(Q36213688)

English

Generation and characterization of ABT-981, a dual variable domain immunoglobulin (DVD-Ig(TM)) molecule that specifically and potently neutralizes both IL-1α and IL-1β.

scientific article

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scholarly article

1 reference

Europe PubMed Central

12 August 2017

Generation and characterization of ABT-981, a dual variable domain immunoglobulin (DVD-Ig(TM)) molecule that specifically and potently neutralizes both IL-1α and IL-1β. (English)

1 reference

Europe PubMed Central

12 August 2017

author name string

Susan E Lacy

1

1 reference

Europe PubMed Central

12 August 2017

Chengbin Wu

2

1 reference

Europe PubMed Central

12 August 2017

Dominic J Ambrosi

3

1 reference

Europe PubMed Central

12 August 2017

Chung-Ming Hsieh

4

1 reference

Europe PubMed Central

12 August 2017

Sahana Bose

5

1 reference

Europe PubMed Central

12 August 2017

Renee Miller

6

1 reference

Europe PubMed Central

12 August 2017

Donna M Conlon

7

1 reference

Europe PubMed Central

12 August 2017

Edit Tarcsa

8

1 reference

Europe PubMed Central

12 August 2017

Ravi Chari

9

1 reference

Europe PubMed Central

12 August 2017

Tariq Ghayur

10

1 reference

Europe PubMed Central

12 August 2017

Rajesh V Kamath

11

1 reference

Europe PubMed Central

12 August 2017

language of work or name

1 reference

based on heuristic

inferred from title

publication date

1 January 2015

1 reference

Europe PubMed Central

12 August 2017

Monoclonal Antibodies

1 reference

Europe PubMed Central

12 August 2017

7

1 reference

Europe PubMed Central

12 August 2017

3

1 reference

Europe PubMed Central

12 August 2017

605-619

1 reference

Europe PubMed Central

12 August 2017

The interleukin-1 family: back to the future

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=4622731

1 October 2017

Treating inflammation by blocking interleukin-1 in a broad spectrum of diseases

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=4622731

1 October 2017

IL-1α and IL-1β recruit different myeloid cells and promote different stages of sterile inflammation

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=4622731

1 October 2017

A randomized, double-blind study of AMG 108 (a fully human monoclonal antibody to IL-1R1) in patients with osteoarthritis of the knee

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=4622731

1 October 2017

Increased interleukin-1β gene expression in peripheral blood leukocytes is associated with increased pain and predicts risk for progression of symptomatic knee osteoarthritis

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=4622731

1 October 2017

Interleukin-1 in the pathogenesis and treatment of inflammatory diseases

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=4622731

1 October 2017

Role of proinflammatory cytokines in the pathophysiology of osteoarthritis

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=4622731

1 October 2017

An improved yeast transformation method for the generation of very large human antibody libraries

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=4622731

1 October 2017

The IL-1 family: regulators of immunity

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=4622731

1 October 2017

Immunological and inflammatory functions of the interleukin-1 family

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=4622731

1 October 2017

The interleukin-1 receptor/Toll-like receptor superfamily: 10 years of progress.

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=4622731

1 October 2017

Evidence that cytokines play a role in rheumatoid arthritis

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=4622731

1 October 2017

Review: Immune cells and mediators of inflammatory arthritis

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=4622731

1 October 2017

The expanding family of interleukin-1 cytokines and their role in destructive inflammatory disorders

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=4622731

1 October 2017

Identification of a key pathway required for the sterile inflammatory response triggered by dying cells

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=4622731

1 October 2017

In vivo osteoarthritis target validation utilizing genetically-modified mice

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=4622731

1 October 2017

Direct chitosan-mediated gene delivery to the rabbit knee joints in vitro and in vivo

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=4622731

1 October 2017

Osteoarthritis - an untreatable disease?

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=4622731

1 October 2017

Dissociation of hyperalgesia from fever following intracerebroventricular administration of interleukin-1beta in the rat.

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=4622731

1 October 2017

Osteoarthritis, angiogenesis and inflammation

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=4622731

1 October 2017

Macrophage- and neutrophil-dominant arthritis in human IL-1 alpha transgenic mice

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=4622731

1 October 2017

In vivo transfer of interleukin-1 receptor antagonist gene in osteoarthritic rabbit knee joints: prevention of osteoarthritis progression

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=4622731

1 October 2017

Biologic basis for interleukin-1 in disease

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=4622731

1 October 2017

Cytokine expression in synovial membranes of patients with rheumatoid arthritis and osteoarthritis

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=4622731

1 October 2017

Interleukin 1 induces leukocyte infiltration and cartilage proteoglycan degradation in the synovial joint

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=4622731

1 October 2017

Interleukin 1 suppresses expression of cartilage-specific types II and IX collagens and increases types I and III collagens in human chondrocytes

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=4622731

1 October 2017

Collagenase Production by Rheumatoid Synovial Cells: Stimulation by a Human Lymphocyte Factor

