(Q36231781)

12 August 2017

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title

Trashing the genome: the role of nucleases during apoptosis (English)

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12 August 2017

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William Charles Earnshaw

object named as

William C Earnshaw

series ordinal

2

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author name string

Kumiko Samejima

series ordinal

1

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12 August 2017

language of work or name

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1 September 2005

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Nature Reviews Molecular Cell Biology

12 August 2017

published in

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12 August 2017

volume

6

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12 August 2017

issue

9

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12 August 2017

page(s)

677-688

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Apoptosis: A Basic Biological Phenomenon with Wideranging Implications in Tissue Kinetics

12 August 2017

cites work

1 reference

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Molecular characterization of mitochondrial apoptosis-inducing factor

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CAD/DFF40 nuclease is dispensable for high molecular weight DNA cleavage and stage I chromatin condensation in apoptosis.

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The role of DNA fragmentation in apoptosis

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Endonuclease activities associated with high molecular weight and internucleosomal DNA fragmentation in apoptosis.

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Nuclear war: the granzyme A-bomb

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DNA fragmentation during apoptosis is caused by frequent single-strand cuts

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The cleavage of nuclear DNA into high molecular weight DNA fragments occurs not only during apoptosis but also accompanies changes in functional activity of the nonapoptotic cells

31 March 2020

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Detection of DNA Cleavage in Apoptotic Cells

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The 40-kDa subunit of DNA fragmentation factor induces DNA fragmentation and chromatin condensation during apoptosis

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DFF, a heterodimeric protein that functions downstream of caspase-3 to trigger DNA fragmentation during apoptosis

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31 March 2020

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Specific chaperone-like activity of inhibitor of caspase-activated DNase for caspase-activated DNase

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31 March 2020

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ICAD/DFF Regulator of Apoptotic Nuclease Is Nuclear

31 March 2020

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Differential Localization of ICAD-L and ICAD-S in Cells Due to Removal of a C-Terminal NLS from ICAD-L by Alternative Splicing

31 March 2020

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Determinants of the nuclear localization of the heterodimeric DNA fragmentation factor (ICAD/CAD).

31 March 2020

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Contrasting nuclear dynamics of the caspase-activated DNase (CAD) in dividing and apoptotic cells

31 March 2020

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Interaction of DNA fragmentation factor (DFF) with DNA reveals an unprecedented mechanism for nuclease inhibition and suggests that DFF can be activated in a DNA-bound state

31 March 2020

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Structural mechanism for inactivation and activation of CAD/DFF40 in the apoptotic pathway

31 March 2020

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DFF45/ICAD can be directly processed by granzyme B during the induction of apoptosis

31 March 2020

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Caspase-3 is the primary activator of apoptotic DNA fragmentation via DNA fragmentation factor-45/inhibitor of caspase-activated DNase inactivation.

31 March 2020

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Cleavage of CAD inhibitor in CAD activation and DNA degradation during apoptosis

31 March 2020

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Cleavage preferences of the apoptotic endonuclease DFF40 (caspase-activated DNase or nuclease) on naked DNA and chromatin substrates

31 March 2020

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Identification of the nuclear factor HMG2 as an activator for DFF nuclease activity

31 March 2020

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DNA topoisomerase IIalpha interacts with CAD nuclease and is involved in chromatin condensation during apoptotic execution

31 March 2020

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Activation of the apoptotic endonuclease DFF40 (caspase-activated DNase or nuclease). Oligomerization and direct interaction with histone H1

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Transition from caspase-dependent to caspase-independent mechanisms at the onset of apoptotic execution.

31 March 2020

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31 March 2020

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Identification of a novel antiapoptotic protein that antagonizes ASK1 and CAD activities

31 March 2020

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Impaired thymic development in mouse embryos deficient in apoptotic DNA degradation

31 March 2020

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Lack of obvious 50 kilobase pair DNA fragments in DNA fragmentation factor 45-deficient thymocytes upon activation of apoptosis

31 March 2020

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DNA fragmentation factor 45-deficient cells are more resistant to apoptosis and exhibit different dying morphology than wild-type control cells

31 March 2020

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Dna fragmentation factor 45 mutant mice exhibit resistance to kainic acid-induced neuronal cell death

31 March 2020

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DNA fragmentation factor 45 deficient mice exhibit enhanced spatial learning and memory compared to wild-type control mice.

31 March 2020

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Primers for mitochondrial DNA replication generated by endonuclease G.

