(Q37814044)

23 August 2017

1 reference

title

Role of proinflammatory cytokines in the pathophysiology of osteoarthritis (English)

1 reference

23 August 2017

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1 reference

Johanne Martel-Pelletier

series ordinal

2

object named as

Johanne Martel-Pelletier

1 reference

PubMed ID

21119608

23 August 2017

Jean-Pierre Pelletier

series ordinal

4

object named as

Jean-Pierre Pelletier

1 reference

23 August 2017

5

Hassan Fahmi

1 reference

23 August 2017

3

Daniel Lajeunesse

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23 August 2017

Mohit Kapoor

1

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PubMed ID

21119608

23 August 2017

language of work or name

English

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publication date

30 November 2010

1 reference

Nature Reviews Rheumatology

23 August 2017

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23 August 2017

7

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23 August 2017

33-42

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23 August 2017

1

1 reference

https://scigraph.springernature.com/pub.10.1038/nrrheum.2010.196

23 August 2017

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cites work

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Expression and activity profiling of selected cysteine cathepsins and matrix metalloproteinases in synovial fluids from patients with rheumatoid arthritis and osteoarthritis

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Gene deletion of either interleukin-1beta, interleukin-1beta-converting enzyme, inducible nitric oxide synthase, or stromelysin 1 accelerates the development of knee osteoarthritis in mice after surgical transection of the medial collateral ligament

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Interleukin-1 receptor antagonist

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12 December 2020

The interleukin-1 receptor in normal and osteoarthritic human articular chondrocytes. Identification as the type I receptor and analysis of binding kinetics and biologic function

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The type II 'decoy' receptor: a novel regulatory pathway for interleukin 1.

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Production of interleukin-1 receptor antagonist by human articular chondrocytes.

31 March 2020

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Tumour necrosis factor α stimulates resorption and inhibits synthesis of proteoglycan in cartilage

31 March 2020

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Transcriptional suppression by interleukin-1 and interferon-gamma of type II collagen gene expression in human chondrocytes

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Sp1 and Sp3 transcription factors mediate interleukin-1 beta down-regulation of human type II collagen gene expression in articular chondrocytes.

31 March 2020

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Curcumin protects human chondrocytes from IL-l1beta-induced inhibition of collagen type II and beta1-integrin expression and activation of caspase-3: an immunomorphological study

31 March 2020

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Interleukin-1beta induces different gene expression of stromelysin, aggrecan and tumor-necrosis-factor-stimulated gene 6 in human osteoarthritic chondrocytes in vitro

31 March 2020

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Interleukin-1beta down-regulates the expression of glucuronosyltransferase I, a key enzyme priming glycosaminoglycan biosynthesis: influence of glucosamine on interleukin-1beta-mediated effects in rat chondrocytes

31 March 2020

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TNFα suppresses link protein and type II collagen expression in chondrocytes: Role of MEK1/2 and NF‐κB signaling pathways

31 March 2020

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Interleukin-1 induction of collagenase 3 (matrix metalloproteinase 13) gene expression in chondrocytes requires p38, c-Jun N-terminal kinase, and nuclear factor kappaB: differential regulation of collagenase 1 and collagenase 3

31 March 2020

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Modulation by interleukin 1 and tumor necrosis factor alpha of production of collagenase, tissue inhibitor of metalloproteinases and collagen types in differentiated and dedifferentiated articular chondrocytes

31 March 2020

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The new collagenase, collagenase-3, is expressed and synthesized by human chondrocytes but not by synoviocytes. A role in osteoarthritis

31 March 2020

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Characterization of and osteoarthritis susceptibility in ADAMTS-4-knockout mice

31 March 2020

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https://api.crossref.org/works/10.1038%2FNRRHEUM.2010.196

Deletion of active ADAMTS5 prevents cartilage degradation in a murine model of osteoarthritis

31 March 2020

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https://api.crossref.org/works/10.1038%2FNRRHEUM.2010.196

The role of ADAM-TS4 (aggrecanase-1) and ADAM-TS5 (aggrecanase-2) in a model of cartilage degradation

31 March 2020

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https://api.crossref.org/works/10.1038%2FNRRHEUM.2010.196

The role of synovial macrophages and macrophage-produced cytokines in driving aggrecanases, matrix metalloproteinases, and other destructive and inflammatory responses in osteoarthritis

