(Q37078072)

18 August 2017

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title

Reappraising metalloproteinases in rheumatoid arthritis and osteoarthritis: destruction or repair? (English)

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18 August 2017

0 references

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Gillian Murphy

1

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18 August 2017

Hideaki Nagase

series ordinal

2

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18 August 2017

publication date

1 March 2008

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Nature Clinical Practice Rheumatology

18 August 2017

published in

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18 August 2017

volume

4

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18 August 2017

issue

3

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18 August 2017

page(s)

128-135

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Sites of collagenase cleavage and denaturation of type II collagen in aging and osteoarthritic articular cartilage and their relationship to the distribution of matrix metalloproteinase 1 and matrix metalloproteinase 13

18 August 2017

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7 January 2021

Turnover of type II collagen and aggrecan in cartilage matrix at the onset of inflammatory arthritis in humans: Relationship to mediators of systemic and local inflammation

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7 January 2021

Aggrecan degradation in human cartilage. Evidence for both matrix metalloproteinase and aggrecanase activity in normal, osteoarthritic, and rheumatoid joints

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7 January 2021

Collagenolytic activity in amphibian tissues: a tissue culture assay

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7 January 2021

Purification of Rheumatoid Synovial Collagenase and Its Action on Soluble and Insoluble Collagen

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7 January 2021

Collagenase at Sites of Cartilage Erosion in the Rheumatoid Joint

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7 January 2021

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7 January 2021

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7 January 2021

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7 January 2021

Purification and cloning of aggrecanase-1: a member of the ADAMTS family of proteins

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7 January 2021

Proteolytic activities of human ADAMTS-5: comparative studies with ADAMTS-4.

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7 January 2021

The ADAMTS metalloproteinases

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A metalloproteinase disintegrin that releases tumour-necrosis factor-alpha from cells

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7 January 2021

Cloning of a disintegrin metalloproteinase that processes precursor tumour-necrosis factor-alpha

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7 January 2021

ADAMs: modulators of cell–cell and cell–matrix interactions

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7 January 2021

Expression and regulation of aggrecanase in arthritis: the role of TGF-beta

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7 January 2021

Synovial tissue inflammation in early and late osteoarthritis

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7 January 2021

Expression profiling of metalloproteinases and their inhibitors in cartilage

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7 January 2021

Matrix metalloproteinase knockout studies and the potential use of matrix metalloproteinase inhibitors in the rheumatic diseases

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7 January 2021

Endothelin 1 promotes osteoarthritic cartilage degradation via matrix metalloprotease 1 and matrix metalloprotease 13 induction.

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7 January 2021

Up-regulation of matrix metalloproteinase expression and activation following cyclical compressive loading of articular cartilage in vitro

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7 January 2021

Mechanical injury of cartilage explants causes specific time-dependent changes in chondrocyte gene expression

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7 January 2021

Mechanisms of disease: role of chondrocytes in the pathogenesis of osteoarthritis--structure, chaos and senescence

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7 January 2021

Evidence for metalloproteinase and metalloproteinase inhibitor imbalance in human osteoarthritic cartilage

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7 January 2021

Matrix metalloproteinases and tissue inhibitors of metalloproteinases in synovial fluids from patients with rheumatoid arthritis or osteoarthritis.

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7 January 2021

Human osteoarthritis synovial fluid and joint cartilage contain both aggrecanase- and matrix metalloproteinase-generated aggrecan fragments

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7 January 2021

Inhibition of cartilage and bone destruction in adjuvant arthritis in the rat by a matrix metalloproteinase inhibitor

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7 January 2021

ADAMTS5 is the major aggrecanase in mouse cartilage in vivo and in vitro

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7 January 2021

Deletion of active ADAMTS5 prevents cartilage degradation in a murine model of osteoarthritis

1 reference

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7 January 2021

MT1-MMP-deficient mice develop dwarfism, osteopenia, arthritis, and connective tissue disease due to inadequate collagen turnover

