(Q36241293)

13 August 2017

Triptolide Induces hepatotoxicity via inhibition of CYP450s in Rat liver microsomes (English)

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13 August 2017

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Yajie Zhang

3

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author name string

Yan Lu

1

1 reference

13 August 2017

Tong Xie

2

1 reference

13 August 2017

Fuqiong Zhou

4

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13 August 2017

Jie Ruan

5

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13 August 2017

Weina Zhu

6

1 reference

13 August 2017

Huaxu Zhu

7

1 reference

13 August 2017

Zhe Feng

8

1 reference

13 August 2017

Xueping Zhou

9

1 reference

13 August 2017

5 January 2017

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BMC Complementary and Alternative Medicine

13 August 2017

1 reference

13 August 2017

17

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13 August 2017

1

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13 August 2017

15

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describes a project that uses

13 August 2017

ImageJ

1 reference

11 June 2022

https://www.ebi.ac.uk/europepmc/webservices/rest/PMC5217299/fullTextXML

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Immunosuppressive, anti-inflammatory and anti-cancer properties of triptolide: A mini review

1 October 2017

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The Protective Effects of Isoliquiritigenin and Glycyrrhetinic Acid against Triptolide-Induced Oxidative Stress in HepG2 Cells Involve Nrf2 Activation

1 October 2017

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CYP2E1 in the Human Retinal Pigment Epithelium: Expression, Activity, and Induction by Ethanol.

1 October 2017

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Subcellular localization of rat CYP2E1 impacts metabolic efficiency toward common substrates

1 October 2017

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Protective Effect of Triptolide against Glomerular Mesangial Cell Proliferation and Glomerular Fibrosis in Rats Involves the TGF- β 1/Smad Signaling Pathway

1 October 2017

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Triptolide: progress on research in pharmacodynamics and toxicology

1 October 2017

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A cocktail approach for assessing the in vitro activity of human cytochrome P450s: an overview of current methodologies

1 October 2017

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Triptolide with potential medicinal value for diseases of the central nervous system

1 October 2017

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Role of reactive metabolites in drug-induced hepatotoxicity

1 October 2017

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Involvement of mitochondrial pathway in triptolide-induced cytotoxicity in human normal liver L-02 cells

1 October 2017

1 reference

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Probing the world of cytochrome P450 enzymes

1 October 2017

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Isolation and characterization of a new major intestinal CYP3A form, CYP3A62, in the rat.

1 October 2017

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THE CARBON MONOXIDE-BINDING PIGMENT OF LIVER MICROSOMES. II. SOLUBILIZATION, PURIFICATION, AND PROPERTIES

1 October 2017

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Immunosuppressive and anti-inflammatory mechanisms of triptolide, the principal active diterpenoid from the Chinese medicinal herb Tripterygium wilfordii Hook. f.

1 October 2017

1 reference

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Clinical importance of the cytochromes P450

1 October 2017

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Expression and inducibility of cytochrome P450 3A9 (CYP3A9) and other members of the CYP3A subfamily in rat liver

1 October 2017

1 reference

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Isolation and characterization of a new rat P450 (CYP3A18) cDNA encoding P450(6)beta-2 catalyzing testosterone 6 beta- and 16 alpha-hydroxylations

1 October 2017

1 reference

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Regulation of two members of the steroid-inducible cytochrome P450 subfamily (3A) in rats

1 October 2017

1 reference

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The P450 superfamily: update on new sequences, gene mapping, accession numbers, early trivial names of enzymes, and nomenclature

1 October 2017

1 reference

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Drug metabolism in human liver in vitro: establishment of a human liver bank.

1 October 2017

1 reference

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Differential expression of cytochrome P450 enzymes from the CYP2C subfamily in the human brain.

1 October 2017

1 reference

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Growth hormone regulation and developmental expression of rat hepatic CYP3A18, CYP3A9, and CYP3A2.

29 June 2018

1 reference

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cDNA cloning and characterization of a novel member of steroid-induced cytochrome P450 3A in rats

29 June 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=5217299

In vivo effect of triptolide combined with glycyrrhetinic acid on rat cytochrome P450 enzymes.

29 June 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=5217299

Assessment of the roles of P-glycoprotein and cytochrome P450 in triptolide-induced liver toxicity in sandwich-cultured rat hepatocyte model

22 September 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=5217299

Metabolic pathways leading to detoxification of triptolide, a major active component of the herbal medicine Tripterygium wilfordii.

22 September 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=5217299

Sex differences in subacute toxicity and hepatic microsomal metabolism of triptolide in rats

22 September 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=5217299

Effects of cytochrome P4503A inducer dexamethasone on the metabolism and toxicity of triptolide in rat.

22 September 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=5217299

Characterization of triptolide hydroxylation by cytochrome P450 in human and rat liver microsomes

22 September 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=5217299

Evaluation of the mutagenic, cytotoxic, and antitumor potential of triptolide, a highly oxygenated diterpene isolated from Tripterygium wilfordii.

22 September 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=5217299

Reactions and enzymes in the metabolism of drugs and other xenobiotics

22 September 2018

1 reference

Crossref

https://api.crossref.org/works/10.1186%2FS12906-016-1504-3

Role of CYP3A in regulating hepatic clearance and hepatotoxicity of triptolide in rat liver microsomes and sandwich-cultured hepatocytes

21 January 2018

1 reference

12 December 2020

Pharmacokinetic study of triptolide, a constituent of immunosuppressive chinese herb medicine, in rats

1 reference

12 December 2020

Investigating human P450s involved in drug metabolism via homology with high-resolution P450 crystal structures of the CYP2C subfamily

1 reference

12 December 2020

Inhibitory Effects of Triptolide on Human Liver Cytochrome P450 Enzymes and P-Glycoprotein

1 reference

12 December 2020

Tumor inhibitors. LXXIV. Triptolide and tripdiolide, novel antileukemic diterpenoid triepoxides from Tripterygium wilfordii

1 reference

12 December 2020

Effects of triptolide on the pharmacokinetics of cyclophosphamide in rats: a possible role of cytochrome P3A4 inhibition

1 reference

12 December 2020

10.1186/S12906-016-1504-3

Identifiers

DOI

1 reference

Dimensions Publication ID

13 August 2017

0 references

1 reference

13 August 2017

PubMed publication ID

28056947

1 reference