(Q36261418)

13 August 2017

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title

Aging and clinical pharmacology: implications for antidepressants (English)

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13 August 2017

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Francis E Lotrich

1

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13 August 2017

Bruce G Pollock

series ordinal

2

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13 August 2017

publication date

1 October 2005

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The Journal of Clinical Pharmacology

13 August 2017

published in

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13 August 2017

volume

45

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13 August 2017

issue

10

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13 August 2017

page(s)

1106-1122

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Adverse reactions as a cause of hospital admission in the aged

13 August 2017

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Probable adverse drug reactions in a rural geriatric nursing home population: a four-year study

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Effect of age on in vitro triazolam biotransformation in male human liver microsomes

21 January 2018

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Pharmacokinetic properties of zolpidem in elderly and young adults: possible modulation by testosterone in men.

21 January 2018

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Clinical pharmacokinetic considerations in the elderly. An update

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When drug therapy gets old: pharmacokinetics and pharmacodynamics in the elderly

21 January 2018

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Hepatic drug metabolism and aging

21 January 2018

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The hepatic sinusoid in aging and cirrhosis: effects on hepatic substrate disposition and drug clearance.

21 January 2018

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The effects of diet, aging and disease-states on presystemic elimination and oral drug bioavailability in humans

21 January 2018

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The effect of age upon liver volume and apparent liver blood flow in healthy man.

21 January 2018

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Differential pharmacokinetics of lithium in elderly patients

21 January 2018

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21 January 2018

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alpha1-acid glycoprotein in late-life depression: relationship to medical burden and genetics

21 January 2018

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Serum anticholinergic activity in a community-based sample of older adults: relationship with cognitive performance.

21 January 2018

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Effectiveness of antidepressants. Meta-analysis of dose-effect relationships in randomised clinical trials

21 January 2018

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Low serum levels of tricyclic antidepressants in amitriptyline- and doxepin-treated inpatients with depressive syndromes are associated with nonresponse.

21 January 2018

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Effects of psychotropic drugs on seizure threshold

21 January 2018

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https://api.crossref.org/works/10.1177%2F0091270005280297

Fluoxetine and norfluoxetine plasma concentrations in major depression: a multicenter study.

21 January 2018

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https://api.crossref.org/works/10.1177%2F0091270005280297

The ambiguous relation between aging and adverse drug reactions

21 January 2018

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https://api.crossref.org/works/10.1177%2F0091270005280297

Estimation of glomerular filtration rate in the elderly: a comparison of creatinine-based formulae with serum cystatin C.

21 January 2018

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https://api.crossref.org/works/10.1177%2F0091270005280297

Utility of sparse concentration sampling for citalopram in elderly clinical trial subjects

21 January 2018

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https://api.crossref.org/works/10.1177%2F0091270005280297

Effect of age on the pharmacokinetics of duloxetine in women

21 January 2018

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https://api.crossref.org/works/10.1177%2F0091270005280297

Population pharmacokinetics of nortriptyline during monotherapy and during concomitant treatment with drugs that inhibit CYP2D6--an evaluation with the nonparametric maximum likelihood method

21 January 2018

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https://api.crossref.org/works/10.1177%2F0091270005280297

Polymorphism of the serotonin transporter: implications for the use of selective serotonin reuptake inhibitors

21 January 2018

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https://api.crossref.org/works/10.1177%2F0091270005280297

Pharmacogenetics of antidepressant medication intolerance

21 January 2018

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https://api.crossref.org/works/10.1177%2F0091270005280297

Recent patterns of medication use in the ambulatory adult population of the United States: the Slone survey

21 January 2018

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https://api.crossref.org/works/10.1177%2F0091270005280297

Polypharmacy, adverse drug-related events, and potential adverse drug interactions in elderly patients presenting to an emergency department

21 January 2018

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https://api.crossref.org/works/10.1177%2F0091270005280297

CYP2D6 genotyping with oligonucleotide microarrays and nortriptyline concentrations in geriatric depression

21 January 2018

1 reference

https://api.crossref.org/works/10.1177%2F0091270005280297

Aging, muscle activity, and balance control: physiologic changes associated with balance impairment.