31 March 2020

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Characterization and expression of the mouse endonuclease G gene

31 March 2020

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Structural and functional characterization of mitochondrial EndoG, a sugar non-specific nuclease which plays an important role during apoptosis

31 March 2020

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Endonuclease G is an apoptotic DNase when released from mitochondria

31 March 2020

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Mitochondrial release of AIF and EndoG requires caspase activation downstream of Bax/Bak-mediated permeabilization

31 March 2020

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Action of recombinant human apoptotic endonuclease G on naked DNA and chromatin substrates: cooperation with exonuclease and DNase I.

31 March 2020

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Mitochondrial endonuclease G is important for apoptosis in C. elegans.

31 March 2020

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Functional genomic analysis of apoptotic DNA degradation in C. elegans.

31 March 2020

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Endonuclease G is required for early embryogenesis and normal apoptosis in mice

31 March 2020

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Generation and characterization of endonuclease G null mice

31 March 2020

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Analysis of the role of the NUC1 endo/exonuclease in yeast mitochondrial DNA recombination

31 March 2020

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31 March 2020

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A role of the Ca2+/Mg2+-dependent endonuclease in apoptosis and its inhibition by Poly(ADP-ribose) polymerase

31 March 2020

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Purification and properties of DNase gamma from apoptotic rat thymocytes

31 March 2020

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Molecular cloning and expression of a cDNA encoding an apoptotic endonuclease DNase gamma

31 March 2020

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Characterization of human DNase I family endonucleases and activation of DNase gamma during apoptosis

31 March 2020

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Identification of two functional nuclear localization signals in DNase gamma and their roles in its apoptotic DNase activity

31 March 2020

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Involvement of DNase gamma in the resected double-strand DNA breaks in immunoglobulin genes

31 March 2020

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Involvement of DNase gamma in apoptosis associated with myogenic differentiation of C2C12 cells

31 March 2020

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Differential DNases are selectively used in neuronal apoptosis depending on the differentiation state

31 March 2020

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A novel inhibitor that protects apoptotic DNA fragmentation catalyzed by DNase gamma

31 March 2020

1 reference

Recombinant cyclophilins lack nuclease activity.

31 March 2020

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AIF and cyclophilin A cooperate in apoptosis-associated chromatinolysis

31 March 2020

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DNase II: genes, enzymes and function

31 March 2020

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The C. elegans apoptotic nuclease NUC-1 is related in sequence and activity to mammalian DNase II.

31 March 2020

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Requirement of DNase II for definitive erythropoiesis in the mouse fetal liver

31 March 2020

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Deoxyribonuclease IIalpha is required during the phagocytic phase of apoptosis and its loss causes perinatal lethality.

31 March 2020

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Mutations affecting programmed cell deaths in the nematode Caenorhabditis elegans

31 March 2020

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Activation of the innate immunity in Drosophila by endogenous chromosomal DNA that escaped apoptotic degradation

31 March 2020

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Impairment of T and B cell development by treatment with a type I interferon

31 March 2020

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Features of systemic lupus erythematosus in Dnase1-deficient mice

31 March 2020

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CRN-1, a Caenorhabditis elegans FEN-1 homologue, cooperates with CPS-6/EndoG to promote apoptotic DNA degradation

31 March 2020

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Mitochondrial release of apoptosis-inducing factor occurs downstream of cytochrome c release in response to several proapoptotic stimuli

31 March 2020

1 reference

The crystal structure of the mouse apoptosis-inducing factor AIF

31 March 2020

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NADH oxidase activity of mitochondrial apoptosis-inducing factor

31 March 2020

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The harlequin mouse mutation downregulates apoptosis-inducing factor

31 March 2020

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AIF deficiency compromises oxidative phosphorylation

31 March 2020

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Mechanisms of AIF-mediated apoptotic DNA degradation in Caenorhabditis elegans

31 March 2020

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Dueling activities of AIF in cell death versus survival: DNA binding and redox activity

31 March 2020

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Apoptosis-inducing factor (AIF): key to the conserved caspase-independent pathways of cell death?

31 March 2020

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DNA binding is required for the apoptogenic action of apoptosis inducing factor

31 March 2020

1 reference

On the evolutionary conservation of the cell death pathway: mitochondrial release of an apoptosis-inducing factor during Dictyostelium discoideum cell death

31 March 2020

1 reference

An AIF orthologue regulates apoptosis in yeast

31 March 2020

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Heat shock protein 70 binding inhibits the nuclear import of apoptosis-inducing factor.