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=4622731

1 October 2017

Interleukin-1, tumor necrosis factor alpha, and interleukin-17 synergistically up-regulate nitric oxide and prostaglandin E2 production in explants of human osteoarthritic knee menisci

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=4622731

29 June 2018

In vivo suppression of early experimental osteoarthritis by interleukin-1 receptor antagonist using gene therapy

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=4622731

29 June 2018

Effects of prostaglandin E2, indomethacin, trifluoperazine and drugs affecting the cytoskeleton on collagenase production by cultured adherent rheumatoid synovial cells

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=4622731

29 June 2018

Molecular construction and optimization of anti-human IL-1alpha/beta dual variable domain immunoglobulin (DVD-Ig) molecules

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=4622731

22 September 2018

Simultaneous targeting of multiple disease mediators by a dual-variable-domain immunoglobulin.

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=4622731

22 September 2018

A broad range of Fab stabilities within a host of therapeutic IgGs.

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=4622731

22 September 2018

Interleukin-1alphabeta gene-deficient mice show reduced nociceptive sensitivity in models of inflammatory and neuropathic pain but not post-operative pain.

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=4622731

22 September 2018

Domain interactions in the Fab fragment: a comparative evaluation of the single-chain Fv and Fab format engineered with variable domains of different stability

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=4622731

22 September 2018

Differential binding to human FcgammaRIIa and FcgammaRIIb receptors by human IgG wildtype and mutant antibodies.

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=4622731

22 September 2018

Tumour necrosis factor-alpha, interleukin-1beta and interleukin-8 induce persistent mechanical nociceptor hypersensitivity

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=4622731

22 September 2018

Flow cytometric screening of yeast surface display libraries

1 reference

https://api.crossref.org/works/10.1080%2F19420862.2015.1026501

21 January 2018

Membrane-associated IL-1 contributes to chronic synovitis and cartilage destruction in human IL-1 alpha transgenic mice

1 reference

https://pubmed.ncbi.nlm.nih.gov/25764208

12 December 2020

based on heuristic

inferred from PubMed ID database lookup

In vitro activation of human chondrocytes and synoviocytes by a human interleukin-1-like factor

1 reference

https://pubmed.ncbi.nlm.nih.gov/25764208

12 December 2020

based on heuristic

inferred from PubMed ID database lookup

Membrane interleukin 1 induction on human endothelial cells and dermal fibroblasts

1 reference

https://pubmed.ncbi.nlm.nih.gov/25764208

12 December 2020

based on heuristic

inferred from PubMed ID database lookup

Modulation by recombinant interleukin 1 of synthesis of types I and III collagens and associated procollagen mRNA levels in cultured human cells

1 reference

https://pubmed.ncbi.nlm.nih.gov/25764208

12 December 2020

based on heuristic

inferred from PubMed ID database lookup

Correlation of gene and mediator expression with clinical endpoints in an acute interleukin-1beta-driven model of joint pathology

1 reference

https://pubmed.ncbi.nlm.nih.gov/25764208

12 December 2020

based on heuristic

inferred from PubMed ID database lookup

Protein secondary structures in water from second-derivative amide I infrared spectra

1 reference

https://pubmed.ncbi.nlm.nih.gov/25764208

12 December 2020

based on heuristic

inferred from PubMed ID database lookup

Interleukin-1 induces interleukin-8 secretion from endothelial cells by a juxtacrine mechanism

1 reference

https://pubmed.ncbi.nlm.nih.gov/25764208

12 December 2020

based on heuristic

inferred from PubMed ID database lookup

Chondroprotective effect of intraarticular injections of interleukin-1 receptor antagonist in experimental osteoarthritis. Suppression of collagenase-1 expression

1 reference

https://pubmed.ncbi.nlm.nih.gov/25764208

12 December 2020

based on heuristic

inferred from PubMed ID database lookup

Safety study of intraarticular injection of interleukin 1 receptor antagonist in patients with painful knee osteoarthritis: a multicenter study

1 reference

https://pubmed.ncbi.nlm.nih.gov/25764208

12 December 2020

based on heuristic

inferred from PubMed ID database lookup

Intraarticular injection of anakinra in osteoarthritis of the knee: a multicenter, randomized, double-blind, placebo-controlled study

1 reference

https://pubmed.ncbi.nlm.nih.gov/25764208

12 December 2020

based on heuristic

inferred from PubMed ID database lookup

The IgG Fc contains distinct Fc receptor (FcR) binding sites: the leukocyte receptors Fc gamma RI and Fc gamma RIIa bind to a region in the Fc distinct from that recognized by neonatal FcR and protein A

1 reference

https://pubmed.ncbi.nlm.nih.gov/25764208

12 December 2020

based on heuristic

inferred from PubMed ID database lookup

Identifiers

10.1080/19420862.2015.1026501

1 reference

Europe PubMed Central

12 August 2017

1 reference

Europe PubMed Central

12 August 2017

1 reference

Europe PubMed Central

12 August 2017

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