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7 January 2021

Homeostatic effects of the metalloproteinase disintegrin ADAM15 in degenerative cartilage remodeling

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7 January 2021

The role of matrix metalloproteinase-2 and matrix metalloproteinase-9 in antibody-induced arthritis

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7 January 2021

Gene deletion of either interleukin-1beta, interleukin-1beta-converting enzyme, inducible nitric oxide synthase, or stromelysin 1 accelerates the development of knee osteoarthritis in mice after surgical transection of the medial collateral ligament

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7 January 2021

Reduction of serum matrix metalloproteinase 1 and matrix metalloproteinase 3 in rheumatoid arthritis patients following anti-tumour necrosis factor-alpha (cA2) therapy

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7 January 2021

Role of interleukin-1 and tumor necrosis factor alpha in matrix degradation of human osteoarthritic cartilage.

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7 January 2021

Insight into the structural determinants for selective inhibition of matrix metalloproteinases

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7 January 2021

Discovery and characterization of a novel inhibitor of matrix metalloprotease-13 that reduces cartilage damage in vivo without joint fibroplasia side effects

1 reference

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7 January 2021

Metalloproteinase inhibitors: biological actions and therapeutic opportunities.

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7 January 2021

Mechanism of inhibition of the human matrix metalloproteinase stromelysin-1 by TIMP-1

1 reference

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7 January 2021

Crystal structure of the complex formed by the membrane type 1-matrix metalloproteinase with the tissue inhibitor of metalloproteinases-2, the soluble progelatinase A receptor

1 reference

https://api.crossref.org/works/10.1038%2FNCPRHEUM0727

7 January 2021

Reactive site mutations in tissue inhibitor of metalloproteinase-3 disrupt inhibition of matrix metalloproteinases but not tumor necrosis factor-alpha-converting enzyme.

1 reference

https://api.crossref.org/works/10.1038%2FNCPRHEUM0727

7 January 2021

Collagenase unwinds triple-helical collagen prior to peptide bond hydrolysis

1 reference

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7 January 2021

Altered proteolytic activities of ADAMTS-4 expressed by C-terminal processing

1 reference

https://api.crossref.org/works/10.1038%2FNCPRHEUM0727

7 January 2021

ADAMTS-13 cysteine-rich/spacer domains are functionally essential for von Willebrand factor cleavage

1 reference

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7 January 2021

Searching for new allosteric sites in enzymes

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7 January 2021

Triptolide, a novel diterpenoid triepoxide from Tripterygium wilfordii Hook. f., suppresses the production and gene expression of pro-matrix metalloproteinases 1 and 3 and augments those of tissue inhibitors of metalloproteinases 1 and 2 in human sy

1 reference

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7 January 2021

Green tea polyphenol epigallocatechin-3-gallate (EGCG) differentially inhibits interleukin-1 beta-induced expression of matrix metalloproteinase-1 and -13 in human chondrocytes

1 reference

https://api.crossref.org/works/10.1038%2FNCPRHEUM0727

7 January 2021

A synthetic triterpenoid selectively inhibits the induction of matrix metalloproteinases 1 and 13 by inflammatory cytokines

1 reference

https://api.crossref.org/works/10.1038%2FNCPRHEUM0727

7 January 2021

Effects of doxycycline on progression of osteoarthritis: results of a randomized, placebo-controlled, double-blind trial

1 reference

https://api.crossref.org/works/10.1038%2FNCPRHEUM0727

7 January 2021

Biological markers in osteoarthritis

1 reference

https://api.crossref.org/works/10.1038%2FNCPRHEUM0727

7 January 2021

A scrutiny of matrix metalloproteinases in osteoclasts: evidence for heterogeneity and for the presence of MMPs synthesized by other cells

1 reference

https://api.crossref.org/works/10.1038%2FNCPRHEUM0727

7 January 2021

Identifiers

DOI

10.1038/NCPRHEUM0727

1 reference

18 August 2017

1 reference