31 March 2020

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Essential role of the mitochondrial apoptosis-inducing factor in programmed cell death

31 March 2020

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Large-scale fragmentation of mammalian DNA in the course of apoptosis proceeds via excision of chromosomal DNA loops and their oligomers

31 March 2020

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Activation of topoisomerase II-mediated excision of chromosomal DNA loops during oxidative stress.

31 March 2020

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ATP-dependent partitioning of the DNA template into supercoiled domains by Escherichia coli UvrAB

31 March 2020

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The role of topoisomerase II in the excision of DNA loop domains during apoptosis

31 March 2020

1 reference

L-DNase II, a molecule that links proteases and endonucleases in apoptosis, derives from the ubiquitous serpin leukocyte elastase inhibitor

31 March 2020

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L-DNase II activation by the 24 kDa apoptotic protease (AP24) in TNFalpha-induced apoptosis

31 March 2020

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The LEI/L-DNase II pathway is activated in light-induced retinal degeneration in rats.

31 March 2020

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Involvement of L-DNase II in nuclear degeneration during chick retina development

31 March 2020

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Differential involvement of DNases in HeLa cell apoptosis induced by etoposide and long term-culture

31 March 2020

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Nuclear translocation of a leukocyte elastase Inhibitor/Elastase complex during staurosporine-induced apoptosis: role in the generation of nuclear L-DNase II activity

31 March 2020

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Involvement of DNase II in nuclear degeneration during lens cell differentiation

31 March 2020

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Degradation of ribosomal RNA precursors by the exosome

31 March 2020

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The yeast exosome and human PM-Scl are related complexes of 3' --> 5' exonucleases

31 March 2020

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Distinct mechanisms underlay DNA disintegration during apoptosis induced by genotoxic and nongenotoxic agents in neuroblastoma cells

31 March 2020

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Two distinct pathways leading to nuclear apoptosis

31 March 2020

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Single-stranded DNA induces ataxia telangiectasia mutant (ATM)/p53-dependent DNA damage and apoptotic signals.

31 March 2020

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DNA-dependent protein kinase enhances DNA damage-induced apoptosis in association with Friend gp70.

31 March 2020

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Involvement of histone H1.2 in apoptosis induced by DNA double-strand breaks

31 March 2020

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Nucleosomes are exposed at the cell surface in apoptosis.

31 March 2020

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Accumulation of histones in cell lysates precedes expression of apoptosis-related phagocytosis signals in human lymphoblasts

31 March 2020

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Blebs and apoptotic bodies are B cell autoantigens

31 March 2020

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Mutation of DNASE1 in people with systemic lupus erythematosus

31 March 2020

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Fine mapping of 28S rRNA sites specifically cleaved in cells undergoing apoptosis

31 March 2020

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Sterile 20 kinase phosphorylates histone H2B at serine 10 during hydrogen peroxide-induced apoptosis in S. cerevisiae

31 March 2020

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31 March 2020

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Plasma membrane alteration is an early signaling event in doxorubicin-induced apoptosis in the yeast Candida utilis

31 March 2020

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Viral killer toxins induce caspase-mediated apoptosis in yeast

31 March 2020

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Yeast cell death during DNA damage arrest is independent of caspase or reactive oxygen species

31 March 2020

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Valproic acid induces apoptosis dependent of Yca1p at concentrations that mildly affect the proliferation of yeast

31 March 2020

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Osmotin is a homolog of mammalian adiponectin and controls apoptosis in yeast through a homolog of mammalian adiponectin receptor.

31 March 2020

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Oxygen stress: a regulator of apoptosis in yeast

31 March 2020

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A yeast mutant showing diagnostic markers of early and late apoptosis

31 March 2020

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Autoimmune disease in mice due to integration of an endogenous retrovirus in an apoptosis gene

31 March 2020

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Purification, characterization, and amino acid sequencing of DNase gamma from rat spleen

31 March 2020

1 reference

Native recombinant cyclophilins A, B, and C degrade DNA independently of peptidylprolyl cis-trans-isomerase activity. Potential roles of cyclophilins in apoptosis

31 March 2020

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Tumor suppressor NM23-H1 is a granzyme A-activated DNase during CTL-mediated apoptosis, and the nucleosome assembly protein SET is its inhibitor

31 March 2020

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Nucleophosmin/B23, a nuclear PI(3,4,5)P(3) receptor, mediates the antiapoptotic actions of NGF by inhibiting CAD

31 March 2020

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31 March 2020

Identifiers

DOI

10.1038/NRM1715

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12 August 2017

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