31 March 2020

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https://api.crossref.org/works/10.1038%2FNRRHEUM.2010.196

Monocyte chemoattractant protein-1 (MCP-1) expression in human articular cartilage. Induction by peptide regulatory factors and differential effects of dexamethasone and retinoic acid

31 March 2020

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https://api.crossref.org/works/10.1038%2FNRRHEUM.2010.196

Production of the chemokine RANTES by articular chondrocytes and role in cartilage degradation

31 March 2020

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https://api.crossref.org/works/10.1038%2FNRRHEUM.2010.196

Reactive oxygen species and superoxide dismutases: role in joint diseases

31 March 2020

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https://api.crossref.org/works/10.1038%2FNRRHEUM.2010.196

Interleukin-1beta and interleukin-6 disturb the antioxidant enzyme system in bovine chondrocytes: a possible explanation for oxidative stress generation

31 March 2020

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Superoxide dismutase downregulation in osteoarthritis progression and end-stage disease

31 March 2020

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https://api.crossref.org/works/10.1038%2FNRRHEUM.2010.196

NF-kappaB as a potential therapeutic target in osteoarthritis and rheumatoid arthritis

31 March 2020

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https://api.crossref.org/works/10.1038%2FNRRHEUM.2010.196

Suppression of early experimental osteoarthritis by in vivo delivery of the adenoviral vector-mediated NF-kappaBp65-specific siRNA.

31 March 2020

1 reference

https://api.crossref.org/works/10.1038%2FNRRHEUM.2010.196

Involvement of the Wnt signaling pathway in experimental and human osteoarthritis: prominent role of Wnt-induced signaling protein 1.

31 March 2020

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https://api.crossref.org/works/10.1038%2FNRRHEUM.2010.196

Wnt/beta-catenin signaling stimulates matrix catabolic genes and activity in articular chondrocytes: its possible role in joint degeneration

31 March 2020

1 reference

https://api.crossref.org/works/10.1038%2FNRRHEUM.2010.196

Wnt signaling antagonists are potential prognostic biomarkers for the progression of radiographic hip osteoarthritis in elderly Caucasian women

31 March 2020

1 reference

https://api.crossref.org/works/10.1038%2FNRRHEUM.2010.196

Pioglitazone, a peroxisome proliferator-activated receptor gamma agonist, reduces the progression of experimental osteoarthritis in guinea pigs

31 March 2020

1 reference

https://api.crossref.org/works/10.1038%2FNRRHEUM.2010.196

The peroxisome proliferator-activated receptor gamma agonist pioglitazone reduces the development of cartilage lesions in an experimental dog model of osteoarthritis: in vivo protective effects mediated through the inhibition of key signaling and ca

31 March 2020

1 reference

https://api.crossref.org/works/10.1038%2FNRRHEUM.2010.196

Role of interleukin-1 and tumor necrosis factor alpha in matrix degradation of human osteoarthritic cartilage.

31 March 2020

1 reference

https://api.crossref.org/works/10.1038%2FNRRHEUM.2010.196

Chondroprotective effect of intraarticular injections of interleukin-1 receptor antagonist in experimental osteoarthritis. Suppression of collagenase-1 expression

31 March 2020

1 reference

https://api.crossref.org/works/10.1038%2FNRRHEUM.2010.196

In vivo suppression of early experimental osteoarthritis by interleukin-1 receptor antagonist using gene therapy

31 March 2020

1 reference

https://api.crossref.org/works/10.1038%2FNRRHEUM.2010.196

In vivo transfer of interleukin-1 receptor antagonist gene in osteoarthritic rabbit knee joints: prevention of osteoarthritis progression

31 March 2020

1 reference

https://api.crossref.org/works/10.1038%2FNRRHEUM.2010.196

Suppression of early experimental osteoarthritis by gene transfer of interleukin-1 receptor antagonist and interleukin-10.

31 March 2020

1 reference

https://api.crossref.org/works/10.1038%2FNRRHEUM.2010.196

Treatment of experimental equine osteoarthritis by in vivo delivery of the equine interleukin-1 receptor antagonist gene

31 March 2020

1 reference

https://api.crossref.org/works/10.1038%2FNRRHEUM.2010.196

Intraarticular injection of anakinra in osteoarthritis of the knee: a multicenter, randomized, double-blind, placebo-controlled study

31 March 2020

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https://api.crossref.org/works/10.1038%2FNRRHEUM.2010.196

Erosive osteoarthritis of the hand: clinical experience with anakinra.

