(Q36216413)

12 August 2017

Protein kinase Cθ C2 domain is a phosphotyrosine binding module that plays a key role in its activation (English)

1 reference

12 August 2017

Robert V Stahelin

1

1 reference

12 August 2017

Kok-Fai Kong

2

1 reference

12 August 2017

Sumita Raha

3

1 reference

12 August 2017

Wen Tian

4

1 reference

12 August 2017

Heather R Melowic

5

1 reference

12 August 2017

Katherine E Ward

6

1 reference

12 August 2017

Diana Murray

7

1 reference

12 August 2017

Amnon Altman

8

1 reference

12 August 2017

Wonhwa Cho

9

1 reference

12 August 2017

language of work or name

English

0 references

publication date

11 July 2012

1 reference

Journal of Biological Chemistry

12 August 2017

1 reference

12 August 2017

287

1 reference

12 August 2017

36

1 reference

12 August 2017

30518-30528

1 reference

Crystal Structure and Allosteric Activation of Protein Kinase C βII

12 August 2017

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=3436300

Physiological role for phosphatidic acid in the translocation of the novel protein kinase C Apl II in Aplysia neurons

1 October 2017

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=3436300

Protein kinase C theta (PKCtheta): a key player in T cell life and death

1 October 2017

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=3436300

Membrane binding and subcellular targeting of C2 domains

1 October 2017

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=3436300

Identification of an alcohol binding site in the first cysteine-rich domain of protein kinase Cdelta

1 October 2017

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=3436300

The C2 domain of PKCdelta is a phosphotyrosine binding domain

1 October 2017

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=3436300

Regulation of ADAM12 cell-surface expression by protein kinase C epsilon

1 October 2017

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=3436300

Mechanism of diacylglycerol-induced membrane targeting and activation of protein kinase Cdelta

1 October 2017

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=3436300

Divergence and complexities in DAG signaling: looking beyond PKC

1 October 2017

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=3436300

The simultaneous production of phosphatidic acid and diacylglycerol is essential for the translocation of protein kinase Cepsilon to the plasma membrane in RBL-2H3 cells

1 October 2017

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=3436300

Tools for comparative protein structure modeling and analysis

1 October 2017

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=3436300

Protein kinase C theta affects Ca2+ mobilization and NFAT cell activation in primary mouse T cells

1 October 2017

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=3436300

Membrane binding mechanisms of the PX domains of NADPH oxidase p40phox and p47phox

1 October 2017

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=3436300

Protein kinase C delta (PKC delta): activation mechanisms and functions

1 October 2017

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=3436300

Activation mechanisms of protein kinase C: maturation, catalytic activation, and targeting

1 October 2017

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=3436300

Move over protein kinase C, you've got company: alternative cellular effectors of diacylglycerol and phorbol esters.

1 October 2017

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=3436300

Translocation of PKC[theta] in T cells is mediated by a nonconventional, PI3-K- and Vav-dependent pathway, but does not absolutely require phospholipase C

1 October 2017

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=3436300

Protein kinase C(theta) in T cell activation

1 October 2017

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=3436300

Regulation of PKC alpha activity by C1-C2 domain interactions

1 October 2017

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=3436300

Protein kinase C: structural and spatial regulation by phosphorylation, cofactors, and macromolecular interactions

1 October 2017

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=3436300

Membrane targeting of C2 domains of phospholipase C-delta isoforms

1 October 2017

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=3436300

Structure of the C2 domain from novel protein kinase Cepsilon. A membrane binding model for Ca(2+)-independent C2 domains

1 October 2017

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=3436300

Membrane targeting by C1 and C2 domains

1 October 2017

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=3436300

Roles of ionic residues of the C1 domain in protein kinase C-alpha activation and the origin of phosphatidylserine specificity.

1 October 2017

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=3436300

T-Coffee: A novel method for fast and accurate multiple sequence alignment

1 October 2017

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=3436300

Protein kinase C-theta participates in NF-kappaB activation induced by CD3-CD28 costimulation through selective activation of IkappaB kinase beta

1 October 2017

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=3436300

NF-kappa B activation induced by T cell receptor/CD28 costimulation is mediated by protein kinase C-theta

1 October 2017

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=3436300

Multiple pathways control protein kinase C phosphorylation

1 October 2017

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=3436300

The immunological synapse: a molecular machine controlling T cell activation

1 October 2017

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=3436300

Three-dimensional segregation of supramolecular activation clusters in T cells

1 October 2017

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=3436300

CD28 mediates transcriptional upregulation of the interleukin-2 (IL-2) promoter through a composite element containing the CD28RE and NF-IL-2B AP-1 sites

1 October 2017

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=3436300

Protein kinase C-theta isoenzyme selective stimulation of the transcription factor complex AP-1 in T lymphocytes

1 October 2017

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=3436300

Site-directed mutagenesis by overlap extension using the polymerase chain reaction

1 October 2017

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=3436300

Protein folding and association: insights from the interfacial and thermodynamic properties of hydrocarbons