21 January 2018

1 reference

https://api.crossref.org/works/10.1177%2F0091270005280297

Drug-induced orthostatic hypotension in the elderly: avoiding its onset

21 January 2018

1 reference

https://api.crossref.org/works/10.1177%2F0091270005280297

Invited Review: Aging and human temperature regulation

21 January 2018

1 reference

https://api.crossref.org/works/10.1177%2F0091270005280297

Risk factors for pneumonia and other lower respiratory tract infections in elderly residents of long-term care facilities

21 January 2018

1 reference

https://api.crossref.org/works/10.1177%2F0091270005280297

Influence of age on thirst and fluid intake

21 January 2018

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https://api.crossref.org/works/10.1177%2F0091270005280297

Serum anticholinergicity in elderly depressed patients treated with paroxetine or nortriptyline

21 January 2018

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https://api.crossref.org/works/10.1177%2F0091270005280297

Paroxetine-induced hyponatremia in older adults: a 12-week prospective study

21 January 2018

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https://api.crossref.org/works/10.1177%2F0091270005280297

Efficacy of venlafaxine in geriatric depression

21 January 2018

1 reference

https://api.crossref.org/works/10.1177%2F0091270005280297

Inhibition of serotonin reuptake by antidepressants and upper gastrointestinal bleeding in elderly patients: retrospective cohort study

21 January 2018

1 reference

https://api.crossref.org/works/10.1177%2F0091270005280297

Evaluation of platelet activation in depressed patients with ischemic heart disease after paroxetine or nortriptyline treatment

21 January 2018

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https://api.crossref.org/works/10.1177%2F0091270005280297

Effect of posture on blood pressure in the elderly

21 January 2018

1 reference

https://api.crossref.org/works/10.1177%2F0091270005280297

21 January 2018

1 reference

https://api.crossref.org/works/10.1177%2F0091270005280297

Fluoxetine. A review of its pharmacodynamic and pharmacokinetic properties, and therapeutic use in older patients with depressive illness

21 January 2018

1 reference

https://api.crossref.org/works/10.1177%2F0091270005280297

Alpha- and beta-adrenergic receptor function in the brain during senescence

21 January 2018

1 reference

https://api.crossref.org/works/10.1177%2F0091270005280297

Steroid hormones and neurosteroids in normal and pathological aging of the nervous system.

21 January 2018

1 reference

https://api.crossref.org/works/10.1177%2F0091270005280297

Serotonin, memory, and the aging brain

21 January 2018

1 reference

https://api.crossref.org/works/10.1177%2F0091270005280297

Serotonin modulation of cerebral glucose metabolism in normal aging.

21 January 2018

1 reference

https://api.crossref.org/works/10.1177%2F0091270005280297

Effects of serotonin transporter promoter polymorphisms on serotonin function

21 January 2018

1 reference

https://api.crossref.org/works/10.1177%2F0091270005280297

Sensitivity to ageing of the limbic dopaminergic system: a review

21 January 2018

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https://api.crossref.org/works/10.1177%2F0091270005280297

21 January 2018

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https://api.crossref.org/works/10.1177%2F0091270005280297

Physostigmine challenge before and after chronic cholinergic blockade in elderly volunteers.

21 January 2018

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https://api.crossref.org/works/10.1177%2F0091270005280297

Evidence for an immune response in major depression: a review and hypothesis

21 January 2018

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https://api.crossref.org/works/10.1177%2F0091270005280297

Age changes in signal transduction and gene expression

21 January 2018

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https://api.crossref.org/works/10.1177%2F0091270005280297

Adrenergic receptors, G proteins, and cell regulation: implications for aging research

21 January 2018

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https://api.crossref.org/works/10.1177%2F0091270005280297

Dysregulation of protein kinase a signaling in the aged prefrontal cortex: new strategy for treating age-related cognitive decline

21 January 2018

1 reference

https://api.crossref.org/works/10.1177%2F0091270005280297

In vivo dehydroepiandrosterone restores age-associated defects in the protein kinase C signal transduction pathway and related functional responses