31 March 2020

1 reference

https://api.crossref.org/works/10.1038%2FNRRHEUM.2010.196

Functional genomic analysis of type II IL-1beta decoy receptor: potential for gene therapy in human arthritis and inflammation

31 March 2020

1 reference

https://api.crossref.org/works/10.1038%2FNRRHEUM.2010.196

Successful treatment of inflammatory knee osteoarthritis with tumour necrosis factor blockade

31 March 2020

1 reference

https://api.crossref.org/works/10.1038%2FNRRHEUM.2010.196

Treatment of erosive osteoarthritis of the hands by intra-articular infliximab injections: a pilot study

31 March 2020

1 reference

https://api.crossref.org/works/10.1038%2FNRRHEUM.2010.196

The design, structure, and clinical update of small molecular weight matrix metalloproteinase inhibitors

31 March 2020

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https://api.crossref.org/works/10.1038%2FNRRHEUM.2010.196

Phase I trial of Marimastat, a novel matrix metalloproteinase inhibitor, administered orally to patients with advanced lung cancer.

31 March 2020

1 reference

https://api.crossref.org/works/10.1038%2FNRRHEUM.2010.196

Reappraising metalloproteinases in rheumatoid arthritis and osteoarthritis: destruction or repair?

31 March 2020

1 reference

https://api.crossref.org/works/10.1038%2FNRRHEUM.2010.196

Development of musculoskeletal toxicity without clear benefit after administration of PG-116800, a matrix metalloproteinase inhibitor, to patients with knee osteoarthritis: a randomized, 12-month, double-blind, placebo-controlled study

31 March 2020

1 reference

https://api.crossref.org/works/10.1038%2FNRRHEUM.2010.196

Targeting matrix metalloproteinases in inflammatory conditions.

31 March 2020

1 reference

https://api.crossref.org/works/10.1038%2FNRRHEUM.2010.196

Discovery and characterization of a novel inhibitor of matrix metalloprotease-13 that reduces cartilage damage in vivo without joint fibroplasia side effects

31 March 2020

1 reference

https://api.crossref.org/works/10.1038%2FNRRHEUM.2010.196

A review of the ADAMTS family, pharmaceutical targets of the future

31 March 2020

1 reference

https://api.crossref.org/works/10.1038%2FNRRHEUM.2010.196

NF-kappaB signaling: multiple angles to target OA.

31 March 2020

1 reference

https://api.crossref.org/works/10.1038%2FNRRHEUM.2010.196

Acute-phase response factor, a nuclear factor binding to acute-phase response elements, is rapidly activated by interleukin-6 at the posttranslational level

31 March 2020

1 reference

https://api.crossref.org/works/10.1038%2FNRRHEUM.2010.196

Stat3: a STAT family member activated by tyrosine phosphorylation in response to epidermal growth factor and interleukin-6

31 March 2020

1 reference

https://api.crossref.org/works/10.1038%2FNRRHEUM.2010.196

Interleukin-1 beta induces synthesis and secretion of interleukin-6 in human chondrocytes

31 March 2020

1 reference

https://api.crossref.org/works/10.1038%2FNRRHEUM.2010.196

Prostaglandin E2 induces interleukin-6 expression in human chondrocytes via cAMP/protein kinase A- and phosphatidylinositol 3-kinase-dependent NF-kappaB activation

31 March 2020

1 reference

https://api.crossref.org/works/10.1038%2FNRRHEUM.2010.196

Shear-induced interleukin-6 synthesis in chondrocytes: roles of E prostanoid (EP) 2 and EP3 in cAMP/protein kinase A- and PI3-K/Akt-dependent NF-kappaB activation

31 March 2020

1 reference

https://api.crossref.org/works/10.1038%2FNRRHEUM.2010.196

IL-6 enhances plasma IL-1ra, IL-10, and cortisol in humans

31 March 2020

1 reference

https://api.crossref.org/works/10.1038%2FNRRHEUM.2010.196

C-reactive protein is expressed and secreted by peripheral blood mononuclear cells.

