpha13 deficiency

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12 December 2020

Thrombin perturbs neurite outgrowth and induces apoptotic cell death in enriched chick spinal motoneuron cultures through caspase activation

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12 December 2020

Role of thrombin in activation of neurons in rat hippocampus

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12 December 2020

beta -Arrestins regulate protease-activated receptor-1 desensitization but not internalization or Down-regulation

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12 December 2020

The thrombin receptor in human platelets is coupled to a GTP binding protein of the G alpha q family

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12 December 2020

Trafficking of proteinase-activated receptor-2 and beta-arrestin-1 tagged with green fluorescent protein. beta-Arrestin-dependent endocytosis of a proteinase receptor

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12 December 2020

Arginine-specific protease from Porphyromonas gingivalis activates protease-activated receptors on human oral epithelial cells and induces interleukin-6 secretion

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12 December 2020

Thrombin-induced events in non-platelet cells are mediated by the unique proteolytic mechanism established for the cloned platelet thrombin receptor

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12 December 2020

Release of mast cell tryptase from human colorectal mucosa in inflammatory bowel disease

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12 December 2020

Tissue-specific expression of mast cell granule serine proteinases and their role in inflammation in the lung and gut.

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12 December 2020

Vanilloid receptors on sensory nerves mediate the vasodilator action of anandamide

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12 December 2020

The capsaicin receptor: a heat-activated ion channel in the pain pathway

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12 December 2020

Protease-activated receptor-2 (PAR-2) is present in the rat hippocampus and is associated with neurodegeneration

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12 December 2020

Thrombin-induced activation of cultured rodent microglia

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12 December 2020

Bradykinin and nerve growth factor release the capsaicin receptor from PtdIns(4,5)P2-mediated inhibition

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12 December 2020

Thrombin modulates and reverses neuroblastoma neurite outgrowth

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12 December 2020

A dual thrombin receptor system for platelet activation

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12 December 2020

Colonic proteinases: increased activity in patients with ulcerative colitis

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12 December 2020

Thrombomodulin as a new marker of lesion-induced astrogliosis: involvement of thrombin through the G-protein-coupled protease-activated receptor-1.

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12 December 2020

Intestinal type 2 proteinase-activated receptors: expression in opioid-sensitive secretomotor neural circuits that mediate epithelial ion transport

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12 December 2020

Modulation of visceral pain and inflammation by protease-activated receptors

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12 December 2020

Proteinase-activated receptor-2-induced colonic inflammation in mice: possible involvement of afferent neurons, nitric oxide, and paracellular permeability

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12 December 2020

Capsazepine partially inhibits neurally mediated gastric mucus secretion following activation of protease-activated receptor 2.

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12 December 2020

Granzyme A released upon stimulation of cytotoxic T lymphocytes activates the thrombin receptor on neuronal cells and astrocytes

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12 December 2020

Protein kinase C activation potentiates gating of the vanilloid receptor VR1 by capsaicin, protons, heat and anandamide

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12 December 2020

Defective platelet activation in G alpha(q)-deficient mice.

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12 December 2020

Thrombin (PAR-1)-induced proliferation in astrocytes via MAPK involves multiple signaling pathways

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12 December 2020

Identifiers

DOI

10.1385/NMM:7:1-2:079

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Dimensions Publication ID

12 August 2017

1012413922

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