(Q36250079)

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CRISPR/gRNA-directed synergistic activation mediator (SAM) induces specific, persistent and robust reactivation of the HIV-1 latent reservoirs

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29 February 2020

CRISPR/gRNA-directed synergistic activation mediator (SAM) induces specific, persistent and robust reactivation of the HIV-1 latent reservoirs (English)

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29 February 2020

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29 February 2020

Philip Regis Fagan

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29 February 2020

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29 February 2020

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Yonggang Zhang

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29 February 2020

Chaoran Yin

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29 February 2020

Ting Zhang

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29 February 2020

Fang Li

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29 February 2020

Wensheng Yang

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29 February 2020

Raj Putatunda

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29 February 2020

Kamel Khalili

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29 February 2020

Wenhui Hu

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5 November 2015

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29 February 2020

Scientific Reports

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29 February 2020

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29 February 2020

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29 February 2020

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5 November 2015

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https://scigraph.springernature.com/pub.10.1038/srep16277

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Mixed effects of suberoylanilide hydroxamic acid (SAHA) on the host transcriptome and proteome and their implications for HIV reactivation from latency

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=4633726

1 October 2017

Innate Immune Activity Correlates with CD4 T Cell-Associated HIV-1 DNA Decline during Latency-Reversing Treatment with Panobinostat

1 reference

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1 October 2017

Genome-editing tools for stem cell biology

1 reference

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1 October 2017

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1 reference

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1 October 2017

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1 reference

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1 October 2017

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1 reference

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1 October 2017

Toward Whole-Transcriptome Editing with CRISPR-Cas9.

1 reference

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1 October 2017

The therapeutic application of CRISPR/Cas9 technologies for HIV.

1 reference

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1 October 2017

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1 reference

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1 October 2017

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1 October 2017

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1 reference

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1 October 2017

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1 reference

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1 October 2017

Engineering complex synthetic transcriptional programs with CRISPR RNA scaffolds

1 reference

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1 October 2017

GUIDE-seq enables genome-wide profiling of off-target cleavage by CRISPR-Cas nucleases

1 reference

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1 October 2017

Genome-wide detection of DNA double-stranded breaks induced by engineered nucleases.

1 reference

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1 October 2017

Genome-scale transcriptional activation by an engineered CRISPR-Cas9 complex

1 reference

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1 October 2017

Designed transcription activator-like effector proteins efficiently induced the expression of latent HIV-1 in latently infected cells

1 reference

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1 October 2017

Broadly neutralizing antibodies and viral inducers decrease rebound from HIV-1 latent reservoirs in humanized mice

1 reference

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1 October 2017

RNA-directed gene editing specifically eradicates latent and prevents new HIV-1 infection.

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1 October 2017

Low incidence of off-target mutations in individual CRISPR-Cas9 and TALEN targeted human stem cell clones detected by whole-genome sequencing.

1 reference

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1 October 2017

Whole-genome sequencing analysis reveals high specificity of CRISPR/Cas9 and TALEN-based genome editing in human iPSCs

1 reference

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1 October 2017

Histone deacetylase inhibitor romidepsin induces HIV expression in CD4 T cells from patients on suppressive antiretroviral therapy at concentrations achieved by clinical dosing

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1 October 2017

Activation of HIV-1 from latent infection via synergy of RUNX1 inhibitor Ro5-3335 and SAHA

1 reference

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1 October 2017

Negative elongation factor is required for the maintenance of proviral latency but does not induce promoter-proximal pausing of RNA polymerase II on the HIV long terminal repeat

1 reference

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1 October 2017

Specific reactivation of latent HIV-1 with designer zinc-finger transcription factors targeting the HIV-1 5'-LTR promoter

1 reference

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1 October 2017

Transcriptional control of HIV latency: cellular signaling pathways, epigenetics, happenstance and the hope for a cure

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1 October 2017

Short communication: SAHA (vorinostat) induces CDK9 Thr-186 (T-loop) phosphorylation in resting CD4+ T cells: implications for reactivation of latent HIV.

1 reference

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1 reference

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1 reference

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1 reference

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1 reference

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1 October 2017

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1 October 2017

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1 reference

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1 reference

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1 reference

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1 October 2017

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1 reference

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1 reference

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1 reference

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1 reference

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1 reference

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1 reference

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1 reference

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1 reference

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1 reference

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22 September 2018

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10.1038/SREP16277

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29 February 2020

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29 February 2020

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29 February 2020

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