31 March 2020

1 reference

https://api.crossref.org/works/10.1038%2FNRRHEUM.2010.196

Elevated high-sensitivity C-reactive protein levels are associated with local inflammatory findings in patients with osteoarthritis

31 March 2020

1 reference

https://api.crossref.org/works/10.1038%2FNRRHEUM.2010.196

Decrease in serum level of matrix metalloproteinases is predictive of the disease-modifying effect of osteoarthritis drugs assessed by quantitative MRI in patients with knee osteoarthritis

31 March 2020

1 reference

https://api.crossref.org/works/10.1038%2FNRRHEUM.2010.196

Serum concentrations of interleukin-6 in patients following unilateral versus bilateral total knee arthroplasty

31 March 2020

1 reference

https://api.crossref.org/works/10.1038%2FNRRHEUM.2010.196

Interleukin-6 is a significant predictor of radiographic knee osteoarthritis: The Chingford Study

31 March 2020

1 reference

https://api.crossref.org/works/10.1038%2FNRRHEUM.2010.196

Interleukin-6 and interleukin-8 levels in serum and synovial fluid of patients with osteoarthritis

31 March 2020

1 reference

https://api.crossref.org/works/10.1038%2FNRRHEUM.2010.196

The role of oncostatin M in animal and human connective tissue collagen turnover and its localization within the rheumatoid joint

31 March 2020

1 reference

https://api.crossref.org/works/10.1038%2FNRRHEUM.2010.196

Synergistic effects of glycoprotein 130 binding cytokines in combination with interleukin-1 on cartilage collagen breakdown

31 March 2020

1 reference

https://api.crossref.org/works/10.1038%2FNRRHEUM.2010.196

Mechanical injury potentiates proteoglycan catabolism induced by interleukin-6 with soluble interleukin-6 receptor and tumor necrosis factor alpha in immature bovine and adult human articular cartilage

31 March 2020

1 reference

https://api.crossref.org/works/10.1038%2FNRRHEUM.2010.196

Interleukin-6 (IL-6) and/or soluble IL-6 receptor down-regulation of human type II collagen gene expression in articular chondrocytes requires a decrease of Sp1.Sp3 ratio and of the binding activity of both factors to the COL2A1 promoter

31 March 2020

1 reference

https://api.crossref.org/works/10.1038%2FNRRHEUM.2010.196

Interleukin 6 is required for the development of collagen-induced arthritis

31 March 2020

1 reference

https://api.crossref.org/works/10.1038%2FNRRHEUM.2010.196

Male IL-6 gene knock out mice developed more advanced osteoarthritis upon aging

31 March 2020

1 reference

https://api.crossref.org/works/10.1038%2FNRRHEUM.2010.196

IL-6 and APPs: anti-inflammatory and immunosuppressive mediators

31 March 2020

1 reference

https://api.crossref.org/works/10.1038%2FNRRHEUM.2010.196

IL-6, RANKL, TNF-alpha/IL-1: interrelations in bone resorption pathophysiology

31 March 2020

1 reference

https://api.crossref.org/works/10.1038%2FNRRHEUM.2010.196

The role of the interleukin-6/gp130 signaling pathway in bone metabolism

31 March 2020

1 reference

https://api.crossref.org/works/10.1038%2FNRRHEUM.2010.196

Can altered production of interleukin-1beta, interleukin-6, transforming growth factor-beta and prostaglandin E(2) by isolated human subchondral osteoblasts identify two subgroups of osteoarthritic patients

31 March 2020

1 reference

https://api.crossref.org/works/10.1038%2FNRRHEUM.2010.196

Increased mRNA expression and protein secretion of interleukin-6 in primary human osteoblasts differentiated in vitro from rheumatoid and osteoarthritic bone

31 March 2020

1 reference

https://api.crossref.org/works/10.1038%2FNRRHEUM.2010.196

Long-term anti-arthritic and anti-osteoporotic effects of raloxifene in established experimental postmenopausal polyarthritis

31 March 2020

1 reference

https://api.crossref.org/works/10.1038%2FNRRHEUM.2010.196

31 March 2020

1 reference

https://api.crossref.org/works/10.1038%2FNRRHEUM.2010.196

Effect of interleukin-6 receptor inhibition with tocilizumab in patients with rheumatoid arthritis (OPTION study): a double-blind, placebo-controlled, randomised trial.