21 January 2018

1 reference

https://api.crossref.org/works/10.1177%2F0091270005280297

Candidate genes for antidepressant response to selective serotonin reuptake inhibitors

21 January 2018

1 reference

https://api.crossref.org/works/10.1177%2F0091270005280297

Alterations in trkB mRNA in the human prefrontal cortex throughout the lifespan

21 January 2018

1 reference

https://api.crossref.org/works/10.1177%2F0091270005280297

Cortisol, DHEAS and aging: resistance to cortisol suppression in frail institutionalized elderly

21 January 2018

1 reference

https://api.crossref.org/works/10.1177%2F0091270005280297

Medication compliance and older people: a review of the literature

21 January 2018

1 reference

https://api.crossref.org/works/10.1177%2F0091270005280297

Treatment-resistant depression in late life

21 January 2018

1 reference

https://api.crossref.org/works/10.1177%2F0091270005280297

Subcortical hyperintensities on magnetic resonance imaging: Clinical correlates and prognostic significance in patients with severe depression

21 January 2018

1 reference

https://api.crossref.org/works/10.1177%2F0091270005280297

Antidepressant pharmacotherapy in the treatment of depression in the very old: a randomized, placebo-controlled trial

21 January 2018

1 reference

https://api.crossref.org/works/10.1177%2F0091270005280297

An 8-week multicenter, parallel-group, double-blind, placebo-controlled study of sertraline in elderly outpatients with major depression

21 January 2018

1 reference

https://api.crossref.org/works/10.1177%2F0091270005280297

Remission in depressed geriatric primary care patients: a report from the PROSPECT study

21 January 2018

1 reference

https://api.crossref.org/works/10.1177%2F0091270005280297

Antidepressant versus placebo for depressed elderly.

21 January 2018

1 reference

https://api.crossref.org/works/10.1177%2F0091270005280297

Course and rate of antidepressant response in the very old.

21 January 2018

1 reference

https://api.crossref.org/works/10.1177%2F0091270005280297

Spotlight on sertraline in the management of major depressive disorder in elderly patients

21 January 2018

1 reference

https://api.crossref.org/works/10.1177%2F0091270005280297

Citalopram Therapy for Depression

21 January 2018

1 reference

https://api.crossref.org/works/10.1177%2F0091270005280297

A controlled multicenter clinical study of citalopram and placebo in elderly depressed patients with and without concomitant dementia

21 January 2018

1 reference

https://api.crossref.org/works/10.1177%2F0091270005280297

Efficacy of citalopram in the prevention of recurrent depression in elderly patients: placebo-controlled study of maintenance therapy

21 January 2018

1 reference

https://api.crossref.org/works/10.1177%2F0091270005280297

Treating depression in Alzheimer disease: efficacy and safety of sertraline therapy, and the benefits of depression reduction: the DIADS.

21 January 2018

1 reference

https://api.crossref.org/works/10.1177%2F0091270005280297

Randomized, placebo-controlled, double-blind clinical trial of sertraline in the treatment of depression complicating Alzheimer's disease: initial results from the Depression in Alzheimer's Disease study

21 January 2018

1 reference

https://api.crossref.org/works/10.1177%2F0091270005280297

Efficacy, safety, and tolerability of sertraline in patients with late-life depression and comorbid medical illness

21 January 2018

1 reference

https://api.crossref.org/works/10.1177%2F0091270005280297

Older community residents with depression: long-term treatment with sertraline. Randomised, double-blind, placebo-controlled study

21 January 2018

1 reference

https://api.crossref.org/works/10.1177%2F0091270005280297

Tricyclic antidepressants: contemporary issues for therapeutic practice

21 January 2018

1 reference

https://api.crossref.org/works/10.1177%2F0091270005280297

Psychotropic drugs and the ECG: focus on the QTc interval

21 January 2018

1 reference

https://api.crossref.org/works/10.1177%2F0091270005280297

Conventional and new antidepressant drugs in the elderly

21 January 2018

1 reference

https://api.crossref.org/works/10.1177%2F0091270005280297

Pharmacokinetic drug interactions of new antidepressants: a review of the effects on the metabolism of other drugs

21 January 2018

1 reference

https://api.crossref.org/works/10.1177%2F0091270005280297

The effect of fluoxetine on the pharmacokinetics and psychomotor responses of diazepam.