1 October 2017

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=3436300

Assessment of protein models with three-dimensional profiles

1 October 2017

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=3436300

Differential roles of phosphatidylserine, PtdIns(4,5)P2, and PtdIns(3,4,5)P3 in plasma membrane targeting of C2 domains. Molecular dynamics simulation, membrane binding, and cell translocation studies of the PKCalpha C2 domain

1 October 2017

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=3436300

A single residue in the C1 domain sensitizes novel protein kinase C isoforms to cellular diacylglycerol production

29 June 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=3436300

Activation mechanisms of conventional protein kinase C isoforms are determined by the ligand affinity and conformational flexibility of their C1 domains

29 June 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=3436300

Regulation of protein kinase Ctheta function during T cell activation by Lck-mediated tyrosine phosphorylation

29 June 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=3436300

The role of C2 domains in Ca2+-activated and Ca2+-independent protein kinase Cs in aplysia.

29 June 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=3436300

Interaction of alcohols and anesthetics with protein kinase Calpha.

29 June 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=3436300

Protein kinase Calpha contains two activator binding sites that bind phorbol esters and diacylglycerols with opposite affinities.

29 June 2018

1 reference

https://api.crossref.org/works/10.1074%2FJBC.M112.391557

Identification of a general anesthetic binding site in the diacylglycerol-binding domain of protein kinase Cdelta

21 January 2018

1 reference

https://api.crossref.org/works/10.1074%2FJBC.M112.391557

Effects of Ethanol on Protein Kinase C α Activity Induced by Association with Rho GTPases

21 January 2018

1 reference

https://api.crossref.org/works/10.1074%2FJBC.M112.391557

Effects of ethanol on protein kinase C activity induced by filamentous actin

21 January 2018

1 reference

https://api.crossref.org/works/10.1074%2FJBC.M112.391557

Characterization of the membrane binding mode of the C2 domain of PKC epsilon.

21 January 2018

1 reference

https://api.crossref.org/works/10.1074%2FJBC.M112.391557

Mechanism of diacylglycerol-induced membrane targeting and activation of protein kinase Ctheta.

21 January 2018

1 reference

https://api.crossref.org/works/10.1074%2FJBC.M112.391557

Ceramide-1-phosphate binds group IVA cytosolic phospholipase a2 via a novel site in the C2 domain

21 January 2018

1 reference

https://api.crossref.org/works/10.1074%2FJBC.M112.391557

Differential roles of ionic, aliphatic, and aromatic residues in membrane-protein interactions: a surface plasmon resonance study on phospholipases A2.

21 January 2018

1 reference

https://api.crossref.org/works/10.1074%2FJBC.M112.391557

Roles of calcium ions in the membrane binding of C2 domains.

21 January 2018

1 reference

https://api.crossref.org/works/10.1074%2FJBC.M112.391557

Phosphatidylinositol 3-phosphate induces the membrane penetration of the FYVE domains of Vps27p and Hrs.

21 January 2018

1 reference

https://api.crossref.org/works/10.1074%2FJBC.M112.391557

Mechanism of membrane binding of the phospholipase D1 PX domain

21 January 2018

1 reference

https://api.crossref.org/works/10.1074%2FJBC.M112.391557

Diacylglycerol-induced Membrane Targeting and Activation of Protein Kinase Cϵ

21 January 2018

1 reference

https://api.crossref.org/works/10.1074%2FJBC.M112.391557

Stimulation of p21 ras upon T-cell activation

21 January 2018

1 reference

https://api.crossref.org/works/10.1074%2FJBC.M112.391557

Diacylglycerol and Protein Kinase D Localization during T Lymphocyte Activation

21 January 2018

1 reference

https://api.crossref.org/works/10.1074%2FJBC.M112.391557

PKC-θ is required for TCR-induced NF-κB activation in mature but not immature T lymphocytes

21 January 2018

1 reference

https://api.crossref.org/works/10.1074%2FJBC.M112.391557

Using multiple structure alignments, fast model building, and energetic analysis in fold recognition and homology modeling

21 January 2018

1 reference

PubMed

https://pubmed.ncbi.nlm.nih.gov/22787157

inferred from PubMed ID database lookup

12 December 2020

based on heuristic

Membrane penetration of cytosolic phospholipase A2 is necessary for its interfacial catalysis and arachidonate specificity

1 reference

PubMed

https://pubmed.ncbi.nlm.nih.gov/22787157

inferred from PubMed ID database lookup

12 December 2020

based on heuristic

Interplay of C1 and C2 domains of protein kinase C-alpha in its membrane binding and activation

1 reference

PubMed

https://pubmed.ncbi.nlm.nih.gov/22787157

inferred from PubMed ID database lookup

12 December 2020

based on heuristic

Identifiers

DOI

10.1074/JBC.M112.391557

1 reference

12 August 2017

1 reference

12 August 2017

PubMed publication ID

22787157

1 reference