31 March 2020

1 reference

https://api.crossref.org/works/10.1038%2FNRRHEUM.2010.196

Rapid and sustained improvement in bone and cartilage turnover markers with the anti-interleukin-6 receptor inhibitor tocilizumab plus methotrexate in rheumatoid arthritis patients with an inadequate response to methotrexate: results from a substudy

31 March 2020

1 reference

https://api.crossref.org/works/10.1038%2FNRRHEUM.2010.196

Antiresorptive therapy conserves some periarticular bone and ligament mechanical properties after anterior cruciate ligament disruption in the rabbit knee

31 March 2020

1 reference

https://api.crossref.org/works/10.1038%2FNRRHEUM.2010.196

In vivo microfocal computed tomography and micro-magnetic resonance imaging evaluation of antiresorptive and antiinflammatory drugs as preventive treatments of osteoarthritis in the rat.

31 March 2020

1 reference

https://api.crossref.org/works/10.1038%2FNRRHEUM.2010.196

Risedronate decreases biochemical markers of cartilage degradation but does not decrease symptoms or slow radiographic progression in patients with medial compartment osteoarthritis of the knee: results of the two-year multinational knee osteoarthri

31 March 2020

1 reference

https://api.crossref.org/works/10.1038%2FNRRHEUM.2010.196

Relationships between biochemical markers of bone and cartilage degradation with radiological progression in patients with knee osteoarthritis receiving risedronate: the Knee Osteoarthritis Structural Arthritis randomized clinical trial

31 March 2020

1 reference

https://api.crossref.org/works/10.1038%2FNRRHEUM.2010.196

Protective effects of licofelone, a 5-lipoxygenase and cyclo-oxygenase inhibitor, versus naproxen on cartilage loss in knee osteoarthritis: a first multicentre clinical trial using quantitative MRI.

31 March 2020

1 reference

https://api.crossref.org/works/10.1038%2FNRRHEUM.2010.196

Local cytokine profiles in knee osteoarthritis: elevated synovial fluid interleukin-15 differentiates early from end-stage disease.

31 March 2020

1 reference

https://api.crossref.org/works/10.1038%2FNRRHEUM.2010.196

Mitogen-activated protein kinase and nuclear factor kappaB together regulate interleukin-17-induced nitric oxide production in human osteoarthritic chondrocytes: possible role of transactivating factor mitogen-activated protein kinase-activated prot

31 March 2020

1 reference

https://api.crossref.org/works/10.1038%2FNRRHEUM.2010.196

Reduction of interleukin-17-induced inhibition of chondrocyte proteoglycan synthesis in intact murine articular cartilage by interleukin-4.

31 March 2020

1 reference

https://api.crossref.org/works/10.1038%2FNRRHEUM.2010.196

Differential effects of IL-8, LIF (pro-inflammatory) and IL-11 (anti-inflammatory) on TNF-alpha-induced PGE(2)release and on signalling pathways in human OA synovial fibroblasts

31 March 2020

1 reference

https://api.crossref.org/works/10.1038%2FNRRHEUM.2010.196

Characterization of infiltrating T cells and Th1/Th2-type cytokines in the synovium of patients with osteoarthritis

31 March 2020

1 reference

https://api.crossref.org/works/10.1038%2FNRRHEUM.2010.196

Cellular immune response toward human articular chondrocytes. T cell reactivities against chondrocyte and fibroblast membranes in destructive joint diseases

31 March 2020

1 reference

https://api.crossref.org/works/10.1038%2FNRRHEUM.2010.196

Contribution of interleukin 17 to human cartilage degradation and synovial inflammation in osteoarthritis

31 March 2020

1 reference

https://api.crossref.org/works/10.1038%2FNRRHEUM.2010.196

Computer-aided method for quantification of cartilage thickness and volume changes using MRI: validation study using a synthetic model.

31 March 2020

1 reference

https://api.crossref.org/works/10.1038%2FNRRHEUM.2010.196

Reliability of a quantification imaging system using magnetic resonance images to measure cartilage thickness and volume in human normal and osteoarthritic knees.