21 January 2018

1 reference

https://api.crossref.org/works/10.1177%2F0091270005280297

Metabolic drug interactions with new psychotropic agents.

21 January 2018

1 reference

https://api.crossref.org/works/10.1177%2F0091270005280297

Heart block in a patient on propranolol and fluoxetine

21 January 2018

1 reference

https://api.crossref.org/works/10.1177%2F0091270005280297

Inhibition of diazepam metabolism by fluvoxamine: a pharmacokinetic study in normal volunteers.

21 January 2018

1 reference

https://api.crossref.org/works/10.1177%2F0091270005280297

Is therapeutic drug monitoring a case for optimizing clinical outcome and avoiding interactions of the selective serotonin reuptake inhibitors?

21 January 2018

1 reference

https://api.crossref.org/works/10.1177%2F0091270005280297

Venlafaxine: in vitro inhibition of CYP2D6 dependent imipramine and desipramine metabolism; comparative studies with selected SSRIs, and effects on human hepatic CYP3A4, CYP2C9 and CYP1A2.

21 January 2018

1 reference

https://api.crossref.org/works/10.1177%2F0091270005280297

Toward individualized evidence-based medicine: five "N of 1" trials of methylphenidate in geriatric patients

21 January 2018

1 reference

https://api.crossref.org/works/10.1177%2F0091270005280297

Pharmacokinetic and pharmacodynamic drug interactions in the treatment of attention-deficit hyperactivity disorder

21 January 2018

1 reference

https://api.crossref.org/works/10.1177%2F0091270005280297

A study of the effect of age and gender on the pharmacokinetics of nefazodone after single and multiple doses

21 January 2018

1 reference

https://api.crossref.org/works/10.1177%2F0091270005280297

Comparative CYP3A4 inhibitory effects of venlafaxine, fluoxetine, sertraline, and nefazodone in healthy volunteers

21 January 2018

1 reference

https://api.crossref.org/works/10.1177%2F0091270005280297

Drug interactions with cisapride: clinical implications

21 January 2018

1 reference

https://api.crossref.org/works/10.1177%2F0091270005280297

Nefazodone, meta-chlorophenylpiperazine, and their metabolites in vitro: cytochromes mediating transformation, and P450-3A4 inhibitory actions

21 January 2018

1 reference

https://api.crossref.org/works/10.1177%2F0091270005280297

Clinical pharmacokinetics of mirtazapine

21 January 2018

1 reference

https://api.crossref.org/works/10.1177%2F0091270005280297

Modafinil augmentation of mirtazapine in a failure-to-thrive geriatric inpatient

21 January 2018

1 reference

https://api.crossref.org/works/10.1177%2F0091270005280297

Clinical pharmacokinetic profile of modafinil

21 January 2018

1 reference

https://api.crossref.org/works/10.1177%2F0091270005280297

Antipsychotic-Induced movement disorders in the elderly: epidemiology and treatment recommendations

21 January 2018

1 reference

https://api.crossref.org/works/10.1177%2F0091270005280297

Pharmacology of antipsychotics in the elderly: a focus on atypicals

21 January 2018

1 reference

https://api.crossref.org/works/10.1177%2F0091270005280297

Combination risperidone and SSRI-induced serotonin syndrome

21 January 2018

1 reference

https://api.crossref.org/works/10.1177%2F0091270005280297

Role of pharmacogenomics in individualising treatment with SSRIs

21 January 2018

1 reference

https://api.crossref.org/works/10.1177%2F0091270005280297

Plasma concentrations of fluvoxamine and maprotiline in major depression: implications on therapeutic efficacy and side effects

21 January 2018

1 reference

https://api.crossref.org/works/10.1177%2F0091270005280297

Risk of Congestive Heart Failure in an Elderly Population Treated with Peripheral Alpha-1 Antagonists

21 January 2018

1 reference

https://api.crossref.org/works/10.1177%2F0091270005280297

21 January 2018

Identifiers

DOI

10.1177/0091270005280297

1 reference

13 August 2017

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