31 March 2020

1 reference

https://api.crossref.org/works/10.1038%2FNRRHEUM.2010.196

Meniscal tear and extrusion are strongly associated with progression of symptomatic knee osteoarthritis as assessed by quantitative magnetic resonance imaging

31 March 2020

1 reference

https://api.crossref.org/works/10.1038%2FNRRHEUM.2010.196

Correlation between bone lesion changes and cartilage volume loss in patients with osteoarthritis of the knee as assessed by quantitative magnetic resonance imaging over a 24-month period

31 March 2020

1 reference

https://api.crossref.org/works/10.1038%2FNRRHEUM.2010.196

A new non-invasive method to assess synovitis severity in relation to symptoms and cartilage volume loss in knee osteoarthritis patients using MRI

31 March 2020

1 reference

https://api.crossref.org/works/10.1038%2FNRRHEUM.2010.196

Human hip joint cartilage: MRI quantitative thickness and volume measurements discriminating acetabulum and femoral head

31 March 2020

1 reference

https://api.crossref.org/works/10.1038%2FNRRHEUM.2010.196

Fully automated system for the quantification of human osteoarthritic knee joint effusion volume using magnetic resonance imaging

31 March 2020

1 reference

https://api.crossref.org/works/10.1038%2FNRRHEUM.2010.196

The effect of human interleukin 1 on proteoglycan metabolism in human and porcine cartilage explants.

31 March 2020

1 reference

12 December 2020

PPARgamma ligands as modulators of inflammatory and catabolic responses in arthritis. An overview.

1 reference

12 December 2020

Interleukin 17 (IL-17) induces collagenase-3 production in human osteoarthritic chondrocytes via AP-1 dependent activation: differential activation of AP-1 members by IL-17 and IL-1beta

1 reference

12 December 2020

Production of interleukin-1 receptor antagonist, inflammatory chemotactic proteins, and prostaglandin E by rheumatoid and osteoarthritic synoviocytes--regulation by IFN-gamma and IL-4

1 reference

12 December 2020

Arthritogenic actions of recombinant IL-1 and tumour necrosis factor alpha in the rabbit: evidence for synergistic interactions between cytokines in vivo

1 reference

12 December 2020

Human synovial fibroblasts coexpress IL-1 receptor type I and type II mRNA. The increased level of the IL-1 receptor in osteoarthritic cells is related to an increased level of the type I receptor

1 reference

12 December 2020

Interleukin 17, a nitric oxide-producing cytokine with a peroxynitrite-independent inhibitory effect on proteoglycan synthesis.

1 reference

12 December 2020

The differential expression of osteoprotegerin (OPG) and receptor activator of nuclear factor kappaB ligand (RANKL) in human osteoarthritic subchondral bone osteoblasts is an indicator of the metabolic state of these disease cells

1 reference

12 December 2020

Osteoarthritic synovial fibroblasts possess an increased level of tumor necrosis factor-receptor 55 (TNF-R55) that mediates biological activation by TNF-alpha

1 reference

12 December 2020

A pilot study of tumor necrosis factor inhibition in erosive/inflammatory osteoarthritis of the hands

1 reference

12 December 2020

Expression of the types A and B tumor necrosis factor (TNF) receptors is independently regulated, and both receptors mediate activation of the transcription factor NF-kappa B. TNF alpha is not needed for induction of a biological effect via TNF rece

1 reference

12 December 2020

Safety study of intraarticular injection of interleukin 1 receptor antagonist in patients with painful knee osteoarthritis: a multicenter study

1 reference

12 December 2020

IL-6 production by human articular chondrocytes. Modulation of its synthesis by cytokines, growth factors, and hormones in vitro

1 reference

12 December 2020

IL-18 is produced by articular chondrocytes and induces proinflammatory and catabolic responses

1 reference

12 December 2020

Involvement of the 55- and 75-kDa tumor necrosis factor receptors in the generation of lymphokine-activated killer cell activity and proliferation of natural killer cells

1 reference

12 December 2020

Cartilage and joint inflammation. Regulation of IL-8 expression by human articular chondrocytes.

1 reference

12 December 2020

Interleukin-6 reduces cartilage destruction during experimental arthritis. A study in interleukin-6-deficient mice

1 reference

12 December 2020

Tumor necrosis factor-alpha receptor expression on chondrocytes isolated from human articular cartilage

1 reference

12 December 2020

Identifiers

DOI

10.1038/NRRHEUM.2010.196

1 reference

23 August 2017

1 reference

PubMed ID

21119608